المؤلفون: Wienert B; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA.; Gladstone Institutes, San Francisco, CA, 94158, USA., Nguyen DN; Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143, USA.; Diabetes Center, University of California, San Francisco, CA, 94143, USA.; Department of Medicine, University of California, San Francisco, CA, 94143, USA., Guenther A; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA., Feng SJ; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA., Locke MN; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA., Wyman SK; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA., Shin J; Department of Biology, Institute of Molecular Health Sciences, ETH Zürich, 8093, Zurich, Switzerland., Kazane KR; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA., Gregory GL; Gladstone Institutes, San Francisco, CA, 94158, USA., Carter MAM; Gladstone Institutes, San Francisco, CA, 94158, USA., Wright F; Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143, USA., Conklin BR; Gladstone Institutes, San Francisco, CA, 94158, USA.; Departments of Medicine, Ophthalmology, and Pharmacology, University of California, San Francisco, CA, 94143, USA., Marson A; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143, USA.; Diabetes Center, University of California, San Francisco, CA, 94143, USA.; Department of Medicine, University of California, San Francisco, CA, 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, 94129, USA.; Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA., Richardson CD; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA. chris.richardson@lifesci.ucsb.edu.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA. chris.richardson@lifesci.ucsb.edu.; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA. chris.richardson@lifesci.ucsb.edu., Corn JE; Innovative Genomics Institute, University of California, Berkeley, CA, 94703, USA. jacob.corn@biol.ethz.ch.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94703, USA. jacob.corn@biol.ethz.ch.; Department of Biology, Institute of Molecular Health Sciences, ETH Zürich, 8093, Zurich, Switzerland. jacob.corn@biol.ethz.ch.

المصدر: Nature communications [Nat Commun] 2020 Apr 30; Vol. 11 (1), pp. 2109. Date of Electronic Publication: 2020 Apr 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Recombinational DNA Repair*, Cell Cycle Proteins/*antagonists & inhibitors , Cell Cycle Proteins/*genetics , Protein Serine-Threonine Kinases/*antagonists & inhibitors , Protein Serine-Threonine Kinases/*genetics, DNA Breaks, Double-Stranded ; Gene Editing ; Genetic Engineering/methods ; HCT116 Cells ; HEK293 Cells ; HeLa Cells ; Homologous Recombination ; Humans ; K562 Cells ; Phenotype ; RNA, Guide, CRISPR-Cas Systems/metabolism ; S Phase