المؤلفون: Wang, Zhe, Choi, Shing, Chami, Nathalie, Boerwinkle, Eric, Fornage, Myriam, Redline, Susan, Bis, Joshua, Brody, Jennifer, Psaty, Bruce, Kim, Wonji, McDonald, Merry-Lynn, Regan, Elizabeth, Silverman, Edwin, Liu, Ching-Ti, Vasan, Ramachandran, Kalyani, Rita, Mathias, Rasika, Yanek, Lisa, Arnett, Donna, Justice, Anne, North, Kari, Kaplan, Robert, Heckbert, Susan, de Andrade, Mariza, Guo, Xiuqing, Lange, Leslie, Rich, Stephen, Rotter, Jerome, Ellinor, Patrick, Lubitz, Steven, Blangero, John, Shoemaker, M, Darbar, Dawood, Gladwin, Mark, Albert, Christine, Chasman, Daniel, Jackson, Rebecca, Kooperberg, Charles, Reiner, Alexander, OReilly, Paul, Loos, Ruth

مصطلحات موضوعية: BMI - body mass index, C+T, PRS-CS, burden score, lassosum, obesity risk, polygenic risk score, rare variants, Gene Frequency, Genetic Variation, Genome-Wide Association Study, Humans, Obesity, Whole Genome Sequencing

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/31h846sx

المؤلفون: Zhe Wang, Shing Wan Choi, Nathalie Chami, Eric Boerwinkle, Myriam Fornage, Susan Redline, Joshua C. Bis, Jennifer A. Brody, Bruce M. Psaty, Wonji Kim, Merry-Lynn N. McDonald, Elizabeth A. Regan, Edwin K. Silverman, Ching-Ti Liu, Ramachandran S. Vasan, Rita R. Kalyani, Rasika A. Mathias, Lisa R. Yanek, Donna K. Arnett, Anne E. Justice, Kari E. North, Robert Kaplan, Susan R. Heckbert, Mariza de Andrade, Xiuqing Guo, Leslie A. Lange, Stephen S. Rich, Jerome I. Rotter, Patrick T. Ellinor, Steven A. Lubitz, John Blangero, M. Benjamin Shoemaker, Dawood Darbar, Mark T. Gladwin, Christine M. Albert, Daniel I. Chasman, Rebecca D. Jackson, Charles Kooperberg, Alexander P. Reiner, Paul F. O’Reilly, Ruth J. F. Loos

المصدر: Wang, Z, Choi, S W, Chami, N, Boerwinkle, E, Fornage, M, Redline, S, Bis, J C, Brody, J A, Psaty, B M, Kim, W, McDonald, M L N, Regan, E A, Silverman, E K, Liu, C T, Vasan, R S, Kalyani, R R, Mathias, R A, Yanek, L R, Arnett, D K, Justice, A E, North, K E, Kaplan, R, Heckbert, SR, de Andrade, M, Guo, X, Lange, L A, Rich, SS, Rotter, J I, Ellinor, P T, Lubitz, S A, Blangero, J, Shoemaker, M B, Darbar, D, Gladwin, M T, Albert, C M, Chasman, D I, Jackson, R D, Kooperberg, C, Reiner, A P, O’Reilly, P F & Loos, R J F 2022, ' The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations ', Frontiers in Endocrinology, vol. 13, 863893 . https://doi.org/10.3389/fendo.2022.863893

مصطلحات موضوعية: burden score, Whole Genome Sequencing, Endocrinology, Diabetes and Metabolism, C+T, Genetic Variation, BMI - body mass index, lassosum, rare variants, PRS-CS, Gene Frequency, obesity risk, polygenic risk score, Humans, Obesity, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c0cfe4da51a038f55313787d41df13
https://doi.org/10.3389/fendo.2022.863893

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المؤلفون: Michael G. B. Blum, Florian Privé, Bjarni J. Vilhjálmsson, Hugues Aschard

المساهمون: Biologie Computationnelle et Mathématique (TIMC-IMAG-BCM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Aarhus University [Aarhus], Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), F.P. and M.G.B.B. acknowledge LabEx PERSYVAL-Lab (ANR-11-LABX-0025-01) and ANR project FROGH (ANR-16-CE12-0033). F.P. and M.G.B.B. also acknowledge the Grenoble Alpes Data Institute that is supported by the French National Research Agency under the 'Investissements d’avenir' program (ANR-15-IDEX-02). F.P. and B.J.V. acknowledge Niels Bohr Professorship from the Danish National Research Foundation to Prof. John J. McGrath, and the Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH (R248-2017-2003). This research has been conducted using the UK Biobank Resource under Application Number 25589., ANR-11-LABX-0025,PERSYVAL-lab,Systemes et Algorithmes Pervasifs au confluent des mondes physique et numérique(2011), ANR-16-CE12-0033,FROGH,Etude Génétique de la Population Française(2016), ANR-15-IDEX-0002,UGA,IDEX UGA(2015), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2019, 105 (6), pp.1213-1221. ⟨10.1016/j.ajhg.2019.11.001⟩
Am J Hum Genet
American Journal of Human Genetics, 2019, 105 (6), pp.1213-1221. ⟨10.1016/j.ajhg.2019.11.001⟩
Privé, F, Vilhjálmsson, B J, Aschard, H & Blum, M G B 2019, ' Making the Most of Clumping and Thresholding for Polygenic Scores ', American Journal of Human Genetics, vol. 105, no. 6, pp. 1213-1221 . https://doi.org/10.1016/j.ajhg.2019.11.001

مصطلحات موضوعية: 0301 basic medicine, MESH: United Kingdom, Multifactorial Inheritance, C+T, PRS, 0302 clinical medicine, Statistics, MESH: Disease, Disease, MESH: Models, Genetic, Linear combination, Genetics (clinical), Mathematics, Biological Specimen Banks, 0303 health sciences, Training set, MESH: Biological Specimen Banks, MESH: Polymorphism, Single Nucleotide, MESH: Genetic Predisposition to Disease, Thresholding, MESH: Case-Control Studies, 3. Good health, polygenic risk scores, stacking, [STAT.ME]Statistics [stat]/Methodology [stat.ME], Algorithms, UK Biobank, MESH: Algorithms, Polymorphism, Single Nucleotide, Article, Set (abstract data type), complex traits, 03 medical and health sciences, Single node, MESH: Computer Simulation, Genetics, Humans, Computer Simulation, Genetic Predisposition to Disease, p-value, 030304 developmental biology, Penalized regression, MESH: Humans, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Models, Genetic, clumping and thresholding, United Kingdom, 030104 developmental biology, Case-Control Studies, MESH: Genome-Wide Association Study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Multifactorial Inheritance, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], 030217 neurology & neurosurgery, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477fe48dcfd1abdc7996cb2d6df19263
https://hal.archives-ouvertes.fr/hal-02414984/file/S0002929719304227.pdf

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المؤلفون: Miguel Fernando Pacheco Muñoz

المصدر: Universidad Nacional Autónoma de México
UNAM
Redalyc-UNAM
Redes (Argentina) Num.25 Vol.12
Redes
RIDAA (UNQ)
Universidad Nacional de Quilmes
instacron:UNQ

مصطلحات موضوعية: Divulgación científica, Estudios sociales de la ciencia, Popularization of science, MUSEOS DE CIENCIA – DIVULGACIÓN DE LA CIENCIA – ESTUDIOS EN CIENCIA, Social studies of science, S&T museums, Museus de C&T, TECNOLOGÍA Y SOCIEDAD (CTS), Museos de C+T, Estudos sociais da ciência, Sociología, Divulgação científica

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22def47a85877eb0cffe2138ed626a34
https://www.redalyc.org/articulo.oa?id=90702507

المؤلفون: Villanueva, Ernesto F.

المصدر: Redes
RIDAA (UNQ)
Universidad Nacional de Quilmes
instacron:UNQ

مصطلحات موضوعية: Universities, Public policy, Sistema nacional de C+T, Argentina, Políticas públicas, Universidades, Argentine, National S&T system

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3056::85576ddca24f048bc45b12eba8a20a83
http://ridaa.unq.edu.ar/handle/20.500.11807/591

المؤلفون: Marí, Manuel, Estébanez, María Elina, Suárez, Daniel

المصدر: Redes
RIDAA (UNQ)
Universidad Nacional de Quilmes
instacron:UNQ

مصطلحات موضوعية: P&D, Mercosur, R&D, Argentina, International S&T cooperation, Argentine, I+D, Mercosul, Cooperación internacional en C+T, Cooperação internacional em C&T

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3056::bc89b460ef4502d23a850b12cf61ed18
http://ridaa.unq.edu.ar/handle/20.500.11807/675

المؤلفون: Dal Poz, María Ester, Brisolla, Sandra de Negraes

المصدر: Redes
RIDAA (UNQ)
Universidad Nacional de Quilmes
instacron:UNQ

مصطلحات موضوعية: Innovaciones, Pesquisa científica, Inovações, Research, Estados Unidos, Conhecimento, EUA, Genética, United States, Knowledge, Conocimiento, Investigación, Genetics, International S&T cooperation, Innovations, Cooperación internacional en C+T, Cooperação internacional em C&T

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3056::2da88608ded333297e0029d5f6a728bf
http://ridaa.unq.edu.ar/handle/20.500.11807/677

المؤلفون: Bonfiglioli, Alberto, Mari, Eduardo A.

المصدر: Redes
RIDAA (UNQ)
Universidad Nacional de Quilmes
instacron:UNQ

مصطلحات موضوعية: Science and technology policy, Pesquisa científica, Economics, Research, Economia, Economía, Europe, Latin America, Política científica y tecnológica, América Latina, Investigación, International S&T cooperation, Política científica e tecnológica, Europa, Cooperación internacional en C+T, Cooperação internacional em C&T

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3056::d0586b706385cdf88c7e9ff2faaa1ebc
http://ridaa.unq.edu.ar/handle/20.500.11807/707