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المؤلفون: Barbara Giabbai, Loredano Pollegioni, Serena Galati, Edi Gabellieri, Vitalia V. Kulikova, Andrea Mozzarelli, Alexey D. Nikulin, Chiara Cocconcelli, Patrizia Cioni, S.V. Revtovich, Nicola Demitri, Serena Faggiano, Samanta Raboni, Annamaria Buschini, Tatyana V. Demidkina, Paola Storici, Elena Rosini, Elena A. Morozova
المصدر: Biochimica et biophysica acta. Proteins and proteomics 1866 (2018): 1260–1270. doi:10.1016/j.bbapap.2018.09.011
info:cnr-pdr/source/autori:Raboni S, Revtovich S, Demitri N, Giabbai B, Storici P, Cocconcelli C, Faggiano S, Rosini E, Pollegioni L, Galati S, Buschini A, Morozova E, Kulikova V, Nikulin A, Gabellieri E, Cioni P, Demidkina T, Mozzarelli A/titolo:Engineering methionine ?-lyase from Citrobacter freundii for anticancer activity/doi:10.1016%2Fj.bbapap.2018.09.011/rivista:Biochimica et biophysica acta. Proteins and proteomics/anno:2018/pagina_da:1260/pagina_a:1270/intervallo_pagine:1260–1270/volume:1866مصطلحات موضوعية: 0301 basic medicine, Cancer therapy, Pyridoxal 5′-phosphate dependent enzyme, Biophysics, Antineoplastic Agents, Crystallography, X-Ray, Protein Engineering, Biochemistry, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Cytotoxicity activity, Methionine depletion, Protein engineering, Site-saturation mutagenesis, Molecular Biology, Bacterial Proteins, Catalytic Domain, Cell Proliferation, chemistry.chemical_classification, Methionine, biology, Mutagenesis, Wild type, Active site, Lyase, biology.organism_classification, Recombinant Proteins, Citrobacter freundii, Amino acid, Protein Structure, Tertiary, Pyridoxal 5?-phosphate dependent enzyme, Carbon-Sulfur Lyases, Kinetics, 030104 developmental biology, Enzyme, chemistry, biology.protein, Mutagenesis, Site-Directed
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المؤلفون: Chiara Pecchini, Chiara Cocconcelli, Andrea Mozzarelli, Gabriele Costantino, Barbara Campanini, Claudia Beato, Marco Pieroni, Marialaura Marchetti
المصدر: Journal of enzyme inhibition and medicinal chemistry
31 (2016): 645–652. doi:10.3109/14756366.2015.1057720
info:cnr-pdr/source/autori:Beato C, Pecchini C, Cocconcelli C, Campanini B, Marchetti ML, Pieroni M, Mozzarelli A, Costantino G/titolo:Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target/doi:10.3109%2F14756366.2015.1057720/rivista:Journal of enzyme inhibition and medicinal chemistry (Print)/anno:2016/pagina_da:645/pagina_a:652/intervallo_pagine:645–652/volume:31مصطلحات موضوعية: Cyclopropanes, 0301 basic medicine, Stereochemistry, Racemases and Epimerases, Malonic acid, Inhibitory postsynaptic potential, Cyclopropane, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Humans, Enzyme Inhibitors, Inhibition, Binding affinities, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, General Medicine, Molecular Docking Simulation, Serine recemase, 030104 developmental biology, Dicarboxylic acid, chemistry, Biochemistry, Serine racemase, Molecular docking, Glycine, Conformational ensemble, NMDA receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf2077a646f095d4b3aa2fb0a0d310f
