يعرض 1 - 10 نتائج من 14 نتيجة بحث عن '"Cai Read"', وقت الاستعلام: 1.03s تنقيح النتائج
  1. 1
    دورية أكاديمية
    The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

    المؤلفون: Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E. Kuc, Thomas L. Williams, Christopher M. Fitzpatrick, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport

    المصدر: Frontiers in Pharmacology, Vol 11 (2021)

    مصطلحات موضوعية: apelin, bias, cardiovascular, in vivo, apoptosis, pulmonary artery endothelial cell, Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.588669/full; https://doaj.org/toc/1663-9812

    URL الوصول: https://doaj.org/article/2d0660c081eb47399d2ca55e2ed4196f

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  2. 2
    دورية أكاديمية
    Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR1), not G‐Protein‐Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

    المؤلفون: Amanda J. Kennedy, Peiran Yang, Cai Read, Rhoda E. Kuc, Lucy Yang, Emily J. A. Taylor, Colin W. Taylor, Janet J. Maguire, Anthony P. Davenport

    المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 10 (2016)

    مصطلحات موضوعية: agonist, antagonist, blood pressure, chemerin, contraction, G‐protein‐coupled receptors, Diseases of the circulatory (Cardiovascular) system, RC666-701

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2047-9980

    URL الوصول: https://doaj.org/article/514a9408dd984b9285682713b98ed396

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  3. 3
    Irreversible and noncompetitive mu opioid receptor agonists

    المؤلفون: Edward Stahl, Cullen L. Schmid, Agnes Acevedo‐Canabal, Cai Read, Travis Grim, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn

    المصدر: The FASEB Journal. 36

    مصطلحات موضوعية: Genetics, Molecular Biology, Biochemistry, Biotechnology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fbaa78bff7307785ba5137b3450afd62
    https://doi.org/10.1096/fasebj.2022.36.s1.r1962

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  4. 4
    International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand

    المؤلفون: Thomas L Williams, David J. Huggins, Petra Sulentic, Janet J. Maguire, Robyn Macrae, Cai Read, Duuamene Nyimanu, Peiran Yang, Robert C. Glen, Anthony P. Davenport

    المصدر: Pharmacological Reviews

    مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, GENE POLYMORPHISM, Protein Conformation, Peptide Hormones, RIGHT-VENTRICULAR FUNCTION, BLOOD-PRESSURE, Peptide, Pharmacology, INHIBITS INSULIN-SECRETION, Ligands, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Animals, Humans, Tissue Distribution, Pharmacology & Pharmacy, Amino Acid Sequence, Peptide sequence, Apelin receptor, Orphan receptor, chemistry.chemical_classification, Apelin Receptors, Science & Technology, THERAPEUTIC TARGET, Chemistry, ORPHAN 7-TRANSMEMBRANE RECEPTOR, IMMUNODEFICIENCY-VIRUS TYPE-1, Small molecule, 3. Good health, Apelin, IUPHAR Nomenclature Report, 030104 developmental biology, CORONARY-ARTERY-DISEASE, HEART-FAILURE, Molecular Medicine, 1115 Pharmacology and Pharmaceutical Sciences, Signal transduction, Life Sciences & Biomedicine, HUMAN APJ RECEPTOR, 030217 neurology & neurosurgery, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e33aeb1af100558c125fd20a12e23d6
    http://europepmc.org/articles/PMC6731456

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  5. 5
    G protein signaling–biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists

    المؤلفون: Nicole M. Kennedy, Cullen L. Schmid, Agnes Acevedo-Canabal, Edward L. Stahl, Laura M. Bohn, Cai Read, Travis W. Grim, Thomas D. Bannister

    المصدر: Proc Natl Acad Sci U S A

    مصطلحات موضوعية: Male, Agonist, G protein, medicine.drug_class, Narcotic Antagonists, Allosteric regulation, Receptors, Opioid, mu, (+)-Naloxone, Pharmacology, Ligands, Partial agonist, Receptors, G-Protein-Coupled, Mice, Piperidines, GTP-Binding Proteins, Functional selectivity, medicine, Animals, G protein-coupled receptor, Multidisciplinary, Chemistry, Biological Sciences, beta-Arrestin 2, Analgesics, Opioid, Mice, Inbred C57BL, Benzimidazoles, μ-opioid receptor, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c3fb22b788a2b9c93de2a22ba74551
    https://doi.org/10.1073/pnas.2102178118

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  6. 6
    A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

    المؤلفون: Robert C. Glen, Anthony P. Davenport, Duuamene Nyimanu, Alexi Crosby, Janet J. Maguire, Guido Buonincontri, Cai Read, Mark Southwood, Thomas L Williams, Nicholas W. Morrell, Peiran Yang, Rhoda E. Kuc, Stephen J. Sawiak

    المساهمون: Maguire, Janet J [0000-0002-9254-7040], Apollo - University of Cambridge Repository

    المصدر: British Journal of Pharmacology

    مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, medicine.drug_class, RIGHT-VENTRICULAR FUNCTION, Vasodilation, Pharmacology, Endothelial NOS, MECHANISMS, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, medicine, Animals, Pharmacology & Pharmacy, ANTAGONIST, Apelin receptor, Apelin Receptors, Pulmonary Arterial Hypertension, Science & Technology, Ejection fraction, Monocrotaline, PLASMA, business.industry, CONCISE GUIDE, Research Papers, 3. Good health, Apelin, Rats, Disease Models, Animal, 030104 developmental biology, DISCOVERY, APJ, Pulmonary artery, Ventricular pressure, LIGAND, 1115 Pharmacology and Pharmaceutical Sciences, business, Life Sciences & Biomedicine, 030217 neurology & neurosurgery, Research Paper

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546664dd224b2e81d071db457495fa1a
    http://europepmc.org/articles/PMC6468262

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  7. 7
    The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis

    المؤلفون: Cai, Read, Duuamene, Nyimanu, Peiran, Yang, Rhoda E, Kuc, Thomas L, Williams, Christopher M, Fitzpatrick, Richard, Foster, Robert C, Glen, Janet J, Maguire, Anthony P, Davenport

    المصدر: Frontiers in Pharmacology

    مصطلحات موضوعية: Pharmacology, in vivo, bias, apelin, pulmonary artery endothelial cell, cardiovascular, apoptosis, G protein coupled receptor, Original Research

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a601ad08053ad6f105fd2efee8281052
    https://pubmed.ncbi.nlm.nih.gov/33716722

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  8. 8
    Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo

    المؤلفون: Rhoda E. Kuc, Robert C. Glen, Anthony P. Davenport, Thomas L Williams, Peiran Yang, Janet J. Maguire, Andrew Smart, Duuamene Nyimanu, Cai Read, Lucy J. Holt, Haren Arulanantham

    المساهمون: Nyimanu, Duuamene [0000-0002-6212-9518], Williams, Thomas [0000-0002-1051-0595], Glen, Robert [0000-0003-1759-2914], Davenport, Anthony [0000-0002-2096-3117], Maguire, Janet [0000-0002-9254-7040], Apollo - University of Cambridge Repository

    مصطلحات موضوعية: Agonist, Male, medicine.drug_class, Peptide, G protein coupled receptor, Blood Pressure, Pharmacology, Toxicology, Total word count = 6189, 030226 pharmacology & pharmacy, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, Animals, Humans, Pharmacology & Pharmacy, G protein-coupled receptor, Cardiac Output, Receptor, Serum Albumin, Apelin receptor, chemistry.chemical_classification, Apelin Receptors, Chemistry, cardiovascular, Albumin, General Medicine, Human serum albumin, Myocardial Contraction, 3. Good health, Apelin, Rats, AlbudAb, in vivo, apelin, Intercellular Signaling Peptides and Proteins, 1115 Pharmacology and Pharmaceutical Sciences, 030217 neurology & neurosurgery, medicine.drug

    وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae3b8d28cc2ad933db5bb33d968d90b
    https://www.repository.cam.ac.uk/handle/1810/290748

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  9. 9
    Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension

    المؤلفون: Benjamin E, Garfield, Alexi, Crosby, Dongmin, Shao, Peiran, Yang, Cai, Read, Steven, Sawiak, Stephen, Moore, Lisa, Parfitt, Carl, Harries, Martin, Rice, Richard, Paul, Mark L, Ormiston, Nicholas W, Morrell, Michael I, Polkey, Stephen John, Wort, Paul R, Kemp

    المصدر: Thorax. 74(2)

    مصطلحات موضوعية: Adult, Male, Growth Differentiation Factor 15, Hypertension, Pulmonary, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Middle Aged, MAP Kinase Kinase Kinases, Real-Time Polymerase Chain Reaction, Immunohistochemistry, Rats, Rats, Sprague-Dawley, Mice, Muscular Atrophy, Transforming Growth Factor beta, Animals, Humans, Female, Muscle, Skeletal, Biomarkers, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::99568eb8a9b4d1131943a42a1f49529b
    https://pubmed.ncbi.nlm.nih.gov/30554140

    Find this article in full text from ProQuest
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  10. 10
    Abstract P183: Chemokine-like Receptor 1 Mediates the Vasoconstrictor Actions of Chemerin in vitro and in vivo

    المؤلفون: Amanda J. Kennedy, Cai Read, Rhoda E. Kuc, Peiran Yang, Janet J. Maguire, Anthony P. Davenport

    المصدر: Hypertension. 68

    مصطلحات موضوعية: biology, In vivo, Chemistry, Internal Medicine, biology.protein, Chemerin, CMKLR1, In vitro, Cell biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::68af986b678c54edb07671d4e275ec14
    https://doi.org/10.1161/hyp.68.suppl_1.p183

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