نتائج البحث - "Cesar O. Lara"

المساهمون: University of Zurich, Moraga-Cid, Gustavo, Universidad de Concepción - University of Concepcion [Chile], Indiana University School of Medicine, Indiana University System, Universität Zürich [Zürich] = University of Zurich (UZH), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Récepteurs Canaux - Channel Receptors, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], This work was supported by FONDECYT 1160851 and VRID N°219.033.111-INV (to G.M.-C), NIH R01AA025718 (to L.G.A) and by FONDECYT 1170252 (to G.E.Y). V. San Martin and A. Sazo were supported by the Graduate School Fellowship of the U. of Concepcion (MSc in Human Physiology, MSc in Neurobiology and PhD in Biological Sciences). C.O. Lara and A.M. Marileo were supported by CONICYT doctoral fellowships., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.4804. ⟨10.1038/s41598-020-61677-w⟩
Scientific Reports, 10 (1)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, 2020, 10 (1), pp.4804. ⟨10.1038/s41598-020-61677-w⟩

مصطلحات موضوعية: MESH: Signal Transduction, 0301 basic medicine, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Intracellular Space, lcsh:Medicine, 10050 Institute of Pharmacology and Toxicology, Receptors, Glycine, 0302 clinical medicine, Hyperekplexia, Phosphorylation, lcsh:Science, Receptor, Glycine receptor, Multidisciplinary, Chemistry, MESH: Amino Acid Substitution, MESH: Receptors, Glycine, MESH: Intracellular Space, MESH: Protein Domains, medicine.symptom, Intracellular, Signal Transduction, GLIC, Biophysics, 610 Medicine & health, Context (language use), MESH: Cyclic AMP-Dependent Protein Kinases, Article, 03 medical and health sciences, Protein Domains, MESH: Receptors, Prostaglandin E, EP2 Subtype, medicine, Humans, MESH: Excitatory Postsynaptic Potentials, Ion channel, 1000 Multidisciplinary, MESH: Humans, MESH: Phosphorylation, lcsh:R, Excitatory Postsynaptic Potentials, Receptors, Prostaglandin E, EP2 Subtype, Cyclic AMP-Dependent Protein Kinases, 030104 developmental biology, Amino Acid Substitution, MESH: Protein Processing, Post-Translational, 570 Life sciences, biology, lcsh:Q, Protein Processing, Post-Translational, Neuroscience, 030217 neurology & neurosurgery

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf6c5d38aaddaada9261c30c262652d
https://doi.org/10.1038/s41598-020-61677-w

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7

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain

المؤلفون: Monica A. Carrasco, Gonzalo E. Yévenes, Gustavo Moraga-Cid, Cesar O. Lara, Carlos F. Burgos

المصدر: Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cfe6f918d2d0494e4ec99ed0e9d1ff
https://www.frontiersin.org/article/10.3389/fphar.2020.00167/full

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Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors

المؤلفون: Pierre-Jean Corringer, José L. Guzmán, Jorge Fuentealba, Tiare Silva-Grecchi, Carola Muñoz-Montesino, Patricio A. Castro, Gustavo Moraga-Cid, Luis G. Aguayo, Carlos F. Burgos, Cesar O. Lara, Gonzalo E. Yévenes

المساهمون: Universidad de Concepción - University of Concepcion [Chile], Récepteurs Canaux - Channel Receptors, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This work was supported by FONDECYT 1160851 (to G.M.), NIH R01AA025718 (to L.G.A.), FONDECYT 1170252 (to G.E.Y.), FONDECYT 1161078 (to J.F.), FONDECYT 11160562 (to P.A.C.), and FONDECYT 1170853 (to L.G.). C.F.B. was supported by the FONDECYT Postdoctoral 3170108. C.O.L. and T.S.-G. were supported by CONICYT doctoral fellowships. The authors thank L.A., I.C.. and J.G. for their outstanding technical assistance.

المصدر: ACS Chemical Neuroscience
ACS Chemical Neuroscience, 2019, 10 (5), pp.2551-2559. ⟨10.1021/acschemneuro.9b00050⟩

مصطلحات موضوعية: Physiology, Cognitive Neuroscience, intracellular domains, GLIC, Allosteric regulation, Neurotransmission, positive allosteric modulators, Cyanobacteria, Biochemistry, Membrane Potentials, chimera, 03 medical and health sciences, pLGICs, Receptors, Glycine, 0302 clinical medicine, Allosteric Regulation, Humans, [CHIM]Chemical Sciences, Receptor, Glycine receptor, Cells, Cultured, Ion channel, 030304 developmental biology, 0303 health sciences, ligand-gated ion channel, Ethanol, Isoflurane, Chemistry, glycine receptors, Central Nervous System Depressants, Intracellular Membranes, Cell Biology, General Medicine, Hydrogen-Ion Concentration, Ligand-Gated Ion Channels, Transmembrane protein, Cell biology, PAMs, Ligand-gated ion channel, Extracellular Space, 030217 neurology & neurosurgery, glycine receptors GLIC pLGICs ligand-gated ion channel chimera PAMs positive allosteric modulators intracellular domains