المؤلفون: Kobayashi N; Tokyo University of Agriculture and Technology, Fuchu-shi, Japan., Iwaide S; Tokyo University of Agriculture and Technology, Fuchu-shi, Japan., Fukui H; Okayama University of Science, Imabari-shi, Japan., Une Y; Okayama University of Science, Imabari-shi, Japan., Itoh Y; Tokyo University of Agriculture and Technology, Fuchu-shi, Japan., Hisada M; Tokyo University of Agriculture and Technology, Fuchu-shi, Japan., Murakami T; Tokyo University of Agriculture and Technology, Fuchu-shi, Japan.

المصدر: Veterinary pathology [Vet Pathol] 2024 Jul; Vol. 61 (4), pp. 574-581. Date of Electronic Publication: 2024 Feb 12.

نوع المنشور: Journal Article; Case Reports

بيانات الدورية: Publisher: Sage Country of Publication: United States NLM ID: 0312020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1544-2217 (Electronic) Linking ISSN: 03009858 NLM ISO Abbreviation: Vet Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Lions* , Amyloidosis*/veterinary , Amyloidosis*/pathology , Amyloidosis*/metabolism , Apolipoprotein C-III*/genetics , Apolipoprotein C-III*/metabolism, Animals ; Male ; Female ; Kidney/pathology ; Amino Acid Sequence ; Amyloid/metabolism ; Kidney Diseases/veterinary ; Kidney Diseases/pathology ; Immunohistochemistry/veterinary

المؤلفون: Valdivielso P; Lipid Unit, Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Departamento de Medicina y Dermatología, Instituto de Investigación Biomédica (IBIMA-Plataforma BIONAND), Universidad de Málaga, Málaga, Spain. Electronic address: valdivielso@uma.es., Coca Prieto I; Lipid Unit, Servicio de Medicina Interna, Hospital Universitario Virgen de la Victoria, Departamento de Medicina y Dermatología, Instituto de Investigación Biomédica (IBIMA-Plataforma BIONAND), Universidad de Málaga, Málaga, Spain.

المصدر: Med (New York, N.Y.) [Med] 2024 Jun 14; Vol. 5 (6), pp. 493-494.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101769215 Publication Model: Print Cited Medium: Internet ISSN: 2666-6340 (Electronic) Linking ISSN: 26666340 NLM ISO Abbreviation: Med Subsets: MEDLINE

مواضيع طبية MeSH: Apolipoprotein C-III*/genetics , Apolipoprotein C-III*/blood , Hyperlipoproteinemia Type I*/genetics , Hyperlipoproteinemia Type I*/blood , Oligonucleotides*/pharmacology , Oligonucleotides*/therapeutic use , Triglycerides*/blood, Humans ; Oligonucleotides, Antisense/pharmacology ; Oligonucleotides, Antisense/therapeutic use ; Pancreatitis/genetics ; Benzimidazoles

SCR Disease Name: Familial hyperchylomicronemia syndrome

المؤلفون: Chan DC; Medical School, University of Western Australia., Watts GF; Medical School, University of Western Australia.; Lipid Disorders Clinic, Department of Cardiology and Internal Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.

المصدر: Current opinion in lipidology [Curr Opin Lipidol] 2024 Jun 01; Vol. 35 (3), pp. 101-109. Date of Electronic Publication: 2024 Feb 19.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9010000 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-6535 (Electronic) Linking ISSN: 09579672 NLM ISO Abbreviation: Curr Opin Lipidol Subsets: MEDLINE

مواضيع طبية MeSH: Apolipoprotein C-III*/antagonists & inhibitors , Apolipoprotein C-III*/blood , Apolipoprotein C-III*/metabolism , Angiopoietin-Like Protein 3* , Angiopoietin-like Proteins*/antagonists & inhibitors , Angiopoietin-like Proteins*/metabolism , Hypertriglyceridemia*/drug therapy , Hypertriglyceridemia*/blood , Hypertriglyceridemia*/metabolism , Angiopoietins*/metabolism , Angiopoietins*/antagonists & inhibitors, Humans ; Animals ; Triglycerides/blood ; Triglycerides/metabolism ; Clinical Trials as Topic

المؤلفون: Koska J; Phoenix VA Health Care System, 650 E Indian School Rd CS111E, Phoenix, AZ, 85012, USA. Electronic address: juraj.koska@va.gov., Hansen S; Department of Biostatistics, University of Washington, 6200 NE 74th St. Bldg. 29 Suite 210, Seattle, WA, 98115, USA., Hu Y; Isoformix Inc., 202 Industrial Blvd Suite 404, Sugar Land, TX, 77478, USA., Jensen MC; Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA; Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1353, Copenhagen, Denmark., Billheimer D; Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N Martin Ave, Tucson, AZ, 85724, USA., Nedelkov D; Isoformix Inc., 202 Industrial Blvd Suite 404, Sugar Land, TX, 77478, USA., Budoff MJ; Lundquist Institute at Harbor-University of California, Los Angeles (UCLA), 1124 W Carson St., Torrance, CA, 90502, USA., Allison M; Department of Family Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., McClelland RL; Department of Biostatistics, University of Washington, 6200 NE 74th St. Bldg. 29 Suite 210, Seattle, WA, 98115, USA., Reaven PD; Phoenix VA Health Care System, 650 E Indian School Rd CS111E, Phoenix, AZ, 85012, USA.

المصدر: Atherosclerosis [Atherosclerosis] 2024 Aug; Vol. 395, pp. 117584. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article; Multicenter Study

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE

مواضيع طبية MeSH: Peripheral Arterial Disease*/blood , Peripheral Arterial Disease*/ethnology , Peripheral Arterial Disease*/diagnosis , Peripheral Arterial Disease*/physiopathology , Ankle Brachial Index* , Apolipoprotein C-III*/blood, Humans ; Male ; Female ; Middle Aged ; Aged ; United States/epidemiology ; Aged, 80 and over ; Biomarkers/blood ; Risk Factors ; Atherosclerosis/blood ; Atherosclerosis/ethnology ; Atherosclerosis/diagnosis ; Glycosylation ; Risk Assessment ; Time Factors

المؤلفون: Wang J; Atherosclerosis Laboratory, ANZAC Research Institute, Concord Repatriation General Hospital and the University of Sydney, Sydney, Australia., Kockx M; Atherosclerosis Laboratory, ANZAC Research Institute, Concord Repatriation General Hospital and the University of Sydney, Sydney, Australia., Bolek M; Atherosclerosis Laboratory, ANZAC Research Institute, Concord Repatriation General Hospital and the University of Sydney, Sydney, Australia., Lambert T; Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Collaborative Centre for Cardiometabolic Health, Charles Perkins Centre, University of Sydney, Sydney, Australia., Sullivan D; Department of Chemical Pathology, Royal Prince Alfred Hospital, Sydney, Australia; Central Clinical Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia., Chow V; Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Collaborative Centre for Cardiometabolic Health, Charles Perkins Centre, University of Sydney, Sydney, Australia; Department of Cardiology, Concord Repatriation General Hospital, Sydney, Australia., Kritharides L; Atherosclerosis Laboratory, ANZAC Research Institute, Concord Repatriation General Hospital and the University of Sydney, Sydney, Australia; Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Cardiology, Concord Repatriation General Hospital, Sydney, Australia. Electronic address: leonard.kritharides@sydney.edu.au.

المصدر: Journal of lipid research [J Lipid Res] 2024 Jul; Vol. 65 (7), pp. 100577. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

مواضيع طبية MeSH: Schizophrenia*/blood , Schizophrenia*/metabolism , Triglycerides*/blood , Cholesterol*/blood , Lipoproteins*/blood , Apolipoprotein C-III*/blood , Apolipoproteins E*/blood, Humans ; Male ; Female ; Adult ; Middle Aged ; Angiopoietin-Like Protein 4/blood ; Angiopoietin-like Proteins/blood ; Apolipoprotein C-II/blood ; Angiopoietin-Like Protein 8 ; Angiopoietin-Like Protein 3/blood ; Case-Control Studies ; Peptide Hormones/blood

المؤلفون: Gaudet D; ECOGENE-21 QC, Department of Medicine, Université de Montréal, Montréal, Quebec, Canada., Pall D; Department of Medical Clinical Pharmacology, University of Debrecen, Debrecen, Hungary., Watts GF; Department of Cardiology, Royal Perth Hospital, School of Medicine, University of Western Australia, Perth, Western Australia, Australia., Nicholls SJ; Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia., Rosenson RS; Icahn School of Medicine at Mt Sinai, Mount Sinai, New York., Modesto K; Arrowhead Pharmaceuticals, Pasadena, California., San Martin J; Arrowhead Pharmaceuticals, Pasadena, California., Hellawell J; Arrowhead Pharmaceuticals, Pasadena, California., Ballantyne CM; Texas Heart Institute, Baylor College of Medicine, Houston, Texas.

المصدر: JAMA cardiology [JAMA Cardiol] 2024 Jul 01; Vol. 9 (7), pp. 620-630.

نوع المنشور: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101676033 Publication Model: Print Cited Medium: Internet ISSN: 2380-6591 (Electronic) NLM ISO Abbreviation: JAMA Cardiol Subsets: MEDLINE

مواضيع طبية MeSH: Hypertriglyceridemia*/drug therapy , Hypertriglyceridemia*/blood , Hypertriglyceridemia*/complications , Apolipoprotein C-III*/blood , Triglycerides*/blood, Humans ; Male ; Female ; Middle Aged ; Double-Blind Method ; Adult ; Dose-Response Relationship, Drug ; Aged

المؤلفون: Huynh K; Nature Reviews Cardiology, . nrcardio@nature.com.

المصدر: Nature reviews. Cardiology [Nat Rev Cardiol] 2024 Jun; Vol. 21 (6), pp. 353.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500075 Publication Model: Print Cited Medium: Internet ISSN: 1759-5010 (Electronic) Linking ISSN: 17595002 NLM ISO Abbreviation: Nat Rev Cardiol Subsets: MEDLINE

مواضيع طبية MeSH: Hypertriglyceridemia*/blood , Hypertriglyceridemia*/therapy , Hypertriglyceridemia*/drug therapy , Triglycerides*/blood , Apolipoprotein C-III*/blood, Humans

المؤلفون: Naber A; Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., Demus D; Center for Proteomics and Metabolomics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands., Slieker RC; Department of Cell and Chemical Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands., Nicolardi S; Center for Proteomics and Metabolomics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands., Beulens JWJ; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.; Amsterdam Public Health, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Elders PJM; Department of General Practice, Amsterdam Public Health Institute, Amsterdam UMC, Location VUmc, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands., Lieverse AG; Department of Internal Medicine, Maxima Medical Center, P.O. Box 90052, 5600 PD Eindhoven, The Netherlands., Sijbrands EJG; Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., 't Hart LM; Department of Cell and Chemical Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.; Amsterdam Public Health, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.; Department of Biomedical Data Science, Section Molecular Epidemiology, Leiden University Medical Center, Postal Zone S5-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands., Wuhrer M; Center for Proteomics and Metabolomics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands., van Hoek M; Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 14; Vol. 25 (10). Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Apolipoprotein C-III*/genetics , Apolipoprotein C-III*/metabolism , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/genetics, Aged ; Female ; Humans ; Male ; Middle Aged ; Diabetic Angiopathies/metabolism ; Diabetic Angiopathies/genetics ; Diabetic Angiopathies/etiology ; Diabetic Retinopathy/metabolism ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/etiology ; Glycosylation ; Polymorphism, Single Nucleotide

المؤلفون: Cervantes J; Division of Metabolism, Endocrinology, and Nutrition, UW Medicine Diabetes Institute, University of Washington, Seattle, Washington, USA., Koska J; VA Phoenix Health Care System, Phoenix, Arizona, USA., Kramer F; Division of Metabolism, Endocrinology, and Nutrition, UW Medicine Diabetes Institute, University of Washington, Seattle, Washington, USA., Akilesh S; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA., Alpers CE; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA., Mullick AE; Ionis Pharmaceuticals, Carlsbad, California, USA., Reaven P; VA Phoenix Health Care System, Phoenix, Arizona, USA., Kanter JE; Division of Metabolism, Endocrinology, and Nutrition, UW Medicine Diabetes Institute, University of Washington, Seattle, Washington, USA.

المصدر: JCI insight [JCI Insight] 2024 May 14; Vol. 9 (12). Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Apolipoprotein C-III*/genetics , Apolipoprotein C-III*/blood , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/etiology , Diabetic Nephropathies*/blood , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/metabolism , Atherosclerosis*/metabolism , Atherosclerosis*/etiology, Animals ; Mice ; Humans ; Male ; Female ; Middle Aged ; Aged ; Oligonucleotides, Antisense/pharmacology ; Disease Models, Animal

المؤلفون: Bergmark BA; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Marston NA; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Prohaska TA; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Alexander VJ; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Zimerman A; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Moura FA; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Murphy SA; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Goodrich EL; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Zhang S; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Gaudet D; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Karwatowska-Prokopczuk E; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Tsimikas S; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Giugliano RP; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.)., Sabatine MS; From the TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston (B.A.B., N.A.M., A.Z., F.A.M., S.A.M., E.L.G., S.Z., R.P.G., M.S.S.); Ionis Pharmaceuticals, Carlsbad (T.A.P., V.J.A., E.K.-P., S.T.), and the Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T.) - both in California; and the Department of Medicine, Université de Montréal and Ecogene-21 Clinical Research Centre, Quebec, QC, Canada (D.G.).

مؤلفون مشاركون: Bridge–TIMI 73a Investigators

المصدر: The New England journal of medicine [N Engl J Med] 2024 May 16; Vol. 390 (19), pp. 1770-1780. Date of Electronic Publication: 2024 Apr 07.

نوع المنشور: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II

بيانات الدورية: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE

مواضيع طبية MeSH: Hypertriglyceridemia*/drug therapy , Hypertriglyceridemia*/complications , Hypertriglyceridemia*/blood , Apolipoprotein C-III*/blood , Triglycerides*/blood , Cardiovascular Diseases*/prevention & control , Cardiovascular Diseases*/etiology , Oligonucleotides*/therapeutic use , Oligonucleotides*/adverse effects, Humans ; Middle Aged ; Male ; Female ; Aged ; Adult ; Double-Blind Method ; Oligonucleotides, Antisense/therapeutic use ; Oligonucleotides, Antisense/adverse effects ; Heart Disease Risk Factors ; Cholesterol, LDL/blood ; Hypolipidemic Agents/therapeutic use ; Hypolipidemic Agents/adverse effects ; Apolipoproteins B/blood