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1دورية أكاديمية
المؤلفون: John R Lamb, Chunsheng Zhang, Tao Xie, Kai Wang, Bin Zhang, Ke Hao, Eugene Chudin, Hunter B Fraser, Joshua Millstein, Mark Ferguson, Christine Suver, Irena Ivanovska, Martin Scott, Ulrike Philippar, Dimple Bansal, Zhan Zhang, Julja Burchard, Ryan Smith, Danielle Greenawalt, Michele Cleary, Jonathan Derry, Andrey Loboda, James Watters, Ronnie T P Poon, Sheung T Fan, Chun Yeung, Nikki P Y Lee, Justin Guinney, Cliona Molony, Valur Emilsson, Carolyn Buser-Doepner, Jun Zhu, Stephen Friend, Mao Mao, Peter M Shaw, Hongyue Dai, John M Luk, Eric E Schadt
المصدر: PLoS ONE, Vol 6, Iss 7, p e20090 (2011)
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Irena Ivanovska, Chunsheng Zhang, Angela M Liu, Kwong F Wong, Nikki P Lee, Patrick Lewis, Ulrike Philippar, Dimple Bansal, Carolyn Buser, Martin Scott, Mao Mao, Ronnie T P Poon, Sheung Tat Fan, Michele A Cleary, John M Luk, Hongyue Dai
المصدر: PLoS ONE, Vol 6, Iss 9, p e24582 (2011)
وصف الملف: electronic resource
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المؤلفون: Pradip K. Majumder, Peter R. Strack, Giulio F. Draetta, Edwin A. Clark, Christopher Winter, Domenico Coppola, Timothy Yeatman, Carolyn Buser, Raymond E. Gibson, John F. Reilly, Giuseppe Mesiti, Shailendra Patel, Jennifer Tammam, Saverio Giampaoli, Timothy Sullivan, Christopher Ware, Christopher T. Winkelmann, Clay L. Efferson
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ed2415b597b108860c97ced4978686
https://doi.org/10.1158/0008-5472.22386984 -
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المؤلفون: Livio Trusolino, David A. Jackson, Francesco Iorio, Dieudonne van der Meer, Gabriele Picco, Julio Saez-Rodriguez, Emanuel Gonçalves, Charlotte M. Beaver, Fiona M. Behan, Yanhua Rao, Sarah Harper, Mathew J. Garnett, Giorgia Migliardi, Marika Pinnelli, Euan A. Stronach, Rachel Pooley, Rebecca McRae, Francesco Sassi, Kosuke Yusa, Carolyn Buser-Doepner, Rita Santos, Piers Wilkinson, Rizwan Ansari, David J. Dow, Andrea Bertotti
المصدر: Nature
مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, Microsatellite instability, Cancer, Computational biology, Biology, medicine.disease, Human genetics, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug development, Genome editing, 030220 oncology & carcinogenesis, Genotype, medicine, CRISPR, Functional genomics
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المؤلفون: Fiona M, Behan, Francesco, Iorio, Gabriele, Picco, Emanuel, Gonçalves, Charlotte M, Beaver, Giorgia, Migliardi, Rita, Santos, Yanhua, Rao, Francesco, Sassi, Marika, Pinnelli, Rizwan, Ansari, Sarah, Harper, David Adam, Jackson, Rebecca, McRae, Rachel, Pooley, Piers, Wilkinson, Dieudonne, van der Meer, David, Dow, Carolyn, Buser-Doepner, Andrea, Bertotti, Livio, Trusolino, Euan A, Stronach, Julio, Saez-Rodriguez, Kosuke, Yusa, Mathew J, Garnett
مصطلحات موضوعية: Gene Editing, Werner Syndrome Helicase, Genome, Human, Reproducibility of Results, Mice, Organ Specificity, Cell Line, Tumor, Neoplasms, Drug Discovery, Biomarkers, Tumor, Animals, Humans, Female, Microsatellite Instability, Molecular Targeted Therapy, Werner Syndrome, CRISPR-Cas Systems, Synthetic Lethal Mutations, Neoplasm Transplantation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3e4160865bd30041e8ccfb533580ca27
http://hdl.handle.net/2318/1714058 -
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المؤلفون: David J. Dow, Carolyn Buser-Doepner, Euan A. Stronach, Emanuel Gonçalves, Rachel Pooley, Mathew J. Garnett, Sarah Harper, Rebecca McRae, Piers Wilkinson, David A. Jackson, Charlotte M. Beaver, Kosuke Yusa, Yanhua Rao, Francesco Iorio, Gabriele Picco, Rizwan Ansari, Fiona M. Behan, Julio Saez-Rodriguez, Rita Santos
مصطلحات موضوعية: Oncology, 0303 health sciences, medicine.medical_specialty, Computer science, RecQ helicase, Cell, Cancer, medicine.disease, Genomic biomarkers, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Drug development, 030220 oncology & carcinogenesis, Internal medicine, medicine, Oncology drug, CRISPR, Clinical efficacy, Gene, Functional genomics, Human cancer, 030304 developmental biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dc8dfa7784cfc9ae07f20c623379d3
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المؤلفون: Cheryl H, Arrowsmith, James E, Audia, Christopher, Austin, Jonathan, Baell, Jonathan, Bennett, Julian, Blagg, Chas, Bountra, Paul E, Brennan, Peter J, Brown, Mark E, Bunnage, Carolyn, Buser-Doepner, Robert M, Campbell, Adrian J, Carter, Philip, Cohen, Robert A, Copeland, Ben, Cravatt, Jayme L, Dahlin, Dashyant, Dhanak, Aled M, Edwards, Mathias, Frederiksen, Stephen V, Frye, Nathanael, Gray, Charles E, Grimshaw, David, Hepworth, Trevor, Howe, Kilian V M, Huber, Jian, Jin, Stefan, Knapp, Joanne D, Kotz, Ryan G, Kruger, Derek, Lowe, Mary M, Mader, Brian, Marsden, Anke, Mueller-Fahrnow, Susanne, Müller, Ronan C, O'Hagan, John P, Overington, Dafydd R, Owen, Saul H, Rosenberg, Bryan, Roth, Brian, Roth, Ruth, Ross, Matthieu, Schapira, Stuart L, Schreiber, Brian, Shoichet, Michael, Sundström, Giulio, Superti-Furga, Jack, Taunton, Leticia, Toledo-Sherman, Chris, Walpole, Michael A, Walters, Timothy M, Willson, Paul, Workman, Robert N, Young, William J, Zuercher
المصدر: Nature chemical biology, vol 11, iss 8
مصطلحات موضوعية: Biochemistry & Molecular Biology, Internet, Biomedical Research, Computer science, Information Dissemination, media_common.quotation_subject, Best practice, Nanotechnology, Cell Biology, Data science, Sensitivity and Specificity, Article, Poor quality, Intellectual Property, Molecular Weight, Small Molecule Libraries, Medicinal and Biomolecular Chemistry, Resource (project management), Molecular Probes, Humans, Quality (business), Generic health relevance, Biochemistry and Cell Biology, Molecular Biology, media_common
وصف الملف: application/pdf
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المؤلفون: Keith W. Rickert, Christine Fernandes, Xianzhi Mao, Kathleen E. Coll, George D. Hartman, Bradley K. Wong, Peter J. Manley, Adrienne E. Balitza, Timothy J. Koester, Mark T. Bilodeau, Debra A. McLoughlin, David C. Heimbrook, Rosemary C. McFall, Sean Yu, William R. Huckle, Jackson B. Gibbs, Jennifer M. Shipman, Kenneth A. Thomas, Raju Subramanian, Joseph J. Lynch, Nancy E. Kohl, Leonard D. Rodman, Cynthia Miller-Stein, Laura Sepp-Lorenzino, Carolyn Buser-Doepner
المصدر: Journal of Medicinal Chemistry. 47:6363-6372
مصطلحات موضوعية: Male, ERG1 Potassium Channel, Pyridines, Stereochemistry, hERG, Administration, Oral, Aminopyridines, Biological Availability, In Vitro Techniques, Cell Line, Rats, Sprague-Dawley, Electrocardiography, Mice, Radioligand Assay, Dogs, In vivo, Drug Discovery, Animals, Tissue Distribution, Phosphorylation, Lung, biology, Kinase, Chemistry, Macaca mulatta, Vascular Endothelial Growth Factor Receptor-2, Ether-A-Go-Go Potassium Channels, In vitro, Rats, Thiazoles, Receptors, Vascular Endothelial Growth Factor, Potassium Channels, Voltage-Gated, Enzyme inhibitor, Microsomes, Liver, biology.protein, Molecular Medicine, Amine gas treating, Signal transduction, Tyrosine kinase
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المؤلفون: Aled M. Edwards, Cheryl H. Arrowsmith, Chas Bountra, Mark E. Bunnage, Marc Feldmann, Julian C. Knight, Dhavalkumar D. Patel, Panagiotis Prinos, Michael D. Taylor, Michael Sundström, Phil Barker, Dalia Barsyte, Mario H. Bengtson, Cindy Bell, Paul Bowness, Kym M. Boycott, Carolyn Buser-Doepner, Christopher L. Carpenter, Andrew J. Carr, Kirk Clark, Anuk M. Das, Dashyant Dhanak, Peter Dirks, James Ellis, Valeria R. Fantin, Christopher Flores, Edward A. Fon, Donald E. Frail, Opher Gileadi, Ronan C. O'Hagan, Trevor Howe, John T. R. Isaac, Nada Jabado, Per-Johan Jakobsson, Lars Klareskog, Stefan Knapp, Wen Hwa Lee, Evelyne Lima-Fernandes, Ingrid E. Lundberg, John Marshall, Katlin B. Massirer, Alex E. MacKenzie, Tetsuyuki Maruyama, Anke Mueller-Fahrnow, Senthil Muthuswamy, Jagdeep Nanchahal, Catherine O'Brien, Udo Oppermann, Nils Ostermann, Kevin Petrecca, Bruce G. Pollock, Viviane Poupon, Rab K. Prinjha, Saul H. Rosenberg, Guy Rouleau, Malcolm Skingle, Arthur S. Slutsky, Garth A. M. Smith, Dominique Verhelle, Hans Widmer, L. Trevor Young
المصدر: Nature Reviews Drug Discovery. 14:149-150
مصطلحات موضوعية: inorganic chemicals, Pharmacology, Patients, Drug discovery, business.industry, Phenotypic screening, Primary Cell Culture, Drug Evaluation, Preclinical, Translational medicine, Public-Private Sector Partnership, MEDLINE, General Medicine, Computational biology, Biology, Public-Private Sector Partnerships, Cell Line, Structural genomics, Biotechnology, Translational Research, Biomedical, Drug development, Drug Discovery, cardiovascular system, Humans, business
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المؤلفون: Christopher Matheny, Carolyn Buser-Doepner, Biju Mangatt, Rakesh Kumar, Gopi Ganji, Neil J. Clarke, Sherry Qin, Crystal Ying Qin
المصدر: Cancer Research. 76:1192-1192
مصطلحات موضوعية: Cancer Research, biology, Combination therapy, business.industry, Cancer, Pharmacology, medicine.disease, medicine.disease_cause, Oncology, ErbB, biology.protein, Medicine, PTEN, ERBB3, skin and connective tissue diseases, business, Carcinogenesis, Protein kinase B, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::444a66d070af56d6c2d2823913b67a5e
https://doi.org/10.1158/1538-7445.am2016-1192
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