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1دورية أكاديمية
المؤلفون: Patrick G Kehoe, Nicholas Turner, Beth Howden, Lina Jarutyt, Shona L Clegg, Ian B Malone, Josephine Barnes, Casper Nielsen, Carole H Sudre, Aileen Wilson, N Jade Thai, Peter S Blair, Elizabeth J Coulthard, J Athene Lane, Peter Passmore, Jodi Taylor, Henk-Jan Mutsaerts, David L Thomas, Nick C Fox, Ian Wilkinson, Yoav Ben-Shlomo
المصدر: Efficacy and Mechanism Evaluation, Vol 8, Iss 19 (2021)
مصطلحات موضوعية: alzheimer’s disease, clinical trial, hypertension, renin–angiotensin system, vascular risk, losartan, mri, Medicine
وصف الملف: electronic resource
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المؤلفون: Patrick Gavin Kehoe, Nicholas Turner, Beth Howden, Lina Jarutyte, Shona Louise Clegg, Ian Brian Malone, Josephine Barnes, Casper Nielsen, Carole Hélène Sudre, Aileen Wilson, Ngoc Jade Thai, Peter Sinclair Blair, Elizabeth Coulthard, Janet Athene Lane, Peter Passmore, Jodi Taylor, Henk-Jan Mutsaerts, David Lee Thomas, Nick Charles Fox, Ian Wilkinson, Yoav Ben-Shlomo, Kirsty Harkness, Tarun Kuruvilla, Rupert McShane, Peter Connelly, Gordon Duncan, Lucy Calvert, Alasdair Lawrie, Matthew Sheridan, Eric Jackson, Bernard Udeze, Stephen Pearson, Tobias Langheinrich, Suvarna Wagle, Joseph Butchart, Ajay Macharouthu, Andrew Donaldson, Wendy Neil, Vivek Pattan, David Findlay, Alan Thomas, Robert Barber, Andrew Byrne, Madhusudan Dalvi, Rashi Negi, Bernadette McGuinness
المساهمون: Radiology and nuclear medicine, Neurology
المصدر: The Lancet. Neurology
Lancet Neurology, 20(11), 895-906. Lancet Publishing Group
Kehoe, P G, Turner, N, Howden, B, Jarutyte, L, Clegg, S L, Malone, I B, Barnes, J, Nielsen, C, Sudre, C H, Wilson, A, Thai, N J, Blair, P S, Coulthard, E, Lane, J A, Passmore, P, Taylor, J, Mutsaerts, H-J, Thomas, D L, Fox, N C, Wilkinson, I, Ben-Shlomo, Y & RADAR investigators 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial) : a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
RADAR investigators 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial ', The Lancet. Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial) : a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
Kehoe, P G, Turner, N, Howden, B, Jarutyte, L, Clegg, S L, Malone, I B, Barnes, J, Nielsen, C, Sudre, C H, Wilson, A, Thai, N J, Blair, P S, Coulthard, E, Lane, J A, Passmore, P, Taylor, J, Mutsaerts, H-J, Thomas, D L, Fox, N C, Wilkinson, I & Ben-Shlomo, Y 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 .مصطلحات موضوعية: medicine.medical_specialty, Angiotensin II receptor antagonist, Blood Pressure, Placebo, Losartan, State Medicine, law.invention, Randomized controlled trial, Double-Blind Method, law, Alzheimer Disease, Internal medicine, medicine, media_common.cataloged_instance, Humans, European union, Stroke, media_common, business.industry, Brain, Articles, Middle Aged, medicine.disease, Angiotensin II, Clinical trial, Treatment Outcome, Neurology (clinical), Atrophy, business, medicine.drug
وصف الملف: application/pdf
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المؤلفون: K Hunter, Dennis Chan, Richard Nicholas, Virginia L. Calder, Jennifer M. Nicholas, Nick C. Fox, Shona Clegg, Jeremy Chataway, Val Anderson, David Wilkie, John Greenwood, Chris Frost, David G. MacManus, Charles R. M. Bangham, A Alsanousi, Casper Nielsen, Nadine Schuerer
المساهمون: Chan, Dennis [0000-0002-4265-3718], Apollo - University of Cambridge Repository
المصدر: The Lancet. 383(9936):2213-2221
مصطلحات موضوعية: Male, Simvastatin, Administration, Oral, THERAPY, law.invention, DOUBLE-BLIND, Randomized controlled trial, law, AUTOIMMUNE-DISEASE, Medicine(all), Brain, General Medicine, Middle Aged, Multiple Sclerosis, Chronic Progressive, Cytokines, Female, Life Sciences & Biomedicine, CLINICAL-TRIALS, medicine.drug, INTERFERON, Adult, medicine.medical_specialty, Adolescent, Placebo, Young Adult, Atrophy, Medicine, General & Internal, VOLUME CHANGES, REDUCTASE INHIBITORS, Double-Blind Method, Internal medicine, General & Internal Medicine, medicine, Humans, Disabled Persons, NITRIC-OXIDE SYNTHASE, Adverse effect, Aged, Intention-to-treat analysis, Science & Technology, Dose-Response Relationship, Drug, business.industry, Multiple sclerosis, CENTRAL-NERVOUS-SYSTEM, OUTCOME MEASURE, medicine.disease, Clinical trial, Physical therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business
وصف الملف: application/pdf
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المؤلفون: Gregg Keith M, Steven Einstein, Nick C. Fox, Enchi Liu, Iulia Cristina Tudor, Casper Nielsen, Bradley T. Wyman, Michael Grundman, H. Robert Brashear, Eric C. Yuen, Shona Clegg, Yuan Lu, Jianing Di, Gerald Novak, Peter C. Collins
المصدر: Journal of Alzheimer's disease : JAD. 49(4)
مصطلحات موضوعية: Apolipoprotein E, Male, medicine.medical_specialty, Pathology, Heterozygote, Dose, Apolipoprotein E4, Placebo, Antibodies, Monoclonal, Humanized, Gastroenterology, Severity of Illness Index, law.invention, Atrophy, Randomized controlled trial, Double-Blind Method, law, Alzheimer Disease, Internal medicine, medicine, Humans, Bapineuzumab, Least-Squares Analysis, Nootropic Agents, Aged, medicine.diagnostic_test, business.industry, General Neuroscience, Repeated measures design, Brain, Magnetic resonance imaging, General Medicine, Organ Size, medicine.disease, Magnetic Resonance Imaging, Psychiatry and Mental health, Clinical Psychology, Treatment Outcome, Female, Geriatrics and Gerontology, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e2443c1059efa6cc108e569918fa56
https://pubmed.ncbi.nlm.nih.gov/26639957 -
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المؤلفون: Matthew J. Clarkson, Nick C. Fox, Michael W. Weiner, Sebastien Ourselin, Josephine Barnes, Jeffrey L. Gunter, Casper Nielsen, Clifford R. Jack, Derek L. G. Hill, Kelvin K. Leung, Jennifer L. Whitwell
المساهمون: Neurology, NCA - Neurodegeneration
المصدر: NeuroImage, 47(4), 1506-1513. Academic Press Inc.
Clarkson, M J, Ourselin, S, Nielsen, C, Leung, K K, Barnes, J, Whitwell, J L, Gunter, J L, Hill, D L G, Weiner, M W, Jack, C R & Fox, N C I 2009, ' Comparison of phantom and registration scaling corrections using the ADNI cohort ', NeuroImage, vol. 47, no. 4, pp. 1506-1513 . https://doi.org/10.1016/j.neuroimage.2009.05.045مصطلحات موضوعية: Cognitive Neuroscience, Image registration, computer.software_genre, Sensitivity and Specificity, Imaging phantom, Article, Cohort Studies, Neuroimaging, Voxel, Alzheimer Disease, Image Interpretation, Computer-Assisted, medicine, Humans, Scaling, Cerebral atrophy, medicine.diagnostic_test, business.industry, Phantoms, Imaging, Reproducibility of Results, Magnetic resonance imaging, medicine.disease, Image Enhancement, Magnetic Resonance Imaging, Neurology, Sample size determination, Subtraction Technique, Nuclear medicine, business, Psychology, Artifacts, computer, Algorithms
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المؤلفون: Gerald Novak, Reisa A. Sperling, Howard Simon, Enchi Liu, Shona Clegg, Steven Einstein, Andrea S. Les, Casper Nielsen, Sylvain Bouix, Derek L. G. Hill, Nick C. Fox, Richard Margolin
المصدر: Alzheimer's & Dementia. 9
مصطلحات موضوعية: Physics, Pathology, medicine.medical_specialty, Epidemiology, Health Policy, Mathematical analysis, Boundary Shift Integral, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, Distortion, medicine, Vector field, Neurology (clinical), Geriatrics and Gerontology
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المؤلفون: Bradley T. Wyman, Michael Grundman, Peter Collins, Nick C. Fox, Enchi Liu, Steven Einstein, Casper Nielsen, Yuan Lu, Gerald Novak, Eric C. Yuen, Gregg Keith M, Robert H. Brashear, Iulia Cristina Tudor
المصدر: Alzheimer's & Dementia. 9
مصطلحات موضوعية: Oncology, medicine.medical_specialty, Pathology, Phase iii trials, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, Correlation, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, Internal medicine, Medicine, Bapineuzumab, Neurology (clinical), Geriatrics and Gerontology, business, Clinical progression, medicine.drug
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المؤلفون: Kelvin Leung, Casper Nielsen, Shona Clegg, Ian Malone, Jennifer Nicholas, David Cash, Sebastien Ourselin, Paul Thompson, Clifford Jack, Michael Weiner, Nick Fox
المصدر: Alzheimer's & Dementia. 9
مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
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المؤلفون: Steven Einstein, Sylvain Bouix, Casper Nielsen, Shona Clegg, Andrea Les, Howard Simon, Derek Hill, Richard Margolin, Reisa Sperling, Nick Fox, Enchi Liu, Gerald Novak
المصدر: Alzheimer's & Dementia. 9
مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
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المؤلفون: Enchi Liu, Robert H. Brashear, Gerald Novak, Iulia Cristina Tudor, Bradley T. Wyman, Casper Nielsen, Gregg Keith M, Eric C. Yuen, Nick C. Fox, Steven Einstein, Michael Grundman, Peter Collins
المصدر: Alzheimer's & Dementia. 9
مصطلحات موضوعية: Oncology, medicine.medical_specialty, Pathology, Phase iii trials, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, Internal medicine, medicine, Bapineuzumab, Neurology (clinical), Geriatrics and Gerontology, business, Clinical progression, medicine.drug