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المؤلفون: Ann M. Williams, Martin P. Vidgeon-Hart, Christopher A. Schofield, Metul Patel, Paul McGill, Carla F. Newman, Justyna M. Macina, Tracy Walker, Maxine A. Taylor, Melanie Z. Sakatis, Denise F. Vlachou
المصدر: Chemical Research in Toxicology. 34:2485-2499
مصطلحات موضوعية: Male, Drug, Cell Survival, media_common.quotation_subject, Drug Evaluation, Preclinical, Computational biology, Toxicology, Models, Biological, Spheroids, Cellular, Animals, Humans, Medicine, Rats, Wistar, media_common, Liver injury, business.industry, Drug candidate, Drug discovery, Spheroid, Hep G2 Cells, General Medicine, medicine.disease, Rats, Human hepatocyte, medicine.anatomical_structure, Pharmaceutical Preparations, Drug development, Hepatocyte, Hepatocytes, Chemical and Drug Induced Liver Injury, business
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المؤلفون: Malcolm Begg, Eleni Pefani, Jonathan Clark, Carla F. Newman, Miriam Marotti, Martin I. Hingle, Disala Fernando, David N. Mallett, Anthony Cahn, Sorif Uddin, Filzah Ehtesham, Josie Morrell, Robert Wilson, Giovanni Vitulli, J. Nicole Hamblin, Jane Gilbert, Chris D. Edwards, Edith M. Hessel, Andrew W Harrell
المصدر: Journal of Pharmacology and Experimental Therapeutics. 369:443-453
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Drug, Indazoles, media_common.quotation_subject, Pharmacology, Bronchoalveolar Lavage, Permeability, Translational Research, Biomedical, Mice, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Administration, Inhalation, Eosinophilia, medicine, Animals, Humans, Dosing, Adverse effect, Lung, Phosphoinositide-3 Kinase Inhibitors, media_common, Sulfonamides, medicine.diagnostic_test, Inhalation, business.industry, Sputum, Middle Aged, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, Solubility, Molecular Medicine, Female, Safety, medicine.symptom, business, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d458b382120aa5c2397a9f4a956bd6f
https://doi.org/10.1124/jpet.119.257311 -
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المؤلفون: Ian S. Gilmore, Peter S. Marshall, Melissa K. Passarelli, Alexander Makarov, Morgan R. Alexander, Dmitry Grinfeld, Stevan Horning, Rudolf Moellers, Colin T. Dollery, Andrew West, Rasmus Havelund, Ewald Niehuis, Carla F. Newman, Alexander Pirkl, Felix Kollmer, Henrik Arlinghaus
المصدر: Nature Methods. 14:1175-1183
مصطلحات موضوعية: 0301 basic medicine, Serotonin, Resolution (mass spectrometry), Dopamine, Phospholipid, Amiodarone, Glycerophospholipids, Tandem mass spectrometry, Mass spectrometry, Orbitrap, Hippocampus, Sensitivity and Specificity, 01 natural sciences, Biochemistry, law.invention, Mice, 03 medical and health sciences, chemistry.chemical_compound, Imaging, Three-Dimensional, Tandem Mass Spectrometry, law, Macrophages, Alveolar, Animals, Metabolomics, Molecular Biology, Cells, Cultured, gamma-Aminobutyric Acid, Drug discovery, Imaging, Mass spectrometry, Metabolomics, Sulfoglycosphingolipids, 010401 analytical chemistry, Equipment Design, Cell Biology, Subcellular localization, Molecular Imaging, 0104 chemical sciences, Secondary ion mass spectrometry, Matrix-assisted laser desorption/ionization, 030104 developmental biology, chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Biophysics, Female, Subcellular Fractions, Biotechnology
وصف الملف:
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المؤلفون: Richard G. Carroll, Elizabeth C. Hinchy, Vincent P. Kelly, Eva M. Palsson-McDermott, Moritz Haneklaus, Elektra K. Robinson, Andrew M. James, Louise K. Modis, Silvia Galván-Peña, Michael P. Murphy, Alan Nadin, Sergio Covarrubias, Susan Carpenter, Carla F. Newman, Luke A. J. O'Neill
المساهمون: Covarrubias, Sergio [0000-0002-7197-9952], Kelly, Vincent P [0000-0001-7067-5407], Murphy, Michael P [0000-0003-1115-9618], Apollo - University of Cambridge Repository
المصدر: Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Lipopolysaccharide, Messenger, General Physics and Astronomy, 02 engineering and technology, Inbred C57BL, chemistry.chemical_compound, Mice, 2.1 Biological and endogenous factors, Glycolysis, RNA, Small Interfering, Aetiology, lcsh:Science, Glyceraldehyde 3-phosphate dehydrogenase, Multidisciplinary, biology, Glyceraldehyde-3-Phosphate Dehydrogenases, RNA-Binding Proteins, Translation (biology), 021001 nanoscience & nanotechnology, 3. Good health, Cell biology, Malonyl Coenzyme A, Cytokines, Tumor necrosis factor alpha, lipids (amino acids, peptides, and proteins), medicine.symptom, Inflammation Mediators, 0210 nano-technology, Science, Inflammation, macromolecular substances, Small Interfering, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, stomatognathic system, Polysome, medicine, Genetics, Animals, Humans, RNA, Messenger, Messenger RNA, Tumor Necrosis Factor-alpha, Macrophages, Lysine, General Chemistry, Brain Disorders, Mice, Inbred C57BL, enzymes and coenzymes (carbohydrates), 030104 developmental biology, HEK293 Cells, chemistry, Mutagenesis, Polyribosomes, biology.protein, RNA, lcsh:Q
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b634af5584f47f1d546a4bcfc38aa5c8
https://escholarship.org/uc/item/4wq0v1m2 -
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المؤلفون: Ian S. Gilmore, Ian Francis, Melissa K. Passarelli, Carla F. Newman, Morgan R. Alexander, Peter S. Marshall, Rasmus Havelund, Andrew West, Colin T. Dollery
المصدر: Analytical chemistry. 89(22)
مصطلحات موضوعية: 0301 basic medicine, Time Factors, Cell, Population, Amiodarone, Spectrometry, Mass, Secondary Ion, Pharmacology, 01 natural sciences, Analytical Chemistry, Flow cytometry, Cell Line, HeLa, 03 medical and health sciences, Tandem Mass Spectrometry, medicine, Animals, Humans, education, education.field_of_study, medicine.diagnostic_test, biology, Chemistry, 010401 analytical chemistry, HEK 293 cells, Hep G2 Cells, biology.organism_classification, Cell counting, Flow Cytometry, 0104 chemical sciences, Rats, 030104 developmental biology, medicine.anatomical_structure, HEK293 Cells, Cell culture, Intracellular, Chromatography, Liquid, HeLa Cells
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المؤلفون: Martina S, Elias, Heather A, Long, Carla F, Newman, Paul A, Wilson, Andrew, West, Paul J, McGill, Keith C, Wu, Michael J, Donaldson, Nick J, Reynolds
المصدر: The Journal of Allergy and Clinical Immunology
مصطلحات موضوعية: Cofilin 1, Keratinocytes, filaggrin, skin, Proteome, RT-qPCR, Quantitative RT-PCR, Filaggrin Proteins, shFLG, Filaggrin knockdown short hairpin RNA, Mass Spectrometry, Article, Dermatitis, Atopic, Intermediate Filament Proteins, Loss of Function Mutation, LSE, Living skin equivalent, Humans, RNA, Small Interfering, CFL1, Cofilin-1, Cells, Cultured, Cytoskeleton, proteomic, dermatitis, IPA, Ingenuity Pathway Analysis, Inflammation, FLG, Filaggrin, VIM, Vimentin, CTSV, Cathepsin V, TXN, Thioredoxin, PPIA, Cyclophilin A, mTOR, Mammalian target of rapamycin, Gene Expression Regulation, eIF, Eukaryotic initiation factor, Proteolysis, KLK7, Kallikrein-7, kallikrein-7, Kallikreins, Atopic eczema, ANXA3, Annexin A3, shNT, Nontargeting control short hairpin RNA, Transcriptome, AE, Atopic eczema, Cyclophilin A, Chromatography, Liquid
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المؤلفون: Ian S. Gilmore, Andrew West, Peter S. Marshall, Melissa K. Passarelli, Carla F. Newman, Josephine Bunch, Morgan R. Alexander, Colin T. Dollery
مصطلحات موضوعية: chemistry.chemical_classification, Chromatography, Biomolecule, Metabolite, Context (language use), Mass spectrometry, Mass Spectrometry, Mass spectrometry imaging, Rats, Analytical Chemistry, Rats, Sprague-Dawley, Secondary ion mass spectrometry, chemistry.chemical_compound, chemistry, Single-cell analysis, Animals, Pharmacokinetics, Single-Cell Analysis, Intracellular, Cell Line, Transformed
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المؤلفون: Morgan R. Alexander, Ewald Niehuis, Ian S. Gilmore, Rudolf Moellers, Rasmus Havelund, Alan M. Race, Alexander G. Shard, Stevan Horning, Colin T. Dollery, Melissa K. Passarelli, Alexander Makarov, Felix Kollmer, Carla F. Newman, Alexander Pirkl, Peter S. Marshall, Paulina D. Rakowska, Henrik Arlinghaus, Andrew West
المصدر: Microscopy and Microanalysis. 22:340-341
مصطلحات موضوعية: Surface (mathematics), Spectrum analyzer, Materials science, business.industry, 3d analysis, 010401 analytical chemistry, DUAL (cognitive architecture), 010502 geochemistry & geophysics, 01 natural sciences, 0104 chemical sciences, Optoelectronics, business, Instrumentation, 0105 earth and related environmental sciences
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المؤلفون: Carla F. Newman, Keith Wu, Paul A. Wilson, H Long, A. West, Nick J. Reynolds, M Elias, M Donaldson, P. McGill
المصدر: Journal of Investigative Dermatology. 136:S182
مصطلحات موضوعية: Immunology, Cell Biology, Dermatology, Biology, Molecular Biology, Biochemistry, Filaggrin
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المؤلفون: M Donaldson, P Mcgil, Paul A. Wilson, Ha Long, Nick J. Reynolds, P Marshall, M Elias, Carla F. Newman
المصدر: Journal of Investigative Dermatology. :S159-S190
مصطلحات موضوعية: Gene knockdown, business.industry, Cell Biology, Dermatology, Biochemistry, Hedgehog signaling pathway, Cell biology, Stress (mechanics), Skin equivalent, Medicine, business, Molecular Biology, Barrier function, Filaggrin
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03182399318258616bf66d3fad77425f
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