نتائج البحث - "Cerny MA"

المؤلفون: Rodrigues D; Pharmacokinetics & Drug Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA., Niosi M; Pharmacokinetics & Drug Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA., Eng H; Pharmacokinetics & Drug Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA., Healy C; Pharmacokinetics & Drug Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA., Lazzaro S; Pharmacokinetics & Drug Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA., Yang Q; Computational Chemistry, Internal Medicine, Medicine Design, Worldwide Research & Development, Cambridge, Massachusetts, USA., Cerny MA; Pharmacokinetics & Drug Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.

المصدر: Journal of clinical pharmacology [J Clin Pharmacol] 2023 Aug; Vol. 63 (8), pp. 875-879. Date of Electronic Publication: 2023 Apr 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Ethinyl Estradiol*/pharmacology , Contraceptives, Oral, Combined*, Humans ; Female ; Drug Interactions ; Sulfotransferases ; Estradiol

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دورية أكاديمية

Characterization of Bile Acid Sulfate Conjugates as Substrates of Human Organic Anion Transporting Polypeptides.

المؤلفون: Orozco CC; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Neuvonen M; Department of Clinical Pharmacology, University of Helsinki, Helsinki FI-00014, Finland.; Individualized Drug Therapy Research Program, University of Helsinki, Helsinki FI-00014, Finland., Bi YA; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Cerny MA; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Mathialagan S; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Tylaska L; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Rago B; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Costales C; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., King-Ahmad A; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Niemi M; Department of Clinical Pharmacology, University of Helsinki, Helsinki FI-00014, Finland.; Individualized Drug Therapy Research Program, University of Helsinki, Helsinki FI-00014, Finland.; Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki FI-00029, Finland., Rodrigues AD; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

المصدر: Molecular pharmaceutics [Mol Pharm] 2023 Jun 05; Vol. 20 (6), pp. 3020-3032. Date of Electronic Publication: 2023 May 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Organic Anion Transporters*/genetics , Organic Anion Transporters*/metabolism, Humans ; Sulfates ; Solute Carrier Organic Anion Transporter Family Member 1B3/metabolism ; Liver-Specific Organic Anion Transporter 1/genetics ; Liver-Specific Organic Anion Transporter 1/metabolism ; Bile Acids and Salts ; Biological Transport/physiology ; Biomarkers/metabolism ; Organic Anion Transporters, Sodium-Independent/metabolism

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8

دورية أكاديمية

Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance.

المؤلفون: Cerny MA; Pharmacokinetics, Dynamics, and Metabolism, Pfizer, Inc., Groton, Connecticut matthew.cerny@pfizer.com., Spracklin DK; Pharmacokinetics, Dynamics, and Metabolism, Pfizer, Inc., Groton, Connecticut., Obach RS; Pharmacokinetics, Dynamics, and Metabolism, Pfizer, Inc., Groton, Connecticut.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2023 Jun; Vol. 51 (6), pp. 647-656. Date of Electronic Publication: 2023 Mar 27.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Metabolic Clearance Rate*, Animals ; Humans ; Inactivation, Metabolic

9

دورية أكاديمية

High-throughput cytochrome P450 loss and metabolic intermediate complex assays to aid in designing out of CYP3A inactivation.

المؤلفون: Russell DA; Department of Medicinal Chemistry, University of Washington, Seattle, WA, United States., Cerny MA; Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, CT, United States. Electronic address: matthew.cerny@pfizer.com.

المصدر: Methods in enzymology [Methods Enzymol] 2023; Vol. 690, pp. 341-368. Date of Electronic Publication: 2023 Sep 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A*/metabolism , Cytochrome P-450 Enzyme Inhibitors*/pharmacology , Cytochrome P-450 Enzyme Inhibitors*/metabolism, Cytochrome P-450 Enzyme System/metabolism ; Drug Interactions ; Heme/metabolism

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دورية أكاديمية

Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease .

المؤلفون: Weng Y; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., United States., Fonseca KR; PDM, Pfizer Inc, United States., Bi YA; Pfizer Inc., United States., Mathialagan S; Pharmacokinetics, Pharmacodynamics, and Metabolism, Medicine Design, Pfizer Inc, United States., Riccardi K; Pfizer, United States., Tseng E; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, United States., Bessire AJ; Pfizer, United States., Cerny MA; PDM, Pfizer Global Research and Development, United States., Tess DA; Medicine Design, Pfizer Inc., United States., Rodrigues AD; Drug Metabolism and Pharmacokinetics, Pfizer, United States., Kalgutkar AS; Medicine Design, Pfizer Worldwide Research and Development, United States., Litchfield JE; PDM, Pfizer, United States., Di L; Pharmacokintics Dynamics and Metabolism, Pfizer Inc., United States., Varma MVS; Pharmacokinetics Dynamics and Metabolism, Pfizer Inc, United States manthena.v.varma@pfizer.com.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2022 Jul 02. Date of Electronic Publication: 2022 Jul 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

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