المؤلفون: Rogers JE; U.T. M.D. Anderson Cancer Center Pharmacy Clinical Programs., Ajani JA; U.T. U.T. M.D. Anderson Cancer Center Department of Gastrointestinal Medical Oncology, Houston, Texas, USA.

المصدر: Current opinion in oncology [Curr Opin Oncol] 2024 Jul 01; Vol. 36 (4), pp. 308-312. Date of Electronic Publication: 2024 Apr 23.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9007265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-703X (Electronic) Linking ISSN: 10408746 NLM ISO Abbreviation: Curr Opin Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Claudins*/antagonists & inhibitors , Claudins*/metabolism , Gastrointestinal Neoplasms*/drug therapy, Humans ; Clinical Trials, Phase III as Topic ; Molecular Targeted Therapy

المؤلفون: Zhang J; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Westcott PMK; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA. Electronic address: westcott@cshl.edu.

المصدر: Immunity [Immunity] 2024 Jun 11; Vol. 57 (6), pp. 1187-1189.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

مواضيع طبية MeSH: Claudins*/metabolism , Claudins*/immunology , Claudins*/genetics, Humans ; Neoplasms/immunology ; Animals ; T-Lymphocytes, Cytotoxic/immunology ; Pancreatic Neoplasms/immunology ; Lung Neoplasms/immunology ; Lymphocyte Activation/immunology ; Immunological Synapses/immunology ; Immunological Synapses/metabolism

المؤلفون: De Sanctis F; Section of Immunology, Department of Medicine, University of Verona, Verona, Italy. Electronic address: francesco.desanctis@univr.it., Dusi S; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy., Caligola S; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy., Anselmi C; Section of Immunology, Department of Medicine, University of Verona, Verona, Italy., Petrova V; Section of Immunology, Department of Medicine, University of Verona, Verona, Italy., Rossi B; Section of General Pathology, Department of Medicine, University of Verona, Verona, Italy., Angelini G; Section of General Pathology, Department of Medicine, University of Verona, Verona, Italy., Erdeljan M; Biopharmaceutical New Technologies (BioNTech) Corporation, Mainz, Germany., Wöll S; Biopharmaceutical New Technologies (BioNTech) Corporation, Mainz, Germany., Schlitter AM; Biopharmaceutical New Technologies (BioNTech) Corporation, Mainz, Germany; Institute of Pathology, School of Medicine, TUM, Munich, Germany., Metzler T; Comparative Experimental Pathology (CEP), Institute of Pathology, School of Medicine, Technical University of Munich, Munich, Germany., Steiger K; Comparative Experimental Pathology (CEP), Institute of Pathology, School of Medicine, Technical University of Munich, Munich, Germany., Borok Z; Department of Medicine, University of California, San Diego, San Diego, CA, USA., Bailey P; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, Scotland., Bauer A; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Halin C; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland., Boschi F; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy., Giugno R; Department of Computer Science, University of Verona, Verona, Italy., Canè S; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy., Lawlor R; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy; ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy., Corbo V; Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy; ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy., Scarpa A; ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Constantin G; Section of General Pathology, Department of Medicine, University of Verona, Verona, Italy; The Center for Biomedical Computing (CBMC), University of Verona, Verona, Italy., Ugel S; Section of Immunology, Department of Medicine, University of Verona, Verona, Italy., Vascotto F; TRON-Translational Oncology at the University Medical Centre of the Johannes Gutenberg University, Mainz, Germany., Sahin U; Biopharmaceutical New Technologies (BioNTech) Corporation, Mainz, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Türeci Ö; Biopharmaceutical New Technologies (BioNTech) Corporation, Mainz, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Bronte V; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. Electronic address: vincenzo.bronte@iov.veneto.it.

المصدر: Immunity [Immunity] 2024 Jun 11; Vol. 57 (6), pp. 1378-1393.e14. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/immunology , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/metabolism , Claudins*/metabolism , Claudins*/genetics , Lymphocyte Activation*/immunology , Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/pathology , T-Lymphocytes, Cytotoxic*/immunology, Animals ; Humans ; Mice ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/immunology ; Immunological Synapses/metabolism ; Immunological Synapses/immunology ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Membrane Microdomains/metabolism ; Membrane Microdomains/immunology ; Mice, Inbred C57BL ; Tumor Microenvironment/immunology

المؤلفون: Hashimoto Y; Smurfit Institute of Genetics, Trinity College Dublin, D02 VF25, Dublin, Ireland., Besmond C; INSERM UMR1163, Institut Imagine, Paris University, F-75015, Paris, France.; Clinical Genetics Department, Necker Hospital, APHP Centre-Paris University, F-75015, Paris, France., Boddaert N; INSERM UMR1163, Institut Imagine, Paris University, F-75015, Paris, France.; Department of Pediatric Radiology, Hospital Necker Enfants Malades, F-75015, Paris, France., Munnich A; INSERM UMR1163, Institut Imagine, Paris University, F-75015, Paris, France.; Clinical Genetics Department, Necker Hospital, APHP Centre-Paris University, F-75015, Paris, France., Campbell M; Smurfit Institute of Genetics, Trinity College Dublin, D02 VF25, Dublin, Ireland.; FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland.

المصدر: Human molecular genetics [Hum Mol Genet] 2024 Jun 05; Vol. 33 (12), pp. 1055-1063.

نوع المنشور: Journal Article; Case Reports

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Claudins*/genetics , Claudins*/metabolism , Pelizaeus-Merzbacher Disease*/genetics , Pelizaeus-Merzbacher Disease*/metabolism, Humans ; Loss of Function Mutation ; Male ; Mutation, Missense ; Female ; Animals ; Amino Acid Sequence

المؤلفون: Katoh M; M & M Precision Medicine, Tokyo, Japan., Nakayama I; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Wainberg ZA; Department of Medicine, University of California Los Angeles, Los Angeles, California, USA., Shitara K; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Katoh M; M & M Precision Medicine, Tokyo, Japan.; Department of Omics Network, National Cancer Center, Tokyo, Japan.

المصدر: Clinical and translational medicine [Clin Transl Med] 2024 Jun; Vol. 14 (6), pp. e1736.

نوع المنشور: Letter; Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326 (Electronic) Linking ISSN: 20011326 NLM ISO Abbreviation: Clin Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Stomach Neoplasms*/genetics , Stomach Neoplasms*/drug therapy , Claudins*/genetics , Claudins*/metabolism , Antibodies, Monoclonal*/therapeutic use , Antibodies, Monoclonal*/pharmacology , Receptor, Fibroblast Growth Factor, Type 2*/genetics, Humans ; Protein Isoforms/genetics ; Neoplasms/genetics ; Neoplasms/drug therapy

المؤلفون: Guo T; Department of Pharmacy, Wuhan Third Hospital, Wuhan, China., Xiong W; Department of Pharmacy, Wuhan Third Hospital, Wuhan, China., Liu C; Department of Thoracic surgery, Wuhan Third Hospital, Wuhan, China., Zhu L; Department of Pharmacy, Wuhan Third Hospital, Wuhan, China., Xie L; Department of Pharmacy, Wuhan Third Hospital, Wuhan, China.

المصدر: Genesis (New York, N.Y. : 2000) [Genesis] 2024 Jun; Vol. 62 (3), pp. e23599.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 100931242 Publication Model: Print Cited Medium: Internet ISSN: 1526-968X (Electronic) Linking ISSN: 1526954X NLM ISO Abbreviation: Genesis Subsets: MEDLINE

مواضيع طبية MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Cell Proliferation*/genetics , Carcinoma, Renal Cell*/genetics , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/metabolism , Cell Movement*/genetics , Kidney Neoplasms*/genetics , Kidney Neoplasms*/pathology , Kidney Neoplasms*/metabolism , Gene Expression Regulation, Neoplastic* , RNA, Circular*/genetics , RNA, Circular*/metabolism , Claudins*/genetics , Claudins*/metabolism , Neoplasm Invasiveness*, Humans ; Animals ; Mice ; Cell Line, Tumor ; Mice, Nude ; Female ; Male

المؤلفون: Sun W; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.; China Institute of Veterinary Drug Control, Beijing, 100081, People's Republic of China., Wu W; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China., Fang X; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China., Ge X; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China., Zhang Y; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China., Han J; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China., Guo X; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China., Zhou L; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China. Leosj@cau.edu.cn.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China. Leosj@cau.edu.cn., Yang H; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China. yanghanchun1@cau.edu.cn.; Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China. yanghanchun1@cau.edu.cn.

المصدر: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 May 28; Vol. 81 (1), pp. 240. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

مواضيع طبية MeSH: Porcine respiratory and reproductive syndrome virus*/physiology , Lung*/metabolism , Lung*/virology , Lung*/pathology , Lung*/blood supply , Endothelial Cells*/metabolism , Endothelial Cells*/virology , Claudins*/metabolism , Claudins*/genetics, Animals ; Swine ; Porcine Reproductive and Respiratory Syndrome/metabolism ; Porcine Reproductive and Respiratory Syndrome/virology ; Porcine Reproductive and Respiratory Syndrome/pathology ; Claudin-4/metabolism ; Claudin-4/genetics ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/virology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/virology ; Endothelium, Vascular/pathology ; Cells, Cultured ; Capillary Permeability ; Acute Lung Injury/metabolism ; Acute Lung Injury/virology ; Acute Lung Injury/pathology ; Cytokines/metabolism

المؤلفون: Joshi P; Arrakis Therapeutics, Waltham, MA, USA., Ayyagari V; Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA., Kandel S; Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA., Modur V; Medpace, Inc., 5400 Medpace Way, Cincinnati, OH 45227, USA., Iqbal MF; Cancer Specialists of North Florida, 80 Pinnacles Drive, Suite 700, Palm Coast, FL 32164, USA., Robinson K; Simmons Cancer Institute at Southern Illinois University, 315 W Carpenter St., Springfield, IL 62702, USA., Gao J; Department of Pathology and Gastroenterology, Memorial Medical Center, Springfield, IL, USA., Rao K; Department of Medical Microbiology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.; Simmons Cancer Institute at Southern Illinois University, 315 W Carpenter St., Springfield, IL 62702, USA.

المصدر: BioMed research international [Biomed Res Int] 2024 May 20; Vol. 2024, pp. 8544837. Date of Electronic Publication: 2024 May 20 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE

مواضيع طبية MeSH: rab GTP-Binding Proteins*/metabolism , rab GTP-Binding Proteins*/genetics , Cell Transformation, Neoplastic*/genetics , Cell Transformation, Neoplastic*/metabolism , Epithelial Cells*/metabolism , Epithelial-Mesenchymal Transition*/genetics , Claudins*/genetics , Claudins*/metabolism, Humans ; Female ; Mammary Glands, Human/metabolism ; Mammary Glands, Human/pathology ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Oncogenes/genetics ; Snail Family Transcription Factors/metabolism ; Snail Family Transcription Factors/genetics ; Mutation/genetics

المؤلفون: Jiang K; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Pathology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China., Cao F; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, 100142, China., Yin L; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Pathology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China., Hu Y; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Pathology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China., Zhao X; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Pathology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China., Huang X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, 100142, China., Ma X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, 100142, China., Li J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, 100142, China., Lu M; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China. qiminglu_mail@126.com., Sun Y; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Pathology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China. sunyu_bch@163.com.

المصدر: Journal of endocrinological investigation [J Endocrinol Invest] 2024 May; Vol. 47 (5), pp. 1251-1260. Date of Electronic Publication: 2023 Dec 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE

مواضيع طبية MeSH: Neuroendocrine Tumors*/metabolism , Neuroendocrine Tumors*/pathology , Claudins*/metabolism , Claudins*/analysis , Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/analysis, Humans ; Female ; Male ; Middle Aged ; Retrospective Studies ; Aged ; Adult ; Aged, 80 and over ; Prognosis ; Digestive System Neoplasms/pathology ; Digestive System Neoplasms/metabolism ; Carcinoma, Neuroendocrine/pathology ; Carcinoma, Neuroendocrine/metabolism

المؤلفون: Naser AN; Department of Anatomy and Cell Biology, University of South Carolina, Columbia, South Carolina, USA., Xing T; Department of Anatomy and Cell Biology, University of South Carolina, Columbia, South Carolina, USA.; Neural and Behavioral Science Department, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Tatum R; Department of Anatomy and Cell Biology, University of South Carolina, Columbia, South Carolina, USA., Lu Q; Department of Anatomy and Cell Biology, University of South Carolina, Columbia, South Carolina, USA.; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina, USA., Boyer PJ; Department of Pathology and Laboratory Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA., Chen YH; Department of Anatomy and Cell Biology, University of South Carolina, Columbia, South Carolina, USA.; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina, USA.

المصدر: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2024 May; Vol. 1535 (1), pp. 92-108. Date of Electronic Publication: 2024 Apr 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1749-6632 (Electronic) Linking ISSN: 00778923 NLM ISO Abbreviation: Ann N Y Acad Sci Subsets: MEDLINE

مواضيع طبية MeSH: Claudins*/metabolism , Claudins*/genetics , Signal Transduction* , Receptors, Notch*/metabolism , Stem Cells*/metabolism , Colon*/metabolism , Colon*/pathology , Hippo Signaling Pathway*, Animals ; Mice ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Mice, Knockout ; Intestinal Mucosa/metabolism ; Cell Differentiation/physiology ; Tight Junctions/metabolism