-
1دورية أكاديمية
المصدر: IEEE Internet of Things Journal IEEE Internet Things J. Internet of Things Journal, IEEE. 7(4):2553-2562 Apr, 2020
-
2دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
3دورية أكاديمية
المؤلفون: Mattias F. Lindberg, Laurent Meijer
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 11, p 6047 (2021)
مصطلحات موضوعية: DYRKs, CLKs, kinase, kinase inhibitor, Alzheimer’s disease, Down syndrome, Biology (General), QH301-705.5, Chemistry, QD1-999
وصف الملف: electronic resource
-
4
المؤلفون: Laurent Meijer, Mattias F. Lindberg
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 6047, p 6047 (2021)
International Journal of Molecular Sciencesمصطلحات موضوعية: DYRK1A, type 1 diabetes, CDKL5, Review, Disease, CLKs, chemistry.chemical_compound, 0302 clinical medicine, CDC2-CDC28 Kinases, Tyrosine, Biology (General), Phosphorylation, Spectroscopy, 0303 health sciences, Kinase, Cell Differentiation, General Medicine, Protein-Tyrosine Kinases, 3. Good health, Computer Science Applications, Chromatin, Chemistry, type 2 diabetes, Alzheimer’s disease, Signal Transduction, kinase, kinase inhibitor, QH301-705.5, viral infections, acute lymphoblastic leukemia, Biology, Protein Serine-Threonine Kinases, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Alzheimer Disease, Diabetes Mellitus, Humans, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Protein Kinase Inhibitors, 030304 developmental biology, Cyclin-dependent kinase 1, Organic Chemistry, Tyrosine phosphorylation, DYRKs, chemistry, Cancer research, Down Syndrome, 030217 neurology & neurosurgery
-
5
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Cerebellum, DYRK1A, Down syndrome, Purkinje cell, TL, torus longitudinalis, DMSO, dimethyl sulfoxide, Biochemistry, CLKs, Cdc2-like kinases, Purkinje Cells, neurological disease, Phosphorylation, Zebrafish, Neurons, education.field_of_study, biology, imaging, Brain, Protein-Tyrosine Kinases, Phenotype, DS, Down syndrome, Cell biology, medicine.anatomical_structure, ca8, carbonic anhydrase 8, AD, Alzheimer's disease, GCL, granule cell layer, Research Article, dpt, days post treatment, PBS, phospahte buffered saline, Cell type, cerebellum, ML, molecular layer, Population, Central nervous system, Protein Serine-Threonine Kinases, PCs, Purkinje cells, 03 medical and health sciences, cpce, ca8 promoter–derived PC-specific enhancer element, medicine, Dyrk1A, Animals, Humans, education, Dyrk1A, dual-specificity tyrosine phosphorylation–regulated kinase 1A, Molecular Biology, dpf, days post fertilization, 030102 biochemistry & molecular biology, da, anterior distance, Cell Biology, Zebrafish Proteins, biology.organism_classification, Disease Models, Animal, 030104 developmental biology, ap, anterior–posterior, PFA, paraformaldehyde, Protein Kinases, SSC, saline sodium citrate
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0952dd9f67f6207359a9f832035fd59
https://doi.org/10.1016/j.jbc.2021.100853 -
6
المؤلفون: Nadège Loaëc, Lyamin Z. Bendjeddou, Laurent Meijer, Eric Prina, Gerald F. Späth, Benoit Villiers, Nassima Oumata, Hervé Galons
المساهمون: Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ManRos Therapeutics, Parasitologie moléculaire et Signalisation / Molecular Parasitology and Signaling, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), This research was supported by grants from the ‘Fonds Unique Interministériel' (FUI) PHARMASEA, and TRIAD projects (HG, LM), the 'Association France Alzheimer (Finistère)' (LM), the 'Fondation Jérôme Lejeune' (LM), ANR-11-RPIB-0016TRANSLEISH and EEC FP7 European Union 7th Framework Program Knowledge-based Bioeconomy (FP7-KBBE) grant BLUEGENICS (LM)., ANR-11-RPIB-0016,TRANSLEISH,Découverte de nouvelles protéines kinases chez Leishmania donovani à partir des inhibiteurs tête de série issus d'un criblage phénotypique(2011), European Project: 311848,EC:FP7:KBBE,FP7-KBBE-2012-6-singlestage,BLUEGENICS(2012), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Ricard Andraos, Christel, RECHERCHES PARTENARIALES ET INNOVATION BIOMEDICALE - Découverte de nouvelles protéines kinases chez Leishmania donovani à partir des inhibiteurs tête de série issus d'un criblage phénotypique - - TRANSLEISH2011 - ANR-11-RPIB-0016 - RPIB - VALID, BlueGenics – From gene to bioactive product: Exploiting marine genomics for an innovative and sustainable European blue biotechnology industry - BLUEGENICS - - EC:FP7:KBBE2012-08-01 - 2016-07-31 - 311848 - VALID
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2017, 125, pp.696-709. ⟨10.1016/j.ejmech.2016.09.064⟩
European Journal of Medicinal Chemistry, Elsevier, 2017, 125, pp.696-709. ⟨10.1016/j.ejmech.2016.09.064⟩مصطلحات موضوعية: 0301 basic medicine, DYRK1A, Cell Survival, 2-b]pyridazine, CLKs, 01 natural sciences, Plasmodium, CLK1, Pyridazine, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Drug Discovery, Kinome, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Protein Kinase Inhibitors, Imidazo[1, Pharmacology, Leishmania, Kinase inhibitor, biology, Antiparasitic Agents, Molecular Structure, 010405 organic chemistry, Kinase, Chemistry, Organic Chemistry, Eukaryota, Plasmodium falciparum, General Medicine, biology.organism_classification, Unicellular parasites, 3. Good health, 0104 chemical sciences, Enzyme Activation, Pyridazines, 030104 developmental biology, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Biochemistry
وصف الملف: application/pdf
-
7
المؤلفون: Burgy, Guillaume, Limanton, Emmanuelle, Carreaux, François, Durieu, Emilie, Meijer, Laurent, Bazureau, Jean-Pierre
المساهمون: ManRos Therapeutics, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), This research was supported by grants from the ‘Fonds Unique Interministériel' (FUI) PHARMASEA project (LM), the 'Association France-Alzheimer (Finistère)' (LM) and 'Fondation Jérôme Lejeune' (LM). Guillaume BURGY is recipient of a 'CIFRE' PhD fellowship., Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)
المصدر: Journal of Applied Pharmaceutical Science
Journal of Applied Pharmaceutical Science, 2014, 4 (6), pp.25-32. ⟨10.7324/JAPS.2014.40604⟩
Journal of Applied Pharmaceutical Science, MediPoeia, 2014, 4 (6), pp.25-32. ⟨10.7324/JAPS.2014.40604⟩مصطلحات موضوعية: isothiorurea, Leucettines, Medicine (miscellaneous), protein kinase, DYRKs, CLKs, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, imidazo[1, 5-a]indol-3-one, intramolecular, sulphur/ nitrogen displacement, [CHIM]Chemical Sciences, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, thiourea
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ef52fdabf285651b95aaabee3854b0
https://doi.org/10.7324/japs.2014.40604 -
8
المؤلفون: Béatrice Foll-Josselin, Laurent Meijer, Guillaume Burgy, Jean Pierre Bazureau, Tania Tahtouh, Emilie Durieu, Emmanuelle Limanton, François Carreaux
المساهمون: Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Molécules et cibles thérapeutiques (MCT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2013, 62, pp.728-37. ⟨10.1016/j.ejmech.2013.01.035⟩
European Journal of Medicinal Chemistry, 2013, 62, pp.728-37. ⟨10.1016/j.ejmech.2013.01.035⟩مصطلحات موضوعية: Swine, Dioxoles, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, CLKs, 010402 general chemistry, 01 natural sciences, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pre-mRNA splicing, Affinity chromatography, GSK-3, Drug Discovery, Animals, Humans, Glycogen synthase, Protein Kinase Inhibitors, Pharmacology, Kinase inhibitor, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Leucettine, Imidazoles, Tyrosine phosphorylation, General Medicine, DYRKs, Alzheimer's disease, Ligand (biochemistry), 0104 chemical sciences, Biochemistry, biology.protein, Leucettamine B, Linker, Protein Kinases
-
9دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
10دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.