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1
المؤلفون: David Gallo, Jordan T. F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Vivek Bhaskaran, Yael Mamane, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel K. Szilard, Ján Tkáč, Shou Yun Yin, Stephen J. Morris, Michael Zinda, C. Gary Marshall, Daniel Durocher
المصدر: Nature. 604:749-756
مصطلحات موضوعية: Gene Expression Regulation, Neoplastic, Ovarian Neoplasms, Multidisciplinary, Neoplasms, CDC2 Protein Kinase, Cyclin E, Gene Amplification, Humans, Membrane Proteins, Female, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Synthetic Lethal Mutations
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المؤلفون: Prasanthi Geda, Mark A. McCoy, Liping Yang, Chaomin Li, Armetta D. Hill, Xavier Fradera, Marianne L. Spatz, Matthew Ernst Voss, Carolyn Michele Cammarano, Pierre Daublain, Xiao Wang, Christopher F. Thompson, B. Wesley Trotter, C. Gary Marshall, Michael H. Reutershan, Peter Goldenblatt, Latha G. Nair, Manami Shizuka, Tammie C. Yeh, John G. Cryan, Isabelle Dussault, Michelle Martinez, Mingmei Cai, Raymond A. Kemper, Binyuan Sun, Michelle R. Machacek, Dietrich Steinhuebel, Giovanna Scapin, Michael D. Altman, Stephane L. Bogen, Matthew Christopher, Dapeng Chen, Victoria Kutilek, Weidong Pan
المصدر: Journal of Medicinal Chemistry. 64:16213-16241
مصطلحات موضوعية: Chemistry, Clinical investigation, Drug Discovery, P53 protein, Molecular Medicine, Computational biology
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المؤلفون: Michael H, Reutershan, Michelle R, Machacek, Michael D, Altman, Stephane, Bogen, Mingmei, Cai, Carolyn, Cammarano, Dapeng, Chen, Matthew, Christopher, John, Cryan, Pierre, Daublain, Xavier, Fradera, Prasanthi, Geda, Peter, Goldenblatt, Armetta D, Hill, Raymond A, Kemper, Victoria, Kutilek, Chaomin, Li, Michelle, Martinez, Mark, McCoy, Latha, Nair, Weidong, Pan, Christopher F, Thompson, Giovanna, Scapin, Manami, Shizuka, Marianne L, Spatz, Dietrich, Steinhuebel, Binyuan, Sun, Matthew E, Voss, Xiao, Wang, Liping, Yang, Tammie C, Yeh, Isabelle, Dussault, C Gary, Marshall, B Wesley, Trotter
المصدر: Journal of medicinal chemistry. 64(21)
مصطلحات موضوعية: Structure-Activity Relationship, Pyridines, Imidazoles, Humans, Proto-Oncogene Proteins c-mdm2, Tumor Suppressor Protein p53, Protein Binding
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4
المؤلفون: Jimmy Fourtounis, John Martino, Rino Stocco, Prasamit Baruah, Nicole Duffy, David Gallo, Sarah Fournier, JingJing Li, Li Li, Elia Aguado, Adam Petrone, Anne Roulston, Yael Mamane, Stephen Morris, Janek Szychowski, Robert Papp, Mike Zinda, C. Gary Marshall
المصدر: Cancer Research. 82:5650-5650
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a8d370be8d0cc60aefdb6d80a50f5ca6
https://doi.org/10.1158/1538-7445.am2022-5650 -
5Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease
المؤلفون: Patricia Schroeder, Keertik Fulzele, Sanjeev Forsyth, Maria D. Ribadeneira, Sylvie Guichard, Erik Wilker, C. Gary Marshall, Adam Drake, Rose Fessler, Diamantis G. Konstantinidis, Katie G. Seu, Theodosia A. Kalfa
المصدر: The Journal of pharmacology and experimental therapeutics. 380(3)
مصطلحات موضوعية: Pharmacology, 2,3-Diphosphoglycerate, Oxygen, Hemoglobins, Adenosine Triphosphate, Erythrocytes, Hemoglobin, Sickle, Pyruvate Kinase, Pyruvic Acid, Molecular Medicine, Animals, Humans, Anemia, Sickle Cell
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cbce16bbd434376b51615d214eb089
https://pubmed.ncbi.nlm.nih.gov/35031585 -
6دورية أكاديمية
المؤلفون: Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz, Eric Bachman, Alexander A Szewczak, Deborah Walker, Lin Xu, Melaney Bouthillette, Kaleen M Childers, Brian Dolinski, Andrew M Haidle, Johnny Kopinja, Linda Lee, Jongwon Lim, Kevin D Little, Yanhong Ma, Anjili Mathur, Jan-Rung Mo, Erin O'Hare, Ryan D Otte, Brandon M Taoka, Wenxian Wang, Hong Yin, Anna A Zabierek, Weisheng Zhang, Shuxia Zhao, Joe Zhu, Jonathan R Young, C Gary Marshall
المصدر: PLoS ONE, Vol 7, Iss 5, p e37207 (2012)
وصف الملف: electronic resource
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المؤلفون: Ross L. Levine, Chiara Conti, Lanzhu Yue, Eva Sahakian, Nathan P. Horvat, Amit Verma, John Powers, Narmin E. Amin, Afua A. Akuffo, Kenneth L. Wright, C. Gary Marshall, Pui Yee Ng, Ling Zhang, Javier Pinilla-Ibarz, Xiaozhang Zheng, John M. Koomen, Julia M.R. Billington, Zonghong Shao, Matthew Beatty, Lancia Darville, Christelle M. Colin, Pearlie K. Epling-Burnette, Eduardo M. Sotomayor, Que T. Lambert-Showers, Jennifer Y. Lee, Matthew W. Martin, Gary W. Reuther, Cem Murdun, H. Leighton Grimes, William E. Goodheart, Vasundhara Sharma
المصدر: Blood
مصطلحات موضوعية: Immunology, Population, Apoptosis, Biology, Biochemistry, Histone Deacetylases, Mice, medicine, Tumor Cells, Cultured, Animals, Humans, Progenitor cell, education, Cell Proliferation, Mice, Knockout, education.field_of_study, Myeloproliferative Disorders, Myeloid Neoplasia, HDAC11, Cell Cycle, food and beverages, Cell Biology, Hematology, Janus Kinase 1, Oncogenes, Hematopoiesis, Transplantation, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, Haematopoiesis, STAT Transcription Factors, medicine.anatomical_structure, Mutation, Cancer research, Histone deacetylase, Bone marrow, Stem cell
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634ceea44a77557b60fe813516a9e8b7
https://pubmed.ncbi.nlm.nih.gov/31750881 -
8
المؤلفون: C. Gary Marshall, Maureen S. Lynes, Collis Alan John, Lili Yao, Kshama Doshi, Pui Yee Ng, Aleksandra Rudnitskaya, Jennifer R. Thomason, Monica A. Alvarez Morales, Xiaozhang Zheng, Matthew W. Martin, Bingsong Han, Jennifer Y. Lee, David R. Lancia, Chiara Conti
المصدر: Bioorganicmedicinal chemistry letters. 28(12)
مصطلحات موضوعية: 0301 basic medicine, Male, Cellular activity, Clinical Biochemistry, Pharmaceutical Science, Mice, Nude, Isoindoles, Biochemistry, Histone Deacetylases, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Mice, Inbred BALB C, Hydroxamic acid, Dose-Response Relationship, Drug, Molecular Structure, HDAC11, Organic Chemistry, Isoindoline, Recombinant Proteins, 030104 developmental biology, chemistry, Molecular Medicine
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المؤلفون: Lin Xu, Grace Chan, Melaney Bouthillette, Craig Rosenstein, Sathyajith E. Kumarasinghe, C. Gary Marshall, Tony Siu, Anjili Mathur, Alan B. Northrup, Michael D. Altman, Christopher J. Dinsmore, Matthew H. Katcher, Catherine White, Eric Bachman, Jonathan R. Young
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:1466-1471
مصطلحات موضوعية: Molecular model, Pyridones, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Molecular Dynamics Simulation, Biochemistry, Structure-Activity Relationship, Adenosine Triphosphate, In vivo, Drug Discovery, Animals, Potency, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Binding Sites, Janus kinase 2, biology, Chemistry, Kinase, Organic Chemistry, Janus Kinase 2, Protein Structure, Tertiary, Rats, Lipophilicity, biology.protein, Molecular Medicine, Selectivity, Half-Life, Tricyclic
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المؤلفون: Ryan D. Otte, Sujata Sharma, Jongwon Lim, Hua-Poo Su, Lin Xu, Brandon M. Taoka, Grace Chan, C. Gary Marshall, Kerrie Spencer, Michael D. Altman, Christopher J. Dinsmore, Hong Yin, Craig Rosenstein, Jonathan R. Young, Joan Zugay-Murphy, Alexander A. Szewczak
المصدر: Journal of Medicinal Chemistry. 54:7334-7349
مصطلحات موضوعية: Models, Molecular, Indoles, Pyridines, medicine.drug_class, Administration, Oral, Carboxamide, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Mice, Structure-Activity Relationship, Dogs, Myeloproliferative Disorders, Drug Discovery, medicine, Animals, Phosphorylation, Polycythemia Vera, Cell potency, Mutation, Janus kinase 2, Molecular Structure, biology, Hyperactivation, Chemistry, Point mutation, Stereoisomerism, Haplorhini, Janus Kinase 2, Rats, Mice, Inbred C57BL, Pyrimidines, Hepatocytes, biology.protein, Molecular Medicine, Tyrosine kinase, Carbolines