المؤلفون: Girish Bankar, Samuel J. Goodchild, Sarah Howard, Karen Nelkenbrecher, Matthew Waldbrook, Michelle Dourado, Noah G. Shuart, Sophia Lin, Clint Young, Zhiwei Xie, Kuldip Khakh, Elaine Chang, Luis E. Sojo, Andrea Lindgren, Sultan Chowdhury, Shannon Decker, Michael Grimwood, Jean-Christophe Andrez, Christoph M. Dehnhardt, Jodie Pang, Jae H. Chang, Brian S. Safina, Daniel P. Sutherlin, James P. Johnson, Jr., David H. Hackos, C. Lee Robinette, Charles J. Cohen

المصدر: Cell Reports, Vol 24, Iss 12, Pp 3133-3145 (2018)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124718313676; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/751235f9fe504fde8c6781b6215d87d8

المؤلفون: Sultan Chowdhury, Christoph Martin Dehnhardt, Tao Sheng, Clint Young, Rainbow Kwan, Michael Scott Wilson, Jun Chen, Matthew Waldbrook, Dinah Misner, C. Lee Robinette, Rebecca M. Reese, Elaine Chang, Henry Verschoof, Tanja S. Zabka, Girish Bankar, Philippe Bergeron, Luis Sojo, Karen Nelkenbrecher, Daniel P. Sutherlin, Amy Kim, Ivan William Hemeon, Andrea Lindgren, Jae H. Chang, Alla Yurevna Zenova, Shaoyi Sun, Jonathan Maher, Shannon D. Shields, Jun Li, Daniel F. Ortwine, David H. Hackos, Zhiwei Xie, Thilo Focken, Charles J. Cohen, Richard T. Dean, Shannon Decker, Janette Mezeyova, Kuldip Khakh, Antonio G. DiPasquale, Chien-An Chen, Andrew D. White, Brian Safina, Jodie Pang, Qi Jia, Sophia Lin, Jean-Christophe Andrez, J. P. Johnson, Steven J. McKerrall

المصدر: Journal of Medicinal Chemistry. 64:2953-2966

مصطلحات موضوعية: 0303 health sciences, Chemistry, Sulfonamide (medicine), Phase 1 trials, Pharmacology, Metabolic stability, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, NAV1, medicine, Molecular Medicine, Dosing, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a9431d81bf8ca2eed0fbbfbb36905
https://doi.org/10.1021/acs.jmedchem.1c00049

المؤلفون: Brian S, Safina, Steven J, McKerrall, Shaoyi, Sun, Chien-An, Chen, Sultan, Chowdhury, Qi, Jia, Jun, Li, Alla Y, Zenova, Jean-Christophe, Andrez, Girish, Bankar, Philippe, Bergeron, Jae H, Chang, Elaine, Chang, Jun, Chen, Richard, Dean, Shannon M, Decker, Antonio, DiPasquale, Thilo, Focken, Ivan, Hemeon, Kuldip, Khakh, Amy, Kim, Rainbow, Kwan, Andrea, Lindgren, Sophia, Lin, Jonathan, Maher, Janette, Mezeyova, Dinah, Misner, Karen, Nelkenbrecher, Jodie, Pang, Rebecca, Reese, Shannon D, Shields, Luis, Sojo, Tao, Sheng, Henry, Verschoof, Matthew, Waldbrook, Michael S, Wilson, Zhiwei, Xie, Clint, Young, Tanja S, Zabka, David H, Hackos, Daniel F, Ortwine, Andrew D, White, J P, Johnson, C Lee, Robinette, Christoph M, Dehnhardt, Charles J, Cohen, Daniel P, Sutherlin

المصدر: Journal of medicinal chemistry. 64(6)

مصطلحات موضوعية: Rats, Sprague-Dawley, Voltage-Gated Sodium Channel Blockers, Sulfonamides, HEK293 Cells, Piperidines, Benzamides, Drug Discovery, NAV1.7 Voltage-Gated Sodium Channel, Animals, Azetidines, Humans, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d744b2a5894fa87236be1caf92c75b8b
https://pubmed.ncbi.nlm.nih.gov/33682420

المؤلفون: Qi Jia, Jean-Christophe Andrez, Charles J. Cohen, Jae H. Chang, Kuldip Khakh, J. P. Johnson, Chien-An Chen, Jun Li, Karen Nelkenbrecher, Thilo Focken, Zhiwei Xie, Daniel F. Ortwine, Brian Safina, Michael Edward Grimwood, Andrew D. White, Christoph Martin Dehnhardt, Shannon Decker, Ivan William Hemeon, David H. Hackos, Sophia Lin, Jodie Pang, Luis Sojo, Girish Bankar, Andrea Lindgren, Matthew Waldbrook, Elaine Chang, C. Lee Robinette, Shaoyi Sun, Antonio G. DiPasquale, Tao Sheng, Clint Young, Rainbow Kwan, Benjamin D. Sellers, Sultan Chowdhury, Michael Scott Wilson, Lunbin Deng, Daniel P. Sutherlin, Alla Yurevna Zenova

المصدر: Journal of Medicinal Chemistry. 62:908-927

مصطلحات موضوعية: 0303 health sciences, Chemistry, Sodium channel, Pharmacology, 01 natural sciences, Molecular Docking Simulation, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, In vivo, Docking (molecular), Drug Discovery, Microsome, Molecular Medicine, Structure–activity relationship, Potency, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f65c95248ff36af0807edf4a8f95cad
https://doi.org/10.1021/acs.jmedchem.8b01621

المؤلفون: Christoph Martin Dehnhardt, Karen Nelkenbrecher, Jean-Christophe Andrez, Zhiwei Xie, David H. Hackos, Michael Edward Grimwood, Jae H. Chang, Sultan Chowdhury, Clint Young, Charles J. Cohen, J. P. Johnson, Elaine Chang, Michelle Dourado, Kuldip Khakh, Noah G. Shuart, Jodie Pang, Matthew Waldbrook, C. Lee Robinette, Sarah Howard, Daniel P. Sutherlin, Girish Bankar, Luis Sojo, Andrea Lindgren, Shannon Decker, Brian Safina, Samuel J. Goodchild, Sophia Lin

المصدر: Cell Reports, Vol 24, Iss 12, Pp 3133-3145 (2018)

مصطلحات موضوعية: 0301 basic medicine, Diabetic neuropathy, business.industry, Sodium channel, Analgesic, Pharmacology, medicine.disease, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), Neuropathic pain, Medicine, Potency, Dosing, business, lcsh:QH301-705.5, IC50, Sensitization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4c353367cd516b2db1286adedfe344
https://doi.org/10.1016/j.celrep.2018.08.063

المؤلفون: Girish Bankar, Charles J. Cohen, Bowen Li, Kuldip Khakh, Sultan Chowdhury, Elaine Chang, Paul Robert Bichler, Christoph Martin Dehnhardt, Daniel P. Sutherlin, Jodie Pang, Michael D. Wilson, Yi Zhang, Zhiwei Xie, Matthew Waldbrook, C. Lee Robinette, Jae H. Chang, Karen Nelkenbrecher, Ivan William Hemeon, Alla Yurevna Zenova, Tao Sheng, Samuel J. Goodchild, Clint Young, Navjot Chahal, Rainbow Kwan, Daniel F. Ortwine, Brian Safina, Sophia Lin, Andrew D. White, Parisa Karimi Tari, Qi Jia, J. P. Johnson, Thilo Focken, Chien-An Chen, David H. Hackos, Shannon Decker, Noah G. Shuart, Luis Sojo, Christine Chabot, Shaoyi Sun, Michael Edward Grimwood

المصدر: Journal of Medicinal Chemistry. 61:4810-4831

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Genetically modified mouse, Stereochemistry, Aryl, Sodium channel, In vitro, Sulfonamide, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, Drug Discovery, Lipophilicity, Molecular Medicine, Potency, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::301a3d7aee1781be0e40a336f69ca411
https://doi.org/10.1021/acs.jmedchem.7b01826

المؤلفون: Shaoyi, Sun, Qi, Jia, Alla Y, Zenova, Michael S, Wilson, Sultan, Chowdhury, Thilo, Focken, Jun, Li, Shannon, Decker, Michael E, Grimwood, Jean-Christophe, Andrez, Ivan, Hemeon, Tao, Sheng, Chien-An, Chen, Andy, White, David H, Hackos, Lunbin, Deng, Girish, Bankar, Kuldip, Khakh, Elaine, Chang, Rainbow, Kwan, Sophia, Lin, Karen, Nelkenbrecher, Benjamin D, Sellers, Antonio G, DiPasquale, Jae, Chang, Jodie, Pang, Luis, Sojo, Andrea, Lindgren, Matthew, Waldbrook, Zhiwei, Xie, Clint, Young, James P, Johnson, C Lee, Robinette, Charles J, Cohen, Brian S, Safina, Daniel P, Sutherlin, Daniel F, Ortwine, Christoph M, Dehnhardt

المصدر: Journal of medicinal chemistry. 62(2)

مصطلحات موضوعية: Male, Voltage-Gated Sodium Channel Blockers, Analgesics, Sulfonamides, Binding Sites, NAV1.7 Voltage-Gated Sodium Channel, Pain, Mice, Transgenic, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Drug Design, Microsomes, Liver, Animals, Humans, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::038f23a54877cc0c450b0a4b2689f99c
https://pubmed.ncbi.nlm.nih.gov/30499663

المؤلفون: Charles J. Cohen, Brian Safina, Daniel P. Sutherlin, Michael Edward Grimwood, Thilo Focken, J. P. Johnson, Shifeng Liu, Maxim Dauphinais, Matthew Waldbrook, C. Lee Robinette, Girish Bankar, Ivan William Hemeon, Noah G. Shuart, Jae H. Chang, Sultan Chowdhury, David Bogucki, Luis Sojo, Clint Young, Rainbow Kwan, Paul Robert Bichler, Renata Oballa, Tarek S. Mansour, Sophia Lin, Christoph Martin Dehnhardt, Jodie Pang, Navjot Chahal

المصدر: ACS Medicinal Chemistry Letters. 7:277-282

مصطلحات موضوعية: 0301 basic medicine, Drug, Gene isoform, biology, Aryl, Sodium channel, media_common.quotation_subject, Organic Chemistry, Analgesic, Pharmacology, Nav1.5, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, Drug Discovery, biology.protein, Potency, 030217 neurology & neurosurgery, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2edc92a10b757ea1080ec9a9cb99aa
https://doi.org/10.1021/acsmedchemlett.5b00447

المؤلفون: Thilo, Focken, Sultan, Chowdhury, Alla, Zenova, Michael E, Grimwood, Christine, Chabot, Tao, Sheng, Ivan, Hemeon, Shannon M, Decker, Michael, Wilson, Paul, Bichler, Qi, Jia, Shaoyi, Sun, Clint, Young, Sophia, Lin, Samuel J, Goodchild, Noah G, Shuart, Elaine, Chang, Zhiwei, Xie, Bowen, Li, Kuldip, Khakh, Girish, Bankar, Matthew, Waldbrook, Rainbow, Kwan, Karen, Nelkenbrecher, Parisa, Karimi Tari, Navjot, Chahal, Luis, Sojo, C Lee, Robinette, Andrew D, White, Chien-An, Chen, Yi, Zhang, Jodie, Pang, Jae H, Chang, David H, Hackos, J P, Johnson, Charles J, Cohen, Daniel F, Ortwine, Daniel P, Sutherlin, Christoph M, Dehnhardt, Brian S, Safina

المصدر: Journal of medicinal chemistry. 61(11)

مصطلحات موضوعية: Voltage-Gated Sodium Channel Blockers, Sulfonamides, NAV1.7 Voltage-Gated Sodium Channel, Molecular Conformation, Pain, Rats, Kinetics, Mice, Dogs, Drug Stability, Drug Design, Animals, Humans, Amino Acid Sequence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::41b8d0a60c84d4f1a2c37587e6288037
https://pubmed.ncbi.nlm.nih.gov/29737846

المؤلفون: Girish, Bankar, Samuel J, Goodchild, Sarah, Howard, Karen, Nelkenbrecher, Matthew, Waldbrook, Michelle, Dourado, Noah G, Shuart, Sophia, Lin, Clint, Young, Zhiwei, Xie, Kuldip, Khakh, Elaine, Chang, Luis E, Sojo, Andrea, Lindgren, Sultan, Chowdhury, Shannon, Decker, Michael, Grimwood, Jean-Christophe, Andrez, Christoph M, Dehnhardt, Jodie, Pang, Jae H, Chang, Brian S, Safina, Daniel P, Sutherlin, James P, Johnson, David H, Hackos, C Lee, Robinette, Charles J, Cohen

المصدر: Cell reports. 24(12)

مصطلحات موضوعية: Analgesics, Inhibitory Concentration 50, Mice, Sulfonamides, Binding Sites, HEK293 Cells, NAV1.7 Voltage-Gated Sodium Channel, Animals, Humans, Neuralgia, Cells, Cultured, Protein Binding, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::24df3eb486dfed5a4642cc263e273e3f
https://pubmed.ncbi.nlm.nih.gov/30231997