المؤلفون: Beckers J; Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium., Van Damme P; Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

المصدر: Autophagy [Autophagy] 2024 Sep; Vol. 20 (9), pp. 2102-2104. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE

مواضيع طبية MeSH: C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism , Autophagy*/genetics , Autophagy*/physiology , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/pathology , Lysosomes*/metabolism , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/metabolism , Frontotemporal Dementia*/pathology , Induced Pluripotent Stem Cells*/metabolism , Motor Neurons*/metabolism , Motor Neurons*/pathology, Humans ; Gain of Function Mutation/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Neurons/metabolism ; Sequestosome-1 Protein/metabolism ; Sequestosome-1 Protein/genetics

المؤلفون: Dong D; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Zhang Z; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Li Y; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Latallo MJ; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Wang S; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Nelson B; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Wu R; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Krishnan G; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Gao FB; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Wu B; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Sun S; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

المصدر: Science signaling [Sci Signal] 2024 Aug 06; Vol. 17 (848), pp. eadl1030. Date of Electronic Publication: 2024 Aug 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

مواضيع طبية MeSH: C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/pathology , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/metabolism , Frontotemporal Dementia*/pathology , Neurons*/metabolism , Neurons*/pathology , Induced Pluripotent Stem Cells*/metabolism , DNA Repeat Expansion*/genetics, Humans ; Peptide Chain Elongation, Translational ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/genetics ; Stress, Physiological/genetics ; Ribosomes/metabolism ; Ribosomes/genetics

SCR Disease Name: Frontotemporal Dementia With Motor Neuron Disease

المؤلفون: Steffke C; Institute of Anatomy and Cell Biology, University of Ulm, 89069 Ulm, Germany.; Department of Neurology, University of Ulm, 89069 Ulm, Germany.; International Graduate School in Molecular Medicine of Ulm (IGraDU), University of Ulm, 89069 Ulm, Germany., Agarwal S; Institute of Anatomy and Cell Biology, University of Ulm, 89069 Ulm, Germany., Kabashi E; Institute Imagine, Necker-Enfants Malades Hospital, University Paris Descartes, 75015 Paris, France., Catanese A; Institute of Anatomy and Cell Biology, University of Ulm, 89069 Ulm, Germany.; Institute Imagine, Necker-Enfants Malades Hospital, University Paris Descartes, 75015 Paris, France.

المصدر: Cells [Cells] 2024 Aug 03; Vol. 13 (15). Date of Electronic Publication: 2024 Aug 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Autophagy* , Neurons*/metabolism , Synapses*/metabolism , C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism, Animals ; Cells, Cultured ; Peptides/metabolism ; Humans ; Protein Aggregates

المؤلفون: Wu Y; Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.; Department of Infectious Diseases, Institute of Pediatrics, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, China., Zheng W; Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China., Xu G; Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China., Zhu L; Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China., Li Z; Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China., Chen J; Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China., Wang L; Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China. lianrong@whu.edu.cn.; Department of Infectious Diseases, Institute of Pediatrics, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, China. lianrong@whu.edu.cn., Chen S; Brain Center, Department of Neurosurgery, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China. shichen_2021@163.com.; Department of Burn and Plastic Surgery, Shenzhen Institute of Translational Medicine, Shenzhen Key Laboratory of Microbiology in Genomic Modification & Editing and Application, Guangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen University Medical School, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China. shichen_2021@163.com.

المصدر: Cell death and differentiation [Cell Death Differ] 2024 Aug; Vol. 31 (8), pp. 1070-1084. Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE

مواضيع طبية MeSH: C9orf72 Protein*/metabolism , C9orf72 Protein*/genetics , Lipid Metabolism* , Sterol Regulatory Element Binding Protein 1*/metabolism , Sterol Regulatory Element Binding Protein 1*/genetics , Endoplasmic Reticulum*/metabolism , Liver*/metabolism, Humans ; Animals ; Monomeric GTP-Binding Proteins/metabolism ; Monomeric GTP-Binding Proteins/genetics ; Mice ; COP-Coated Vesicles/metabolism ; Vesicular Transport Proteins/metabolism ; Vesicular Transport Proteins/genetics ; Lipogenesis/genetics

المؤلفون: Jiang L; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia; Perron Institute for Neurological and Translational Science, Perth, Australia; School of Biological Sciences, University of Western Australia, Perth, Australia. Electronic address: leanne.jiang@uq.edu.au., Tracey TJ; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia., Gill MK; School of Biomedical Sciences, The University of Queensland, Brisbane, Australia., Howe SL; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia., Power DT; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia., Bharti V; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., McCombe PA; Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia; Centre for Clinical Research, The University of Queensland, Brisbane, Australia., Henderson RD; Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia; Centre for Clinical Research, The University of Queensland, Brisbane, Australia., Steyn FJ; School of Biomedical Sciences, The University of Queensland, Brisbane, Australia; Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia., Ngo ST; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia; Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia. Electronic address: s.ngo@uq.edu.au.

المصدر: Stem cell research [Stem Cell Res] 2024 Aug; Vol. 78, pp. 103447. Date of Electronic Publication: 2024 May 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/pathology , Amyotrophic Lateral Sclerosis*/metabolism , Induced Pluripotent Stem Cells*/metabolism , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/pathology , Frontotemporal Dementia*/metabolism , C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism , Superoxide Dismutase-1*/genetics , Superoxide Dismutase-1*/metabolism, Humans ; Female ; Male ; Cell Line ; Middle Aged

المؤلفون: Celona B; Cardiovascular Research Institute, University of California, San Francisco, CA 94143., Salomonsson SE; Weill Institute for Neurosciences, University of California, San Francisco, CA 94143.; Memory & Aging Center, Department of Neurology, University of California, San Francisco, CA 94143., Wu H; Cardiovascular Research Institute, University of California, San Francisco, CA 94143.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143., Dang B; Cardiovascular Research Institute, University of California, San Francisco, CA 94143.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143., Kratochvil HT; Cardiovascular Research Institute, University of California, San Francisco, CA 94143.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143., Clelland CD; Weill Institute for Neurosciences, University of California, San Francisco, CA 94143.; Memory & Aging Center, Department of Neurology, University of California, San Francisco, CA 94143., DeGrado WF; Cardiovascular Research Institute, University of California, San Francisco, CA 94143.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143., Black BL; Cardiovascular Research Institute, University of California, San Francisco, CA 94143.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 30; Vol. 121 (31), pp. e2220020121. Date of Electronic Publication: 2024 Jul 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/metabolism , C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism , G-Quadruplexes* , RNA*/metabolism , RNA*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Animals ; Humans ; Mice ; DNA Repeat Expansion ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/genetics ; Protein Binding ; Protein Biosynthesis

المؤلفون: Meng Q; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, Jiangsu 211166, China., Chen J; Department of Pharmacology, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu 210023, China., Liang Y; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, Jiangsu 211166, China., Zhang X; Department of Pharmacology, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu 210023, China., Ding J; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, Jiangsu 211166, China., Fang Y; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, Jiangsu 211166, China. Electronic address: fangyinquan26@njmu.edu.cn., Hu G; Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, Jiangsu 211166, China; Department of Pharmacology, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu 210023, China.

المصدر: Neuroscience letters [Neurosci Lett] 2024 Jul 27; Vol. 836, pp. 137887. Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE

مواضيع طبية MeSH: MicroRNAs*/metabolism , MicroRNAs*/genetics , Apoptosis* , Neurons*/metabolism , Neurons*/pathology , Parkinson Disease*/genetics , Parkinson Disease*/metabolism , Parkinson Disease*/pathology , Autophagy*/physiology , C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism, Animals ; Humans ; Male ; Mice

المؤلفون: Halim DO; Frontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Krishnan G; Frontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Hass EP; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Lee S; Frontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Verma M; Frontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Almeida S; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Gu Y; Neuromuscular & Muscle Disorders, Biogen, Cambridge, MA 02142, USA., Kwon DY; Neuromuscular & Muscle Disorders, Biogen, Cambridge, MA 02142, USA., Fazzio TG; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Gao FB; Frontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address: fen-biao.gao@umassmed.edu.

المصدر: Cell reports [Cell Rep] 2024 Jul 23; Vol. 43 (7), pp. 114375. Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/pathology , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/pathology , Frontotemporal Dementia*/metabolism , Induced Pluripotent Stem Cells*/metabolism , DNA Repeat Expansion*/genetics, Humans ; Motor Neurons/metabolism ; Motor Neurons/pathology

SCR Disease Name: Frontotemporal Dementia With Motor Neuron Disease

المؤلفون: Geng Y; Clinical Research Institute of the First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.; Institute for Advanced Study and State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.; Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China., Liu C; Institute for Advanced Study and State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.; HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen, Guangdong, China., Xu N; Institute for Advanced Study and State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.; HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen, Guangdong, China., Suen MC; Institute for Advanced Study and State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.; HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen, Guangdong, China., Miao H; Institute for Advanced Study and State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China., Xie Y; Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China., Zhang B; Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China., Chen X; Clinical Research Institute of the First Affiliated Hospital of Xiamen University, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China., Song Y; Jiangsu Key Laboratory of Brain Disease Bioinformation, Department of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu, China., Wang Z; Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China., Cai Q; State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China., Zhu G; Institute for Advanced Study and State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.; HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen, Guangdong, China.

المصدر: Nucleic acids research [Nucleic Acids Res] 2024 Jul 22; Vol. 52 (13), pp. 7961-7970.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: C9orf72 Protein*/genetics , C9orf72 Protein*/chemistry , G-Quadruplexes* , Amyotrophic Lateral Sclerosis*/genetics , Frontotemporal Dementia*/genetics , RNA*/chemistry , RNA*/genetics , DNA Repeat Expansion*/genetics, Humans ; Crystallography, X-Ray ; Models, Molecular

SCR Disease Name: Frontotemporal Dementia With Motor Neuron Disease

المؤلفون: Scaber J; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK. Electronic address: jakub.scaber@ndcn.ox.ac.uk., Thomas-Wright I; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Clark AJ; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK; Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Queen Mary University, E1 2AT London, UK., Xu Y; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Chinese Academy of Medical Sciences (CAMS), CAMS Oxford Institute (COI), Nuffield Department of Medicine, University of Oxford, OX3 7FZ Oxford, UK., Vahsen BF; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Carcolé M; UK Dementia Research Institute at UCL and Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, WCIN 3BG London, UK., Dafinca R; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Farrimond L; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Isaacs AM; UK Dementia Research Institute at UCL and Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, WCIN 3BG London, UK., Bennett DL; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK., Talbot K; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK. Electronic address: kevin.talbot@ndcn.ox.ac.uk.

المصدر: Stem cell reports [Stem Cell Reports] 2024 Jul 09; Vol. 19 (7), pp. 957-972. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE

مواضيع طبية MeSH: Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , C9orf72 Protein*/genetics , C9orf72 Protein*/metabolism , Motor Neurons*/metabolism , Sensory Receptor Cells*/metabolism , Axonal Transport* , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/metabolism , Phenotype* , DNA Repeat Expansion*/genetics, Humans