المؤلفون: Skudlarek JW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Cooke AJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mitchell HJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Babaoglu K; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Shaw AW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tong L; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Nomland AB; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Labroli M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Sha D; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mulhearn JJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu C; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Li SW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Beshore DC; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hughes JME; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Jouffroy M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wang H; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Balibar CJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Painter RE; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Shen P; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Lange HS; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Ishchenko A; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Chen YT; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Klein DJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tracy RW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Miller RR; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Cabalu TD; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu Z; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Leithead A; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Scapin G; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hruza AW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Dzhekieva L; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bukhtiyarova M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Homsher MF; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Xu M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bahnck-Teets C; Merck & Co., Inc., Rahway, New Jersey 07065, United States., McKenney D; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Buevich AV; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Liu J; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhang LK; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Meng T; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Kelly T; Merck & Co., Inc., Rahway, New Jersey 07065, United States., DiNunzio E; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Soisson S; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Cheng RKY; leadXpro AG, CH-5234 Villigen, Switzerland., Hennig M; leadXpro AG, CH-5234 Villigen, Switzerland., Raheem I; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Walker SS; Merck & Co., Inc., Rahway, New Jersey 07065, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22. Date of Electronic Publication: 2024 Aug 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

المؤلفون: Alvarez N; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Adam GC; Merck & Co., Inc., Rahway, NJ 07065, USA., Howe JA; Merck & Co., Inc., Rahway, NJ 07065, USA., Sharma V; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Zimmerman MD; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Dolgov E; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Rasheed R; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Nizar F; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Sahay K; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Nelson AM; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Park S; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Zhou X; Merck & Co., Inc., Rahway, NJ 07065, USA., Burlein C; Merck & Co., Inc., Rahway, NJ 07065, USA., Fay JF; Merck & Co., Inc., Rahway, NJ 07065, USA., Iwamoto DV; Merck & Co., Inc., Rahway, NJ 07065, USA., Bahnck-Teets CM; Merck & Co., Inc., Rahway, NJ 07065, USA., Getty KL; Merck & Co., Inc., Rahway, NJ 07065, USA., Lin Goh S; Merck & Co., Inc., Rahway, NJ 07065, USA., Salhab I; Merck & Co., Inc., Rahway, NJ 07065, USA., Smith K; Merck & Co., Inc., Rahway, NJ 07065, USA., Boyce CW; Merck & Co., Inc., Rahway, NJ 07065, USA., Cabalu TD; Merck & Co., Inc., Rahway, NJ 07065, USA., Murgolo N; Merck & Co., Inc., Rahway, NJ 07065, USA., Fox NG; Merck & Co., Inc., Rahway, NJ 07065, USA., Mayhood TW; Merck & Co., Inc., Rahway, NJ 07065, USA., Shurtleff VW; Merck & Co., Inc., Rahway, NJ 07065, USA., Layton ME; Merck & Co., Inc., Rahway, NJ 07065, USA., Parish CA; Merck & Co., Inc., Rahway, NJ 07065, USA., McCauley JA; Merck & Co., Inc., Rahway, NJ 07065, USA., Olsen DB; Merck & Co., Inc., Rahway, NJ 07065, USA., Perlin DS; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA.

المصدر: Viruses [Viruses] 2024 Jul 18; Vol. 16 (7). Date of Electronic Publication: 2024 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

مواضيع طبية MeSH: SARS-CoV-2*/drug effects , Antiviral Agents*/pharmacology, Animals ; Mice ; Humans ; Coronavirus 3C Proteases/antagonists & inhibitors ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Middle East Respiratory Syndrome Coronavirus/genetics ; COVID-19 Drug Treatment ; Protease Inhibitors/pharmacology ; COVID-19/virology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology

المؤلفون: Wang H; Merck & Co., Inc., West Point, PA, USA., Ishchenko A; Merck & Co., Inc., West Point, PA, USA., Skudlarek J; Merck & Co., Inc., West Point, PA, USA., Shen P; Merck & Co., Inc., West Point, PA, USA., Dzhekieva L; Merck & Co., Inc., West Point, PA, USA., Painter RE; Merck & Co., Inc., West Point, PA, USA., Chen YT; Merck & Co., Inc., West Point, PA, USA., Bukhtiyarova M; Merck & Co., Inc., West Point, PA, USA., Leithead A; Merck & Co., Inc., West Point, PA, USA., Tracy R; Merck & Co., Inc., West Point, PA, USA., Babaoglu K; Merck & Co., Inc., West Point, PA, USA., Bahnck-Teets C; Merck & Co., Inc., West Point, PA, USA., Buevich A; Merck & Co., Inc., Rahway, NJ, USA., Cabalu TD; Merck & Co., Inc., West Point, PA, USA., Labroli M; Merck & Co., Inc., West Point, PA, USA., Lange H; Merck & Co., Inc., West Point, PA, USA., Lei Y; Merck & Co., Inc., West Point, PA, USA., Li W; Merck & Co., Inc., West Point, PA, USA., Liu J; Merck & Co., Inc., West Point, PA, USA., Mann PA; Merck & Co., Inc., West Point, PA, USA., Meng T; Merck & Co., Inc., Rahway, NJ, USA., Mitchell HJ; Merck & Co., Inc., West Point, PA, USA., Mulhearn J; Merck & Co., Inc., West Point, PA, USA., Scapin G; Merck & Co., Inc., Rahway, NJ, USA., Sha D; Merck & Co., Inc., West Point, PA, USA., Shaw AW; Merck & Co., Inc., West Point, PA, USA., Si Q; Merck & Co., Inc., West Point, PA, USA., Tong L; Merck & Co., Inc., West Point, PA, USA., Wu C; Merck & Co., Inc., West Point, PA, USA., Wu Z; Merck & Co., Inc., West Point, PA, USA., Xiao JC; Merck & Co., Inc., West Point, PA, USA., Xu M; Merck & Co., Inc., West Point, PA, USA., Zhang LK; Merck & Co., Inc., Rahway, NJ, USA., McKenney D; Merck & Co., Inc., West Point, PA, USA., Miller RR; Merck & Co., Inc., Rahway, NJ, USA., Black TA; Merck & Co., Inc., West Point, PA, USA., Cooke A; Merck & Co., Inc., West Point, PA, USA., Balibar CJ; Merck & Co., Inc., West Point, PA, USA., Klein DJ; Merck & Co., Inc., West Point, PA, USA., Raheem I; Merck & Co., Inc., West Point, PA, USA., Walker SS; Merck & Co., Inc., West Point, PA, USA. scott.walker@merck.com.

المصدر: Nature microbiology [Nat Microbiol] 2024 May; Vol. 9 (5), pp. 1244-1255. Date of Electronic Publication: 2024 Apr 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Acinetobacter baumannii*/drug effects , Acinetobacter baumannii*/metabolism , Lipopolysaccharides*/metabolism , Acinetobacter Infections*/microbiology , Acinetobacter Infections*/drug therapy , Anti-Bacterial Agents*/pharmacology , Bacterial Proteins*/metabolism, Animals ; Mice ; Biological Transport ; Microbial Sensitivity Tests ; Humans ; Cryoelectron Microscopy ; Carbapenems/pharmacology ; Carbapenems/metabolism ; Disease Models, Animal ; Female ; ATP-Binding Cassette Transporters

المؤلفون: Shurtleff VW; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Layton ME; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Parish CA; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Perkins JJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Schreier JD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Wang Y; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Adam GC; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Alvarez N; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Bahmanjah S; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bahnck-Teets CM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Boyce CW; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Burlein C; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cabalu TD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Campbell BT; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Carroll SS; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Chang W; Merck & Co., Inc., Rahway, New Jersey 07065, United States., de Lera Ruiz M; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Dolgov E; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Fay JF; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Fox NG; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Goh SL; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hartingh TJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hurzy DM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kelly MJ 3rd; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Klein DJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Klingler FM; MSD (U.K.) Limited, London EC2M 6UR, U.K., Krishnamurthy H; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kudalkar S; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Mayhood TW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., McKenna PM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Murray EM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Nahas D; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Nawrat CC; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Park S; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Qian D; Viva Biotech Ltd., Shanghai 201318, China., Roecker AJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Sharma V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Shipe WD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Su J; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Taggart RV; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Truong Q; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu Y; Viva Biotech Ltd., Shanghai 201318, China., Zhou X; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhuang N; Viva Biotech Ltd., Shanghai 201318, China., Perlin DS; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Olsen DB; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Howe JA; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., McCauley JA; Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3935-3958. Date of Electronic Publication: 2024 Feb 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Glutamine*/chemistry , COVID-19*, Humans ; SARS-CoV-2 ; Cysteine Endopeptidases/chemistry ; Inventions ; Protease Inhibitors/pharmacology ; Amides ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry

المؤلفون: Morriello GJ; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA. Electronic address: greg_morriello@merck.com., Dwyer MP; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Chen Y; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Ginetti AT; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Xu S; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA., Lu J; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Abeywickrema P; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Wang D; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Crespo A; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Cabalu TD; Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Wilson JE; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Stachel SJ; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Paone DV; Discovery Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Sinz C; Discovery Chemistry, Merck & Co., Inc., 213 E. Grand Avenue, South San Fransisco, CA 94080, USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jul 15; Vol. 44, pp. 128082. Date of Electronic Publication: 2021 May 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Cyclic Nucleotide Phosphodiesterases, Type 2/*antagonists & inhibitors , Phosphodiesterase Inhibitors/*pharmacology , Pyrazoles/*pharmacology , Pyrimidinones/*pharmacology, Crystallography, X-Ray ; Cyclic Nucleotide Phosphodiesterases, Type 2/metabolism ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/chemistry ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Pyrimidinones/chemical synthesis ; Pyrimidinones/chemistry ; Structure-Activity Relationship

المؤلفون: Yee KL; Merck & Co., Inc., Kenilworth, New Jersey, USA., Cabalu TD; Merck & Co., Inc., Kenilworth, New Jersey, USA., Kuo Y; Merck & Co., Inc., Kenilworth, New Jersey, USA., Fillgrove KL; Merck & Co., Inc., Kenilworth, New Jersey, USA., Liu Y; Merck & Co., Inc., Kenilworth, New Jersey, USA., Triantafyllou I; Merck & Co., Inc., Kenilworth, New Jersey, USA., McClain S; Merck & Co., Inc., Kenilworth, New Jersey, USA., Dreyer D; Merck & Co., Inc., Kenilworth, New Jersey, USA., Wenning L; Merck & Co., Inc., Kenilworth, New Jersey, USA., Stoch SA; Merck & Co., Inc., Kenilworth, New Jersey, USA., Iwamoto M; Merck & Co., Inc., Kenilworth, New Jersey, USA., Sanchez RI; Merck & Co., Inc., Kenilworth, New Jersey, USA., Khalilieh SG; Merck & Co., Inc., Kenilworth, New Jersey, USA.

المصدر: Journal of clinical pharmacology [J Clin Pharmacol] 2021 Mar; Vol. 61 (3), pp. 394-405. Date of Electronic Publication: 2020 Sep 28.

نوع المنشور: Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological*, Pyridones/*pharmacokinetics , Reverse Transcriptase Inhibitors/*pharmacokinetics , Rifabutin/*pharmacology , Triazoles/*pharmacokinetics, Adult ; Alkynes/pharmacology ; Benzoxazines/pharmacology ; Computer Simulation ; Cyclopropanes/pharmacology ; Cytochrome P-450 CYP3A/drug effects ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP3A Inducers/pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Humans ; Male ; Middle Aged ; Pyridones/administration & dosage ; Reverse Transcriptase Inhibitors/administration & dosage ; Rifabutin/administration & dosage ; Rifampin/pharmacology ; Triazoles/administration & dosage ; Young Adult

المؤلفون: Monroe JJ; Safety Assessment & Laboratory Animal Resources., Tanis KQ; Human Genetics & Pharmacogenomics., Podtelezhnikov AA; Human Genetics & Pharmacogenomics., Nguyen T; Safety Assessment & Laboratory Animal Resources., Machotka SV; Safety Assessment & Laboratory Animal Resources., Lynch D; Safety Assessment & Laboratory Animal Resources., Evers R; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Palamanda J; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Miller RR; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Pippert T; Safety Assessment & Laboratory Animal Resources., Cabalu TD; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Johnson TE; Safety Assessment & Laboratory Animal Resources., Aslamkhan AG; Safety Assessment & Laboratory Animal Resources., Kang W; Safety Assessment & Laboratory Animal Resources., Tamburino AM; Human Genetics & Pharmacogenomics., Mitra K; Safety Assessment & Laboratory Animal Resources.; Janssen Research & Development, LLC, Spring House, PA 19486., Agrawal NGB; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Sistare FD; Safety Assessment & Laboratory Animal Resources.

المصدر: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2020 Sep 01; Vol. 177 (1), pp. 281-299.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Chemical and Drug Induced Liver Injury* , Pharmaceutical Preparations*, Animals ; Drug Development ; Kelch-Like ECH-Associated Protein 1 ; Male ; NF-E2-Related Factor 2/metabolism ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar

المؤلفون: Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., a member of the Roche Group, South San Francisco, California, USA., Cabalu TD; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey, USA., Callegari E; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut, USA., Einolf H; Modeling & Simulation, PK Sciences, Novartis Institutes for Biomedical Research, East Hanover, New Jersey, USA., Liu L; Genentech Inc., a member of the Roche Group, South San Francisco, California, USA., Parrott N; Pharmaceutical Sciences, Pharmaceutical Research and Early Development, Roche Innovation Centre, Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Peters SA; Translational Quantitative Pharmacology, Merck KGaA, Darmstadt, Germany., Schuck E; Modeling & Simulation, Clinical Pharmacology Science/Medicine Development Center (MDC), Eisai Inc., Woodcliff Lake, New Jersey, USA., Sharma P; Mechanistic Safety and ADME Sciences, Drug Safety and Metabolism, Innovative Medicines (IMED) Biotech Unit , AstraZeneca R&D, Cambridge, UK., Tracey H; Department of Mechanistic Safety and Disposition, GlaxoSmithKline, Hertfordshire, UK., Upreti VV; Clinical Pharmacology Modeling and Simulation, Amgen Inc., South San Francisco, California, USA., Zheng M; Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb Company, Princeton, New Jersey, USA., Zhu AZX; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA., Hall SD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2019 Sep; Vol. 8 (9), pp. 685-695. Date of Electronic Publication: 2019 Aug 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A/*metabolism , Itraconazole/*pharmacokinetics, Area Under Curve ; Drug Dosage Calculations ; Drug Interactions ; Food-Drug Interactions ; Humans ; Itraconazole/pharmacology ; Models, Statistical

المؤلفون: Forster AB; Discovery Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA. Electronic address: Ashley_nomland@merck.com., Abeywickrema P; Target Protein Design, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Bunda J; Discovery Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Cox CD; Discovery Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Cabalu TD; PPDM Preclinical ADME, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Egbertson M; Discovery Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Fay J; Pharmacology, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Getty K; Assay Development, Protein Science, 770 Sumneytown Pike, MRL, West Point, PA 19486, USA., Hall D; Target Protein Design, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Kornienko M; Target Protein Design, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Lu J; Structural Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Parthasarathy G; Structural Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Reid J; Structural Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Sharma S; Target Protein Design, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Shipe WD; Discovery Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Smith SM; Neuroscience, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Soisson S; Structural Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Stachel SJ; Discovery Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Su HP; Structural Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Wang D; Chemical Modeling & Informatics, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA., Berger R; Discovery Chemistry, MRL, 770 Sumneytown Pike, West Point, PA 19486, USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Dec 01; Vol. 27 (23), pp. 5167-5171. Date of Electronic Publication: 2017 Oct 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Cyclic Nucleotide Phosphodiesterases, Type 2/*antagonists & inhibitors , Phosphodiesterase Inhibitors/*chemistry, Animals ; Binding Sites ; Catalytic Domain ; Crystallography, X-Ray ; Cyclic Nucleotide Phosphodiesterases, Type 2/metabolism ; Half-Life ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Molecular Conformation ; Molecular Dynamics Simulation ; Phosphodiesterase Inhibitors/metabolism ; Phosphodiesterase Inhibitors/pharmacokinetics ; Pyrazoles/chemistry ; Pyrazoles/metabolism ; Pyrazoles/pharmacokinetics ; Pyrimidines/chemistry ; Pyrimidines/metabolism ; Pyrimidines/pharmacokinetics ; Rats ; Structure-Activity Relationship

المؤلفون: Hurzy DM; Department of Medicinal Chemistry, MRL, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Electronic address: danielle_mcmaster@merck.com., Henze DA; Department of Pain Research, MRL, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Cabalu TD; Department of Drug Metabolism, MRL, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA., Narayan K; Analytical Process and Technology, Sanofi Pasteur, Discovery Drive, Swiftwater, PA 18370, USA., Heller A; Scientific Operations, Lab Connect, LLC., 605 First Avenue, Ste. 300, Seattle, WA 98104, USA., Cooke AJ; Department of Medicinal Chemistry, MRL, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 15; Vol. 27 (12), pp. 2695-2701. Date of Electronic Publication: 2017 Apr 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Indoles/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Receptor, trkA/*antagonists & inhibitors, Dose-Response Relationship, Drug ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Receptor, trkA/metabolism ; Structure-Activity Relationship