المؤلفون: Mosleh E; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Ou K; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Haemmerle MW; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Tembo T; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Yuhas A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Carboneau BA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Townsend SE; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Bosma KJ; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Gannon M; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; United States Department of Veteran Affairs, Nashville, Tennessee., O'Brien RM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Stoffers DA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Golson ML; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.

المصدر: Endocrinology [Endocrinology] 2020 Aug 01; Vol. 161 (8).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation/*genetics , Insulin/*genetics , Insulin-Secreting Cells/*metabolism , Integrases/*genetics , Recombination, Genetic/*genetics, Alleles ; Animals ; Cells, Cultured ; Female ; Gene Silencing ; HEK293 Cells ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/physiology ; Integrases/metabolism ; Islets of Langerhans/metabolism ; Islets of Langerhans/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Organ Specificity/genetics

المؤلفون: Ji Y; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA., Sun S; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.; Center for Molecular Medicine and Genetics, Department of Microbiology, Immunology and Biochemistry, Wayne State University School of Medicine, Detroit, MI, USA., Shrestha N; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Darragh LB; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.; Department of Radiation Oncology, School of Medicine, University of Colorado, Aurora, CO, USA., Shirakawa J; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA., Xing Y; Department of Surgery, University of Virginia, Charlottesville, VA, USA., He Y; Department of Surgery, University of Virginia, Charlottesville, VA, USA., Carboneau BA; Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA., Kim H; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.; XBiotech USA, Inc., Austin, TX, USA., An D; Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA., Ma M; Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA., Oberholzer J; Department of Surgery, University of Virginia, Charlottesville, VA, USA., Soleimanpour SA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Gannon M; Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA., Liu C; Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Naji A; Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Kulkarni RN; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA., Wang Y; Department of Surgery, University of Virginia, Charlottesville, VA, USA., Kersten S; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.; Nutrition Metabolism and Genomics group, Wageningen University, Wageningen, the Netherlands., Qi L; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA. lingq@med.umich.edu.; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA. lingq@med.umich.edu.; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. lingq@med.umich.edu.

المصدر: Nature immunology [Nat Immunol] 2019 Jun; Vol. 20 (6), pp. 677-686. Date of Electronic Publication: 2019 May 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Insulin-Secreting Cells/*metabolism , Obesity/*etiology , Obesity/*metabolism , Toll-Like Receptor 2/*genetics , Toll-Like Receptor 4/*genetics, Animals ; Cell Proliferation ; Cyclin D2/metabolism ; Cyclin-Dependent Kinase 4/metabolism ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Female ; Humans ; Insulin/blood ; Insulin/metabolism ; Insulin-Secreting Cells/ultrastructure ; Islets of Langerhans/drug effects ; Islets of Langerhans/metabolism ; MAP Kinase Signaling System ; Male ; Mice ; Mice, Knockout ; Multiprotein Complexes/metabolism ; Obesity/drug therapy ; Parabiosis ; Protein Binding ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 4/metabolism

المؤلفون: Diaz-Ruiz A; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.; Nutritional Interventions Group, Precision Nutrition and Aging, Institute IMDEA Food, Madrid, Spain., Di Francesco A; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Carboneau BA; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Levan SR; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Pearson KJ; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington., Price NL; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT., Ward TM; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Bernier M; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., de Cabo R; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.; Nutritional Interventions Group, Precision Nutrition and Aging, Institute IMDEA Food, Madrid, Spain., Mercken EM; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

المصدر: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2019 Jan 16; Vol. 74 (2), pp. 155-162.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE

مواضيع طبية MeSH: Body Composition* , Longevity* , Oxidative Stress*, Caloric Restriction/*adverse effects , NAD(P)H Dehydrogenase (Quinone)/*metabolism , Neoplasms, Experimental/*prevention & control, Animals ; Biomarkers, Tumor/metabolism ; Carcinogenesis ; Immunoblotting ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasms, Experimental/etiology ; Neoplasms, Experimental/metabolism

المؤلفون: Kropp PA; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee., Dunn JC; Department of Veterans Affairs, Tennessee Valley Health Authority, Vanderbilt University , Nashville, Tennessee.; Department of Medicine, Vanderbilt University , Nashville, Tennessee., Carboneau BA; Department of Veterans Affairs, Tennessee Valley Health Authority, Vanderbilt University , Nashville, Tennessee.; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee., Stoffers DA; Department of Medicine, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania., Gannon M; Department of Veterans Affairs, Tennessee Valley Health Authority, Vanderbilt University , Nashville, Tennessee.; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.; Department of Medicine, Vanderbilt University , Nashville, Tennessee.; Department of Cell and Developmental Biology, Vanderbilt University , Nashville, Tennessee.

المصدر: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2018 Apr 01; Vol. 314 (4), pp. E308-E321. Date of Electronic Publication: 2017 Dec 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocyte Nuclear Factor 6/*physiology , Homeodomain Proteins/*physiology , Insulin-Secreting Cells/*physiology , Islets of Langerhans/*growth & development , Multipotent Stem Cells/*metabolism , Trans-Activators/*physiology, Adaptation, Physiological/drug effects ; Adaptation, Physiological/genetics ; Animals ; Animals, Newborn ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cells, Cultured ; Diet, High-Fat ; Gene Expression Regulation, Developmental/drug effects ; Glucose/pharmacology ; Hepatocyte Nuclear Factor 6/genetics ; Homeodomain Proteins/genetics ; Insulin-Secreting Cells/drug effects ; Islets of Langerhans/drug effects ; Islets of Langerhans/physiology ; Male ; Mice ; Mice, Transgenic ; Multipotent Stem Cells/drug effects ; Multipotent Stem Cells/physiology ; Organogenesis/drug effects ; Organogenesis/genetics ; Trans-Activators/genetics

المؤلفون: Carboneau BA; Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA., Breyer RM; Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN, USA.; Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, USA., Gannon M; Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN, USA. maureen.gannon@vanderbilt.edu.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. maureen.gannon@vanderbilt.edu.; Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA. maureen.gannon@vanderbilt.edu.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. maureen.gannon@vanderbilt.edu.; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA. maureen.gannon@vanderbilt.edu.

المصدر: Journal of cell communication and signaling [J Cell Commun Signal] 2017 Jun; Vol. 11 (2), pp. 105-116. Date of Electronic Publication: 2017 Jan 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: Netherlands NLM ID: 101308338 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1873-9601 (Print) Linking ISSN: 18739601 NLM ISO Abbreviation: J Cell Commun Signal Subsets: PubMed not MEDLINE

المؤلفون: Mercken EM; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224 USA., Capri M; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy.; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, 40126 Bologna, Italy., Carboneau BA; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224 USA., Conte M; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy.; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, 40126 Bologna, Italy., Heidler J; Functional Proteomics, SFB815 Core Unit, Cluster of Excellence Frankfurt 'Macromolecular Complexes,' Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Santoro A; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy.; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, 40126 Bologna, Italy., Martin-Montalvo A; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224 USA., Gonzalez-Freire M; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224 USA., Khraiwesh H; Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario ceiA3, Campus Rabanales Edificio Severo Ochoa, 3ª planta, 14014 Córdoba, Spain., González-Reyes JA; Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario ceiA3, Campus Rabanales Edificio Severo Ochoa, 3ª planta, 14014 Córdoba, Spain., Moaddel R; Bioanalytical and Drug Development Unit, National institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224 USA., Zhang Y; Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224 USA., Becker KG; Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224 USA., Villalba JM; Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario ceiA3, Campus Rabanales Edificio Severo Ochoa, 3ª planta, 14014 Córdoba, Spain., Mattison JA; Translational Gerontology Branch, National Institute on Aging, Intramural Research Program, Poolesville, MD 20837 USA., Wittig I; Functional Proteomics, SFB815 Core Unit, Cluster of Excellence Frankfurt 'Macromolecular Complexes,' Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany., Franceschi C; IRCCS, Institute of Neurological Sciences of Bologna, 40139 Bologna, Italy., de Cabo R; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224 USA.

المصدر: NPJ aging and mechanisms of disease [NPJ Aging Mech Dis] 2017 May 05; Vol. 3, pp. 8. Date of Electronic Publication: 2017 May 05 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group, published in partnership with Japanese Society of Anti-Aging Medicine Country of Publication: England NLM ID: 101678947 Publication Model: eCollection Cited Medium: Print ISSN: 2056-3973 (Print) Linking ISSN: 20563973 NLM ISO Abbreviation: NPJ Aging Mech Dis Subsets: PubMed not MEDLINE

المؤلفون: Carboneau BA; Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA., Allan JA; School of Medicine, Virginia Commonwealth University, Richmond, VA, USA., Townsend SE; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Kimple ME; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Breyer RM; Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Gannon M; Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.

المصدر: Molecular metabolism [Mol Metab] 2017 Apr 05; Vol. 6 (6), pp. 548-559. Date of Electronic Publication: 2017 Apr 05 (Print Publication: 2017).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: eCollection Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation*, Insulin-Secreting Cells/*drug effects , Receptors, Prostaglandin E, EP3 Subtype/*antagonists & inhibitors , Receptors, Prostaglandin E, EP4 Subtype/*antagonists & inhibitors, Acrylamides/pharmacology ; Animals ; Cell Survival ; Cells, Cultured ; Dinoprostone/analogs & derivatives ; Dinoprostone/pharmacology ; Humans ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Phospholipase C gamma/metabolism ; Protein Kinase C/metabolism ; Receptors, Prostaglandin E, EP3 Subtype/agonists ; Receptors, Prostaglandin E, EP4 Subtype/agonists ; Sulfones/pharmacology

المؤلفون: Carboneau BA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee., Le TD; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Dunn JC; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Gannon M; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, Tennessee Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee maureen.gannon@vanderbilt.edu.

المصدر: Physiological reports [Physiol Rep] 2016 Sep; Vol. 4 (18).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: PubMed not MEDLINE

المؤلفون: Villa SR; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Priyadarshini M; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Fuller MH; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Bhardwaj T; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Brodsky MR; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Angueira AR; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mosser RE; Vanderbilt University, Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Nashville, TN, USA., Carboneau BA; Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, TN, USA., Tersey SA; Department of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Mancebo H; Multispan Inc., Hayward, CA, USA., Gilchrist A; Midwestern University Department of Pharmaceutical Sciences, Downers Grove, IL, USA., Mirmira RG; Department of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medicine, Indiana University School of Medicine, Indiana University, Indianapolis, IN, USA., Gannon M; Vanderbilt University, Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Nashville, TN, USA.; Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, TN, USA.; Tennessee Valley Health Authority, Department of Veterans Affairs, Nashville, TN, USA., Layden BT; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.

المصدر: Scientific reports [Sci Rep] 2016 Jun 21; Vol. 6, pp. 28159. Date of Electronic Publication: 2016 Jun 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2/*metabolism , Insulin-Secreting Cells/*metabolism , Pancreas/*pathology , Receptors, Cell Surface/*metabolism, Animals ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Fatty Acids, Nonesterified/metabolism ; Fatty Acids, Volatile/metabolism ; Humans ; Insulin Resistance ; Insulin-Secreting Cells/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Cell Surface/genetics ; Signal Transduction

المؤلفون: Ceddia RP; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Lee D; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Maulis MF; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Carboneau BA; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Threadgill DW; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Poffenberger G; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Milne G; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Boyd KL; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Powers AC; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., McGuinness OP; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Gannon M; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232., Breyer RM; Department of Veterans Affairs (A.C.P., M.G., R.M.B.), Tennessee Valley Health Authority, and Department of Medicine (R.M.B.), Division of Nephrology and Hypertension; Departments of Pharmacology (R.P.C., G.M., R.M.B.) and Cell and Developmental Biology (D.L., D.W.T., M.G.); Department of Medicine (M.F.M., G.P., A.C.P., M.G.), Division of Diabetes, Endocrinology, and Metabolism; and Departments of Molecular Physiology and Biophysics (B.A.C., A.C.P., O.P.G., M.G.) and Pathology, Microbiology, and Immunology (K.L.B.), Vanderbilt University Medical Center, Nashville, Tennessee 37232.

المصدر: Endocrinology [Endocrinology] 2016 Jan; Vol. 157 (1), pp. 220-32. Date of Electronic Publication: 2015 Oct 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

مواضيع طبية MeSH: Adiposity*, Adipose Tissue, White/*metabolism , Diabetes Mellitus, Type 2/*etiology , Diet, High-Fat/*adverse effects , Obesity/*metabolism , Panniculitis/*etiology , Receptors, Prostaglandin E, EP3 Subtype/*metabolism, Adipose Tissue, White/immunology ; Adipose Tissue, White/pathology ; Animals ; Cell Size ; Crosses, Genetic ; Diabetes Mellitus, Type 2/immunology ; Insulin Resistance ; Lipid Metabolism ; Liver/immunology ; Liver/metabolism ; Liver/pathology ; Macrophage Activation ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle, Skeletal/immunology ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Necrosis ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/immunology ; Obesity/etiology ; Obesity/pathology ; Obesity/physiopathology ; Panniculitis/immunology ; Receptors, Prostaglandin E, EP3 Subtype/genetics ; Weight Gain