المؤلفون: Coxon, CR, Wong, C, Bayliss, RWA, Boxall, K, Carr, KH, Fry, AM, Hardcastle, IR, Matheson, CJ, Newell, DR, Sivaprakasam, M, Thomas, H, Turner, D, Yeoh, S, Wang, LZ, Griffin, RJ, Golding, BT, Cano, C

المصدر: Oncotarget

مصطلحات موضوعية: Nek2, Structure-Activity Relationship, Magnetic Resonance Spectroscopy, Cell Line, Tumor, Drug Design, cancer, Humans, NIMA-Related Kinases, Antineoplastic Agents, structure-guided design, small molecule inhibitors, Research Paper

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2a81c9e348a99e3a06a93c16991f5ec9

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المؤلفون: Bhatia K; Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA., Ladd LM; Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA., Carr KH; Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA., Di Napoli M; Neurological Service, SS Annunziata Hospital, Sulmona, L'Aquila, Italy., Saver JL; Department of Neurology, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA., McCullough LD; Department of Neurology, McGovern Medical School, University of Texas Health Sciences Center, Houston, TX, USA., Hosseini Farahabadi M; Department of Neurology, University of New Mexico, Albuquerque, NM, USA., Alsbrook DL; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA., Hinduja A; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Ortiz Garcia JG; Department of Neurology, the University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Sabbagh SY; Department of Neurology, University of New Mexico, Albuquerque, NM, USA., Jafarli A; Department of Neurology, Tufts Medical Center, Boston, MA, USA., Divani AA; Department of Neurology, University of New Mexico, Albuquerque, NM, USA. adivani@gmail.com.

المصدر: Current neurology and neuroscience reports [Curr Neurol Neurosci Rep] 2023 May; Vol. 23 (5), pp. 235-262. Date of Electronic Publication: 2023 Apr 11.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Current Science Inc Country of Publication: United States NLM ID: 100931790 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6293 (Electronic) Linking ISSN: 15284042 NLM ISO Abbreviation: Curr Neurol Neurosci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Ischemic Attack, Transient*/drug therapy , Ischemic Attack, Transient*/prevention & control , Ischemic Stroke* , Stroke*/etiology , Stroke*/prevention & control, Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Clopidogrel ; Warfarin/therapeutic use ; Anticoagulants/adverse effects ; Aspirin/therapeutic use ; Hemorrhage/chemically induced ; Drug Therapy, Combination ; Secondary Prevention

المؤلفون: Byrne MJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K., Nasir N; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K., Basmadjian C; Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, U.K., Bhatia C; Department of Molecular and Cell Biology, University of Leicester, Leicester, U.K., Cunnison RF; Department of Molecular and Cell Biology, University of Leicester, Leicester, U.K., Carr KH; Department of Molecular and Cell Biology, University of Leicester, Leicester, U.K., Mas-Droux C; Section of Structural Biology, The Institute of Cancer Research, London, U.K., Yeoh S; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K., Cano C; Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, U.K., Bayliss R; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K.

المصدر: The Biochemical journal [Biochem J] 2020 Apr 30; Vol. 477 (8), pp. 1525-1539.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*metabolism , NIMA-Related Kinases/*chemistry , NIMA-Related Kinases/*metabolism, Catalysis ; Enzyme Inhibitors/chemistry ; Humans ; Kinetics ; Mutation ; NIMA-Related Kinases/genetics ; Protein Binding ; Protein Conformation ; Protein Engineering

المؤلفون: Turner DD; Department of Chemistry and Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road, Leicester LE1 7RH, England, United Kingdom., Lad L; Department of Chemistry and Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road, Leicester LE1 7RH, England, United Kingdom., Kwon H; Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, England, United Kingdom., Basran J; Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, England, United Kingdom., Carr KH; Department of Chemistry and Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road, Leicester LE1 7RH, England, United Kingdom., Moody PCE; Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, England, United Kingdom., Raven EL; Department of Chemistry and Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road, Leicester LE1 7RH, England, United Kingdom. Electronic address: emma.raven@le.ac.uk.

المصدر: Journal of inorganic biochemistry [J Inorg Biochem] 2018 Mar; Vol. 180, pp. 230-234. Date of Electronic Publication: 2017 Dec 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Alanine/*metabolism , Ascorbate Peroxidases/*metabolism, Alanine/genetics ; Ascorbic Acid/metabolism ; Catalysis ; Chromatography, High Pressure Liquid ; Guaiacol/metabolism ; Heme/metabolism ; Kinetics ; Models, Molecular ; Mutagenesis, Site-Directed ; Oxidation-Reduction ; Proline/genetics ; Substrate Specificity

المؤلفون: McEwan PA; Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, United Kingdom., Yang W, Carr KH, Mo X, Zheng X, Li R, Emsley J

المصدر: Blood [Blood] 2011 Nov 10; Vol. 118 (19), pp. 5292-301. Date of Electronic Publication: 2011 Sep 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Bernard-Soulier Syndrome/*blood , Bernard-Soulier Syndrome/*genetics , Platelet Glycoprotein GPIb-IX Complex/*chemistry , Platelet Glycoprotein GPIb-IX Complex/*genetics, Amino Acid Sequence ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Crystallography, X-Ray ; Humans ; Models, Molecular ; Molecular Sequence Data ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutation, Missense ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Sequence Homology, Amino Acid