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1
المؤلفون: Doreen E. Cashen, Constantin Tamvakopoulos, Qianping Peng, William J. Martin, David H. Weinberg, Charles Rosenblum, Arthur A. Patchett, Tanya MacNeil, Patrick G. Pollard, Zhixiong Ye, Raman K. Bakshi, Ralph A. Stearns, Rubana N. Kalyani, Palucki Brenda, Joseph M. Metzger, Alison M. Strack, Lex H.T. Van der Ploeg, D. Euan MacIntyre, Iyassu K. Sebhat, Aurawan Vongs, Airu S. Chen, Ravi P. Nargund, Liangqin Guo, Matthew J. Wyvratt, Randy R. Miller, Rui Tang, Howard Y. Chen, Khaled J. Barakat
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3501-3505
مصطلحات موضوعية: Male, Agonist, Quinuclidines, Time Factors, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Rodentia, Carboxamide, Biochemistry, Chemical synthesis, Piperazines, Rats, Sprague-Dawley, Eating, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Aza Compounds, Bicyclic molecule, Chemistry, Penile Erection, digestive, oral, and skin physiology, Organic Chemistry, Small molecule, Rats, Microsomes, Liver, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
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2
المؤلفون: George A. Doss, Lex H.T. Van der Ploeg, Qianping Peng, Ravi P. Nargund, Charles Rosenblum, Randall R. Miller, Aurawan Vongs, Palucki Brenda, Tanya MacNeil, Ralph A. Stearns, Min K. Park, David H. Weinberg, Rui Tang, Arthur A. Patchett, Constantin Tamvakopoulos
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:1993-1996
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Piperazines, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Receptor, Molecular Biology, biology, Chemistry, Organic Chemistry, biology.organism_classification, In vitro, Piperazine, Microsoma, Microsome, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin
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3
المؤلفون: William J. Martin, D. Euan MacIntyre, Ravi P. Nargund, Rubana N. Kalyani, Rui Tang, George A. Doss, Min K. Park, Alison M. Strack, Erin McGowan, Joseph M. Metzger, Charles Rosenblum, Randall R. Miller, Palucki Brenda, Qianping Peng, Arthur A. Patchett, Ralph A. Stearns, Patrick G. Pollard, Lex H.T. Van der Ploeg, Iyassu K. Sebhat, Constantin Tamvakopoulos, Cherrie Shepherd, Aurawan Vongs, Tanya MacNeil, David H. Weinberg, Zhixiong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:171-175
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Piperazines, Mice, Dogs, Erectile Dysfunction, Piperidines, In vivo, Drug Discovery, medicine, Animals, Obesity, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Haplorhini, In vitro, Rats, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin
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4
المؤلفون: Charles Rosenblum, Nicole M Lynn, Aurawan Vongs
المصدر: Regulatory Peptides. 120:113-118
مصطلحات موضوعية: endocrine system, Physiology, Morpholines, Clinical Biochemistry, CHO Cells, Mitogen-activated protein kinase kinase, environment and public health, Biochemistry, MAP2K7, Wortmannin, Phosphatidylinositol 3-Kinases, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Endocrinology, Cricetinae, Cyclic AMP, Animals, ASK1, Melanocyte-Stimulating Hormones, c-Raf, Enzyme Inhibitors, Protein kinase A, Protein Kinase Inhibitors, Cells, Cultured, Mitogen-Activated Protein Kinase 3, MAP kinase kinase kinase, Chemistry, Akt/PKB signaling pathway, Cyclic AMP-Dependent Protein Kinases, Cell biology, Androstadienes, Enzyme Activation, enzymes and coenzymes (carbohydrates), Chromones, Receptor, Melanocortin, Type 4, biological phenomena, cell phenomena, and immunity, hormones, hormone substitutes, and hormone antagonists, Signal Transduction
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5
المؤلفون: Mark T. Goulet, Lihu Yang, Aurawan Vongs, David H. Weinberg, Charles Rosenblum, Changyou Zhou, Feroze Ujjainwalla, Thomas F. Walsh, Matthew J. Wyvratt, Tanya MacNeil, Rubana N. Kalyani, Rui Tang, Lex H.T. Van der Ploeg, Warner Daniel
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:4431-4435
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Archetype, Binding Sites, integumentary system, Chemistry, digestive, oral, and skin physiology, Organic Chemistry, Stereoisomerism, Pyridazines, Kinetics, Receptor, Melanocortin, Type 4, Molecular Medicine, Indicators and Reagents, Melanocortin, hormones, hormone substitutes, and hormone antagonists
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6
المؤلفون: Christopher P. Austin, Doreen E. Cashen, Sheng-Shung Pong, Brian D. Spar, Brett Connolly, Tung Ming Fong, D. Euan MacIntyre, Carina P. Tan, Michael R. Tota, Ravi P. Nargund, R. S. L. Chang, Oksana C. Palyha, Constantin Tamvakopoulos, Deborah L. Drazen, Anthony G. DiLella, Jennifer E. Drisko, David J. Figueroa, Tanya MacNeil, Andreas W. Sailer, David H. Weinberg, Randy J. Nelson, Charles Rosenblum, Cathy R.-R.C. Huang, Rui Tang, Arthur A. Patchett, Xiao-Ming Guan, Hong Yu, George J. Christ, Andrew D. Howard, Lex H.T. Van der Ploeg, William J. Martin, Aurawan Vongs, Iyassu K. Sebhat, Ralph A. Stearns
المصدر: Proceedings of the National Academy of Sciences. 99:11381-11386
مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, DNA, Complementary, Intracranial Pressure, medicine.drug_class, Blood Pressure, In Vitro Techniques, Biology, Somatosensory system, Mice, Sexual Behavior, Animal, Nerve Fibers, Internal medicine, Copulation, medicine, Animals, Glans, In Situ Hybridization, DNA Primers, Multidisciplinary, Reverse Transcriptase Polymerase Chain Reaction, Human penis, Feeding Behavior, Ribonuclease, Pancreatic, Biological Sciences, Spinal cord, Electric Stimulation, Mice, Inbred C57BL, Melanocortin 4 receptor, medicine.anatomical_structure, Endocrinology, Receptors, Corticotropin, Models, Animal, Receptor, Melanocortin, Type 4, Brainstem, Energy Metabolism, Penis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341db11f0e12a0307d07e04176cd4aad
https://doi.org/10.1073/pnas.172378699 -
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المؤلفون: Michael R. Tota, Ravi P. Nargund, Xiao-Ming Guan, Howard Y. Chen, Douglas J. MacNeil, David H. Weinberg, Tanya MacNeil, Euan Macintyre, Alison M. Strack, Charles Rosenblum, Maria A. Bednarek, Andrew D. Howard, Chun-Pyn Shen, Tung M. Fong, Mark T. Goulet, Lex H.T. Van der Ploeg, Airu S. Chen, Donald J. Marsh
المصدر: European Journal of Pharmacology. 440:141-157
مصطلحات موضوعية: endocrine system, medicine.medical_specialty, Gene Expression, Biology, Melanocortin receptor, Proopiomelanocortin, Internal medicine, medicine, Animals, Humans, Melanocyte-Stimulating Hormones, Obesity, Receptor, Melanocortins, Pharmacology, integumentary system, Receptors, Melanocortin, digestive, oral, and skin physiology, Body Weight, Melanocortin 3 receptor, Melanocortin 4 receptor, Endocrinology, Receptors, Corticotropin, biology.protein, Anti-Obesity Agents, Melanocortin, hormones, hormone substitutes, and hormone antagonists, Melanocortin 1 receptor
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8
المؤلفون: Xiao-Ming Guan, Charles Rosenblum, Hong Yu, Yue Feng, D. Euan MacIntyre, Alison M. Strack, Lex H.T. Van der Ploeg, Christian N. Nunes, Airu S. Chen, Joseph M. Metzger, Linhai Cao, Easter G. Frazier, Jill K. Fisher, Ramon E. Camacho, William Min, Shobhna Gopal-Truter, Aurawan Vongs, Howard Y. Chen, Theodore N. Mellin, Donald J. Marsh, Myrna E. Trumbauer
المصدر: Nature Genetics. 26:97-102
مصطلحات موضوعية: Leptin, Male, Time Factors, Energy homeostasis, Body Temperature, Mice, Insulin, Protein Isoforms, Tissue Distribution, In Situ Hybridization, Mice, Knockout, Recombination, Genetic, Age Factors, Melanocortin 3 receptor, Blotting, Southern, Phenotype, medicine.anatomical_structure, Adipose Tissue, Receptor, Melanocortin, Type 4, Female, medicine.symptom, Melanocortin, Oligopeptides, Receptor, Melanocortin, Type 3, medicine.medical_specialty, Genotype, Receptors, Peptide, Calorimetry, Motor Activity, Biology, Feed conversion ratio, Melanocortin receptor, Central melanocortin system, Hyperinsulinism, Internal medicine, Genetics, medicine, Animals, Humans, Obesity, Models, Genetic, Body Weight, Feeding Behavior, Thyroxine, Glucose, Endocrinology, Receptors, Corticotropin, alpha-MSH, Lean body mass, Corticosterone, Weight gain
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9
المؤلفون: Jeffrey P Varnerin, T. Smith, Aurawan Vongs, Patricia J. Hey, M. Chou, Joseph J. King, Theodore N. Mellin, Easter G. Frazier, Michael R. Tota, D. E. Macintyre, Beth Junker, Beth Ann Murphy, Charles Rosenblum, Christian N. Nunes, B. W. Burgess, L. H. T. Van Der Ploeg
المصدر: Protein Expression and Purification. 14:335-342
مصطلحات موضوعية: Leptin, Protein Folding, medicine.medical_specialty, Recombinant Fusion Proteins, medicine.medical_treatment, Genetic Vectors, Radioimmunoassay, Mice, Obese, Inclusion bodies, Cell Line, Mice, In vivo, Internal medicine, Weight Loss, Escherichia coli, medicine, Animals, Humans, Histidine, Inclusion Bodies, Leptin receptor, Chemistry, Insulin, digestive, oral, and skin physiology, Proteins, Mice, Mutant Strains, Endotoxins, Diafiltration, Endocrinology, Biochemistry, Protein Biosynthesis, Biological Assay, Peptides, Filtration, hormones, hormone substitutes, and hormone antagonists, Ex vivo, Biotechnology
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10
المؤلفون: Philip S. Paress, Sheng-Shung Pong, Donna L. Hreniuk, Paul A. Liberator, Michael Rigby, Roy G. Smith, Oksana C. Palyha, Arthur A. Patchett, Michel J. Hamelin, Robert P. Heavens, Andrew D. Howard, Patrick R. Griffin, David G. Melillo, Charles Rosenblum, Lee-Yuh Chaung, Ravi P. Nargund, Michael Chou, Jennifer W. Anderson, Dennis C. Dean, Sunil Gupta, Alex Elbrecht, Scott D. Feighner, Dalip J. S. Sirinathsinghji, Joseph P. Arena, Carmen Diaz, Julie A. DeMartino, Mike Dashkevicz, Doris F. Cully, Karen K. McKee, Lex H.T. Van der Ploeg, James M. Schaeffer, Ken K. Liu
المصدر: Science. 273:974-977
مصطلحات موضوعية: medicine.medical_specialty, Pituitary gland, DNA, Complementary, Indoles, Somatotropic cell, Swine, Molecular Sequence Data, Hypothalamus, Middle, Receptors, Cell Surface, Biology, Gonadotropic cell, Cell Line, RNA, Complementary, Receptors, G-Protein-Coupled, chemistry.chemical_compound, GTP-Binding Proteins, Growth hormone secretagogue, Internal medicine, medicine, Animals, Humans, Spiro Compounds, Hormone metabolism, Amino Acid Sequence, GHRP-6, Codon, Receptors, Ghrelin, Multidisciplinary, Base Sequence, Macaca mulatta, Hormones, Rats, Endocrinology, medicine.anatomical_structure, chemistry, Hypothalamus, Growth Hormone, Pituitary Gland, Oligopeptides, Endocrine gland