المؤلفون: Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e

المؤلفون: Elena Sandoval, Maria Santos Martinez-Martinez, Beatriz Hernández Díaz, Esther Fernández, Maria Jose Lafuente-Monasterio, Jeremy N. Burrows, Simon J. F. Macdonald, Sara Prats, John N. Haselden, Gerard Drewes, Pablo Castañeda, Francisco J. Gamo, J. Vidal, Jose Ignacio Martin Hernando, Benigno Crespo, Margarita Puente, David Matthew Wilson, Paul Bamborough, María Luisa León, Maria Jesus Almela, Sonja Ghidelli-Disse, Rubén M. Gómez, Jaime de Mercado, Carolyn Selenski, Jose M. Coteron, Anne Rodríguez, Cristina de Cozar, Michael J Witty, Juan C. de la Rosa, Paul Willis, Iñigo Angulo-Barturen, María J. Chaparro, Lourdes Rueda, Félix Calderón, Nicholas Cammack, Santiago Ferrer-Bazaga, Sophie Huss, María T. Fraile, María Belén Jiménez Díaz

المصدر: Journal of Medicinal Chemistry. 60:6880-6896

مصطلحات موضوعية: Scaffold, Antiparasitic, medicine.drug_class, Plasmodium falciparum, Pharmacology, Parasitemia, 01 natural sciences, Antimalarials, Mice, Structure-Activity Relationship, 2,2'-Dipyridyl, Drug Discovery, medicine, Animals, Humans, Artemisinin, Mode of action, Atovaquone, Oxadiazoles, Virtual screening, Aqueous medium, Mutagenicity Tests, 010405 organic chemistry, Chemistry, Chloroquine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Hydrazines, Pyrimethamine, Drug Design, Molecular Medicine, Female, Pharmacophore, Mutagens, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfce1c3bf707c62527d304e5e25cb21
https://doi.org/10.1021/acs.jmedchem.6b01441

المؤلفون: Lucy Ellis, Yumi Park, Ola Epemolu, Paul G. Wyatt, Stefano Donini, Laura E. Via, Carolyn Selenski, Matthew Axtman, Thomas R. Ioerger, Menico Rizzi, Tom L. Blundell, Nian Zhou, Simon Green, Olalla Sanz, Maria Osuna-Cabello, David B. Ascher, Helena I. Boshoff, Laste Stojanovski, Travis Hartman, Dale J. Kempf, Clifton E. Barry, Joël Lelièvre, Tracy Bayliss, Zhe Wang, Fred Simeons, Claire J. MacKenzie, Hannah Pflaumer, Valerie Mizrahi, Fabio Zuccotto, James C. Sacchettini, Gracia Santos Diaz, Véronique Dartois, Angela Pacitto, Susan Davis, Kyu Y. Rhee, Laura A. T. Cleghorn, Margaret Huggett, Matthew D. Kurnick, Dinakaran Murugesan, Penelope A. Turner, Kriti Arora, Gerard Drewes, Lluis Ballell, Markus Bösche, Gail M. Freiberg, Kevin D. Read, Surendranadha Reddy Jonnala, Kirsteen I. Buchanan, Maria Jose Lafuente-Monasterio, María José Rebollo-López, Sonja Ghidelli-Disse, Peter C. Ray, Alasdair Smith, Myron Srikumaran, Ardala Breda

المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, 030106 microbiology, Antitubercular Agents, Gene Expression Regulation, Enzymologic, Article, Green fluorescent protein, IMPDH, Mycobacterium tuberculosis, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, IMP Dehydrogenase, Biosynthesis, IMP dehydrogenase, Drug Discovery, Drug Resistance, Bacterial, Animals, Humans, Tuberculosis, guanine, Nucleotide salvage, Sulfonamides, Indazole, Molecular Structure, biology, Gene Expression Regulation, Bacterial, biology.organism_classification, Molecular biology, 3. Good health, Mice, Inbred C57BL, 030104 developmental biology, Infectious Diseases, target validation, chemistry, Biochemistry, Drug Design, Mutation, purine salvage, Rabbits, Growth inhibition, indazole sulfonamide, Intracellular

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896be08dd9046b3b0b9f82d81de880f5
https://doi.org/10.1021/acsinfecdis.6b00103

المؤلفون: Colleen A. McHorney, Paul Wannamaker, William V. Williams, Larissa Stassek, Carolyn Selenski, Cindy Garris, Leandro Mena, Gary I Sinclair, Maggie Czarnogorski, Michael Wohlfeiler, Ronald D’Amico, David Margolis

المصدر: Open Forum Infectious Diseases

مصطلحات موضوعية: Social stigma, business.industry, Human immunodeficiency virus (HIV), medicine.disease_cause, chemistry.chemical_compound, Infectious Diseases, Long acting, Cabotegravir, AcademicSubjects/MED00290, Oncology, Nursing, chemistry, Rilpivirine, Health care, Poster Abstracts, medicine, Implementation effectiveness, Hiv treatment, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd1362e689e7f37d98d476144ecfaa9
http://europepmc.org/articles/PMC7777284

المؤلفون: Paul Willis, Elena Sandoval, Carolyn Selenski, Michael J Witty, Maria Jesus Almela, Jaime de Mercado, Sonja Ghidelli-Disse, Jeremy N. Burrows, Simon J. F. Macdonald, Anne Rodríguez, Santiago Ferrer-Bazaga, Cristina de Cozar, Beatriz Hernández Díaz, Paul Bamborough, Sara Prats, Rubén M. Gómez, María Belén Jiménez Díaz, Maria Jose Lafuente-Monasterio, Iñigo Angulo-Barturen, Margarita Puente, David M. Wilson, Jose M. Coteron, Juan C. de la Rosa, Pablo Castañeda, María Luisa León, Francisco J. Gamo, Jose Ignacio Martin Hernando, John N. Haselden, María J. Chaparro, Sophie Huss, María T. Fraile, Lourdes Rueda, Félix Calderón, Nicholas Cammack, Maria Santos Martinez-Martinez, Gerard Drewes, J. Vidal, Benigno Crespo, Esther Fernández

المصدر: Journal of medicinal chemistry. 60(23)

مصطلحات موضوعية: Scaffold, Chemistry, Drug Discovery, Molecular Medicine, Computational biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca0175d454f38a34fcaa02c5eae30f5
https://pubmed.ncbi.nlm.nih.gov/28806082

المؤلفون: Robert H. Bates, Alfonso Mendoza, Joaquín Rullas, Joël Lelièvre, Chun Wa Chung, Ruth Casanueva, Sudagar S. Gurcha, Maria Santos Martinez-Martinez, Patrick J. Moynihan, Margarete Neu, Nicholas Cammack, Gurdyal S. Besra, Nicholas J. Loman, Jonathan A. G. Cox, Katherine A. Abrahams, Paul Homes, Marcus Bantscheff, Anthony Shillings, Gerard Drewes, Elena Jimenez-Navarro, Lluis Ballell, Matthew Axtman, Carolyn Selenski, Argyrides Argyrou, Monica Cacho Izquierdo, Iñigo Angulo-Barturen, Laurent Kremer, María José Rebollo-López, David Barros, Sonja Ghidelli-Disse

المصدر: Nature Communications
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

مصطلحات موضوعية: 0301 basic medicine, Indazoles, Science, 030106 microbiology, Mutant, Antitubercular Agents, General Physics and Astronomy, Microbial Sensitivity Tests, Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, Mycobacterium tuberculosis, 03 medical and health sciences, Minimum inhibitory concentration, Mice, Bacterial Proteins, In vivo, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase, Drug Resistance, Bacterial, Animals, Tuberculosis, Pulmonary, chemistry.chemical_classification, Sulfonamides, Multidisciplinary, Drug discovery, General Chemistry, biology.organism_classification, Molecular biology, In vitro, 3. Good health, Mice, Inbred C57BL, Enzyme, Biochemistry, chemistry, Biological target, Female

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bc616023998dc8cdc5fc5ed68a4c7e
https://pubmed.ncbi.nlm.nih.gov/27581223

المؤلفون: Jennifer Cockrell, Carolyn Selenski, Marie Pariollaud

المصدر: Tetrahedron Letters. 55:2484-2486

مصطلحات موضوعية: chemistry.chemical_classification, Ketone, Organic Chemistry, Total synthesis, Regioselectivity, Methylene bridge, Condensation reaction, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Organic chemistry, Hexafluorophosphoric acid, Trifluoroacetic anhydride, Methylene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::38bc296c2f41c4711410f8438942c386
https://doi.org/10.1016/j.tetlet.2014.03.011

المؤلفون: Thomas R. R. Pettus, Carolyn Selenski

المصدر: Tetrahedron. 62:5298-5307

مصطلحات موضوعية: Naringenin, Catechol, Stereochemistry, Organic Chemistry, Regioselectivity, Eriodictyol, Biochemistry, Article, Benzopyran, chemistry.chemical_compound, Aglycone, chemistry, Drug Discovery, Reactivity (chemistry), Flavanone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ca300c6d2f6f55e5117521243ad216
https://doi.org/10.1016/j.tet.2006.01.109

المؤلفون: Jennifer Cockrell, Carolyn Selenski, Marie Pariollaud

المصدر: ChemInform. 45

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Ketone, Chemistry, Organic chemistry, Total synthesis, Regioselectivity, Hexafluorophosphoric acid, General Medicine, Methylene bridge, Trifluoroacetic anhydride, Methylene, Condensation reaction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f0763edc02dc2331236066617aa95f70
https://doi.org/10.1002/chin.201438215

المؤلفون: Carolyn Selenski, Thomas R. R. Pettus, Lupe H. Mejorado

المصدر: Synlett. :1101-1103

مصطلحات موضوعية: chemistry.chemical_classification, Lactol, Organic Chemistry, Enantioselective synthesis, Total synthesis, Vinyl ether, Cycloaddition, Benzopyran, chemistry.chemical_compound, chemistry, medicine, Enol ether, Organic chemistry, Benzopyrans, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::525d0f867191f633492fe40fdffcc5d1
https://doi.org/10.1055/s-2004-822888