المؤلفون: Sardar S; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20817, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, 20817 USA., McNair CM; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA., Ravindranath L; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20817, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, 20817 USA., Chand SN; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA., Yuan W; The Institute of Cancer Research, London, United Kingdom., Bogdan D; The Institute of Cancer Research, London, United Kingdom., Welti J; The Institute of Cancer Research, London, United Kingdom., Sharp A; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital, London, United Kingdom., Ryan NK; South Australian Immunogenomics Cancer Institute, The University of Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Schiewer MJ; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA., DeArment EG; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20817, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, 20817 USA., Janas T; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20817, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, 20817 USA., Su XA; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20817, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, 20817 USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Butler LM; South Australian Immunogenomics Cancer Institute, The University of Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., de Bono JS; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital, London, United Kingdom., Frese K; CellCentric Ltd., Cambridge, United Kingdom., Brooks N; CellCentric Ltd., Cambridge, United Kingdom., Pegg N; CellCentric Ltd., Cambridge, United Kingdom., Knudsen KE; The American Cancer Society, Philadelphia, Pennsylvania, 19103, USA., Shafi AA; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20817, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, 20817 USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 07. Date of Electronic Publication: 2024 May 07.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Mandigo AC; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Yuan W; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, London, United Kingdom., Xu K; The University of Texas Health Science Center at San Antonio, San Antonio, Texas., Gallagher P; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Pang A; School of Medical Sciences and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia., Guan YF; School of Medical Sciences and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia., Shafi AA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Thangavel C; Departments of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Sheehan B; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, London, United Kingdom., Bogdan D; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, London, United Kingdom., Paschalis A; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, London, United Kingdom., McCann JJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Laufer TS; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Gordon N; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Vasilevskaya IA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Dylgjeri E; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Chand SN; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Schiewer MJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Domingo-Domenech J; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Den RB; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Departments of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Holst J; Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania., McCue PA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., de Bono JS; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, London, United Kingdom., McNair C; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Knudsen KE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. karen.knudsen@jefferson.edu.; Departments of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

المصدر: Cancer discovery [Cancer Discov] 2021 Sep; Vol. 11 (9), pp. 2334-2353. Date of Electronic Publication: 2021 Apr 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: E2F1 Transcription Factor/*genetics , Retinal Neoplasms/*genetics , Retinoblastoma/*genetics , Retinoblastoma Protein/*genetics, Animals ; Cell Line, Tumor ; Humans ; Mice ; Neoplasm Metastasis ; Retinal Neoplasms/pathology ; Retinoblastoma/secondary ; Signal Transduction ; Xenograft Model Antitumor Assays

المؤلفون: Welti J; The Institute of Cancer Research, London, United Kingdom., Sharp A; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital, London, United Kingdom., Brooks N; CellCentric Ltd., Cambridge, United Kingdom., Yuan W; The Institute of Cancer Research, London, United Kingdom., McNair C; Thomas Jefferson University, Philadelphia, Pennsylvania., Chand SN; Thomas Jefferson University, Philadelphia, Pennsylvania., Pal A; The Royal Marsden Hospital, London, United Kingdom., Figueiredo I; The Institute of Cancer Research, London, United Kingdom., Riisnaes R; The Institute of Cancer Research, London, United Kingdom., Gurel B; The Institute of Cancer Research, London, United Kingdom., Rekowski J; The Institute of Cancer Research, London, United Kingdom., Bogdan D; The Institute of Cancer Research, London, United Kingdom., West W; CellCentric Ltd., Cambridge, United Kingdom., Young B; Sygnature Discovery Services, Nottingham, United Kingdom., Raja M; Sygnature Discovery Services, Nottingham, United Kingdom., Prosser A; Sygnature Discovery Services, Nottingham, United Kingdom., Lane J; Sygnature Discovery Services, Nottingham, United Kingdom., Thomson S; Sygnature Discovery Services, Nottingham, United Kingdom., Worthington J; Axis Bioservices, Coleraine, Northern Ireland., Onions S; Sygnature Discovery Services, Nottingham, United Kingdom., Shannon J; Sygnature Discovery Services, Nottingham, United Kingdom., Paoletta S; Sygnature Discovery Services, Nottingham, United Kingdom., Brown R; Sygnature Discovery Services, Nottingham, United Kingdom., Smyth D; Sygnature Discovery Services, Nottingham, United Kingdom., Harbottle GW; Sygnature Discovery Services, Nottingham, United Kingdom., Gil VS; The Institute of Cancer Research, London, United Kingdom., Miranda S; The Institute of Cancer Research, London, United Kingdom., Crespo M; The Institute of Cancer Research, London, United Kingdom., Ferreira A; The Institute of Cancer Research, London, United Kingdom., Pereira R; The Institute of Cancer Research, London, United Kingdom., Tunariu N; The Royal Marsden Hospital, London, United Kingdom., Carreira S; The Institute of Cancer Research, London, United Kingdom., Neeb AJ; The Institute of Cancer Research, London, United Kingdom., Ning J; The Institute of Cancer Research, London, United Kingdom., Swain A; The Institute of Cancer Research, London, United Kingdom., Taddei D; Sygnature Discovery Services, Nottingham, United Kingdom., Schiewer MJ; Thomas Jefferson University, Philadelphia, Pennsylvania., Knudsen KE; Thomas Jefferson University, Philadelphia, Pennsylvania., Pegg N; CellCentric Ltd., Cambridge, United Kingdom., de Bono JS; The Institute of Cancer Research, London, United Kingdom. johann.de-bono@icr.ac.uk.; The Royal Marsden Hospital, London, United Kingdom.

مؤلفون مشاركون: SU2C/PCF International Prostate Cancer Dream Team

المصدر: Cancer discovery [Cancer Discov] 2021 May; Vol. 11 (5), pp. 1118-1137. Date of Electronic Publication: 2021 Jan 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Androgen Receptor Antagonists/*therapeutic use , Imidazoles/*therapeutic use , Oxazoles/*therapeutic use , Prostatic Neoplasms, Castration-Resistant/*drug therapy , p300-CBP Transcription Factors/*antagonists & inhibitors, Androgen Receptor Antagonists/pharmacology ; Animals ; Cell Line, Tumor/drug effects ; Cell Proliferation/drug effects ; Humans ; Imidazoles/pharmacology ; Male ; Mice ; Oxazoles/pharmacology ; Xenograft Model Antitumor Assays

المؤلفون: Shafi AA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., McNair CM; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA., McCann JJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Duke University, Durham, NC, 27708, USA., Alshalalfa M; Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA, 94115, USA., Shostak A; Biochemistry Center, University of Heidelberg, Heidelberg, Germany., Severson TM; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Zhu Y; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Bergman A; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Gordon N; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Mandigo AC; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Chand SN; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Gallagher P; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Dylgjeri E; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Laufer TS; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Vasilevskaya IA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Schiewer MJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Department of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA., Brunner M; Biochemistry Center, University of Heidelberg, Heidelberg, Germany., Feng FY; Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA, 94115, USA., Zwart W; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Knudsen KE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA. karen.knudsen@jefferson.edu.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA. karen.knudsen@jefferson.edu.; Department of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA. karen.knudsen@jefferson.edu.

المصدر: Nature communications [Nat Commun] 2021 Jan 15; Vol. 12 (1), pp. 401. Date of Electronic Publication: 2021 Jan 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, Carcinogenesis/*genetics , Cryptochromes/*metabolism , Prostatic Neoplasms, Castration-Resistant/*genetics , Recombinational DNA Repair/*genetics, Aged ; Androgen Receptor Antagonists/pharmacology ; Androgen Receptor Antagonists/therapeutic use ; Androgens/metabolism ; Carcinogenesis/drug effects ; Cell Line, Tumor ; Chromatin Immunoprecipitation Sequencing ; Cryptochromes/genetics ; DNA Breaks, Double-Stranded/drug effects ; Datasets as Topic ; Disease Progression ; Follow-Up Studies ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Promoter Regions, Genetic/genetics ; Prospective Studies ; Prostate/pathology ; Prostate/surgery ; Prostatectomy ; Prostatic Neoplasms, Castration-Resistant/mortality ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/therapy ; RNA-Seq ; Receptors, Androgen/metabolism ; Recombinational DNA Repair/drug effects ; Retrospective Studies

المؤلفون: Dylgjeri E; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., McNair C; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Goodwin JF; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Raymon HK; Celgene Corporation, San Francisco, California., McCue PA; Department of Urology, Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, Pennsylvania., Shafi AA; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Leiby BE; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania.; Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania., de Leeuw R; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Kothari V; Department of Urology, Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, Pennsylvania., McCann JJ; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Mandigo AC; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Chand SN; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Schiewer MJ; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Brand LJ; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Vasilevskaya I; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Gordon N; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Laufer TS; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania., Gomella LG; Department of Urology, Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, Pennsylvania., Lallas CD; Department of Urology, Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, Pennsylvania., Trabulsi EJ; Department of Urology, Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, Pennsylvania., Feng FY; Department of Radiation Oncology, University of California, San Francisco, San Francisco, California.; Department of Urology, University of California, San Francisco, San Francisco, California.; Department of Medicine, University of California, San Francisco, San Francisco, California., Filvaroff EH; Celgene Corporation, San Francisco, California., Hege K; Celgene Corporation, San Francisco, California., Rathkopf D; Memorial Sloan Kettering Cancer Center, New York, New York., Knudsen KE; Department of Cancer Biology at Thomas Jefferson University, Philadelphia, Pennsylvania. karen.knudsen@jefferson.edu.; Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania.; Department of Urology, Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, Pennsylvania.; Departments of Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Sep 15; Vol. 25 (18), pp. 5623-5637. Date of Electronic Publication: 2019 Jul 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: DNA-Activated Protein Kinase/*metabolism , Neoplasms/*metabolism, Androgen Receptor Antagonists/pharmacology ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA-Activated Protein Kinase/antagonists & inhibitors ; DNA-Activated Protein Kinase/genetics ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Receptors, Androgen/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Transcription, Genetic ; Xenograft Model Antitumor Assays

المؤلفون: Jain A; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Agostini LC; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., McCarthy GA; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Chand SN; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Ramirez A; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Nevler A; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Cozzitorto J; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Schultz CW; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Lowder CY; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Smith KM; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom., Waddell ID; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom., Raitses-Gurevich M; Oncology Institute, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel., Stossel C; Oncology Institute, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Gorman YG; Oncology Institute, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel., Atias D; Oncology Institute, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel., Yeo CJ; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Winter JM; Surgical Oncology, University Hospitals Cleveland Medical Center, Cleveland, Ohio., Olive KP; Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Golan T; Oncology Institute, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Pishvaian MJ; Department of Gastrointestinal Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas., Ogilvie D; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom., James DI; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom., Jordan AM; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom., Brody JR; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania. jonathan.brody@jefferson.edu.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

المصدر: Cancer research [Cancer Res] 2019 Sep 01; Vol. 79 (17), pp. 4491-4502. Date of Electronic Publication: 2019 Jul 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal/*drug therapy , Glycoside Hydrolases/*antagonists & inhibitors , Pancreatic Neoplasms/*drug therapy, Animals ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; DNA Damage ; Enzyme Inhibitors/pharmacology ; Female ; Gene Silencing ; Glycoside Hydrolases/genetics ; Humans ; Mice, Nude ; Molecular Targeted Therapy ; Oxaliplatin/pharmacology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Recombinational DNA Repair ; Small Molecule Libraries/pharmacology ; Xenograft Model Antitumor Assays

المؤلفون: Pan H; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China., Strickland A; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Madhu V; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Johnson ZI; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Chand SN; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Brody JR; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Fertala A; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Zheng Z; Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China., Shapiro IM; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Risbud MV; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: makarand.risbud@jefferson.edu.

المصدر: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2019 Apr; Vol. 77, pp. 23-40. Date of Electronic Publication: 2018 Aug 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9432592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-1802 (Electronic) Linking ISSN: 0945053X NLM ISO Abbreviation: Matrix Biol

مواضيع طبية MeSH: Gene Expression Regulation*, ELAV-Like Protein 1/*genetics , Extracellular Matrix/*genetics , Hypoxia-Inducible Factor 1, alpha Subunit/*genetics , Nucleus Pulposus/*metabolism, Aggrecans/genetics ; Aggrecans/metabolism ; Animals ; Cell Hypoxia ; Collagen Type I/genetics ; Collagen Type I/metabolism ; ELAV-Like Protein 1/antagonists & inhibitors ; ELAV-Like Protein 1/metabolism ; Extracellular Matrix/chemistry ; Extracellular Matrix/metabolism ; HEK293 Cells ; Homeostasis/genetics ; Humans ; Hydrogen-Ion Concentration ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Matrix Metalloproteinase 13/genetics ; Matrix Metalloproteinase 13/metabolism ; Nucleus Pulposus/cytology ; Oxygen Consumption/genetics ; Primary Cell Culture ; Protein Binding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Rats ; Sequence Analysis, RNA ; Signal Transduction ; Syndecan-4/genetics ; Syndecan-4/metabolism ; Transforming Growth Factor beta3/genetics ; Transforming Growth Factor beta3/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism

المؤلفون: Schiewer MJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA karen.knudsen@jefferson.edu.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Mandigo AC; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Gordon N; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Huang F; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gaur S; Cedars-Sinai Medical Center, Los Angeles, CA, USA., de Leeuw R; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Zhao SG; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Evans J; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Han S; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Parsons T; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA., Birbe R; Cooper University Health, Camden, NJ, USA., McCue P; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA., McNair C; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Chand SN; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Cendon-Florez Y; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Gallagher P; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., McCann JJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Poudel Neupane N; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Shafi AA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Dylgjeri E; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Brand LJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA., Visakorpi T; University of Tampere, Tampere, Finland., Raj GV; UT Southwestern, Dallas, TX, USA., Lallas CD; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA., Trabulsi EJ; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA., Gomella LG; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA., Dicker AP; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA., Kelly WK; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA., Leiby BE; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA., Knudsen B; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Feng FY; Departments of Radiation Oncology, Urology, and Medicine, University of California, San Francisco, San Francisco, CA, USA., Knudsen KE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.; Sidney Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.; Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA.; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.

المصدر: EMBO molecular medicine [EMBO Mol Med] 2018 Dec; Vol. 10 (12).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: EMBO Press Country of Publication: England NLM ID: 101487380 Publication Model: Print Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE

مواضيع طبية MeSH: DNA Repair*, E2F1 Transcription Factor/*metabolism , Poly (ADP-Ribose) Polymerase-1/*metabolism , Prostatic Neoplasms/*pathology, Animals ; Cell Line ; Disease Progression ; Gene Expression Profiling ; Homologous Recombination ; Humans ; Immunohistochemistry ; Male ; Mice, Inbred BALB C ; Tissue Array Analysis

المؤلفون: Chand SN; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Zarei M; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Schiewer MJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Kamath AR; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Romeo C; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Lal S; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Cozzitorto JA; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Nevler A; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Scolaro L; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Londin E; Computational Medicine Center, Thomas Jefferson University, Philadelphia, Pennsylvania.; Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania., Jiang W; Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania., Meisner-Kober N; Novartis Institute for Biomedical Research, Basel, Switzerland., Pishvaian MJ; Division of Hematology and Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC., Knudsen KE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Yeo CJ; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, Canada., Winter JM; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Brody JR; Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania. jonathan.brody@jefferson.edu.

المصدر: Cancer research [Cancer Res] 2017 Sep 15; Vol. 77 (18), pp. 5011-5025. Date of Electronic Publication: 2017 Jul 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: RNA Processing, Post-Transcriptional*, DNA Repair/*genetics , Drug Resistance, Neoplasm/*genetics , ELAV-Like Protein 1/*metabolism , Glycoside Hydrolases/*genetics , Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology , Poly(ADP-ribose) Polymerases/*chemistry , RNA, Messenger/*genetics, Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Nucleus/drug effects ; Cell Nucleus/genetics ; Cell Proliferation ; DNA Damage/drug effects ; DNA Damage/genetics ; DNA Repair/drug effects ; ELAV-Like Protein 1/antagonists & inhibitors ; ELAV-Like Protein 1/genetics ; Female ; Humans ; Mice ; Mice, Nude ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Tumor Cells, Cultured ; Up-Regulation ; Xenograft Model Antitumor Assays ; Pancreatic Neoplasms

المؤلفون: Zarei M; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Lal S; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Parker SJ; Department of Bioengineering, University of California, San Diego, La Jolla, California., Nevler A; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Vaziri-Gohar A; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Dukleska K; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Mambelli-Lisboa NC; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Moffat C; MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania., Blanco FF; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Chand SN; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Jimbo M; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Cozzitorto JA; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Jiang W; Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania., Yeo CJ; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Londin ER; Computational Medicine Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Seifert EL; MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania., Metallo CM; Moores Cancer Center, University of California, San Diego, La Jolla, California., Brody JR; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Winter JM; Department of Surgery, Division of Surgical Research, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania. jordan.winter@jefferson.edu.

المصدر: Cancer research [Cancer Res] 2017 Aug 15; Vol. 77 (16), pp. 4460-4471. Date of Electronic Publication: 2017 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: ELAV-Like Protein 1/*metabolism , Isocitrate Dehydrogenase/*metabolism , Pancreatic Neoplasms/*metabolism, Animals ; Cell Line, Tumor ; Cell Proliferation/physiology ; Cohort Studies ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Drug Resistance, Neoplasm ; ELAV-Like Protein 1/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Mice ; Mice, Nude ; Organoplatinum Compounds/pharmacology ; Oxaliplatin ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Phenotype ; Protein Processing, Post-Translational ; Survival Analysis ; Transcriptional Activation ; Transfection ; Up-Regulation ; Gemcitabine