المؤلفون: Wijeratne A; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Xiao J; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Reutter C; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Furness KW; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Leon R; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Zia-Ebrahimi M; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Cavitt RN; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Strelow JM; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Van Horn RD; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Peng SB; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Barda DA; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Engler TA; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Chalmers MJ; Discovery Chemistry Research and Technologies and Oncology Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 May 21; Vol. 9 (6), pp. 557-562. Date of Electronic Publication: 2018 May 21 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Strelow JM; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA strelow_john_mark@lilly.com., Xiao M; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Cavitt RN; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Fite NC; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Park KJ; Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.

المصدر: Journal of biomolecular screening [J Biomol Screen] 2016 Sep; Vol. 21 (8), pp. 786-94. Date of Electronic Publication: 2016 Jul 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays/*methods , Histone-Lysine N-Methyltransferase/*metabolism , Nucleosomes/*genetics , Peptides/*isolation & purification, Adenosine/analogs & derivatives ; Adenosine/metabolism ; DNA Damage/genetics ; Histone-Lysine N-Methyltransferase/genetics ; Histones/genetics ; Humans ; Lysine/genetics ; Nucleosomes/metabolism ; PR-SET Domains/genetics ; Peptides/genetics ; Protein Binding ; Structure-Activity Relationship ; Substrate Specificity

المؤلفون: Durham TB; From the Discovery Chemistry Research and Technologies, durham_timothy_barrett@lilly.com., Toth JL; From the Discovery Chemistry Research and Technologies., Klimkowski VJ; From the Discovery Chemistry Research and Technologies., Cao JX; Endocrine Discovery., Siesky AM; Endocrine Discovery., Alexander-Chacko J; Endocrine Discovery., Wu GY; Endocrine Discovery., Dixon JT; From the Discovery Chemistry Research and Technologies., McGee JE; From the Discovery Chemistry Research and Technologies., Wang Y; From the Discovery Chemistry Research and Technologies., Guo SY; From the Discovery Chemistry Research and Technologies., Cavitt RN; From the Discovery Chemistry Research and Technologies., Schindler J; From the Discovery Chemistry Research and Technologies., Thibodeaux SJ; Translational Science and Technologies, and., Calvert NA; Drug Disposition, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Coghlan MJ; From the Discovery Chemistry Research and Technologies., Sindelar DK; Endocrine Discovery., Christe M; Endocrine Discovery., Kiselyov VV; Endocrine Discovery., Michael MD; Endocrine Discovery., Sloop KW; Endocrine Discovery.

المصدر: The Journal of biological chemistry [J Biol Chem] 2015 Aug 14; Vol. 290 (33), pp. 20044-59. Date of Electronic Publication: 2015 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacology , Insulin/*metabolism , Insulysin/*antagonists & inhibitors, Animals ; Binding Sites ; Crystallography, X-Ray ; Enzyme Inhibitors/pharmacokinetics ; HEK293 Cells ; Humans ; Insulysin/chemistry ; Models, Molecular ; Proteolysis