المؤلفون: Isozaki H; Massachusetts General Hospital Cancer Center, Boston, MA, USA. hisozaki@mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. hisozaki@mgh.harvard.edu., Sakhtemani R; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Abbasi A; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Nikpour N; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Stanzione M; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Oh S; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA., Langenbucher A; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Monroe S; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Su W; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Cabanos HF; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Siddiqui FM; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Phan N; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Jalili P; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA., Timonina D; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Bilton S; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Gomez-Caraballo M; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Archibald HL; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Nangia V; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Dionne K; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Riley A; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Lawlor M; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Banwait MK; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Cobb RG; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Zou L; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Dyson NJ; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ott CJ; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Benes C; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Getz G; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Chan CS; Department of Medicine, Rutgers Robert Wood Johnson Medical School and Center for Systems and Computational Biology, Rutgers Cancer Institute, New Brunswick, NJ, USA., Shaw AT; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Gainor JF; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lin JJ; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Sequist LV; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Piotrowska Z; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Yeap BY; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Engelman JA; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lee JJ; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Maruvka YE; Faculty of Biotechnology and Food Engineering, Lorey Loki Center for Life Science and Engineering, Technion, Haifa, Israel., Buisson R; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.; Department of Pharmaceutical Sciences, School of Pharmacy & Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA., Lawrence MS; Massachusetts General Hospital Cancer Center, Boston, MA, USA. mslawrence@mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mslawrence@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. mslawrence@mgh.harvard.edu., Hata AN; Massachusetts General Hospital Cancer Center, Boston, MA, USA. ahata@mgh.harvard.edu.; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. ahata@mgh.harvard.edu.

المصدر: Nature [Nature] 2023 Aug; Vol. 620 (7973), pp. 393-401. Date of Electronic Publication: 2023 Jul 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cytidine Deaminase*/deficiency , Cytidine Deaminase*/drug effects , Cytidine Deaminase*/genetics , Cytidine Deaminase*/metabolism , Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology, Humans ; DNA Breaks, Double-Stranded ; Genomic Instability ; Molecular Targeted Therapy ; Mutation ; Drug Resistance, Neoplasm

المؤلفون: Oren Y; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Tsabar M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Cuoco MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Amir-Zilberstein L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cabanos HF; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Medicine, Harvard Medical School, Boston, MA, USA., Hütter JC; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hu B; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Tabaka M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Colgan W; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuevas BM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hurvitz SA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Slamon DJ; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Deik A; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Pierce KA; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Clish C; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Hata AN; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Medicine, Harvard Medical School, Boston, MA, USA., Zaganjor E; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Lahav G; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Politi K; Section of Medical Oncology, Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Center, New Haven, CT, USA., Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. joan_brugge@hms.harvard.edu.; Ludwig Center at Harvard, Boston, MA, USA. joan_brugge@hms.harvard.edu., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com.

المصدر: Nature [Nature] 2021 Aug; Vol. 596 (7873), pp. 576-582. Date of Electronic Publication: 2021 Aug 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle*/drug effects , Cell Lineage*/drug effects, Neoplasm Recurrence, Local/*drug therapy , Neoplasm Recurrence, Local/*pathology , Neoplasms/*drug therapy , Neoplasms/*pathology, Antioxidants/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Clone Cells/drug effects ; Clone Cells/metabolism ; Clone Cells/pathology ; DNA Barcoding, Taxonomic ; Fatty Acids/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Lentivirus/genetics ; Neoplasm Recurrence, Local/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Oncogene Proteins/antagonists & inhibitors ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Transcription, Genetic/drug effects

المؤلفون: Cabanos HF; Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Hata AN; Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

المصدر: Cancers [Cancers (Basel)] 2021 May 28; Vol. 13 (11). Date of Electronic Publication: 2021 May 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE