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المؤلفون: Yvonne J. Vos, Wilhelmina S. Kerstjens-Frederikse, Ludolf G. Boven, Albert J. H. Suurmeijer, Maarten P. van den Berg, Jop H. van Berlo, Stefan J. White, Johan T. den Dunnen, Gerard J. te Meerman, Jan Osinga, Dirk J. van Veldhuisen, Annemarie H. van der Hout, Robert M.W. Hofstra, René A. Tio, Yigal M. Pinto, J. Peter van Tintelen, Charles H.C.M. Buys
المساهمون: Other departments, Cardiology, Cardiovascular Centre (CVC)
المصدر: Journal of the American College of Cardiology, 49(25), 2430-2439. Elsevier USA
Journal of the American College of Cardiology, 49(25), 2430-2439. ELSEVIER SCIENCE INCمصطلحات موضوعية: Adult, Male, MISSENSE MUTATIONS, PROTEINS, CONDUCTION-SYSTEM DISEASE, LMNA, FAMILIAL DILATED CARDIOMYOPATHY, medicine.disease_cause, Risk Assessment, Severity of Illness Index, DREIFUSS MUSCULAR-DYSTROPHY, Electrocardiography, HUTCHINSON-GILFORD PROGERIA, Age Distribution, DOMAIN, Medicine, Missense mutation, Humans, Genetic Predisposition to Disease, Sex Distribution, Gene, Regulation of gene expression, Genetics, Mutation, IDENTIFICATION, business.industry, Incidence, Biopsy, Needle, Middle Aged, Endomyocardial Fibrosis, Lamin Type A, Prognosis, Molecular biology, Immunohistochemistry, Pedigree, Survival Rate, Blotting, Southern, Gene Expression Regulation, PARTIAL LIPODYSTROPHY, Myocardial fibrosis, Female, business, Cardiology and Cardiovascular Medicine, Lamin, Gene Deletion
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المؤلفون: Inge Davelaar, Anneke Y. van der Veen, Arja ter Elst, Wytske Kamminga, Klaas Kok, Bea E. Hiemstra, Charles H.C.M. Buys, Peter Terpstra, Gerard J. te Meerman, Frans Gerbens, Pieter van der Vlies
المساهمون: Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: GENES CHROMOSOMES & CANCER, 45(12), 1077-1093. Wiley
مصطلحات موضوعية: Male, Cancer Research, Lung Neoplasms, endocrine system diseases, Transplantation, Heterologous, education, Cell, INSTABILITY, Gene Expression, Mice, Nude, Biology, Transfection, Mice, Cell Line, Tumor, Chromosomal Instability, health services administration, Chromosome instability, NASOPHARYNGEAL CARCINOMA, Genetics, medicine, Animals, Humans, Genes, Tumor Suppressor, Carcinoma, Small Cell, Gene, IN-VIVO, Mice, Inbred BALB C, CELL-LINE, IDENTIFICATION, Chromosomes, Artificial, P1 Bacteriophage, Cell growth, food and beverages, Cancer, Promoter, RASSF1A, medicine.disease, Molecular biology, CANCER, GENE, humanities, medicine.anatomical_structure, Regulatory sequence, Chromosomal region, Female, Chromosomes, Human, Pair 3, HUMAN-CHROMOSOME 3P21.3, HOMOZYGOUS DELETION REGION, Neoplasm Transplantation
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المؤلفون: Arend Karrenbeld, Mjw Berends, Ying Wu, Rolf H. Sijmons, Jan H. Kleibeuker, de Hermien Walle, M.J.L. Ligtenberg, Charles H.C.M. Buys, van der Aukje Zee, Robert M.W. Hofstra, de Elisabeth G. E. Vries, Harmen Hollema, Renee C. Niessen
المساهمون: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Targeted Gynaecologic Oncology (TARGON), Reproductive Origins of Adult Health and Disease (ROAHD)
المصدر: Gut, 55, 1781-8
Gut, 55(12), 1781-1788. BMJ PUBLISHING GROUP
Gut, 55, 12, pp. 1781-8مصطلحات موضوعية: Oncology, Male, Pathology, Base Pair Mismatch, MICROSATELLITE INSTABILITY, DNA Mutational Analysis, Gene mutation, DNA Mismatch Repair, Neoplasms, Multiple Primary, GENOMIC DELETIONS, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], Cancer, REVISED BETHESDA GUIDELINES, Gastroenterology, Nuclear Proteins, CLINICAL-CRITERIA, DNA, Neoplasm, GERMLINE MUTATIONS, Middle Aged, CARRIERS, Lynch syndrome, Neoplasm Proteins, DNA-Binding Proteins, MutS Homolog 2 Protein, Growth and differentiation [NCMLS 3], Female, Colorectal Neoplasms, MutL Protein Homolog 1, Adult, medicine.medical_specialty, Heterozygote, congenital, hereditary, and neonatal diseases and abnormalities, Adolescent, Biology, MLH1, LYNCH-SYNDROME, Genomic disorders and inherited multi-system disorders [IGMD 3], Germline mutation, Translational research [ONCOL 3], Predictive Value of Tests, Internal medicine, medicine, HMSH2 GENE, Humans, IMMUNOHISTOCHEMISTRY, neoplasms, Germ-Line Mutation, Adaptor Proteins, Signal Transducing, Aged, Family Health, Hereditary cancer and cancer-related syndromes [ONCOL 1], Microsatellite instability, nutritional and metabolic diseases, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, digestive system diseases, MSH2, MSH6, Carrier Proteins
وصف الملف: application/pdf
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المؤلفون: Gerard J. te Meerman, Katelijne Bouman, Bauke de Jong, Charles H.C.M. Buys, Birgit Sikkema-Raddatz, R.F. Suijkerbuijk
المصدر: Prenatal Diagnosis, 26(9), 791-800. Wiley-Blackwell
مصطلحات موضوعية: Quality Control, Pathology, medicine.medical_specialty, Amniotic fluid, CHROMOSOME, Cell Culture Techniques, Chorionic villus sampling, Prenatal diagnosis, Specimen Handling, Andrology, Pregnancy, medicine, slide preparation, Humans, Prospective Studies, Prospective cohort study, Genetics (clinical), Fixative, Retrospective Studies, Analysis of Variance, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, chorionic villi, Amniotic Fluid, MIDTRIMESTER AMNIOCENTESIS, medicine.anatomical_structure, Chorionic Villi Sampling, Amniocentesis, EXPERIENCE, GROWTH, Regression Analysis, Gestation, Chorionic villi, primary in situ cultures, Female, business
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المؤلفون: Jantine L. Westra, Karin A. Oien, R. M. W. Hofstra, W N Keith, Harry Hollema, Michael Schaapveld, J.Th.M. Plukker, R. Mauritz, G.J. Peters, Inge Platteel, Charles H.C.M. Buys
المساهمون: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Targeted Gynaecologic Oncology (TARGON), VU University medical center
المصدر: Westra, J L, Hollema, H, Schaapveld, M, Platteel, I, Oien, K A, Keith, W N, Mauritz, R, Peters, G J, Buys, C H, Hofstra, R M & Plukker, JT 2005, ' Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients ', Annals of Oncology, vol. 16, no. 10, pp. 1646-1653 . https://doi.org/10.1093/annonc/mdi316
Annals of Oncology, 16(10), 1646-1653. Oxford University Pressمصطلحات موضوعية: Male, THYMIDINE PHOSPHORYLASE, MONOCLONAL-ANTIBODY, Colorectal cancer, DNA Mutational Analysis, Thymidylate synthase, Antineoplastic Combined Chemotherapy Protocols, Medicine, TP53, MESSENGER-RNA EXPRESSION, Age of Onset, ADVANCED COLORECTAL-CANCER, IN-VIVO, GENE-EXPRESSION, Tissue microarray, biology, Hematology, Middle Aged, Immunohistochemistry, colon cancer, Oncology, Biochemistry, Chemotherapy, Adjuvant, Fluorouracil, Colonic Neoplasms, 5-FLUOROURACIL, Female, medicine.drug, medicine.drug_class, CELL-LINES, thymidylate synthase, Antimetabolite, FLUOROPYRIMIDINE-BASED CHEMOTHERAPY, Predictive Value of Tests, Biomarkers, Tumor, Dihydropyrimidine dehydrogenase, Humans, Thymidine phosphorylase, Dihydrouracil Dehydrogenase (NADP), Survival analysis, business.industry, dihydropyrimidine dehydrogenase, CLINICAL-RESPONSE, Genes, p53, medicine.disease, Survival Analysis, prediction 5-fluorouracil regimen, biology.protein, Cancer research, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836e97f8c173040fd965a2cd2bece6dd
https://doi.org/10.1093/annonc/mdi316 -
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المؤلفون: Nanno Mulder, Harry Hollema, Jantine L. Westra, John T. M. Plukker, Arja ter Elst, Marian M.J. Kraak, Michael Schaapveld, Robert M.W. Hofstra, Jelle P. de Boer, Debora de Jong, Charles H.C.M. Buys
المساهمون: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Targeted Gynaecologic Oncology (TARGON)
المصدر: Journal of Clinical Oncology, 23(24), 5635-5643. AMER SOC CLINICAL ONCOLOGY
مصطلحات موضوعية: Oncology, Male, Cancer Research, Pathology, Multivariate analysis, Colorectal cancer, DNA Mutational Analysis, Gene mutation, medicine.disease_cause, PROGNOSTIC-SIGNIFICANCE, Univariate analysis, TUMOR SITE, Middle Aged, Prognosis, Treatment Outcome, Chemotherapy, Adjuvant, Colonic Neoplasms, YOUNG-PATIENTS, DNA-REPLICATION ERRORS, Female, KRAS, Fluorouracil, K-RAS, medicine.medical_specialty, Antimetabolites, Antineoplastic, SPORADIC COLORECTAL-CANCER, Disease-Free Survival, Internal medicine, GENE MUTATION, medicine, Humans, neoplasms, Survival analysis, Neoplasm Staging, Proportional Hazards Models, Analysis of Variance, Chi-Square Distribution, RECTAL-CANCER, business.industry, Proportional hazards model, P53 POINT MUTATION, Microsatellite instability, medicine.disease, Genes, p53, Survival Analysis, digestive system diseases, Genes, ras, business, Microsatellite Repeats, GENOMIC INSTABILITY
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea8a0138dba8a0a83f1deb07ed1808f
https://hdl.handle.net/11370/1d46ad25-35db-4b4a-ae92-aa672eec0f3c -
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المؤلفون: Hendrika Faber, Harry Hollema, Charles H.C.M. Buys, Ludolf G. Boven, Trijnie Dijkhuizen, John T. M. Plukker, Jantine L. Westra, Birgit Sikkema, Michael Schaapveld, Klaas Kok, Pieter van der Vlies, Robert M.W. Hofstra
المساهمون: Targeted Gynaecologic Oncology (TARGON), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: GENES CHROMOSOMES & CANCER, 43(2), 194-201. Wiley
مصطلحات موضوعية: Cancer Research, Chromosomes, Artificial, Bacterial, Biology, medicine.disease_cause, SPORADIC COLORECTAL-CANCER, chemistry.chemical_compound, Chromosome instability, Gene duplication, PROGNOSTIC-SIGNIFICANCE, Genetics, medicine, Humans, COMPARATIVE GENOMIC HYBRIDIZATION, DNA-PLOIDY, GENE AMPLIFICATION, neoplasms, Microsatellite instability, Chromosome, WILD-TYPE P53, medicine.disease, Genes, p53, Molecular biology, chemistry, CARCINOMAS, Colonic Neoplasms, Mutation, CELLS, SURVIVAL, Microsatellite, KRAS, K-RAS, DNA, Comparative genomic hybridization, Microsatellite Repeats
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المصدر: Clinical Colorectal Cancer. 4:252-259
مصطلحات موضوعية: Genome instability, Colorectal cancer, Aneuploidy, Biology, Bioinformatics, Familial adenomatous polyposis, Chromosomal Instability, Chromosome instability, Biomarkers, Tumor, medicine, Humans, neoplasms, Patient Selection, Gastroenterology, Microsatellite instability, Prognosis, medicine.disease, Phenotype, digestive system diseases, Adenomatous Polyposis Coli, Oncology, Chemotherapy, Adjuvant, Colonic Neoplasms, Mutation, Cancer research, DNA mismatch repair, Microsatellite Repeats
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المؤلفون: Pia A. M. de Koning-Gans, Inge M. Mulder, Marian Kraak, Annemarie H. van der Hout, Charles H.C.M. Buys, Robert M.W. Hofstra, Rolf H. A. M. Vossen, Ieke B. Ginjaar, Egbert Bakker, Gert-Jan B. van Ommen, Anthonie J. van Essen, Johan T. den Dunnen
المصدر: Human Mutation, 23(1), 57-66. Wiley
مصطلحات موضوعية: musculoskeletal diseases, Duchenne muscular dystrophy, Heterozygote, congenital, hereditary, and neonatal diseases and abnormalities, mutation scanning, DNA Mutational Analysis, Nonsense mutation, Gene mutation, POINT MUTATIONS, Polymerase Chain Reaction, dystrophin, PROTEIN TRUNCATION TEST, Glycoprotein complex, BMD, GRADIENT GEL-ELECTROPHORESIS, Obligate carrier, DMD, Genetics, medicine, Humans, Point Mutation, NONSENSE MUTATION, DGGE, Genetics (clinical), Polymorphism, Genetic, MESSENGER-RNA DECAY, biology, TRANSLATION-TERMINATING MUTATIONS, Point mutation, Reproducibility of Results, Amplicon, medicine.disease, Molecular biology, Muscular Dystrophy, Duchenne, DELETIONS, Becker muscular dystrophy, DMD-GENE, biology.protein, TEST PTT, Electrophoresis, Polyacrylamide Gel, Dystrophin, GLYCOPROTEIN COMPLEX
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المؤلفون: Marian J.E. Mourits, Tineke van der Sluis, Rolf H. Sijmons, Neeltje Arts, Ying Wu, Harry Hollema, Wietske Boersmavan Ek, Charles H.C.M. Buys, Marjolijn J. L. Ligtenberg, Maran J.W. Berends, Klaske A. ten Hoor, Ate G.J. van der Zee, Elisabeth G.E. de Vries, Jan H. Kleibeuker, Robert M.W. Hofstra
المساهمون: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Targeted Gynaecologic Oncology (TARGON)
المصدر: Journal of Clinical Oncology, 21, 4364-70
Journal of Clinical Oncology, 21(23), 4364-4370. AMER SOC CLINICAL ONCOLOGY
Journal of Clinical Oncology, 21, 23, pp. 4364-70مصطلحات موضوعية: Male, Oncology, Cancer Research, Pathology, DNA Repair, PROTEIN EXPRESSION, Base Pair Mismatch, MICROSATELLITE INSTABILITY, DNA Mutational Analysis, MSH6 GERMLINE MUTATIONS, HEREDITARY, Immunoenzyme Techniques, Medicine, Age of Onset, Family history, GENOMIC DELETIONS, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], MLH1, Nuclear Proteins, NONPOLYPOSIS COLORECTAL-CANCER, DNA, Neoplasm, Middle Aged, TUMORS, Neoplasm Proteins, DNA-Binding Proteins, MutS Homolog 2 Protein, CARCINOMAS, Female, DNA mismatch repair, MutL Protein Homolog 1, Adult, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Germline mutation, Proto-Oncogene Proteins, Internal medicine, Humans, Genetic Predisposition to Disease, Germ-Line Mutation, Adaptor Proteins, Signal Transducing, business.industry, Patient Selection, Endometrial cancer, Microsatellite instability, nutritional and metabolic diseases, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, Carcinoma, Papillary, digestive system diseases, Cystadenocarcinoma, Serous, Endometrial Neoplasms, Tumor microenvironment [UMCN 1.3], MSH6, Genetic defects of metabolism [UMCN 5.1], MSH2, PROMOTER HYPERMETHYLATION, Carrier Proteins, business, Microsatellite Repeats
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3803a2b5fef27c853589ad562f07604a
https://doi.org/10.1200/JCO.2003.04.094
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