المؤلفون: Kim E. Barrett, Mamata Sivagnanam, Jocelyn Young, Barun Das, Kevin Okamoto, John Rabalais

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1353-1371 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Malabsorption, Cellular differentiation, Mutant, Enteroendocrine cell, RC799-869, IEC, intestinal epithelial cell, Pathogenesis, Mice, chemistry.chemical_compound, UPR, unfolded protein response, Intestinal Mucosa, Original Research, EDM, enteroid-derived monolayer, MVID, microvillous inclusion disease, Gastroenterology, qRT-PCR, quantitative real-time polymerase chain reaction, Cell Differentiation, Epithelial cell adhesion molecule, ELISA, enzyme-linked immunosorbent assay, Congenital Diarrhea, Diseases of the digestive system. Gastroenterology, Epithelial Cell Adhesion Molecule, mRNA, messenger RNA, Cell biology, EpCAM, epithelial cell adhesion molecule, ISC, intestinal stem cell, Defective Enterocyte, Disease Susceptibility, IHC, immunohistochemistry, Signal Transduction, Enteroendocrine Cells, CTE, congenital tufting enteropathy, PBS, phosphate-buffered saline, Notch signaling pathway, CHGA, chromogranin A, Biology, Permeability, Intestinal Failure, Malabsorption Syndromes, medicine, Animals, Humans, Intestinal epithelial cell differentiation, Genetic Predisposition to Disease, NICD, Notch intracellular domain, Hepatology, Congenital Tufting Enteropathy, medicine.disease, Congenital tufting enteropathy, TBS, Tris-buffered saline, Disease Models, Animal, PAS, periodic acid-Schiff, Glucose, Gene Expression Regulation, chemistry, EpCAM, Diarrhea, Infantile, Mutation, Intestinal Cell Differentiation, Cancer research, H&E, hematoxylin and eosin, Biomarkers, Immunostaining

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd57cdfe5b62c31ab3e478c97bd8551
http://www.sciencedirect.com/science/article/pii/S2352345X21001302

المؤلفون: Noah F. Shroyer, Amy C. Engevik, Sridevi Devaraj, Bradley T. Endres, Berkley Luck, James Versalovic, Heather A. Danhof, Faith D. Ihekweazu, Anne Hall, Zhongcheng Shi, Chonnikant Visuthranukul, Kevin W. Garey, Anthony M. Haag, Robert A. Britton, Sigmund J. Haidacher, Melinda A. Engevik, Alexandra Chang-Graham, Joseph M. Hyser, Thomas D. Horvath

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 221-248 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, FISH, fluorescence in situ hybridization, Cell Culture Techniques, Acetates, HIE, human intestinal enteroid, Mice, 0302 clinical medicine, CFU, colony-forming unit, Brain-Gut Axis, LDM4, Lactic Acid Bacteria Defined Media 4, Intestinal Mucosa, SRM, selected reaction monitoring, qPCR, quantitative real-time polymerase chain reaction, Receptor, Serotonin transporter, Original Research, FA, formic acid, CM, conditioned media, Behavior, Animal, biology, Chemistry, Gastroenterology, NGN3, Neurogenin-3, GI, gastrointestinal, Serotonin Transporter, Bifidobacterium dentium, mRNA, messenger RNA, FFAR, free fatty acid receptor, Organoids, Models, Animal, SCFA, short-chain fatty acid, Enterochromaffin cell, LPS, lipopolysaccharide, 030211 gastroenterology & hepatology, Serotonin, ChgA, chromogranin A, PBS, phosphate-buffered saline, In situ hybridization, CNS, central nervous system, Serotonergic, SERT, serotonin transporter, SPF, specific pathogen free, cDNA, complementary DNA, 03 medical and health sciences, 3D, 3-dimensional, Free fatty acid receptor 2, Enterochromaffin Cells, Animals, Germ-Free Life, Humans, MRS, de Man, Rogosa and Sharpe, lcsh:RC799-869, Short-Chain Fatty Acids (SCFAs), ENS, enteric nervous system, Host Microbial Interactions, Hepatology, Probiotics, Free Fatty Acid Receptor (FFAR)2, ISH, in situ hybridization, ACN, acetonitrile, biology.organism_classification, Molecular biology, Gastrointestinal Microbiome, 030104 developmental biology, Receptors, Serotonin, 2D, 2-dimensional, Enteroids, biology.protein, Tph-1, tryptophan hydroxylase-1, lcsh:Diseases of the digestive system. Gastroenterology, Bifidobacterium, LC-MS/MS, liquid chromatography with tandem mass spectrometry, 5-HT, 5-hydroxytryptamine (serotonin), GABA, γ-aminobutyric acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f511aee01ee5a2ae18950cf2bea32bbc
https://doi.org/10.1016/j.jcmgh.2020.08.002

المؤلفون: Jitender Monga, Indra Adrianto, Craig Rogers, Shirish Gadgeel, Dhananjay Chitale, Joshi J. Alumkal, Himisha Beltran, Amina Zoubeidi, Jagadananda Ghosh

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: TRIB2, Tribbles 2, Male, NE, neuroendocrine, Accelerated Communication, transdifferentiation, Cell Plasticity, pseudokinase, lineage plasticity, CHGA, Chromogranin-A, Biochemistry, Cell Line, Tumor, Nitriles, Phenylthiohydantoin, TMA, tissue microarray, neuroendocrine, Humans, Cell Lineage, TRIB2-OE, TRIB2-overexpressing, Molecular Biology, BRN2, Brain-2, TRIB2, enzalutamide resistance, Prostatic Neoplasms, Cell Biology, AFA, Afatinib, SOX2, SRY-box 2, prostate cancer, CK-8, cytokeratin 8, Drug Resistance, Neoplasm, Receptors, Androgen, SYP, Synaptophysin, Benzamides, Calcium-Calmodulin-Dependent Protein Kinases, AR, androgen receptor, NSE, Enolase-2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8bb1662a1499b7161cd3cc524395ab
http://europepmc.org/articles/PMC8800106

المؤلفون: Tomoki Yamashita, Seiichi Ishida, Hiroshi Yamada, Hiroyuki Mizuguchi, Kazuo Harada, Moe Ichikawa, Kazuo Takayama, Kazumasa Hirata, Kanae Kawai, Noriyuki Nakatsu, Ryosuke Negoro, Yoshiyuki Yamaura, Takanori Mori, Sumito Ito

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 513-526 (2019)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, CYP3A4, TF, transcription factor, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Cell Culture Techniques, SI, sucrose isomerase, Intestinal absorption, IEC, intestinal epithelial cell, Papp, apparent permeability coefficient, ZO-1, zonula occludens-1, Food-Drug Interactions, 0302 clinical medicine, Transduction, Genetic, BIO, 6-Bromoindirubin-3′-oxime, Adenovirus, Cytochrome P-450 CYP3A, CDX2 Transcription Factor, Drug Interactions, VP, vector particle, Induced pluripotent stem cell, CDX2, Cells, Cultured, Original Research, LY, Lucifer yellow, Chemistry, Gastroenterology, Cell Differentiation, FD-4, FITC-Dextran 4 kDa, Cell biology, Fruit and Vegetable Juices, Intestines, RIF, rifampicin, medicine.anatomical_structure, Fa, fraction absorbed, Differentiation, MDZ, midazolam, 030211 gastroenterology & hepatology, Rifampin, Ad-TF, transcription factor–expressing Ad vector, iPSC, induced pluripotent stem cell, Intestinal First-Pass Effect, RT-PCR, reverse transcription-polymerase chain reaction, IECM, intestinal epithelial cell monolayer, Induced Pluripotent Stem Cells, CHGA, chromogranin A, Fg, fraction passing the gut wall, TEER, transepithelial electrical resistance, 03 medical and health sciences, Pharmacokinetics, GFJ, grapefruit juice, medicine, Humans, HBSS, Hank's Balanced Salt Solution, Progenitor cell, lcsh:RC799-869, MRM, multiple-reaction monitoring, Hepatology, LYZ, lysozyme, Epithelial Cells, Epithelium, Small intestine, MUC2, mucin 2, 030104 developmental biology, Intestinal Absorption, Cell culture, UPLC-MS/MS, ultra-performance liquid chromatography tandem mass spectrometry, VD3, 1,25-dihydroxyvitamin D3, lcsh:Diseases of the digestive system. Gastroenterology, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836b9fc4e81bc0f2d53e50d6ad87bcd2
http://www.sciencedirect.com/science/article/pii/S2352345X19300827

المؤلفون: Andrea Varro, Carrie A. Duckworth, Katie A. Lloyd, Yongxiang Fang, Stamatia Papoutsopoulou, Nathan Howes, Klaire Exarchou, Lucille Rainbow, Andrew R. Moore, D. Mark Pritchard, Neil Hall, Claus Oxvig, Michael D. Burkitt, Steven Dodd, Bryony N. Parsons, Malcolm Boyce

المصدر: Lloyd, K A, Parsons, B N, Burkitt, M D, Moore, A R, Papoutsopoulou, S, Boyce, M, Duckworth, C A, Exarchou, K, Howes, N, Rainbow, L, Fang, Y, Oxvig, C, Dodd, S, Varro, A, Hall, N & Pritchard, D M 2020, ' Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors ', Cellular and Molecular Gastroenterology and Hepatology, vol. 10, no. 1, pp. 113-132 . https://doi.org/10.1016/j.jcmgh.2020.01.010
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 113-132 (2020)

مصطلحات موضوعية: HDC, histidine decarboxylase, 0301 basic medicine, IGF, insulin-like growth factor, Atrophic gastritis, Carcinogenesis, IGFBP3, Achlorhydria, Benzodiazepines, Mice, 0302 clinical medicine, Pregnancy-Associated Plasma Protein-A, Original Research, Gastrin, Benzodiazepinones, Gene knockdown, IGFBP, insulin-like growth factor binding protein, Stomach, Gastroenterology, mRNA, messenger RNA, Organoids, MMP, matrix metalloproteinase, Neuroendocrine Tumors, Treatment Outcome, medicine.anatomical_structure, Gene Knockdown Techniques, Cholecystokinin B receptor, qPCR, quantitative polymerase chain reaction, Immunohistochemistry, 030211 gastroenterology & hepatology, Signal Transduction, Primary Cell Culture, PBS, phosphate-buffered saline, TIMP, tissue inhibitors of metalloproteinases, Mice, Transgenic, CHGA, chromogranin A, PAPPA2, pappalysin 2, 03 medical and health sciences, Stomach Neoplasms, Cell Line, Tumor, Gastrins, CCK2R, cholecystokinin type-2 receptor, medicine, Animals, Humans, lcsh:RC799-869, Mouse Model, Hepatology, business.industry, Phenylurea Compounds, medicine.disease, Hormone, Receptor, Cholecystokinin B, Disease Models, Animal, 030104 developmental biology, gNET, gastric neuroendocrine tumor, Gastric Mucosa, siRNA, small interfering RNA, ECL, enterochromaffin-like, Tumorigenesis, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, BSA, bovine serum albumin, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7554914bc0596db17395b9f59dbcfa2f
https://ueaeprints.uea.ac.uk/id/eprint/73860/

المؤلفون: Nicholas C. Zachos

المصدر: Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: VIL1, villin, Enteroendocrine cell, CMGF+, complete media with growth factors, HIE, human intestinal enteroid, TNF-α, tumor necrosis factor-α, EEC, enteroendocrine cell, Basic Helix-Loop-Helix Transcription Factors, DIC, differential interference contrast, Original Research, GIP, glucose-dependent insulinotropic peptide, Secretory Pathway, Gastroenterology, tet, tetracycline, GLP-1, glucagon-like peptide-1, MCP-1, monocyte chemoattractant protein-1, GI, gastrointestinal, mRNA, messenger RNA, Cell biology, Intestines, Editorial, hpi, hours postinfection, qPCR, quantitative polymerase chain reaction, Serotonin, ChgA, chromogranin A, hW-CMGF+, high Wnt complete media with growth factors, PP, pancreatic polypeptide, Enteroendocrine Cells, PBS, phosphate-buffered saline, Nerve Tissue Proteins, CMGF-, complete medium without growth factors, Biology, HIO, human intestinal organoid, Enteroendocrine Cell, Models, Biological, Gastrointestinal Hormones, cDNA, complementary DNA, NGN3, neurogenin-3, DMEM, Dulbecco’s modified Eagle medium, Spheroids, Cellular, PYY, peptide YY, 3D, 3-dimensional, Humans, Enteroid, SI, sucrase isomaltase, Hepatology, IL, interleukin, stomatognathic diseases, Gene Expression Regulation, RV, rotavirus, 2D, 2-dimensional, DAPI, 4′,6-diamidino-2-phenylindole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0f6dd45b5640cb29f7142f60db0943
https://doi.org/10.1016/j.jcmgh.2019.05.005

المؤلفون: Miranda G. Kiernan, Calvin J. Coffey

المصدر: EBioMedicine
EBioMedicine, Vol 23, Iss C, Pp 193-194 (2017)

مصطلحات موضوعية: Male, IBMX, 3-isobutyl-1-methylxanthine, Pathology, STAT3, signal transducer and activator of transcription 3, Drug target, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, lcsh:Medicine, PPAR, peroxisome proliferator-activated receptor, iPSC, induced-pluripotent stem cell, Epithelium, IEC, intestinal epithelial cell, chemistry.chemical_compound, Mice, 0302 clinical medicine, Crohn Disease, Adipocyte, Adipocytes, Mesentery, RPMI, Roswell Park Memorial Institute, DSS, dextran sodium sulfate, Intestinal Mucosa, ChgA, Chromogranin A, Cells, Cultured, ANOVA, analysis of variance, Crohn's disease, lcsh:R5-920, TNF, tumor necrosis factor, DMEM, Dulbecco's modified Eagle's medium, Muc2, mucin 2, IBD, inflammatory bowel disease, NF-kappa B, WAT, white adipose tissue, General Medicine, ELISA, enzyme-linked immunosorbent assay, Intestine, ECM, extracellular matrix, MMP, matrix metalloproteinase, Organoids, medicine.anatomical_structure, Adipose Tissue, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, lcsh:Medicine (General), Signal Transduction, Research Paper, R-spo1, R-spondin1, STAT3 Transcription Factor, medicine.medical_specialty, Induced Pluripotent Stem Cells, PBS, phosphate-buffered saline, NF-κB, nuclear factor-κB, Biology, digestive system, General Biochemistry, Genetics and Molecular Biology, Cell Line, TER, transepithelial electrical resistance, 03 medical and health sciences, CM, conditioned medium, RT-PCR, reverse transcription polymerase chain reaction, FBS, fetal bovine serum, pIgR, polymeric immunoglobulin receptor, Internal medicine, medicine, Animals, Humans, IFN, interferon, EGF, epidermal growth factor, lcsh:R, Epithelial Cells, medicine.disease, Inflammatory Bowel Diseases, Coculture Techniques, FGF, fibroblast growth factor, IL, interleukin, Disease Models, Animal, UC, ulcerative colitis, Endocrinology, chemistry, SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Commentary, BSA, bovine serum albumin, CD, Crohn's disease, Induced-pluripotent stem cells, Co-culture, Intestinal epithelial cells, DAPI, 4′,6-diamidino-2-phenylindole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1991ee585e65e0c28fbe456974640ce1
https://pubmed.ncbi.nlm.nih.gov/28789943

المؤلفون: Carina Conzelmann, Steffen Stenger, Rüdiger Groß, Jana Krüger, Lennart Koepke, Janis A. Müller, Jan Münch, Alexander Kleger, Thomas F. E. Barth, Tatjana Weil, Desiree Schütz, Thomas Seufferlein, Konstantin M. J. Sparrer, Sandra Heller

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 935-948 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Human Embryonic Stem Cells, Virus Replication, DMEM, Dulbecco’s modified Eagle’s medium, Pathogenesis, 0302 clinical medicine, IC50, half-maximal inhibitory concentration, Intestinal mucosa, Medicine, RT-qPCR, reverse-transcription quantitative polymerase chain reaction, Intestinal Mucosa, Induced pluripotent stem cell, Original Research, COVID-19, coronavirus disease 2019, Gastrointestinal tract, Alanine, TCID50, Tissue culture infection dose 50, Gastroenterology, Famotidine, 3. Good health, Organoids, 030211 gastroenterology & hepatology, Intestinal Organoids, S, spike, PBS, phosphate-buffered saline, Remdesivir, CHGA, chromogranin A, ACE2, angiotensin-converting enzyme 2, HIO, human intestinal organoid, PSC-HIO, pluripotent stem cell derived from human intestinal organoid, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, 03 medical and health sciences, Viral entry, 3D, 3-dimensional, Organoid, Humans, lcsh:RC799-869, Hepatology, SARS-CoV-2, business.industry, LYZ, lysozyme, COVID-19, Embryonic stem cell, Adenosine Monophosphate, MUC2, mucin 2, COVID-19 Drug Treatment, 030104 developmental biology, Viral replication, Immunology, TMPRSS2, transmembrane serine protease 2, lcsh:Diseases of the digestive system. Gastroenterology, FCS, fetal calf serum, PFA, paraformaldehyde, Caco-2 Cells, business, N, nucleocapsid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edeaf52b4a427a39d474074b4da4bdc

المؤلفون: Chisayo Kozuka, Keiko Abe, Naoki Watanabe, Tomiko Asakura, Masataka Narukawa, Misako Yoshioka, Naomi Osakabe, Hiroaki Masuzaki, Shota Ushiama, Makoto Tsunoda, Yoshiro Ishimaru

المصدر: Scipedia Open Access
Scipedia SL
EBioMedicine, Vol 8, Iss C, Pp 60-71 (2016)
EBioMedicine

مصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, medicine.medical_treatment, OGTT, oral glucose tolerance test, Gene Dosage, lcsh:Medicine, Energy homeostasis, Mice, Catecholamines, Adrenal Glands, Insulin, T4, tetraiodothyronine, RER, respiratory exchange ratio, GIP, glucose-dependent insulinotropic peptide, Mice, Knockout, Gastrointestinal tract, Pnmt, phenylethanolamine N-methyltransferase, lcsh:R5-920, Dclk1, doublecortin-like kinase 1, NEFA, non-esterified fatty acid, Brain, GLP-1, glucagon-like peptide-1, WAT, white adipose tissue, General Medicine, Dbh, dopamine-β-hydroxylase, GI, gastrointestinal, Glucagon-like peptide-1, CT, computed tomography, TG, triacylglycerol, Up-Regulation, SCC, solitary chemosensory cells, TSH, thyroid stimulating hormone, IPGTT, intraperitoneal glucose tolerance test, Catecholamine, Octamer Transcription Factors, lcsh:Medicine (General), Ddc, dopa decarboxylase, Research Paper, medicine.medical_specialty, ChgA, chromogranin A, Trpm5, transient receptor potential melastatin 5, Gut–brain axis, Abdominal Fat, Biology, Diet, High-Fat, DNA, Mitochondrial, General Biochemistry, Genetics and Molecular Biology, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, Islets of Langerhans, Medicine, General & Internal, Downregulation and upregulation, Internal medicine, medicine, Animals, TRPM5, Obesity, Muscle, Skeletal, ITT, insulin tolerance test, T3, triiodothyronine, KO, knockout, Ucp3, uncoupling proteins 3, lcsh:R, Th, tyrosine hydroxylase, Energy metabolism, BAT, brown adipose tissue, Gastrointestinal Tract, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Brush cells, Homeostasis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d6ac2df967dce276974b994240aff6

المؤلفون: Nakanishi A; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan., Toyama S; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan., Onozato D; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan., Watanabe C; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan., Hashita T; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan., Iwao T; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan., Matsunaga T; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.; Educational Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

المصدر: Regenerative therapy [Regen Ther] 2022 Sep 09; Vol. 21, pp. 351-361. Date of Electronic Publication: 2022 Sep 09 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: The Japanese Society for Regenerative Medicine. Production and Hosting by Elsevier B.V Country of Publication: Netherlands NLM ID: 101709085 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-3204 (Electronic) Linking ISSN: 23523204 NLM ISO Abbreviation: Regen Ther Subsets: PubMed not MEDLINE