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المؤلفون: Pirjo Nummela, Colin Nixon, William C. Clark, Ella Gilchrist, Simon J. Leedham, Michael C. Hodder, Nalle Pentinmikko, Arafath Kaja Najumudeen, Nathalie Sphyris, E. Yvonne Jones, Jean-Paul Vincent, Hans Clevers, Nicky J. Willis, Alexander Raven, Kristina Kirschner, Dustin J. Flanagan, Paul V. Fish, Emma Minnee, Pekka Katajisto, Ville Hietakangas, Owen J. Sansom, Christine Perret, Lynn McGarry, Nadia Nasreddin, Rachel A. Ridgway, Ann C. Williams, Kathryn Gilroy, Kalle Luopajärvi, Sandra Scharaw, Béatrice Romagnolo, Marianne Lähde, Ari Ristimäki, Johanna Englund, Anna Taylor Webb, Kari Alitalo, Ann Hedley
المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Institute of Biotechnology (-2009), University of Helsinki, CAN-PRO - Translational Cancer Medicine Program, Centre of Excellence in Stem Cell Metabolism, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Juha Klefström / Principal Investigator, Research Programs Unit, Department of Pathology, Doctoral Programme in Biomedicine, ATG - Applied Tumor Genomics, Doctoral Programme in Integrative Life Science, HUSLAB, Kari Alitalo / Principal Investigator, Molecular and Integrative Biosciences Research Programme, Biosciences, Nutrient sensing laboratory
المصدر: Nature, 594(7863), 430-435. Nature Publishing Group
Flanagan, D J, Williams, A C, Katajisto, P K, Sampson, O J & al., E 2021, ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ', Nature, vol. 594, pp. 430–435 (2021) . https://doi.org/10.1038/s41586-021-03525-zمصطلحات موضوعية: 0301 basic medicine, Male, HOMEOSTASIS, Cell, medicine.disease_cause, Cell Transformation, Inbred C57BL, Ligands, BETA-CATENIN, ACTIVATION, PATHWAY, Mice, 0302 clinical medicine, Conditioned, INTESTINE, Stem Cells/cytology, Wnt Signaling Pathway, Cell Competition/genetics, Esterases/antagonists & inhibitors, Mutation, Multidisciplinary, biology, Stem Cells, Cell Transformation, Neoplastic/genetics, Wnt signaling pathway, Esterases, Cell Differentiation, Neoplastic/genetics, Cell biology, Organoids, POLYPOSIS, medicine.anatomical_structure, Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Disease Progression, Organoids/cytology, Female, Stem cell, Colorectal Neoplasms, STEM-CELLS, BONE-FORMATION, Adenoma, Beta-catenin, Genes, APC, 3122 Cancers, Crypt, Adenomatous Polyposis Coli Protein, WNT, 03 medical and health sciences, Cancer stem cell, Wnt Proteins/metabolism, medicine, Animals, Humans, Adenomatous Polyposis Coli Protein/genetics, Cell Proliferation, Adenoma/genetics, Colorectal Neoplasms/genetics, Notum, Culture Media, APC, Wnt Proteins, Mice, Inbred C57BL, 030104 developmental biology, Genes, Cell Competition, Culture Media, Conditioned, biology.protein, 1182 Biochemistry, cell and molecular biology
وصف الملف: application/pdf
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2مورد إلكتروني
المصدر: Nature vol.594 (2021) nr.7863 p.430-435 [ISSN 0028-0836]
مصطلحات الفهرس: Adenoma/genetics, Adenomatous Polyposis Coli Protein/genetics, Animals, Cell Competition/genetics, Cell Differentiation, Cell Proliferation, Cell Transformation, Neoplastic/genetics, Colorectal Neoplasms/genetics, Culture Media, Conditioned, Disease Progression, Esterases/antagonists & inhibitors, Female, Genes, APC, Humans, Ligands, Male, Mice, Mice, Inbred C57BL, Mutation, Organoids/cytology, Stem Cells/cytology, Wnt Proteins/metabolism, Wnt Signaling Pathway, Artikel, Article
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3مورد إلكتروني
المصدر: Nature vol.594 (2021) nr.7863 p.430-435 [ISSN 0028-0836]
مصطلحات الفهرس: Adenoma/genetics, Adenomatous Polyposis Coli Protein/genetics, Animals, Cell Competition/genetics, Cell Differentiation, Cell Proliferation, Cell Transformation, Neoplastic/genetics, Colorectal Neoplasms/genetics, Culture Media, Conditioned, Disease Progression, Esterases/antagonists & inhibitors, Female, Genes, APC, Humans, Ligands, Male, Mice, Mice, Inbred C57BL, Mutation, Organoids/cytology, Stem Cells/cytology, Wnt Proteins/metabolism, Wnt Signaling Pathway, Artikel, Article
Find this article in full text from Springer Verlag.