المؤلفون: Giuliani V; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. VGiuliani@mdanderson.org., Miller MA; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu CY; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hartono SR; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Class CA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Pharmaceutical Sciences, Butler University, Indianapolis, IN, USA., Bristow CA; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Suzuki E; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sanz LA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Gao G; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gay JP; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rose JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tomihara H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, Kindai University Nara Hospital, Nara, JP, USA., Daniele JR; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Peoples MD; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bardenhagen JP; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Geck Do MK; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang QE; ORBIT, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vangamudi B; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Exo Therapeutics, Cambridge, MA, USA., Vellano C; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ying H; Department of Cellular and Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Deem AK; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Do KA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Marszalek JR; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kovacs JJ; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kim M; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fleming JB; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Division of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA., Guccione E; Department of Oncological Sciences and Pharmacological Sciences at Icahn School of Medicine at Mount Sinai, New York, NY, USA., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maitra A; Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Emilia Di Francesco M; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yap TA; Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Jones P; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Draetta G; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Carugo A; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chedin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Heffernan TP; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. TPHeffernan@mdanderson.org.

المصدر: Nature communications [Nat Commun] 2021 Jul 30; Vol. 12 (1), pp. 4626. Date of Electronic Publication: 2021 Jul 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: DNA Damage*, Carcinoma, Pancreatic Ductal/*genetics , Pancreatic Neoplasms/*genetics , Protein-Arginine N-Methyltransferases/*genetics , RNA/*genetics , Repressor Proteins/*genetics, Animals ; Biocatalysis/drug effects ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/prevention & control ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/prevention & control ; Protein-Arginine N-Methyltransferases/metabolism ; RNA/metabolism ; RNA Interference ; Repressor Proteins/metabolism ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays/methods ; Mice

المؤلفون: Lee MS; Division of Hematology and Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Helms TL; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gay J; Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang QE; Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tian F; Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wu JY; Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Toniatti C; Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Co-Clinical Trials, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heffernan TP; Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Co-Clinical Trials, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Powis G; Sanford-Burnham Medical Research Institute, La Jolla, CA, USA., Kwong LN; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kopetz S; Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

المصدر: Oncotarget [Oncotarget] 2016 Jun 28; Vol. 7 (26), pp. 39595-39608.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Colorectal Neoplasms/*drug therapy , Cyclin-Dependent Kinase 4/*antagonists & inhibitors , Cyclin-Dependent Kinase 6/*antagonists & inhibitors , MAP Kinase Kinase Kinase 1/*antagonists & inhibitors, Animals ; Cell Line, Tumor ; Cell Proliferation ; Clinical Trials as Topic ; Colorectal Neoplasms/genetics ; Disease Models, Animal ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Genes, ras ; Humans ; Mice ; Mice, Nude ; Mutation ; Neoplasm Transplantation ; Phosphorylation ; Piperazines/pharmacology ; Pyridines/pharmacology ; Treatment Outcome

المؤلفون: Lissanu Deribe Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; ylissanu@mdanderson.org lchin@mdanderson.org., Shi Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborate Center for Cancer Medicine, Guangzhou 510060, China;, Rai K; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Nezi L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Amin SB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Wu CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Akdemir KC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Mahdavi M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Peng Q; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Chang QE; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, TX 77030;, Hornigold K; The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom;, Arold ST; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900 Saudi Arabia;, Welch HC; The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom;, Garraway LA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215; Broad Institute of MIT and Harvard, Boston, MA 02141., Chin L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, TX 77030; ylissanu@mdanderson.org lchin@mdanderson.org.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Mar 01; Vol. 113 (9), pp. E1296-305. Date of Electronic Publication: 2016 Feb 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Guanine Nucleotide Exchange Factors/*metabolism , Melanoma, Experimental/*metabolism, Animals ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Melanoma, Experimental/genetics ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction

المؤلفون: Tsang YH; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Dogruluk T; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Tedeschi PM; Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, USA., Wardwell-Ozgo J; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Lu H; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Espitia M; Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Nair N; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Minelli R; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Chong Z; Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Chen F; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Chang QE; Department of Genomics Medicine, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Dennison JB; Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Dogruluk A; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Li M; Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA., Ying H; Department of Genomics Medicine, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Bertino JR; Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, USA., Gingras MC; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Ittmann M; Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Kerrigan J; Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, USA., Chen K; Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Creighton CJ; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.; Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA., Eterovic K; Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Mills GB; Department of Systems Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Scott KL; Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

المصدر: Nature communications [Nat Commun] 2016 Jan 25; Vol. 7, pp. 10500. Date of Electronic Publication: 2016 Jan 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms/*genetics , Phosphotransferases (Alcohol Group Acceptor)/*genetics, Animals ; Carcinogenesis ; Cell Line, Tumor ; Female ; Humans ; Mice ; Mice, Nude ; Mutation ; Pancreatic Neoplasms/enzymology ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Reactive Oxygen Species/metabolism ; Pancreatic Neoplasms