المؤلفون: Caryn Hampton, Raymond Rosa, Daphne Szeto, Gail Forrest, Barry Campbell, Richard Kennan, Shubing Wang, Chin-Hu Huang, Loise Gichuru, Xiaoli Ping, Xiaolan Shen, Kersten Small, Jeffrey Madwed, Joseph J Lynch

المصدر: SAGE Open Medicine, Vol 5 (2017)

مصطلحات موضوعية: Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2050-3121

URL الوصول: https://doaj.org/article/f63b2f7ff471419f8b3ad093784171db

المؤلفون: Xin Gu, Brande Thomas-Fowlkes, Dorothy Levorse, Harry R. Chobanian, Timothy Cutarelli, Alexander Pasternak, Adam B. Weinglass, Ian W. Davies, Martin Koehler, Michael Margulis, Fa-Xiang Ding, Joel B. Yudkovitz, Jinlong Jiang, Haifeng Tang, Lee-Yuh Pai, Barbara Pio, Shuzhi Dong, Mengwei Hu, Kathleen A. Sullivan, Jack Gibson, Thomas Bateman, Koppara Samuel, Xiaoyan Zhou, Caryn Hampton, Reynalda deJesus, Kevin Houle, Emma R. Parmee

المصدر: Journal of medicinal chemistry. 64(11)

مصطلحات موضوعية: Male, medicine.medical_treatment, Diuresis, Action Potentials, Blood Pressure, Pharmacology, 01 natural sciences, Piperazines, Natriuresis, Excretion, 03 medical and health sciences, Dogs, Rats, Inbred SHR, Drug Discovery, medicine, Potassium Channel Blockers, Animals, Humans, Dosing, Potassium Channels, Inwardly Rectifying, Diuretics, 030304 developmental biology, Benzofurans, 0303 health sciences, Chemistry, Furosemide, Haplorhini, medicine.disease, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Heart failure, ROMK, Potassium, Molecular Medicine, Natriuretic Agents, Diuretic, medicine.drug, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c25db7e0321a07221c83e7a37add1c
https://pubmed.ncbi.nlm.nih.gov/34038119

المؤلفون: Haifeng Tang, Zack Zhiqiang Guo, Lee-Yuh Pai, Adam B. Weinglass, Xin Gu, Shuzhi Dong, Alexander Pasternak, Yang Yu, Kathleen A. Sullivan, Mengwei Hu, Kelsey VanGelder, Gloria J. Zingaro, Sophie Roy, Jessica Liu, Qinghong Fu, Birgit T. Priest, Michael Margulis, Brande Thomas-Fowlkes, Pierre Morissette, Robin E. Haimbach, Zhicai Wu, Juliann Ehrhart, Karen Owens, Caryn Hampton, Zhi-Cai Shi, Jessica Frie, Ron Ferguson, Shiyao Xu, Vincent Tong

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2559-2566

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Scaffold, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Dogs, 0302 clinical medicine, Thiadiazoles, In vivo, Rats, Inbred SHR, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Structure–activity relationship, Spiro Compounds, Potassium Channels, Inwardly Rectifying, Molecular Biology, biology, Chemistry, Organic Chemistry, Potassium channel blocker, Rats, Disease Models, Animal, Pyrimidines, 030104 developmental biology, 030220 oncology & carcinogenesis, Hypertension, ROMK, biology.protein, Molecular Medicine, Pharmacophore, Half-Life, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2dc6104dc29c3168c501b413896773
https://doi.org/10.1016/j.bmcl.2017.03.086

المؤلفون: Kersten M. Small, Caryn Hampton, Loise Gichuru, Joseph J. Lynch, Xiaoli Ping, Ray Rosa, Richard Kennan, Jeffrey B. Madwed, Xiaolan Shen, Barry R. Campbell

المصدر: Journal of Pharmacological and Toxicological Methods. 84:93-101

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Diastole, Hemodynamics, 030204 cardiovascular system & hematology, Toxicology, Ventricular Function, Left, Constriction, Mice, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Animals, Heart Failure, Pharmacology, Pressure overload, Ejection fraction, Receiver operating characteristic, business.industry, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Stenosis, 030104 developmental biology, Echocardiography, Heart failure, Cardiology, Hypertrophy, Left Ventricular, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6727b68ed4cd0d8e428f81c3429ec1eb
https://doi.org/10.1016/j.vascn.2016.12.001

المؤلفون: Lee-Yuh Pai, Aaron Corona, Harry R. Chobanian, John P. Felix, Matthew J. Clements, Karen Owens, Haifeng Tang, Brande Thomas-Fowlkes, Kathleen A. Sullivan, Alexander Pasternak, Caryn Hampton, Jessica Frie, Vincent Tong, Ron Ferguson, Jessica Liu, Birgit T. Priest, Barbara Pio, Yan Guo, Elizabeth Joshi, Nardos Teumelsan, Ling Xu, Martin Köhler, Joseph M. Metzger, Zach Guo, Kevin M. Maloney

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1109-1114

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, hERG, Pharmaceutical Science, Diuresis, Biochemistry, Natriuresis, Sulfone, 03 medical and health sciences, chemistry.chemical_compound, Heterocyclic Compounds, Rats, Inbred SHR, Drug Discovery, medicine, Animals, Moiety, Organic chemistry, Sulfones, Enzyme Inhibitors, Potassium Channels, Inwardly Rectifying, Diuretics, Molecular Biology, biology, Chemistry, Organic Chemistry, Rats, 030104 developmental biology, Drug Design, ROMK, biology.protein, Molecular Medicine, Diuretic, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c5ab8a2efa0d6babaaad56a9277a67
https://doi.org/10.1016/j.bmcl.2016.10.032

المؤلفون: Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5695-5702

مصطلحات موضوعية: 0301 basic medicine, QTC PROLONGATION, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Dog model, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Transcriptional Regulator ERG, Pharmacokinetics, In vivo, Oxazines, Drug Discovery, Animals, Humans, Potassium Channels, Inwardly Rectifying, Molecular Biology, Heart Failure, biology, Chemistry, Organic Chemistry, Macaca mulatta, Small molecule, Diuresis, Piperazine, 030104 developmental biology, 030220 oncology & carcinogenesis, Hypertension, ROMK, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ba115f699ab80f9a1176691245bcc
https://doi.org/10.1016/j.bmcl.2016.10.064

المؤلفون: Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour

المصدر: ACS Medicinal Chemistry Letters. 7:697-701

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Kidney, biology, Chemistry, Organic Chemistry, hERG, Diuresis, Nephron, Pharmacology, Biochemistry, Natriuresis, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Internal medicine, Drug Discovery, medicine, biology.protein, Loop of Henle, ROMK, Thiazide, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e7bac5379921d8eb6098d8804f901
https://doi.org/10.1021/acsmedchemlett.6b00122

المؤلفون: Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey

المصدر: ACS Medicinal Chemistry Letters. 6:747-752

مصطلحات موضوعية: Pharmacokinetics, Chemistry, Pharmacodynamics, Organic Chemistry, Drug Discovery, ROMK, Pharmacology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c1f32ec6c3f7a915fe446fd2867a1
https://doi.org/10.1021/ml500440u

المؤلفون: Yan Yan, Richard M. Brochu, Maria L. Garcia, Lihu Yang, Sophie Roy, Gregory J. Kaczorowski, Reynald K. de Jesus, Birgit T. Priest, Xiaoyan Zhou, Lee-Yuh Pai, Shawn P. Walsh, Yuping Zhu, Karen Owens, Caryn Hampton, Timothy Bailey, Andrew M. Swensen, Brande Thomas-Fowlkes, Magdalena Alonso-Galicia, John P. Felix, Melba Hernandez, Alexander Pasternak, Haifeng Tang

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:5829-5832

مصطلحات موضوعية: Natriuretic Agents, Isobenzofuran, Stereochemistry, Clinical Biochemistry, hERG, Tetrazoles, Pharmaceutical Science, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Potassium Channels, Inwardly Rectifying, Molecular Biology, Benzofurans, biology, Chemistry, Organic Chemistry, Small molecule, Ether-A-Go-Go Potassium Channels, Diuresis, Rats, ROMK, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5c348f365905a62caacd72f218a844
https://doi.org/10.1016/j.bmcl.2013.08.104

المؤلفون: Haifeng Tang, Kashmira Shah, Maria L. Garcia, Alexander Pasternak, Magdalena Alonso-Galicia, Brande Thomas-Fowlkes, Cordelia Rasa, Joseph M. Metzger, Sophie Roy, Lee-Yuh Pai, Jessica Liu, Olga Price, Vince Tong, Birgit T. Priest, Gregory J. Kaczorowski, James D. Ormes, Charles Gill, Aaron Corona, John P. Felix, Jianying Xiao, Kathleen A. Sullivan, Karen Owens, Caryn Hampton, Xiaoyan Zhou, Martin Köhler

المصدر: The Journal of pharmacology and experimental therapeutics. 359(1)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Diuresis, Tetrazoles, Blood Pressure, Pharmacology, Bartter syndrome, Piperazines, Natriuresis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Internal medicine, medicine, Potassium Channel Blockers, Animals, Humans, Potassium Channels, Inwardly Rectifying, Benzofurans, Aldosterone, Dose-Response Relationship, Drug, Chemistry, Biphenyl Compounds, Bartter Syndrome, Potassium channel blocker, Drug Synergism, medicine.disease, Rats, Bartter's syndrome, 030104 developmental biology, Endocrinology, HEK293 Cells, Hydrochlorothiazide, Phenotype, 030220 oncology & carcinogenesis, Kaliuresis, ROMK, Molecular Medicine, Benzimidazoles, Female, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a55d5d0f3672edd7db9d025d76d0fd
https://pubmed.ncbi.nlm.nih.gov/27432892