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1دورية أكاديمية
المؤلفون: JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield
المصدر: eLife, Vol 11 (2022)
مصطلحات موضوعية: epilepsy, SCN8A, NBI-921352, anti-seizure medicine, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb, Charles J. Cohen
مصطلحات موضوعية: Pharmacology, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a8fd089f5e95fb80b88ed63e8dd321
https://doi.org/10.1101/2022.09.01.506269 -
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المؤلفون: Sultan Chowdhury, Christoph Martin Dehnhardt, Tao Sheng, Clint Young, Rainbow Kwan, Michael Scott Wilson, Jun Chen, Matthew Waldbrook, Dinah Misner, C. Lee Robinette, Rebecca M. Reese, Elaine Chang, Henry Verschoof, Tanja S. Zabka, Girish Bankar, Philippe Bergeron, Luis Sojo, Karen Nelkenbrecher, Daniel P. Sutherlin, Amy Kim, Ivan William Hemeon, Andrea Lindgren, Jae H. Chang, Alla Yurevna Zenova, Shaoyi Sun, Jonathan Maher, Shannon D. Shields, Jun Li, Daniel F. Ortwine, David H. Hackos, Zhiwei Xie, Thilo Focken, Charles J. Cohen, Richard T. Dean, Shannon Decker, Janette Mezeyova, Kuldip Khakh, Antonio G. DiPasquale, Chien-An Chen, Andrew D. White, Brian Safina, Jodie Pang, Qi Jia, Sophia Lin, Jean-Christophe Andrez, J. P. Johnson, Steven J. McKerrall
المصدر: Journal of Medicinal Chemistry. 64:2953-2966
مصطلحات موضوعية: 0303 health sciences, Chemistry, Sulfonamide (medicine), Phase 1 trials, Pharmacology, Metabolic stability, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, NAV1, medicine, Molecular Medicine, Dosing, 030304 developmental biology, medicine.drug
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المؤلفون: Sultan Chowdhury, David Bogucki, Rostam Namdari, Girish Bankar, Wei Zhang, James Roy Empfield, Matthew Waldbrook, Stephanie M Lee, Lofstrand Verner Alexander, Karen Nelkenbrecher, Samuel J. Goodchild, Rhena Yoo, Noah G. Shuart, Wesolowski Steven Sigmund, Elaine Chang, Mandy Feng, Clint Young, Christoph Martin Dehnhardt, Jenny Li, Zhiwei Xie, Michael Edward Grimwood, Abid Hasan, Sophia Lin, Kristen Burford, Raymond J. Winquist, Charles J. Cohen, Alla Yurevna Zenova, Simon N. Pimstone, Michael R. Wilson, Parisa Karimi Tari, Kuldip Khakh, Celine Dube, Aaron M. Williams, Robin Sherrington, Luis Sojo, Andrea Lindgren, J. P. Johnson, Thilo Focken, Qi Jia, Jean-Christophe Andrez, Shannon Decker, Matthew Taron, Diana Weeratunge, Richard T. Dean, Janette Mezeyova, Shaoyi Sun, Wei Gong, Angela Hussainkhel, Gina de Boer, Alison Jane Cutts
مصطلحات موضوعية: Phenytoin, Glutamatergic, Lacosamide, Chemistry, Sodium channel, Excitatory postsynaptic potential, medicine, Carbamazepine, Pharmacology, Inhibitory postsynaptic potential, IC50, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::32e2e6674136369f3abcd5070b52e762
https://doi.org/10.1101/2021.08.29.458125 -
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المؤلفون: J P, Johnson, Thilo, Focken, Kuldip, Khakh, Parisa Karimi, Tari, Celine, Dube, Samuel J, Goodchild, Jean-Christophe, Andrez, Girish, Bankar, David, Bogucki, Kristen, Burford, Elaine, Chang, Sultan, Chowdhury, Richard, Dean, Gina, de Boer, Shannon, Decker, Christoph, Dehnhardt, Mandy, Feng, Wei, Gong, Michael, Grimwood, Abid, Hasan, Angela, Hussainkhel, Qi, Jia, Stephanie, Lee, Jenny, Li, Sophia, Lin, Andrea, Lindgren, Verner, Lofstrand, Janette, Mezeyova, Rostam, Namdari, Karen, Nelkenbrecher, Noah Gregory, Shuart, Luis, Sojo, Shaoyi, Sun, Matthew, Taron, Matthew, Waldbrook, Diana, Weeratunge, Steven, Wesolowski, Aaron, Williams, Michael, Wilson, Zhiwei, Xie, Rhena, Yoo, Clint, Young, Alla, Zenova, Wei, Zhang, Alison J, Cutts, Robin P, Sherrington, Simon N, Pimstone, Raymond, Winquist, Charles J, Cohen, James R, Empfield
المصدر: eLife. 11
مصطلحات موضوعية: Neurons, Mice, Epilepsy, NAV1.6 Voltage-Gated Sodium Channel, Gain of Function Mutation, Mutation, Sodium, Animals, Rats, Sodium Channel Blockers
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المؤلفون: Shaoyi, Sun, Qi, Jia, Alla Y, Zenova, Sophia, Lin, Angela, Hussainkhel, Janette, Mezeyova, Elaine, Chang, Samuel J, Goodchild, Zhiwei, Xie, Andrea, Lindgren, Gina, de Boer, Rainbow, Kwan, Kuldip, Khakh, Luis, Sojo, Paul, Bichler, J P, Johnson, James R, Empfield, Charles J, Cohen, Christoph M, Dehnhardt, Richard, Dean
المصدر: Bioorganicmedicinal chemistry letters. 45
مصطلحات موضوعية: Structure-Activity Relationship, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Humans, NAV1.5 Voltage-Gated Sodium Channel
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المؤلفون: Parisa Karimi Tari, Charles J. Cohen, Matthew Waldbrook, Christoph Martin Dehnhardt, Clint Young, Maegan Soriano, Rainbow Kwan, Matt Taron, Kristen Burford, Sultan Chowdhury, Noah G. Shuart, Lofstrand Verner Alexander, Michael D. Wilson, Karen Nelkenbrecher, Jean-Christophe Andrez, Michael Edward Grimwood, Wei Gong, Robert J. DeVita, J. P. Johnson, James Roy Empfield, Alla Yurevna Zenova, Luis Sojo, Andrea Lindgren, Thilo Focken, Shannon Decker, Gina de Boer, Samuel J. Goodchild, Wesolowski Steven Sigmund, Sophia Lin, Stephanie Lee
المصدر: Journal of Medicinal Chemistry. 62:9618-9641
مصطلحات موضوعية: Drug, 0303 health sciences, media_common.quotation_subject, Sodium channel, medicine.medical_treatment, Pregnane, Pharmacology, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Epilepsy, chemistry.chemical_compound, Anticonvulsant, chemistry, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Efflux, Penetrant (biochemical), 030304 developmental biology, media_common
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المؤلفون: Jodie Pang, Lunbin Deng, Girish Bankar, Jun Chen, Sultan Chowdhury, William R Proctor, Philippe Bergeron, Jennifer Vogt, Daniel F. Ortwine, Daniel P. Sutherlin, Jian Payandeh, Lilia Schumann, Shannon D. Shields, Christoph Martin Dehnhardt, Jae H. Chang, David H. Hackos, Elisa Ballini, Teresa Nguyen, Pengfei Ji, Glauco Tarozzo, Charles J. Cohen, Antonio G. DiPasquale, Kwong Wah Lai, Jonathan Maher, Kuldip Khakh, Steven J. McKerrall, Tania Chernov-Rogan, Wenfeng Liu, Brian Safina, Sophia Lin, Abid Hasan, J. P. Johnson
المصدر: Journal of Medicinal Chemistry. 62:4091-4109
مصطلحات موضوعية: 0303 health sciences, Ligand efficiency, Ligand, Chemistry, Stereochemistry, Mutagenesis, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Lipophilicity, Molecular Medicine, Structure–activity relationship, Chromane, Binding site, 030304 developmental biology
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المؤلفون: Qi Jia, Jean-Christophe Andrez, Charles J. Cohen, Jae H. Chang, Kuldip Khakh, J. P. Johnson, Chien-An Chen, Jun Li, Karen Nelkenbrecher, Thilo Focken, Zhiwei Xie, Daniel F. Ortwine, Brian Safina, Michael Edward Grimwood, Andrew D. White, Christoph Martin Dehnhardt, Shannon Decker, Ivan William Hemeon, David H. Hackos, Sophia Lin, Jodie Pang, Luis Sojo, Girish Bankar, Andrea Lindgren, Matthew Waldbrook, Elaine Chang, C. Lee Robinette, Shaoyi Sun, Antonio G. DiPasquale, Tao Sheng, Clint Young, Rainbow Kwan, Benjamin D. Sellers, Sultan Chowdhury, Michael Scott Wilson, Lunbin Deng, Daniel P. Sutherlin, Alla Yurevna Zenova
المصدر: Journal of Medicinal Chemistry. 62:908-927
مصطلحات موضوعية: 0303 health sciences, Chemistry, Sodium channel, Pharmacology, 01 natural sciences, Molecular Docking Simulation, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, In vivo, Docking (molecular), Drug Discovery, Microsome, Molecular Medicine, Structure–activity relationship, Potency, 030304 developmental biology
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المؤلفون: Brian S, Safina, Steven J, McKerrall, Shaoyi, Sun, Chien-An, Chen, Sultan, Chowdhury, Qi, Jia, Jun, Li, Alla Y, Zenova, Jean-Christophe, Andrez, Girish, Bankar, Philippe, Bergeron, Jae H, Chang, Elaine, Chang, Jun, Chen, Richard, Dean, Shannon M, Decker, Antonio, DiPasquale, Thilo, Focken, Ivan, Hemeon, Kuldip, Khakh, Amy, Kim, Rainbow, Kwan, Andrea, Lindgren, Sophia, Lin, Jonathan, Maher, Janette, Mezeyova, Dinah, Misner, Karen, Nelkenbrecher, Jodie, Pang, Rebecca, Reese, Shannon D, Shields, Luis, Sojo, Tao, Sheng, Henry, Verschoof, Matthew, Waldbrook, Michael S, Wilson, Zhiwei, Xie, Clint, Young, Tanja S, Zabka, David H, Hackos, Daniel F, Ortwine, Andrew D, White, J P, Johnson, C Lee, Robinette, Christoph M, Dehnhardt, Charles J, Cohen, Daniel P, Sutherlin
المصدر: Journal of medicinal chemistry. 64(6)
مصطلحات موضوعية: Rats, Sprague-Dawley, Voltage-Gated Sodium Channel Blockers, Sulfonamides, HEK293 Cells, Piperidines, Benzamides, Drug Discovery, NAV1.7 Voltage-Gated Sodium Channel, Animals, Azetidines, Humans, Cells, Cultured