المؤلفون: Jianqing Li, Daniel Smith, John S. Tokarski, Lihong Cheng, John E. Macor, Javed Khan, Adriana Zupa-Fernandez, Anil Thankappan, Chunjian Liu, Charu Chaudhry, David S. Weinstein, Percy H. Carter, Kathleen M. Gillooly, Kim W. McIntyre, Yifan Zhang, Anjaneya Chimalakonda, Joann Strnad, James Lin, James R. Burke, David J. Shuster, Manoj Chiney, Paul A. Elzinga, Max Ruzanov, Louis J. Lombardo, Charles M. Langevine

المصدر: Journal of Medicinal Chemistry. 64:677-694

مصطلحات موضوعية: Cyclopropanes, TYK2 Kinase, Chemistry, Hydrogen bond, Drug discovery, Ligand, Stereochemistry, Plasma protein binding, Crystallography, X-Ray, Catalysis, Pyridazine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Amide, Drug Discovery, Animals, Humans, Psoriasis, Molecular Medicine, Structure–activity relationship, Moiety, Oxazoles, Protein Kinase Inhibitors, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c717944d40cbaa5837d6bde470301607
https://doi.org/10.1021/acs.jmedchem.0c01698

المؤلفون: Jun Dai, Arvind Mathur, Lihong Cheng, Kim W. McIntyre, Dawn Sun, Joseph A. Tino, Shiuhang Yip, Douglas G. Batt, Jodi K. Muckelbauer, James R. Burke, Joel C. Barrish, Rodney Vickery, Celia D’Arienzo, Luisa Salter-Cid, Qingjie Liu, Tracy L. Taylor, Hua Gong, Mark A. Pattoli, Elizabeth M. Heimrich, Yingru Zhang, Andy J. Tebben, Myra Beaudoin Bertrand, Kathleen M. Gillooly, Chiehying Chang, Percy H. Carter, Scott H. Watterson, Mary T. Obermeier, Claudine Pulicicchio, Aberra Fura, Chunlei Wang, Michael Galella, Charles M. Langevine, Sarah C. Traeger, Lorell Discenza, Peng Li, Yifan Zhang, Qing Shi, Stacey Skala, Dauh-Rurng Wu, Richard Rampulla, George V. De Lucca

المصدر: Journal of Medicinal Chemistry. 59:9173-9200

مصطلحات موضوعية: 0301 basic medicine, Atropisomer, biology, 010405 organic chemistry, medicine.drug_class, Kinase, Chemistry, Stereochemistry, B-cell receptor, Carboxamide, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, immune system diseases, hemic and lymphatic diseases, Drug Discovery, medicine, biology.protein, Molecular Medicine, Structure–activity relationship, Bruton's tyrosine kinase, Transferase, Tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7b451ee92e76fc192317aad794597941
https://doi.org/10.1021/acs.jmedchem.6b01088

المؤلفون: Hai-Yun, Xiao, Scott H, Watterson, Charles M, Langevine, Anurag S, Srivastava, Soo S, Ko, Yanlei, Zhang, Robert J, Cherney, Wei-Wei, Guo, John L, Gilmore, James E, Sheppeck, Dauh-Rurng, Wu, Peng, Li, Duraisamy, Ramasamy, Piramanayagam, Arunachalam, Arvind, Mathur, Tracy L, Taylor, David J, Shuster, Kim W, McIntyre, Ding-Ren, Shen, Melissa, Yarde, Mary Ellen, Cvijic, Anthony M, Marino, Praveen V, Balimane, Zheng, Yang, Dana M, Banas, Georgia, Cornelius, Celia J, D'Arienzo, Bethanne M, Warrack, Lois, Lehman-McKeeman, Luisa M, Salter-Cid, Jenny, Xie, Joel C, Barrish, Percy H, Carter, Alaric J, Dyckman, T G Murali, Dhar

المصدر: Journal of medicinal chemistry. 59(21)

مصطلحات موضوعية: Male, Dose-Response Relationship, Drug, Molecular Structure, Fingolimod Hydrochloride, Freund's Adjuvant, Ligands, Arthritis, Experimental, Mycobacterium, Rats, Macaca fascicularis, Mice, Receptors, Lysosphingolipid, Structure-Activity Relationship, Dogs, Rats, Inbred Lew, Drug Design, Animals, Tissue Distribution, Lymphocytes, Heterocyclic Compounds, 3-Ring

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f9eb88b5ba2b222a1d206be47d1ac90e
https://pubmed.ncbi.nlm.nih.gov/27726358

المؤلفون: Jenny Xie, Tracy L. Taylor, Sandra Rex-Rabe, Joel C. Barrish, William J. Pitts, Kim W. McIntyre, Percy H. Carter, Scott H. Watterson, Murray McKinnon, Richard Liu, Bethanne M. Warrack, Suzanne J. Suchard, Mary Ellen Cvijic, Charles M. Langevine, Celia D’Arienzo, S. H. Spergel, Ding Ren Shen, Melissa Yarde, Dana Banas, Georgia Cornelius, Robert V. Moquin, Luisa Salter-Cid, Anthony M. Marino, Kathleen M. Gillooly, David J. Shuster, Praveen Balimane, Junqing Guo, Alaric J. Dyckman

المصدر: Journal of medicinal chemistry. 59(6)

مصطلحات موضوعية: 0301 basic medicine, Encephalomyelitis, Autoimmune, Experimental, Lymphocyte, Arthritis, Stimulation, CHO Cells, Thymus Gland, Pharmacology, Lymphatic System, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cricetulus, Cell Movement, Sphingosine, Cricetinae, Drug Discovery, medicine, Animals, Humans, Sphingosine-1-phosphate, Lymphocytes, Isoxazole, Receptor, Cell Proliferation, Experimental autoimmune encephalomyelitis, Isoxazoles, medicine.disease, Arthritis, Experimental, Rats, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, chemistry, Biochemistry, Rats, Inbred Lew, Molecular Medicine, Lysophospholipids, Immunosuppressive Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b442f2b835175b1ee0b7bde5377e100
https://pubmed.ncbi.nlm.nih.gov/26924461

المؤلفون: Alaric J. Dyckman, David J. Shuster, James Kempson, Georgia Cornelius, Sandra Rex-Rabe, Tracy L. Taylor, Kim W. McIntyre, Anthony M. Marino, Percy H. Carter, Junqing Guo, Dana Banas, Celia D’Arienzo, Luisa Salter-Cid, Praveen Balimane, Suzanne J. Suchard, Jenny Xie, Kathleen M. Gillooly, Steven H. Spergel, Mary Ellen Cvijic, William J. Pitts, Scott H. Watterson, Murray McKinnon, Richard Liu, Joel C. Barrish, Charles M. Langevine, Ding Ren Shen, Melissa Yarde

المصدر: Bioorganicmedicinal chemistry letters. 26(10)

مصطلحات موضوعية: 0301 basic medicine, Male, Stereochemistry, Clinical Biochemistry, Dose dependence, Drug Evaluation, Preclinical, Pharmaceutical Science, Arthritis, Administration, Oral, Chemistry Techniques, Synthetic, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Pharmacokinetics, Sphingosine, Drug Discovery, medicine, Animals, Humans, Sphingosine-1-phosphate, Lymphocyte Count, Isoxazole, Molecular Biology, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Rodent model, Isoxazoles, medicine.disease, Arthritis, Experimental, In vitro, Receptors, Lysosphingolipid, 030104 developmental biology, Rats, Inbred Lew, Molecular Medicine, Lysophospholipids, Selectivity, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3262618d2b41ca82905ff4092e0e3f0
https://pubmed.ncbi.nlm.nih.gov/27055941

المؤلفون: William J. Pitts, Alaric J. Dyckman, Scott H. Watterson, Robert V. Moquin, Kim W. McIntyre, Zheng Yang, Jagabandhu Das, Katy Van Kirk, James R. Burke, David B. Wang-Iverson, Hollie Booth-Lute, James Kempson, Laishun Chen, Charles M. Langevine, Joel C. Barrish, Guchen Yang, Xiaoxia Yang, John H. Dodd, David S. Nirschl, Murray McKinnon, Steven H. Spergel, Mark A. Pattoli, Michael Galella, Kurt R. Gregor, Junquing Guo

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7006-7012

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Acetamides, Drug Discovery, Animals, Humans, Inhibitory concentration 50, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Drug discovery, Organic Chemistry, Inflammatory Bowel Diseases, In vitro, I-kappa B Kinase, Rats, Enzyme Activation, chemistry, Molecular Medicine, Heterocyclic Compounds, 3-Ring, Acetamide, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d20db656b0bd7d293349f9329e548bb
https://doi.org/10.1016/j.bmcl.2011.09.111

المؤلفون: James Kempson, Joel C. Barrish, Laishun Chen, Alaric J. Dyckman, Robert V. Moquin, Kim W. McIntyre, Kathleen M. Gillooly, William J. Pitts, James R. Burke, Steven H. Spergel, Jagabandhu Das, Mark A. Pattoli, Scott H. Watterson, John H. Dodd, Murray McKinnon, Xiao Xia Yang, Junqing Guo, Charles M. Langevine

المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2646-2649

مصطلحات موضوعية: Lipopolysaccharides, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, IκB kinase, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Structure–activity relationship, skin and connective tissue diseases, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Tumor Necrosis Factor-alpha, Organic Chemistry, Imidazoles, I-kappa B Kinase, Rats, Pyrimidines, Enzyme, chemistry, Molecular Medicine, Amine gas treating, Lead compound, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a3d5262cca9942cd0069b8a7d78124
https://doi.org/10.1016/j.bmcl.2009.03.159

المؤلفون: Charles M. Langevine, Joseph A. Furch, Dominique Belanger, Mark A. Pattoli, Joel C. Barrish, Alaric J. Dyckman, Marco Dodier, James Kempson, Jagabandhu Das, David S. Nirschl, Laishun Chen, Punit Marathe, Kathleen M. Gillooly, Junqing Guo, Robert V. Moquin, John H. Dodd, Murray McKinnon, Anne Marinier, Zheng Yang, Steven H. Spergel, Claude A. Quesnelle, Kim W. McIntyre, Katy Van Kirk, James R. Burke, William J. Pitts, Scott H. Watterson, Alain Martel, Patrice Gill, David B. Wang-Iverson, Tianle Li

المصدر: Journal of Medicinal Chemistry. 52:1994-2005

مصطلحات موضوعية: Lipopolysaccharides, Recombinant Fusion Proteins, IκB kinase, In Vitro Techniques, Crystallography, X-Ray, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Thiazole, Oxazoles, Glutathione Transferase, Oxazole, chemistry.chemical_classification, Mice, Inbred BALB C, Tumor Necrosis Factor-alpha, Imidazoles, Biological activity, I-kappa B Kinase, Rats, Thiazoles, Enzyme, chemistry, Biochemistry, Leukocytes, Mononuclear, Microsomes, Liver, Molecular Medicine, Female, Signal transduction, Heterocyclic Compounds, 3-Ring, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4567117bd8910f92df6183547c38087
https://doi.org/10.1021/jm8015816

المؤلفون: Cort S. Madsen, Cindy Chen, Donald W. Combs, Jeffrey A. Robl, Charles M. Langevine, David S. Weinstein, Khehyong Ngu, Wen Liu, Shaobin Zhuang, Timothy W. Harper

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5115-5120

مصطلحات موضوعية: Male, Stereochemistry, Clinical Biochemistry, Cell, Pharmaceutical Science, CHO Cells, Biochemistry, Isozyme, Rats, Sprague-Dawley, chemistry.chemical_compound, Lipoxygenase, Cricetulus, Cricetinae, Drug Discovery, medicine, Animals, Humans, Imidazole, Lipoxygenase Inhibitors, Molecular Biology, Sulfamide, chemistry.chemical_classification, biology, Organic Chemistry, Imidazoles, In vitro, Rats, medicine.anatomical_structure, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ef0ce05d6a51167d01503dc8819a57
https://doi.org/10.1016/j.bmcl.2007.07.011

المؤلفون: Saleem Ahmad, Cort S. Madsen, Charles M. Langevine, Xing Chen, Shaobin Zhuang, Wen Liu, Timothy W. Harper, Khehyong Ngu, Jeffrey A. Robl, David S. Weinstein, Donald W. Combs

المصدر: Bioorganicmedicinal chemistry letters. 21(14)

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Pyrazole, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Lipoxygenase, Structure-Activity Relationship, Cricetulus, Cricetinae, Drug Discovery, Hydroxyeicosatetraenoic Acids, Structure–activity relationship, Animals, Arachidonate 15-Lipoxygenase, Humans, Lipoxygenase Inhibitors, Molecular Biology, Sulfamide, chemistry.chemical_classification, Sulfonamides, biology, Organic Chemistry, Amides, Sulfonamide, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Pyrazoles, Rabbits

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d913c6022d0118d72a258707bb441c9
https://pubmed.ncbi.nlm.nih.gov/21696952