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المؤلفون: James Morrison, Rachel H. Munday, Thomas O. Ronson, Matthew R. Tatton, Hucheng Zhao, Calum Cook, Daniël de Bruin, Kevin William Leslie, Kuangchu Dai, David Buttar, Catalina Ferrer, James Douglas
المصدر: The Journal of Organic Chemistry. 87:2075-2086
مصطلحات موضوعية: Piperazine, chemistry.chemical_compound, Atropisomer, Nitromethane, Chemistry, Organic Chemistry, API MANUFACTURE, Protecting group, Ring (chemistry), Racemization, Combinatorial chemistry, Carbonylation
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المؤلفون: Andrew D. Campbell, Staffan Karlsson, Štefan Moravčík, Hanna Leek, Kuangchu Dai, Matthew R. Tatton, Kristina Öhlén, Hucheng Zhao, Marcus Malmgren, Hans Emtenäs, Anna-Carin C. Carlsson, Grigorios Nikitidis, Calum Cook, Anna C. Jonson, Subhash Pithani
المصدر: Organic Process Research & Development. 26:710-729
مصطلحات موضوعية: Chromatography, Chemistry, Organic Chemistry, Physical and Theoretical Chemistry
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المؤلفون: Staffan Karlsson, Helen Benson, Calum Cook, Gordon Currie, Jerome Dubiez, Hans Emtenäs, Janet Hawkins, Rebecca Meadows, Peter D. Smith, Jeffrey Varnes
المصدر: Organic Process Research & Development. 26:601-615
مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry
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المؤلفون: Tieguang Yao, Liangwei Wu, Craig S. Donald, Douglas Ferguson, Lei Wang, Andrew Pike, Jianyan Wang, Justin Cidado, Dedong Wu, Kurt Gordon Pike, Kumar Thakur, Chungang Gu, Calum Cook, James Horstick, Tyler Grebe, Theresa Proia, Darren Stead, Alexander Hird, Michelle Lamb, Wenlin Shao, Nichole O'Connell, Yun Jiang, Sudhir M. Hande, Bin Yang, Janet Hawkins, Barlaam Bernard Christophe, Neil Sumner, Melissa Vasbinder, Andrew D. Ferguson, Jane E. Moore, Jeffrey G. Varnes, Bryan Roberts, Maryann San Martin, Lisa Drew, Ujjal Sarkar, Allan Dishington, Chris De Savi, Robert Casella, Steve C. Glossop, Jane L. Holmes, Thomas M. McGuire
المصدر: Journal of Medicinal Chemistry. 63:15564-15590
مصطلحات موضوعية: Pyridines, Drug Evaluation, Preclinical, Apoptosis, Pharmacology, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, Dogs, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Binding Sites, Chemistry, Cyclin-Dependent Kinase 9, Xenograft Model Antitumor Assays, Effective dose (pharmacology), Rats, 0104 chemical sciences, Molecular Docking Simulation, Clinical trial, 010404 medicinal & biomolecular chemistry, Solubility, Cell culture, Hematologic Neoplasms, Cancer cell, Myeloid Cell Leukemia Sequence 1 Protein, Molecular Medicine, Half-Life
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المؤلفون: James J, Douglas, Matthew R, Tatton, Daniël, de Bruin, David, Buttar, Calum, Cook, Kuangchu, Dai, Catalina, Ferrer, Kevin, Leslie, James, Morrison, Rachel, Munday, Thomas O, Ronson, Hucheng, Zhao
المصدر: The Journal of organic chemistry. 87(4)
مصطلحات موضوعية: Proto-Oncogene Proteins p21(ras), Methane, Nitroparaffins
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المؤلفون: Jia Tang, Richard A. Ward, Paul A. Bethel, Scott G. Lamont, Julian A. Hudson, Philip Hopcroft, Clifford David Jones, Steve Swallow, Richard J. Lewis, Tomkinson Gary Peter, Baochang Zhai, Nicola Lindsay, Jason Breed, Emma J. Davies, Yongchao Li, Vikki Flemington, Michael Tonge, Paul Farrington, Ryan Greenwood, Mark A. Graham, Linda Sandin, Thomas M. McGuire, James F. McCabe, Mark J. Anderton, Michael R. James, Andrew Hornby Dobson, Philip B. Rawlins, Lyndsey Hanson, Iain Simpson, Karen Roberts, Gary Fairley, Rachel L. Howells, Christopher R. Jones, Calum Cook, Francis D. Gibbons, Zhiqiang Dong, Lyman Feron, Zhenhua Wang
المصدر: Journal of medicinal chemistry. 62(24)
مصطلحات موضوعية: MAPK/ERK pathway, Lung Neoplasms, Combination therapy, Administration, Oral, Mice, Nude, Antineoplastic Agents, Apoptosis, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, Mice, Carcinoma, Non-Small-Cell Lung, Drug Discovery, medicine, Tumor Cells, Cultured, Animals, Humans, Protein Kinase Inhibitors, 030304 developmental biology, ADME, Cell Proliferation, Mitogen-Activated Protein Kinase 1, 0303 health sciences, Mitogen-Activated Protein Kinase 3, Molecular Structure, Cell growth, Chemistry, Kinase, Drug discovery, Melanoma, Imidazoles, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Pyrimidines, Pyrazines, Cancer research, Molecular Medicine, Drug Therapy, Combination, Female, Carcinogenesis
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المؤلفون: Hans Emtenäs, Paul M. Gillespie, Staffan Karlsson, Mubina Mohamed, Calum Cook, Kenny J. H. Fan
المصدر: Organic Process Research & Development. 21:1668-1674
مصطلحات موضوعية: 010405 organic chemistry, Organic Chemistry, Triazole, Continuous manufacturing, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, Acetic acid, chemistry, Sodium azide, Physical and Theoretical Chemistry, Isopropyl
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المؤلفون: Calum Cook, Tina Howard, Emma J. Davies, Lyman Feron, Jia Tang, Mark A. Graham, Paul A. Bethel, Vikki Flemington, Scott G. Lamont, Judit E. Debreczeni, Gary Fairley, Michael Tonge, Steve St-Gallay, Clifford David Jones, Karen Roberts, Christopher R. Jones, Baochang Zhai, Iain Simpson, Julian A. Hudson, Lyndsey Hanson, Zhenhua Wang, Richard A. Ward, Michael James, Richard J. Lewis, Nicola Griffin, Steve Swallow, Philip Hopcroft, Nicola Lindsay, Ryan Greenwood
المصدر: Journal of Medicinal Chemistry. 60:3438-3450
مصطلحات موضوعية: 0301 basic medicine, MAP Kinase Signaling System, Chemistry, Drug discovery, Erk signaling, Biological Availability, Pharmacology, Methylation, 03 medical and health sciences, Dogs, 030104 developmental biology, 0302 clinical medicine, Acquired resistance, In vivo, Cell culture, Cell Line, Tumor, 030220 oncology & carcinogenesis, Drug Discovery, Animals, Humans, Molecular Medicine, Transferase, Protein Kinase Inhibitors, Biological availability
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المؤلفون: Anil Patel, Rebecca E. Meadows, Kurt Gordon Pike, Jane E. Moore, Turner Paul, Darren Stead, Barlaam Bernard Christophe, Andrew Stark, Jemma Clark, Janet Hawkins, Bin Yang, Bryan Roberts, Craig S. Donald, Gemma Davison, Esther Moore, Chris De Savi, Tyler Grebe, Calum Cook, Melissa Vasbinder, Simon C. C. Lucas, Andrew Lister, Jeffrey G. Varnes, Kumar Thakur, Sudhir M. Hande, Jane L. Holmes, Thomas M. McGuire, Alexander Hird, Allan Dishington
المصدر: Tetrahedron Letters. 57:4718-4722
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Pinacol, Organic Chemistry, Late stage, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, Yield (chemistry), Drug Discovery, Organic chemistry
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المؤلفون: Stephan Krapp, James J. Crawford, Lyn Rosenbrier Ribeiro, Andrew David Morley, Jonathan E. Finlayson, Calum Cook, Caroline Smith, Jonathan Bowyer, Anja Jestel, Julian A. Hudson, Stefan Steinbacher, Benjamin P. McDermott, Thomas M. McGuire, Adrian John Highton, Alexander G. Dossetter, Ken Page, Peter W. Kenny, Morris Jeffrey James, Christine Heyes, Philip A. MacFaul, Helen Sawney, Scott W. Martin
المصدر: Journal of Medicinal Chemistry. 55:8827-8837
مصطلحات موضوعية: Male, Models, Molecular, Indazoles, Stereochemistry, Metabolite, Cathepsin K, education, Stereoisomerism, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Cyclohexanes, Drug Discovery, Animals, Humans, Structure–activity relationship, Rats, Wistar, Cells, Cultured, Indazole, Blood Proteins, Metabolic stability, humanities, Rats, chemistry, Drug Design, Hepatocytes, Molecular Medicine, Selectivity, Protein Binding
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