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المؤلفون: Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher, Kalindjian, S. Barret, Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
المصدر: Bioorganic & Medicinal Chemistry Letters
Goncalves, M B, Clarke, E, Jarvis, C, Kalindjian, S B, Pitcher, T, Grist, J, Hobbs, C, Carlstedt, T, Jack, J, Brown, J T, Mills, M, Mumford, P, Borthwick, A D & Corcoran, J P T 2019, ' Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury ', Bioorganic & medicinal chemistry letters, vol. 29, no. 8, pp. 995-1000 . https://doi.org/10.1016/j.bmcl.2019.02.011مصطلحات موضوعية: Neurite outgrowth, Retinoic acid receptor, C286, Beta agonist, Axon regrowth, Retinoic acid receptor, Beta agonist, SAR, Neurite outgrowth, Axon regrowth, C286, Article, ComputingMethodologies_COMPUTERGRAPHICS, SAR
وصف الملف: application/pdf
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المؤلفون: Alan D. Borthwick, Jonathan Corcoran, Maria B. Goncalves
المصدر: Bioorganic & Medicinal Chemistry
مصطلحات موضوعية: Nerve injury, Receptors, Retinoic Acid, Clinical Biochemistry, Carboxylic Acids, Retinoic acid, Administration, Oral, Biological Availability, Pharmaceutical Science, Review Article, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Drug Discovery, Embryonic morphogenesis, Humans, AC-261066, Beta agonist, Receptor, Molecular Biology, ComputingMethodologies_COMPUTERGRAPHICS, Molecular Structure, 010405 organic chemistry, Chemistry, Cell growth, Retinoic Acid Receptor alpha, Alpha agonist, Organic Chemistry, Retinoic acid receptor, RAR586, C286, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Nuclear receptor, Apoptosis, Drug Design, Lipophilicity, Molecular Medicine, SAR
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