المؤلفون: Jonathan J Cherry, Christine J DiDonato, Elliot J Androphy, Alessandro Calo, Kyle Potter, Sara K Custer, Sarah Du, Timothy L Foley, Ariamala Gopalsamy, Emily J Reedich, Susana M Gordo, William Gordon, Natalie Hosea, Lyn H Jones, Daniel K Krizay, Gregory LaRosa, Hongxia Li, Sachin Mathur, Carol A Menard, Paraj Patel, Rebeca Ramos-Zayas, Anne Rietz, Haojing Rong, Baohong Zhang, Michael A Tones

المصدر: PLoS ONE, Vol 12, Iss 9, p e0185079 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5612656?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/d509895517b840fca86c06c702f957d6

المؤلفون: Martin Hegen, David C. Wood, Patrik Rhönnstad, Felix Vajdos, Atli Thorarensen, Mark E. Schnute, Timothy Braden, Kimberly Crouse, Maria Sjöberg, John I. Trujillo, Ravi G. Kurumbail, Bolette Husman, Konrad F. Koehler, Mattias Wennerstål, Tomas Bonn, Joakim Löfstedt, Eva Backström-Rydin, Bo Carlsson, Aron Sundell, Ming Z. Chen, Steven E. Heasley, John David Trzupek, Annika Goos-Nilsson, Carol A. Menard, Peter Harris, James R. Kiefer, Martin Bengtsson, Leon P. Collis, Michael J. Prinsen, Philippe Nuhant, Jennifer Alley, Scott A. Long, Alexander E. Hromockyj, Andrew C. Flick, Johnny Sandberg, Christoph W. Zapf, Edouard Zamaratski, Xiao Hu, Lee Napierata, Björn Kauppi, Nicole Caspers, Kimberly F. Fennell, Robert E. Kyne, Gabriel Berstein, Neelu Kaila, Lars Kruger, Wei Li, Li Xing, Ray Unwalla, Elisabet Kallin, Matthew J. Pelc, Susan Fish, James Robert Blinn, Hjalmar Gullberg, Marvin J. Meyers, Scot Richard Mente, Chulho Choi, Falgun Shah, Mathias Färnegårdh, Dean Messing, Peter G. Jones, Yajuan Zhao, Alexandria P. Taylor, Maria Sandström, Charles W. Bolten, Daniel Nöteberg, Robin A. Weinberg, Tomasz Janosik, John D. Knafels, Anna Wilhelmsson

المصدر: Journal of medicinal chemistry. 61(23)

مصطلحات موضوعية: 0301 basic medicine, Drug Inverse Agonism, Stereochemistry, Pyridines, Retinoic acid, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Mice, RAR-related orphan receptor gamma, Drug Discovery, Inverse agonist, Animals, Humans, Benzamide, Receptor, Orphan receptor, 010405 organic chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, Retinoic acid receptor, 030104 developmental biology, chemistry, Nuclear receptor, Drug Design, Molecular Medicine, Th17 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b335f732a3ffd4d00a80bd0f813c732
https://pubmed.ncbi.nlm.nih.gov/30130103

المؤلفون: Shenping Liu, Lee R. Roberts, Erik C. Hett, Mihir D. Parikh, Ariamala Gopalsamy, Kieran F. Geoghegan, Ralph P. Robinson, Michael A. Tones, Lyn H. Jones, Robert E. Kyne, Hua Xu, Carol A. Menard, Arjun Narayanan

المصدر: ACS Chemical Biology. 10:1094-1098

مصطلحات موضوعية: DCPS, Chemical biology, Chemistry Techniques, Synthetic, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Catalytic Domain, Endoribonucleases, Humans, Structure–activity relationship, Molecular Targeted Therapy, Enzyme Inhibitors, Binding site, Tyrosine, Cells, Cultured, chemistry.chemical_classification, biology, Chemistry, Active site, General Medicine, Sulfinic Acids, Enzyme, Covalent bond, Molecular Probes, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ccf8d774527c711c78291b05503aba
https://doi.org/10.1021/cb5009475

المؤلفون: Sachin Mathur, Jonathan J. Cherry, Baohong Zhang, Christine J. DiDonato, Rebeca Ramos-Zayas, Kyle Potter, Gregory LaRosa, Michael A. Tones, Haojing Rong, Natalie Hosea, Alessandro Calo, Timothy L. Foley, Sarah Du, William Gordon, Carol A. Menard, Paraj Patel, Susana Gordo, Elliot J. Androphy, Anne Rietz, Lyn H. Jones, Sara K. Custer, Daniel K. Krizay, Emily J. Reedich, Ariamala Gopalsamy, Hongxia Li

المصدر: PLoS ONE, Vol 12, Iss 9, p e0185079 (2017)
PLoS ONE

مصطلحات موضوعية: Male, 0301 basic medicine, Molecular biology, Reporter Gene Assay, lcsh:Medicine, SMN1, Molecular biology assays and analysis techniques, Nervous System, Biochemistry, Transcriptome, Mice, Medicine and Health Sciences, Enzyme Inhibitors, Promoter Regions, Genetic, lcsh:Science, Mice, Knockout, Regulation of gene expression, Gene knockdown, Multidisciplinary, Nucleic acid analysis, Animal Models, RNA analysis, Cell biology, Nucleic acids, Survival of Motor Neuron 2 Protein, Spinal Cord, Experimental Organism Systems, Gene Knockdown Techniques, Female, Anatomy, Cellular Structures and Organelles, Research Article, DCPS, Mouse Models, Biology, Research and Analysis Methods, Cell Line, Muscular Atrophy, Spinal, 03 medical and health sciences, Model Organisms, In vivo, Endoribonucleases, Genetics, medicine, Animals, Humans, RNA, Messenger, Non-coding RNA, Messenger RNA, lcsh:R, Biology and Life Sciences, Cell Biology, Spinal muscular atrophy, medicine.disease, Gene regulation, nervous system diseases, Neuroanatomy, MicroRNAs, Disease Models, Animal, Molecular biology techniques, HEK293 Cells, 030104 developmental biology, Quinazolines, RNA, lcsh:Q, Gene expression, Lysosomes, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a8004254f0368601d90fc794482243
http://europepmc.org/articles/PMC5612656?pdf=render

المؤلفون: Lisa Mullins, Daniel P. Uccello, Justin I. Montgomery, Ye Che, John P. O'Donnell, Mark S. Plummer, Joseph A. Abramite, Seung Won Chung, Loren M. Price, Mark C. Noe, Laura A. McAllister, Rose Barham, Mark J. Mitton-Fry, Andrew P. Tomaras, Usa Reilly, Matthew Frank Brown, Jinshan M. Chen, Joseph Penzien, Carol A. Menard, Veerabahu Shanmugasundaram, Robert M. Oliver

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:6832-6838

مصطلحات موضوعية: Gram-negative bacteria, Klebsiella pneumoniae, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Hydroxamic Acids, Biochemistry, Amidohydrolases, Structure-Activity Relationship, chemistry.chemical_compound, Heterocyclic Compounds, Gram-Negative Bacteria, Drug Discovery, Structure–activity relationship, Sulfones, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Hydroxamic acid, biology, Organic Chemistry, biology.organism_classification, Anti-Bacterial Agents, Enzyme, chemistry, Pseudomonas aeruginosa, Molecular Medicine, Antibacterial activity, Bacterial outer membrane, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698632622184881fc9d9e040335da17
https://doi.org/10.1016/j.bmcl.2012.09.058

المؤلفون: Matthew David Doroski, Joel T. Arcari, Mark S. Plummer, Andrea Marra, Thomas M. Harris, Justin I. Montgomery, Usa Reilly, Carol A. Menard, Michael D. Huband, Anthony Marfat, Jinshan Michael Chen, Christy Thoma, Karen L. Leach, John P. O'Donnell, Seung Won Chung, Loren M. Price, Joseph A. Abramite, Charlene R. Desbonnet, Eric B. McElroy, Veerabahu Shanmugasundaram, Michael Melnick, Shenping Liu, Matthew Frank Brown, Mark C. Noe, Joseph S. Warmus, Juntyma J. Engtrakul, Daniel P. Uccello, Donn G. Wishka, Robert M. Oliver, Rose Barham, Joseph Penzien, Jonathan L. Doty, John D. Knafels, Ye Che, Lisa Mullins, Elizabeth M. Collantes

المصدر: Journal of medicinal chemistry. 55(2)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Conformation, Sulfides, Crystallography, X-Ray, Hydroxamic Acids, Amidohydrolases, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Catalytic Domain, Drug Discovery, Drug Resistance, Bacterial, Animals, Pseudomonas Infections, Sulfones, Gram, Hydroxamic acid, Phenyl Ethers, Biphenyl Compounds, Hydrogen Bonding, Stereoisomerism, Anti-Bacterial Agents, Rats, chemistry, Pseudomonas aeruginosa, Molecular Medicine, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcf3eac90ca18e20f4de1258188335d
https://pubmed.ncbi.nlm.nih.gov/22175825