المؤلفون: Maxim Norkin, Paloma Ordóñez-Morán, Joerg Huelsken

المصدر: Cell Reports, Vol 35, Iss 3, Pp 109026- (2021)

مصطلحات موضوعية: differentiation therapy, colorectal cancer, CRC organoids, high-content screening, organoid screening, drug mode of action, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721003405; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/70e083ad24844fb3b6e7da3afa4bd07a

المؤلفون: Enza Lonardo, Donatella Delle Cave, Xavier Hernando-Momblona, Gabriella Minchiotti, Marta Sevillano

المصدر: Theranostics
Theranostics 11 (2021): 5686–5699. doi:10.7150/thno.54027
info:cnr-pdr/source/autori:Delle Cave D.; Hernando-Momblona X.; Sevillano M.; Minchiotti G.; Lonardo E./titolo:Nodal-induced L1CAM%2FCXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids/doi:10.7150%2Fthno.54027/rivista:Theranostics/anno:2021/pagina_da:5686/pagina_a:5699/intervallo_pagine:5686–5699/volume:11

مصطلحات موضوعية: 0301 basic medicine, Receptors, CXCR4, Colorectal cancer, Nodal Protein, Population, colorectal cancer (CRC), organoids, transforming growth factor (TGF)-β signaling, L1 cell adhesion molecule (L1CAM, Medicine (miscellaneous), Nodal signaling, Neural Cell Adhesion Molecule L1, Biology, CXCR4, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, Cancer stem cell, Cell Movement, Cell Line, Tumor, medicine, Tumor Microenvironment, Animals, Humans, Neoplasm Metastasis, education, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Cell Proliferation, education.field_of_study, CD171), medicine.disease, Organoids, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, NODAL, Colorectal Neoplasms, colorectal cancer (CRC)organoidstransforming growth factor (TGF)-beta signalingL1 cell adhesion molecule (L1CAM, Research Paper, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caebcb4011875d3cdc3f216be65a5458
http://europepmc.org/articles/PMC8058729

مصطلحات موضوعية: CRC organoids, therapy resistance, anti-EGFR therapy, NF1, CRISPR, BRAF fusion genes, RASGAP loss, digestive system diseases, CRC, RAS, BRAF

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dris___00893::e982678578015190a5d6e8a91c5a3b8e
https://hdl.handle.net/1874/386446

المؤلفون: Post, Jasmin Barry

المساهمون: van Rheenen, Jacco, Snippert, HJG, University Utrecht

مصطلحات موضوعية: CRC organoids, therapy resistance, anti-EGFR therapy, NF1, CRISPR, BRAF fusion genes, RASGAP loss, digestive system diseases, CRC, RAS, BRAF

وصف الملف: image/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0c6d879905f232196939168abd5b4254
https://dspace.library.uu.nl/handle/1874/386446

المؤلفون: Joerg Huelsken, Maxim Norkin, Paloma Ordóñez-Morán

المصدر: Cell Reports, Vol 35, Iss 3, Pp 109026-(2021)

مصطلحات موضوعية: 0301 basic medicine, Paneth Cells, Prescription Drugs, QH301-705.5, Cellular differentiation, genetic processes, Cell, colorectal cancer, Antineoplastic Agents, RNA-Seq, Computational biology, Biology, high-content screening, General Biochemistry, Genetics and Molecular Biology, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Organoid, Humans, Gene Regulatory Networks, natural sciences, Biology (General), organoid screening, Early Detection of Cancer, Sequence Analysis, RNA, Drug discovery, Drug Repositioning, Cancer, RNA, Cell Differentiation, medicine.disease, High-Throughput Screening Assays, Neoplasm Proteins, CRC organoids, Gene Expression Regulation, Neoplastic, Organoids, differentiation therapy, drug mode of action, Enterocytes, 030104 developmental biology, medicine.anatomical_structure, High-content screening, Neoplastic Stem Cells, Goblet Cells, Colorectal Neoplasms, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965b9fee3738f23a578a50beb2c7aaca
https://doi.org/10.1016/j.celrep.2021.109026

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المؤلفون: Cave DD; Institute of Genetics and Biophysics'Adriano Buzzati-Traverso' (IGB), CNR, Via Pietro Castellino 111, 80131 Naples, Italy., Hernando-Momblona X; Institute for Research in Biomedicine Barcelona (IRB), Barcelona, Spain., Sevillano M; Institute for Research in Biomedicine Barcelona (IRB), Barcelona, Spain., Minchiotti G; Institute of Genetics and Biophysics'Adriano Buzzati-Traverso' (IGB), CNR, Via Pietro Castellino 111, 80131 Naples, Italy., Lonardo E; Institute of Genetics and Biophysics'Adriano Buzzati-Traverso' (IGB), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.; Institute for Research in Biomedicine Barcelona (IRB), Barcelona, Spain.

المصدر: Theranostics [Theranostics] 2021 Mar 31; Vol. 11 (12), pp. 5686-5699. Date of Electronic Publication: 2021 Mar 31 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation/*physiology , Colorectal Neoplasms/*metabolism , Neoplasm Metastasis/*pathology , Neural Cell Adhesion Molecule L1/*metabolism , Nodal Protein/*metabolism , Organoids/*metabolism , Receptors, CXCR4/*metabolism, Animals ; Cell Line, Tumor ; Cell Movement/physiology ; Colorectal Neoplasms/pathology ; Humans ; Mice ; Organoids/pathology ; Signal Transduction/physiology ; Tumor Microenvironment/physiology