المؤلفون: Zhang, Lingling, Wen, Xiang, Li, Mengmeng, Li, Shiming, Zhao, Hui

المصدر: BioFactors (Oxford, England), 44 (1), 61 - 68 (2018-01)

مصطلحات موضوعية: cancer, ptereostilbene, resveratrol, signaling pathways, stem cells, Antineoplastic Agents, Phytogenic, Neoplasm Proteins, Stilbenes, pterostilbene, Resveratrol, Animals, Antineoplastic Agents, Phytogenic/pharmacology, Apoptosis/drug effects, Breast Neoplasms/drug therapy, Breast Neoplasms/genetics, Breast Neoplasms/metabolism, Breast Neoplasms/pathology, Carcinogenesis/drug effects, Carcinogenesis/genetics, Carcinogenesis/metabolism, Carcinogenesis/pathology, Cell Communication/drug effects, Cell Line, Tumor, Female, Humans, Mice, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Neoplastic Stem Cells/drug effects, Neoplastic Stem Cells/metabolism, Neoplastic Stem Cells/pathology, Signal Transduction, Stilbenes/pharmacology, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Apoptosis, Breast Neoplasms, Carcinogenesis, Cell Communication, Neoplastic Stem Cells, Biochemistry, Molecular Medicine, Clinical Biochemistry, General Medicine, Life sciences, Food science, Sciences du vivant, Sciences des denrées alimentaires

Relation: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiof.1398; urn:issn:0951-6433; urn:issn:1872-8081

URL الوصول: https://orbi.uliege.be/handle/2268/316054

المؤلفون: Matteo Ramazzotti, Luca Viganò, Mirella Pastore, Maria Letizia Taddei, Monika Lewinska, Javier Cibella, Clelia Peano, Erica Pranzini, Luca Di Tommaso, Elena Sacco, Jessica Iorio, Paola Chiarugi, S. Madiai, Jesper B. Andersen, Chiara Raggi, Ivan Orlandi, B. Piombanti, Giovanni Di Maira, Margherita Correnti, N. Navari, Tiziano Lottini, Annarosa Arcangeli, Giulia Lori, Claudia Campani, Fabio Marra

المساهمون: Raggi, C, Taddei, M, Sacco, E, Navari, N, Correnti, M, Piombanti, B, Pastore, M, Campani, C, Pranzini, E, Iorio, J, Lori, G, Lottini, T, Peano, C, Cibella, J, Lewinska, M, Andersen, J, di Tommaso, L, Vigano, L, Di Maira, G, Madiai, S, Ramazzotti, M, Orlandi, I, Arcangeli, A, Chiarugi, P, Marra, F

المصدر: Raggi, C, Taddei, M L, Sacco, E, Navari, N, Correnti, M, Piombanti, B, Pastore, M, Campani, C, Pranzini, E, Iorio, J, Lori, G, Lottini, T, Peano, C, Cibella, J, Lewinska, M, Andersen, J B, di Tommaso, L, Viganò, L, Di Maira, G, Madiai, S, Ramazzotti, M, Orlandi, I, Arcangeli, A, Chiarugi, P & Marra, F 2021, ' Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma ', Journal of Hepatology, vol. 74, no. 6, pp. 1373-1385 . https://doi.org/10.1016/j.jhep.2020.12.031

مصطلحات موضوعية: Male, 0301 basic medicine, Indoles, Carcinogenesis, Propanols, PGC-1α, Mice, SCID, Mitochondrion, Oxidative Phosphorylation, Cholangiocarcinoma, Mice, Metformin/administration & dosage, 0302 clinical medicine, Mice, Inbred NOD, Signal Transduction/drug effects, SR-18292, CCLP1, Propanols/administration & dosage, Oxidative Phosphorylation/drug effects, Electron Transport Complex II, Indoles/administration & dosage, OXPHOS, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/antagonists & inhibitors, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Phenotype, Metformin, Progression-Free Survival, Mitochondria, Tumor Burden, Treatment Outcome, Neoplastic Stem Cells, 030211 gastroenterology & hepatology, Epithelial-Mesenchymal Transition/drug effects, Signal transduction, Electron Transport Complex II/metabolism, Tumor Burden/drug effects, Signal Transduction, Epithelial-Mesenchymal Transition, Oxidative phosphorylation, Biology, Transfection, 03 medical and health sciences, HUCCT1, Neoplastic Stem Cells/metabolism, Cancer stem cell, Cell Line, Tumor, Mitochondria/metabolism, Cholangiocarcinoma/drug therapy, Animals, Humans, Gene silencing, Gene Silencing, Hepatology, Bile Duct Neoplasms/drug therapy, Carcinogenesis/drug effects, Xenograft Model Antitumor Assays, Embryonic stem cell, 030104 developmental biology, Bile Duct Neoplasms, Mitochondrial biogenesis, Cancer research

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef501d3fbda1682299d6ec0832b7ea5
https://doi.org/10.1016/j.jhep.2020.12.031

المؤلفون: Barbara Tomic, Dora Višnjić, Tomislav Smoljo, Hrvoje Lalic, Vilma Dembitz

المصدر: Cells
Cells, Vol 10, Iss 1095, p 1095 (2021)

مصطلحات موضوعية: AMPK, pyrimidine, Carcinogenesis, Hypoglycemic Agents / pharmacology, Ribonucleotides / pharmacology, Review, Pharmacology, chemistry.chemical_compound, 0302 clinical medicine, Aminoimidazole Carboxamide / pharmacology, AMP-Activated Protein Kinase Kinases, Ampk signaling, Myocytes, Cardiac, Biology (General), 0303 health sciences, exercise, Acadesine, Cell Cycle, leukemia, General Medicine, Cell cycle, 3. Good health, 030220 oncology & carcinogenesis, Energy Metabolism / drug effects, medicine.symptom, QH301-705.5, Myocytes, Cardiac / drug effects, Carcinogenesis / drug effects, Protein Kinases / metabolism, Context (language use), Cell Cycle / drug effects, 03 medical and health sciences, Downregulation and upregulation, medicine, Hypoglycemic Agents, cancer, Animals, Humans, AICAr, metabolism, acadesine, cell cycle, purine, 030304 developmental biology, Activator (genetics), Ribonucleotides, Hypoxia (medical), Aminoimidazole Carboxamide, Aminoimidazole Carboxamide / analogs & derivatives, chemistry, Energy Metabolism, Protein Kinases

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaf70488006988fb844a4a694beb3de
https://doi.org/10.3390/cells10051095

المؤلفون: Zaineb Abdelkafi-Koubaa, Mohamed El Ayeb, Erij Messadi, Najet Srairi Abid, Maram Morjen, Jed Jebali, Houcemeddine Othman, José Luis, Naziha Marrakchi

المساهمون: Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), This work was supported in part by MERST (Ministère de l'Enseignement Supérieur de la Recherche et de la Technologie) (Laboratoire des venins et biomolécules thérapeutiques: LR11IPT08), INSERM UMR911 (Institut National de la Santé et de la Recherche Médicale) and by grants ARCUS (Action en Région de Coopération Universitaire et Scientifique (2008–2012)) and PHC Utique (17G0811: 2017–2019)., We thank Pr Hechmi Louzir, head of Institut Pasteur de Tunis for his continuous interest in this study and for his support. Dr. Benlasfar Zakaria (Institut Pasteur de Tunis) is acknowledged for providing viper venom., Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

المصدر: International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩
International Journal of Biological Macromolecules, Elsevier, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩

مصطلحات موضوعية: 0301 basic medicine, Snake venom, MESH: Neovascularization, Pathologic/drug therapy, MESH: Viper Venoms/therapeutic use, Carcinogenesis, Angiogenesis, Integrin, Angiogenesis Inhibitors, Peptide, Venom, MESH: Amino Acid Sequence, medicine.disease_cause, PC12 Cells, Biochemistry, MESH: Carcinogenesis/drug effects, MESH: Cell Movement/drug effects, MESH: Cell Proliferation/drug effects, MESH: Cricetulus, Cell Movement, Structural Biology, MESH: Animals, MESH: Angiogenesis Inhibitors/pharmacology, Migration, chemistry.chemical_classification, MESH: Integrin alpha1beta1/chemistry, Neovascularization, Pathologic, biology, Chinese hamster ovary cell, General Medicine, 3. Good health, Cell biology, Adhesion, MESH: Protein Domains, MESH: Rats, CHO Cells, Viper Venoms, Integrin alpha1beta1, 03 medical and health sciences, Cricetulus, MESH: Cell Adhesion/drug effects, Protein Domains, MESH: Viper Venoms/pharmacology, MESH: CHO Cells, MESH: Integrin alpha1beta1/metabolism, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Cell Adhesion, medicine, MESH: PC12 Cells, Animals, Amino Acid Sequence, Molecular Biology, Cell Proliferation, In vitro, Rats, 030104 developmental biology, MESH: Viper Venoms/chemistry, chemistry, MESH: Angiogenesis Inhibitors/therapeutic use, biology.protein, MESH: Viper Venoms/metabolism, MESH: Angiogenesis Inhibitors/metabolism, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e51ea875cbc6ee35aa79287c5c9f3b
https://doi.org/10.1016/j.ijbiomac.2018.05.230

المؤلفون: Saleem, H., Kulsoom Abdul, U., Küçükosmanoglu, A., Houweling, M., Cornelissen, FMG, Heiland, D.H., Hegi, M.E., Kouwenhoven, MCM, Bailey, D., Würdinger, T., Westerman, B.A.

المصدر: Drug resistance updates, vol. 43, pp. 29-37

مصطلحات موضوعية: Brain Neoplasms/drug therapy, Brain Neoplasms/genetics, Brain Neoplasms/pathology, Carcinogenesis/drug effects, Carcinogenesis/genetics, Drug Resistance, Neoplasm, ErbB Receptors/antagonists & inhibitors, ErbB Receptors/genetics, ErbB Receptors/metabolism, Glioblastoma/drug therapy, Glioblastoma/genetics, Glioblastoma/pathology, Humans, Molecular Targeted Therapy/methods, Mutation, Oncogenes/genetics, Protein Kinase Inhibitors/pharmacology, Protein Kinase Inhibitors/therapeutic use, Proto-Oncogene Proteins c-met/metabolism, Proto-Oncogene Proteins c-sis/metabolism, Receptor, IGF Type 1/metabolism, Signal Transduction/drug effects, Signal Transduction/genetics, Treatment Outcome, CMET, EGFR inhibition, Glioblastoma, IGFR1, Target compensation, PDGFR, Target independence, Therapy resistance

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1900::3d56dc6b4adf1bb1b8998c015d970023
https://serval.unil.ch/resource/serval:BIB_2AF864642976.P001/REF.pdf

المؤلفون: Verónica Nogueira, Bruno Araujo, Fátima Gärtner, Nuno Vale, Maria João Gouveia

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Molecules, Vol 24, Iss 21, p 3842 (2019)
Molecules
Volume 24
Issue 21

مصطلحات موضوعية: 0301 basic medicine, Carcinogenesis, Metabolite, Drug repurposing, Schistosoma haematobium / drug effects, Pharmaceutical Science, Pharmacology, Resveratrol, medicine.disease_cause, Schistosomiasis haematobia / drug therapy, Antioxidants, Analytical Chemistry, Carcinogenesis / pathology, chemistry.chemical_compound, 0302 clinical medicine, Schistosomiasis haematobia / metabolism, Drug Discovery, Opisthorchis viverrini, Schistosomiasis haematobia / complications, Drug combination, Neoplasms / metabolism, CYP enzymes, media_common, drug repurposing, biology, Resveratrol / pharmacology, Opisthorchiasis / metabolism, Opisthorchiasis / parasitology, Praziquantel / pharmacology, Neoplasms / drug therapy, Acetylcysteine / chemistry, helminth infections, Drug Combinations, Drug repositioning, antioxidants, Chemistry (miscellaneous), Molecular Medicine, carcinogenesis, Drug, Helminth infections, DNA Adducts / drug effects, Carcinogenesis / drug effects, media_common.quotation_subject, 030231 tropical medicine, drug combination, Opisthorchis / pathogenicity, cyp enzymes, Opisthorchiasis / complications, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, parasitic diseases, medicine, Animals, Humans, Neoplasms / parasitology, Physical and Theoretical Chemistry, Opisthorchiasis / drug therapy, Schistosomiasis haematobia / parasitology, Carcinogen, Opisthorchis / drug effects, Antioxidants / pharmacology, Metabolome / drug effects, Organic Chemistry, DNA adducts, Schistosoma haematobium / pathogenicity, biology.organism_classification, Carcinogens / chemistry, In vitro, 030104 developmental biology, Metabolome / genetics, chemistry, dna adducts

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b4ee668b60493c520f7b076eb4b022
https://doi.org/10.3390/molecules24213842

المؤلفون: Wassim Moslah, Soumaya Souid, Jed Jebali, Dorra Aissaoui, Houcemeddine Othman, Mohamed Elayeb, Saoussen Mlayah-Bellalouna, José Luis, Zaineb Abdelkafi-Koubaa, Khadija Essafi-Benkhadir, Naziha Marrakchi, Najet Srairi-Abid

المساهمون: Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut National des Sciences Appliquées et de Technologie - Carthage (INSAT Carthage), Université de Tunis El Manar (UTM), Laboratoire d'Epidémiologie Moléculaire et de Pathologie Expérimentale Appliquée aux Maladies Infectieuses (LR11IPT04), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Tunisian Ministry of Higher Education and Scientific Research (LR11IPT08) and the research grant Partenariat Hubert Curien-Utique (PHC-Utique) [code 17G 0811]., We would like to thank Daniel Lafitte and Claude Villard (INSERM UMR 911-CRO2. Faculty of Pharmacy, Marseille, France) for mass spectrometry studies, Maram Morjan, Thouraya Chagour and Amene Allah Ellafi (LVMT, Pasteur Institute of Tunis) for their technical help., Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

المصدر: International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, 2018, 111, pp.1146-1155. ⟨10.1016/j.ijbiomac.2018.01.144⟩
International Journal of Biological Macromolecules, Elsevier, 2018, 111, pp.1146-1155. ⟨10.1016/j.ijbiomac.2018.01.144⟩

مصطلحات موضوعية: 0301 basic medicine, Carcinogenesis, MESH: Scorpions/chemistry, [SDV]Life Sciences [q-bio], Proliferation, Venom, MESH: Neoplasms/drug therapy, Biochemistry, MESH: Peptides/pharmacology, 0302 clinical medicine, MESH: Cell Proliferation/drug effects, Structural Biology, Neoplasms, Neoplastic progression, MESH: Animals, U87, MESH: Potassium Channel Blockers/pharmacology, MESH: Kv1.3 Potassium Channel/genetics, Cancer, Kv1.3 Potassium Channel, biology, Chemistry, General Medicine, MESH: Shaker Superfamily of Potassium Channels/genetics, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Scorpion peptide, biological phenomena, cell phenomena, and immunity, MESH: Cell Line, Tumor, MESH: Carcinogenesis/drug effects, Scorpion, MESH: Gene Expression Regulation, Neoplastic/drug effects, Scorpion Venoms, Adhesion and migration, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, complex mixtures, Scorpions, MESH: Peptides/chemistry, 03 medical and health sciences, Breast cancer, biology.animal, Cell Line, Tumor, Homologous chromosome, medicine, Potassium Channel Blockers, Animals, Humans, natural sciences, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Amino Acid Sequence, Potassium channel subtypes, Molecular Biology, Cell Proliferation, MESH: Amino Acid Sequence/genetics, MESH: Potassium Channel Blockers/chemistry, MESH: Humans, MESH: Scorpion Venoms/pharmacology, urogenital system, MESH: Potassium/metabolism, medicine.disease, 030104 developmental biology, nervous system, Cell culture, MESH: Scorpion Venoms/chemistry, Cancer research, Potassium, Shaker Superfamily of Potassium Channels, MESH: Neoplasms/genetics, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9397ccddf29007935bd17cae2ee4bb23
https://hal-amu.archives-ouvertes.fr/hal-01765752

المؤلفون: Alaattin Sen, Sevki Arslan, Gulsum Terzioglu, Pelin Atmaca

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Carcinogenesis, Drug interaction, protein p53, Apoptosis, Plant Science, Coumaric acid, Cell cycle arrests, protein induction, chemistry.chemical_compound, Carcinogen activation, Drug Discovery, caspase 3, cytochrome P450 3A4, cytochrome P450 2C9, messenger RNA, Cell Cycle, article, o-Coumaric acid, General Medicine, CYP2E1, cytotoxicity assay, Biochemistry, MCF-7 Cells, Female, Aryl Hydrocarbon Hydroxylases, coumaric acid, cytochrome P450 1A2, cytochrome P450 1A1, protein Bax, medicine.medical_specialty, Coumaric Acids, Tumor suppressors, Breast Neoplasms, antineoplastic activity, Biology, Adenocarcinoma, Cyclin D1, Internal medicine, medicine, Humans, controlled study, human, cyclin dependent kinase 1, cyclin dependent kinase 2, protein expression, Carcinogen, Pharmacology, carcinogenic activity, CYP3A4, human cell, Tumor Suppressor Proteins, CYP1A2, chemoprophylaxis, phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase, Adenocarcinoma/metabolism/*prevention & control, Apoptosis/drug effects, Aryl Hydrocarbon Hydroxylases/metabolism, Breast Neoplasms/metabolism/*prevention & control, Carcinogenesis/drug effects, Cell Cycle/drug effects, Coumaric Acids/*therapeutic use/toxicity, Tumor Suppressor Proteins/metabolism, eye diseases, Endocrinology, cell proliferation, Complementary and alternative medicine, chemistry, MCF 7 cell line, concentration response, cytochrome P450 2E1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91adc9e56526dd569a309e50f9c4208
https://pubmed.ncbi.nlm.nih.gov/24273864

المؤلفون: Korhan, Peyda, Yılmaz, Yeliz, Bağırsakçı, Ezgi, Güneş, Ayşim, Topel, Hande, Carr, Brian I, Atabey, Neşe

المصدر: Korhan , P , Yılmaz , Y , Bağırsakçı , E , Güneş , A , Topel , H , Carr , B I & Atabey , N 2018 , ' Pleiotropic Effects of Heparins : From Clinical Applications to Molecular Mechanisms in Hepatocellular Carcinoma ' , Canadian Journal of Gastroenterology , vol. 2018 , pp. 7568742 .

مصطلحات الفهرس: Anticoagulants/pharmacology, Carcinogenesis/drug effects, Carcinoma, Hepatocellular/complications, Genetic Pleiotropy/drug effects, Heparin/pharmacology, Humans, Liver Neoplasms/complications, Venous Thromboembolism/drug therapy, article

URL: https://curis.ku.dk/portal/da/publications/pleiotropic-effects-of-heparins(112d291a-ae56-472d-8ec1-4dd1eab9a2c1).html
https://doi.org/10.1155/2018/7568742