المؤلفون: Thomas SL; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Xu TH; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Carpenter BL; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Pierce SE; Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA., Dickson BM; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Liu M; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Liang G; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA., Jones PA; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.

المصدر: Nucleic acids research [Nucleic Acids Res] 2023 Jul 07; Vol. 51 (12), pp. 5997-6005.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: CCCTC-Binding Factor*/metabolism , DNA Methylation* , Repressor Proteins*/metabolism, Animals ; Binding Sites ; Chromatin ; CpG Islands ; DNA/metabolism ; Mammals/genetics

المؤلفون: Carpenter BL; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503., Remba TK; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503., Thomas SL; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503., Madaj Z; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503., Brink L; Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Cape Town, Western Cape, 7530, South Africa., Tiedemann RL; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503., Odendaal HJ; Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Stellenbosch University, Cape Town, Western Cape, 7530, South Africa., Jones PA; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503; peter.jones@vai.org.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 23; Vol. 118 (12).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation* , Epigenesis, Genetic* , Genomic Imprinting*, Alcohol Drinking/*adverse effects , Maternal Exposure/*adverse effects , Oocytes/*metabolism , RNA, Untranslated/*genetics, Alleles ; CpG Islands ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Maternal Age ; Pregnancy

المؤلفون: Webb GM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Molden J; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America., Busman-Sahay K; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Abdulhaqq S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Wu HL; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Weber WC; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Bateman KB; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Reed JS; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Northrup M; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Maier N; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Tanaka S; ImmunityBio, Los Angeles, California, United States of America., Gao L; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Davey B; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America., Carpenter BL; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America., Axthelm MK; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America., Stanton JJ; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Smedley J; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Greene JM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Safrit JT; NantKWest, Los Angeles, California, United States of America., Estes JD; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America., Skinner PJ; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America., Sacha JB; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.

المصدر: PLoS pathogens [PLoS Pathog] 2020 Mar 12; Vol. 16 (3), pp. e1008339. Date of Electronic Publication: 2020 Mar 12 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Retroviral Agents/*administration & dosage , B-Lymphocytes/*drug effects , CD8-Positive T-Lymphocytes/*drug effects , HIV Infections/*drug therapy , Interleukin-15/*antagonists & inhibitors , Killer Cells, Natural/*drug effects , Proteins/*administration & dosage, Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Cell Movement/drug effects ; Disease Models, Animal ; HIV Infections/genetics ; HIV Infections/immunology ; HIV Infections/physiopathology ; HIV-1/drug effects ; HIV-1/physiology ; Humans ; Interleukin-15/genetics ; Interleukin-15/immunology ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Lymph Nodes/drug effects ; Lymph Nodes/immunology ; Macaca mulatta ; Recombinant Fusion Proteins ; Simian Acquired Immunodeficiency Syndrome/drug therapy ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/physiopathology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/drug effects ; Simian Immunodeficiency Virus/physiology ; Virus Latency/drug effects

المؤلفون: Carpenter BL; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503., Zhou W; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503., Madaj Z; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503., DeWitt AK; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503., Ross JP; Nutrition and Health Program, CSIRO Health and Biosecurity, North Ryde, NSW 2113, Australia., Grønbæk K; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.; Biotech Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark., Liang G; Department of Urology, University of Southern California, Los Angeles, CA 90089.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089., Clark SJ; Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Molloy PL; Nutrition and Health Program, CSIRO Health and Biosecurity, North Ryde, NSW 2113, Australia., Jones PA; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503; peter.jones@vai.org.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Dec 18; Vol. 115 (51), pp. E11970-E11977. Date of Electronic Publication: 2018 Dec 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation* , Epigenomics* , Genomic Imprinting* , Polymorphism, Genetic*, Alleles ; Binding Sites ; CCCTC-Binding Factor ; Child ; Child, Preschool ; DNA-Binding Proteins/metabolism ; Female ; Gene Expression Regulation ; Haplotypes ; Humans ; Maternal Age ; MicroRNAs/genetics ; Mothers ; Pregnancy ; RNA, Untranslated/genetics

المؤلفون: Masarapu H; Department of Virology, Sri Venkateswara University , Tirupati, 517 502 Andhra Pradesh, India., Patel BK, Chariou PL, Hu H, Gulati NM, Carpenter BL; Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States., Ghiladi RA; Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States., Shukla S, Steinmetz NF

المصدر: Biomacromolecules [Biomacromolecules] 2017 Dec 11; Vol. 18 (12), pp. 4141-4153. Date of Electronic Publication: 2017 Nov 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE

مواضيع طبية MeSH: Drug Carriers/*chemistry , Indicators and Reagents/*chemistry , Nanoparticles/*chemistry , Pharmaceutical Preparations/*chemistry , Tymovirus/*chemistry, Animals ; Cell Line ; Cell Line, Tumor ; Doxorubicin/chemistry ; HeLa Cells ; Humans ; Lysine/chemistry ; Maleimides/chemistry ; Mice ; Mitoxantrone/chemistry ; Neoplasms/diagnosis ; Neoplasms/diagnostic imaging ; Photosensitizing Agents/chemistry ; RAW 264.7 Cells

SCR Organism: Physalis mottle virus

المؤلفون: Carpenter BL; Markey Cancer Center, University of Kentucky, Lexington, 40506-0509, USA.; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, 40506-0509, USA., Liu J; Markey Cancer Center, University of Kentucky, Lexington, 40506-0509, USA., Qi L; Markey Cancer Center, University of Kentucky, Lexington, 40506-0509, USA.; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, 40506-0509, USA., Wang C; Markey Cancer Center, University of Kentucky, Lexington, 40506-0509, USA.; Department of Biostatistics, Division of Cancer Biostatistics, University of Kentucky, Lexington, 40506-0509, USA., O'Connor KL; Markey Cancer Center, University of Kentucky, Lexington, 40506-0509, USA. kloconnor@uky.edu.; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, 40506-0509, USA. kloconnor@uky.edu.

المصدر: Scientific reports [Sci Rep] 2017 Jul 21; Vol. 7 (1), pp. 6174. Date of Electronic Publication: 2017 Jul 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Up-Regulation*, Amphiregulin/*genetics , Epiregulin/*genetics , Integrin alpha6beta4/*metabolism , Pancreatic Neoplasms/*metabolism, Cell Line, Tumor ; Cell Survival ; DNA Methylation ; DNA Repair ; Enhancer Elements, Genetic ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; High-Throughput Nucleotide Sequencing ; Humans ; Pancreatic Neoplasms/genetics ; Whole Genome Sequencing

المؤلفون: Stewart RL; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40506, USA., Carpenter BL; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40506, USA., West DS; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40506, USA., Knifley T; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA., Liu L; Department of Toxicology, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, Guangdong, 510300, PR China., Wang C; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.; Department of Biostatistics, University of Kentucky, Lexington, KY 40506, USA., Weiss HL; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.; Department of Biostatistics, University of Kentucky, Lexington, KY 40506, USA., Gal TS; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.; Division of Biomedical Informatics, University of Kentucky, Lexington, KY 40506, USA., Durbin EB; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.; Division of Biomedical Informatics, University of Kentucky, Lexington, KY 40506, USA., Arnold SM; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA., O'Connor KL; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40506, USA., Chen M; Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40506, USA.

المصدر: Oncotarget [Oncotarget] 2016 Jun 07; Vol. 7 (23), pp. 34630-42.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*drug therapy , Antineoplastic Agents/*pharmacology , Carcinoma, Non-Small-Cell Lung/*drug therapy , Lung Neoplasms/*drug therapy , Niclosamide/*pharmacology , S100 Calcium-Binding Protein A4/*antagonists & inhibitors , S100 Calcium-Binding Protein A4/*metabolism, A549 Cells ; Adenocarcinoma/pathology ; Adenocarcinoma of Lung ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; Lung Neoplasms/pathology ; Matrix Metalloproteinase 9/biosynthesis ; NF-kappa B/metabolism ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Prognosis ; RNA Interference ; RNA, Small Interfering/genetics ; S100 Calcium-Binding Protein A4/genetics ; Tumor Necrosis Factor-alpha/metabolism

المؤلفون: Wen AM, Lee KL, Cao P, Pangilinan K, Carpenter BL; Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States., Lam P, Veliz FA, Ghiladi RA; Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States., Advincula RC, Steinmetz NF

المصدر: Bioconjugate chemistry [Bioconjug Chem] 2016 May 18; Vol. 27 (5), pp. 1227-35. Date of Electronic Publication: 2016 Apr 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

مواضيع طبية MeSH: Photochemotherapy*, Comovirus/*chemistry , Dendrimers/*chemistry , Macrophages/*metabolism , Melanoma, Experimental/*pathology , Nanoparticles/*chemistry , Photosensitizing Agents/*metabolism, Animals ; Drug Carriers/chemistry ; Mice ; Photosensitizing Agents/chemistry ; RAW 264.7 Cells

المؤلفون: Lee KL; Department of Biomedical Engineering, Schools of Medicine and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States., Carpenter BL; Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States., Wen AM; Department of Biomedical Engineering, Schools of Medicine and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States., Ghiladi RA; Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States., Steinmetz NF; Department of Biomedical Engineering, Schools of Medicine and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.; Department of Radiology, Schools of Medicine and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.; Department of Materials Science and Engineering, Schools of Medicine and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.; Department of Macromolecular Science and Engineering, Schools of Medicine and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.; Case Comprehensive Cancer Center, Schools of Medicine and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.

المصدر: ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2016 May 09; Vol. 2 (5), pp. 838-844. Date of Electronic Publication: 2016 Mar 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2373-9878 (Print) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: PubMed not MEDLINE

المؤلفون: Carpenter BL; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509; Departments of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40506-0509., Chen M; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509; Departments of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40506-0509., Knifley T; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509., Davis KA; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509., Harrison SMW; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509., Stewart RL; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509; Departments of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky 40506-0509., O'Connor KL; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506-0509; Departments of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40506-0509. Electronic address: kloconnor@uky.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2015 Nov 06; Vol. 290 (45), pp. 27228-27238. Date of Electronic Publication: 2015 Sep 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: ErbB Receptors/*metabolism , Hepatocyte Growth Factor/*metabolism , Integrin alpha6beta4/*metabolism, Amphiregulin ; Cell Line, Tumor ; Cell Movement ; EGF Family of Proteins/genetics ; EGF Family of Proteins/metabolism ; Epiregulin/genetics ; Epiregulin/metabolism ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Gene Knockdown Techniques ; Humans ; Integrin alpha6beta4/genetics ; Matrix Metalloproteinase 1/genetics ; Matrix Metalloproteinase 1/metabolism ; Models, Biological ; Neoplasm Invasiveness ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Neoplasm/genetics ; RNA, Neoplasm/metabolism ; Signal Transduction ; Tumor Microenvironment ; Up-Regulation