المؤلفون: Ghoshal A; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Asressu KH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Hossain MA; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Brown PJ; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Nandakumar M; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Vala A; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej, Bavla Highway, Ahmedabad, Gujarat 382213, India., Merten EM; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Sears JD; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Law I; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Burdick JE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Morales NL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Perveen S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Pearce KH; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Popov KI; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Moorman NJ; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Heise MT; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; READDI AViDD Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16505-16532. Date of Electronic Publication: 2024 Sep 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , Sulfones*/pharmacology , Sulfones*/chemistry , Sulfones*/chemical synthesis , Chikungunya virus*/drug effects , Chikungunya virus*/enzymology , Cysteine Endopeptidases*/metabolism, Structure-Activity Relationship ; Cysteine Proteinase Inhibitors/pharmacology ; Cysteine Proteinase Inhibitors/chemical synthesis ; Cysteine Proteinase Inhibitors/chemistry ; Humans ; Animals ; Virus Replication/drug effects

المؤلفون: Cerutti JP; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba (FCQ-UNC), Haya de la Torre y Medina Allende, Córdoba 5000, Argentina.; Sustainable Chemistry for Metals and Molecules, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium., Diniz LA; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil., Santos VC; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil., Vilchez Larrea SC; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Vuelta de Obligado 2490, Ciudad de Buenos Aires 1428, Argentina., Alonso GD; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Vuelta de Obligado 2490, Ciudad de Buenos Aires 1428, Argentina., Ferreira RS; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte 31270-901, Brazil., Dehaen W; Sustainable Chemistry for Metals and Molecules, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium., Quevedo MA; Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba (FCQ-UNC), Haya de la Torre y Medina Allende, Córdoba 5000, Argentina.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Sep 05; Vol. 29 (17). Date of Electronic Publication: 2024 Sep 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis , Cysteine Endopeptidases*/chemistry , Protozoan Proteins*/antagonists & inhibitors , Protozoan Proteins*/chemistry , Trypanosoma cruzi*/drug effects , Trypanosoma cruzi*/enzymology , Molecular Docking Simulation*, Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Cysteine Proteinase Inhibitors/chemical synthesis ; Molecular Dynamics Simulation ; Structure-Activity Relationship ; Computer-Aided Design ; Drug Design ; Humans ; Molecular Structure ; Trypanocidal Agents/pharmacology ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/chemical synthesis ; Chagas Disease/drug therapy

المؤلفون: Liu F; Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, Shenzhen, China.; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Laboratory Center of Stomatology, Department of Paediatric Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, China., Zhu B; Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.; Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China., An Y; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, China., Zhou Z; Department of Stomatology, General Hospital of Tibetan Military Command, Lhasa, China., Xiong P; Department of Stomatology Center, Shenzhen Hospital, Southern Medical University, Shenzhen, China., Li X; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, China., Mi Y; Department of Obstetrics, Northwest Women's and Children's Hospital, Xi'an, China., He T; Department of Obstetrics, Northwest Women's and Children's Hospital, Xi'an, China., Chen F; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, China. cfmsunhh@fmmu.edu.cn., Wu B; Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, Shenzhen, China. bulingwu@smu.edu.cn.

المصدر: International journal of oral science [Int J Oral Sci] 2024 Aug 01; Vol. 16 (1), pp. 53. Date of Electronic Publication: 2024 Aug 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: India NLM ID: 101504351 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-3169 (Electronic) Linking ISSN: 16742818 NLM ISO Abbreviation: Int J Oral Sci Subsets: MEDLINE

مواضيع طبية MeSH: Porphyromonas gingivalis*/metabolism , Insulin Resistance* , Receptor, Insulin*/metabolism , Gingipain Cysteine Endopeptidases*/metabolism, Animals ; Mice ; Humans ; Male ; Adhesins, Bacterial/metabolism ; Cysteine Endopeptidases/metabolism ; Proteolysis ; Female ; Adipocytes/metabolism ; Periodontitis/microbiology ; Coculture Techniques

المؤلفون: Zimmer C; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudingerweg 5, 55128 Mainz, Germany., Brauer J; Department of Chemistry, University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany., Ferenc D; Department of Chemistry, University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany., Meyr J; Institute of Physical and Theoretical Chemistry, Julius-Maximilians-University Würzburg, Am Hubland, 97074 Würzburg, Germany., Müller P; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudingerweg 5, 55128 Mainz, Germany., Räder HJ; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany., Engels B; Institute of Physical and Theoretical Chemistry, Julius-Maximilians-University Würzburg, Am Hubland, 97074 Würzburg, Germany., Opatz T; Department of Chemistry, University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany., Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudingerweg 5, 55128 Mainz, Germany.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 04; Vol. 29 (11). Date of Electronic Publication: 2024 Jun 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine Proteinase Inhibitors*/chemistry , Cysteine Proteinase Inhibitors*/pharmacology , Cysteine Proteinase Inhibitors*/metabolism , Molecular Docking Simulation* , Cysteine Proteases*/metabolism , Cysteine Proteases*/chemistry, Structure-Activity Relationship ; Cysteine Endopeptidases/metabolism ; Cysteine Endopeptidases/chemistry ; Molecular Structure

المؤلفون: van Midden KP; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia., Mantz M; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany; CECAD, Medical Faculty and University Hospital, University of Cologne, 50931 Cologne, Germany., Fonovič M; Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia., Gazvoda M; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia., Svete J; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia., Huesgen PF; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Jülich, Germany; CECAD, Medical Faculty and University Hospital, University of Cologne, 50931 Cologne, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany; CIBSS- Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany., van der Hoorn RAL; The Plant Chemetics Laboratory, Department of Biology, University of Oxford, OX1 3RB Oxford, UK., Klemenčič M; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia. Electronic address: marina.klemencic@fkkt.uni-lj.si.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Jun; Vol. 271 (Pt 1), pp. 132505. Date of Electronic Publication: 2024 May 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine Proteases*/metabolism , Cysteine Proteases*/chemistry , Chlamydomonas reinhardtii*/enzymology, Oxidative Stress ; Photosystem II Protein Complex/metabolism ; Photosystem II Protein Complex/chemistry ; Plant Proteins/metabolism ; Plant Proteins/chemistry ; Hydrogen Peroxide/metabolism ; Cysteine Endopeptidases/metabolism ; Cysteine Endopeptidases/chemistry

المؤلفون: Nemčovičová I; Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Lopušná K; Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Štibrániová I; Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Benedetti F; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy., Berti F; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy., Felluga F; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy., Drioli S; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy., Vidali M; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy., Katrlík J; Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia., Pažitná L; Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia., Holazová A; Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia., Blahutová J; Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia., Lenhartová S; Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Sláviková M; Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Klempa B; Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia., Ondrejovič M; Department of Biotechnology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius in Trnava, Trnava, Slovakia.; ICARST n.o, Bratislava, Slovakia., Chmelová D; Department of Biotechnology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius in Trnava, Trnava, Slovakia., Legerská B; Department of Biotechnology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius in Trnava, Trnava, Slovakia., Miertuš S; Department of Biotechnology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius in Trnava, Trnava, Slovakia.; ICARST n.o, Bratislava, Slovakia., Klacsová M; Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia., Uhríková D; Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia., Kerti L; Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia., Frecer V; Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2301772. Date of Electronic Publication: 2024 Jan 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Cysteine Proteases*, Humans ; SARS-CoV-2 ; Cysteine Endopeptidases/metabolism ; Viral Nonstructural Proteins/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Protease Inhibitors/pharmacology ; Protease Inhibitors/chemistry ; Molecular Docking Simulation

المؤلفون: Nkungli NK; Department of Chemistry, Faculty of Science, The University of Bamenda, Bambili, P. O. Box 39, Bamenda, Cameroon. nyiangken@gmail.com., Fouegue ADT; Department of Chemistry, Higher Teacher Training College Bertoua, University of Bertoua, P.O. Box 652, Bertoua, Cameroon., Tasheh SN; Department of Chemistry, Faculty of Science, The University of Bamenda, Bambili, P. O. Box 39, Bamenda, Cameroon.; Department of Chemistry, Faculty of Science, University of Dschang, P. O. Box 67, Dschang, Cameroon., Bine FK; Department of Chemistry, Faculty of Science, University of Dschang, P. O. Box 67, Dschang, Cameroon., Hassan AU; Department of Chemistry, University of Gujrat, Gujrat, 54400, PK, Pakistan., Ghogomu JN; Department of Chemistry, Faculty of Science, The University of Bamenda, Bambili, P. O. Box 39, Bamenda, Cameroon.; Department of Chemistry, Faculty of Science, University of Dschang, P. O. Box 67, Dschang, Cameroon.

المصدر: Molecular diversity [Mol Divers] 2024 Apr; Vol. 28 (2), pp. 475-496. Date of Electronic Publication: 2023 Jan 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Docking Simulation* , Antimalarials*/chemistry , Antimalarials*/pharmacology , Molecular Dynamics Simulation* , Benzimidazoles*/chemistry , Benzimidazoles*/pharmacology , Cysteine Endopeptidases*/chemistry , Cysteine Endopeptidases*/metabolism , Thiosemicarbazones*/chemistry , Thiosemicarbazones*/pharmacology , Plasmodium falciparum*/drug effects , Plasmodium falciparum*/enzymology, Kinetics ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Structure-Activity Relationship ; Thermodynamics ; Computer Simulation

المؤلفون: Chen J; Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States., Matye D; Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States., Dai Clayton Y; Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States., Du Y; Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States., Nazmul Hasan M; Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States., Gu L; Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States., Li T; Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States. Electronic address: tiangang-li@ouhsc.edu.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2024 Apr; Vol. 222, pp. 116103. Date of Electronic Publication: 2024 Feb 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Chemical and Drug Induced Liver Injury*/metabolism , Cysteine Dioxygenase*/genetics , Cysteine Dioxygenase*/metabolism , Drug-Related Side Effects and Adverse Reactions* , Glutathione*/metabolism, Animals ; Mice ; Acetaminophen/metabolism ; Acetaminophen/toxicity ; Antioxidants/pharmacology ; Bile Acids and Salts/metabolism ; Coenzyme A/metabolism ; Cysteine/metabolism ; Hepatocytes/metabolism ; Liver/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Taurine/pharmacology ; Taurine/metabolism

المؤلفون: Lei Z; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Ma Q; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Tu Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Qiu Y; Department of Endodontics, The Affiliated Stomatology Hospital, Southwest Medical University, Luzhou, China., Gong T; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Lin Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Zhou X; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Li Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China.

المصدر: Molecular oral microbiology [Mol Oral Microbiol] 2024 Oct; Vol. 39 (5), pp. 321-333. Date of Electronic Publication: 2024 Jan 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: Denmark NLM ID: 101524770 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1014 (Electronic) Linking ISSN: 20411006 NLM ISO Abbreviation: Mol Oral Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Porphyromonas gingivalis*/drug effects , Porphyromonas gingivalis*/pathogenicity , Porphyromonas gingivalis*/metabolism , Gingipain Cysteine Endopeptidases* , Niacinamide*/pharmacology , Heme*/metabolism , Adhesins, Bacterial*/metabolism , Adhesins, Bacterial*/drug effects , Periodontitis*/microbiology , Periodontitis*/prevention & control, Virulence/drug effects ; Animals ; Mice ; Hemolysis/drug effects ; Alveolar Bone Loss/prevention & control ; Alveolar Bone Loss/microbiology ; Disease Models, Animal ; Anti-Bacterial Agents/pharmacology ; Cysteine Endopeptidases/metabolism ; Hemagglutination/drug effects ; Bacteroidaceae Infections/microbiology ; Bacteroidaceae Infections/drug therapy ; Bacteroidaceae Infections/prevention & control ; Humans

المؤلفون: Di Chio C; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Starvaggi J; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Totaro N; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Previti S; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Natale B; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy., Cosconati S; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy., Bogacz M; Institute of Organic Chemistry & Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstraße, 10, DE 07743 Jena, Germany., Schirmeister T; Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, DE 55128 Mainz, Germany., Legac J; Department of Medicine, San Francisco General Hospital, University of California, 1001 Potrero Avenue, San Francisco, CA 94110, USA., Rosenthal PJ; Department of Medicine, San Francisco General Hospital, University of California, 1001 Potrero Avenue, San Francisco, CA 94110, USA., Zappalà M; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Ettari R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 17; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine Proteinase Inhibitors*/pharmacology , Cysteine Proteinase Inhibitors*/therapeutic use , Cysteine Proteinase Inhibitors*/chemistry , Nitriles*/therapeutic use , Plasmodium falciparum*/drug effects , Trypanosoma brucei rhodesiense*/drug effects , Trypanosomiasis, African*/drug therapy, Humans ; Antimalarials/therapeutic use ; Antimalarials/pharmacology ; Cysteine Endopeptidases/metabolism ; Malaria/drug therapy ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/metabolism ; Trypanocidal Agents/pharmacology ; Trypanocidal Agents/therapeutic use