المؤلفون: Cull JJ; School of Biological Sciences, University of Reading, Reading, U.K., Cooper STE; Molecular and Clinical Sciences Institute, St. George's University of London, London, U.K., Alharbi HO; School of Biological Sciences, University of Reading, Reading, U.K., Chothani SP; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore., Rackham OJL; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore.; School of Biological Sciences, University of Southampton, Southampton, U.K., Meijles DN; Molecular and Clinical Sciences Institute, St. George's University of London, London, U.K., Dash PR; School of Biological Sciences, University of Reading, Reading, U.K., Kerkelä R; Research Unit of Biomedicine and Internal Medicine, Medical Research Centre Oulu (Oulu University Hospital) and Biocenter Oulu, University of Oulu, Oulu, Finland., Ruparelia N; School of Biological Sciences, University of Reading, Reading, U.K.; Department of Cardiology, Royal Berkshire Hospital, Reading, U.K., Sugden PH; School of Biological Sciences, University of Reading, Reading, U.K., Clerk A; School of Biological Sciences, University of Reading, Reading, U.K.

المصدر: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2024 May 22; Vol. 138 (10), pp. 573-597.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

مواضيع طبية MeSH: Angiotensin II*/pharmacology , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , Cardiomegaly*/genetics , Cardiomegaly*/pathology , Cardiomegaly*/metabolism , Cardiomegaly*/physiopathology , Mice, Knockout*, Animals ; Male ; Humans ; Muscle Proteins/metabolism ; Muscle Proteins/genetics ; Ventricular Remodeling ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Calmodulin-Binding Proteins ; Nerve Tissue Proteins

المؤلفون: Wieder N; Big Data Institute, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., D'Souza EN; Big Data Institute, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Martin-Geary AC; Big Data Institute, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Lassen FH; Big Data Institute, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Talbot-Martin J; Imperial College London, London, UK., Fernandes M; Big Data Institute, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Chothani SP; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore, 169857, Singapore., Rackham OJL; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore, 169857, Singapore.; School of Biological Sciences, University of Southampton, Southampton, UK., Schafer S; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore, 169857, Singapore., Aspden JL; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom.; LeedsOmics, University of Leeds, Leeds, LS2 9JT, United Kingdom.; Astbury Centre of Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom., MacArthur DG; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Centre for Population Genomics, Garvan Institute of Medical Research, and UNSW Sydney, Sydney, NSW, Australia.; Centre for Population Genomics, Murdoch Children's Research Institute, Melbourne, VIC, Australia., Davies RW; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Whiffin N; Big Data Institute, University of Oxford, Oxford, UK. nwhiffin@well.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. nwhiffin@well.ox.ac.uk.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. nwhiffin@well.ox.ac.uk.

المصدر: Genome biology [Genome Biol] 2024 Apr 29; Vol. 25 (1), pp. 111. Date of Electronic Publication: 2024 Apr 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

مواضيع طبية MeSH: 5' Untranslated Regions* , Open Reading Frames* , Protein Biosynthesis*, Humans ; Gene Dosage ; Gene Expression Regulation ; Transcription Initiation Site ; Alternative Splicing ; Nucleic Acid Conformation

المؤلفون: Chothani SP; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Adami E; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany., Widjaja AA; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Langley SR; Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, Singapore 308232, Singapore., Viswanathan S; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Pua CJ; National Heart Research Institute Singapore (NHRIS), National Heart Centre Singapore, Singapore 169609, Singapore., Zhihao NT; Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, Singapore 308232, Singapore., Harmston N; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore; Science Division, Yale-NUS College, Singapore 138527, Singapore., D'Agostino G; Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, Singapore 308232, Singapore., Whiffin N; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Mao W; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Ouyang JF; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Lim WW; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore; National Heart Research Institute Singapore (NHRIS), National Heart Centre Singapore, Singapore 169609, Singapore., Lim S; National Heart Research Institute Singapore (NHRIS), National Heart Centre Singapore, Singapore 169609, Singapore., Lee CQE; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Grubman A; Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Wellington Road, Clayton, VIC 3800, Australia; Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, VIC 3800, Australia., Chen J; Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Wellington Road, Clayton, VIC 3800, Australia; Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, VIC 3800, Australia., Kovalik JP; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Tryggvason K; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Polo JM; Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Wellington Road, Clayton, VIC 3800, Australia; Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, VIC 3800, Australia., Ho L; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore., Cook SA; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore; National Heart Research Institute Singapore (NHRIS), National Heart Centre Singapore, Singapore 169609, Singapore; London Institute of Medical Sciences, London W12 ONN, UK., Rackham OJL; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore; School of Biological Sciences, University of Southampton, Southampton, UK. Electronic address: owen.rackham@duke-nus.edu.sg., Schafer S; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore 169857, Singapore; National Heart Research Institute Singapore (NHRIS), National Heart Centre Singapore, Singapore 169609, Singapore. Electronic address: sebastian@duke-nus.edu.sg.

المصدر: Molecular cell [Mol Cell] 2022 Aug 04; Vol. 82 (15), pp. 2885-2899.e8. Date of Electronic Publication: 2022 Jul 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation* , Ribosomes*/genetics , Ribosomes*/metabolism, Genome, Human/genetics ; Humans ; Open Reading Frames/genetics ; Protein Biosynthesis ; Proteins/metabolism ; RNA/metabolism

المؤلفون: Clerk A; School of Biological Sciences, University of Reading, Reading, U.K., Meijles DN; Molecular and Clinical Sciences Institute, St. George's University of London, London, U.K., Hardyman MA; School of Biological Sciences, University of Reading, Reading, U.K., Fuller SJ; School of Biological Sciences, University of Reading, Reading, U.K., Chothani SP; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore., Cull JJ; School of Biological Sciences, University of Reading, Reading, U.K., Cooper STE; Molecular and Clinical Sciences Institute, St. George's University of London, London, U.K., Alharbi HO; School of Biological Sciences, University of Reading, Reading, U.K., Vanezis K; National Heart and Lung Institute, Imperial College London, London, U.K.; MRC London Institute of Medical Sciences, Imperial College London, London, U.K., Felkin LE; National Heart and Lung Institute, Imperial College London, London, U.K.; Cardiovascular Research Centre, Royal Brompton and Harefield Hospitals, London, U.K., Markou T; School of Biological Sciences, University of Reading, Reading, U.K., Leonard SJ; School of Biological Sciences, University of Reading, Reading, U.K., Shaw SW; School of Biological Sciences, University of Reading, Reading, U.K., Rackham OJL; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore., Cook SA; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore City, Singapore.; MRC London Institute of Medical Sciences, Imperial College London, London, U.K.; National Heart Centre Singapore, Singapore City, Singapore., Glennon PE; University Hospitals Coventry and Warwickshire, University Hospital Cardiology Department, Clifford Bridge Road, Coventry, U.K., Sheppard MN; CRY Cardiovascular Pathology Department, St. George's Healthcare NHS Trust, London, U.K., Sembrat JC; Division of Pulmonary, Allergy and Critical Care Medicine, and Dorothy P & Richard P Simmons Center for Interstitial Lung Disease, Department of Medicine, University of Pittsburgh, Pittsburgh, U.S.A., Rojas M; Division of Pulmonary, Allergy and Critical Care Medicine, and Dorothy P & Richard P Simmons Center for Interstitial Lung Disease, Department of Medicine, University of Pittsburgh, Pittsburgh, U.S.A., McTiernan CF; Heart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, U.S.A., Barton PJ; National Heart and Lung Institute, Imperial College London, London, U.K.; Cardiovascular Research Centre, Royal Brompton and Harefield Hospitals, London, U.K., Sugden PH; School of Biological Sciences, University of Reading, Reading, U.K.

المصدر: The Biochemical journal [Biochem J] 2022 Feb 11; Vol. 479 (3), pp. 401-424.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

مواضيع طبية MeSH: Cardiomegaly/*pathology , MAP Kinase Signaling System/*physiology , Myocytes, Cardiac/*pathology , Proto-Oncogene Proteins B-raf/*physiology, Animals ; Carbamates/pharmacology ; Carbamates/toxicity ; Cardiomegaly/metabolism ; Cell Size/drug effects ; Cells, Cultured ; Dimerization ; Gene Knock-In Techniques ; Heart Failure/pathology ; Humans ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mutation, Missense ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Point Mutation ; Protein Conformation/drug effects ; Protein Interaction Mapping ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins c-raf/antagonists & inhibitors ; Proto-Oncogene Proteins c-raf/biosynthesis ; Rats ; Rats, Sprague-Dawley ; Sulfonamides/pharmacology ; Sulfonamides/toxicity

المؤلفون: Ng B; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Viswanathan S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Dong J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Chothani SP; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Lim S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Shekeran SG; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Tan J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., McGregor NE; Bone Biology and Disease Unit, St. Vincent's Institute of Medical Research, Melbourne, Australia., Walker EC; Bone Biology and Disease Unit, St. Vincent's Institute of Medical Research, Melbourne, Australia., Sims NA; Bone Biology and Disease Unit, St. Vincent's Institute of Medical Research, Melbourne, Australia.; Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Melbourne, Australia., Schafer S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Cook SA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. stuart.cook@duke-nus.edu.sg.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore. stuart.cook@duke-nus.edu.sg.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK. stuart.cook@duke-nus.edu.sg.

المصدر: Scientific reports [Sci Rep] 2021 Jul 08; Vol. 11 (1), pp. 14088. Date of Electronic Publication: 2021 Jul 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Fertility*, Craniosynostoses/*complications , Inflammation/*complications , Inflammation/*pathology , Interleukin-11/*metabolism , Interleukin-11 Receptor alpha Subunit/*metabolism , Lung/*pathology, Animals ; Bleomycin ; Cell Differentiation ; Craniosynostoses/blood ; Female ; Fibronectins/metabolism ; Humans ; Infertility, Female/blood ; Infertility, Female/pathology ; Inflammation/blood ; Metabolomics ; Mice, Knockout ; Myofibroblasts/pathology ; NF-kappa B/metabolism ; Phosphorylation ; Pulmonary Fibrosis/blood ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/pathology ; STAT3 Transcription Factor/metabolism ; Smad2 Protein ; Mice

المؤلفون: Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore. stuart.cook@duke-nus.edu.sg anissa.widjaja@duke-nus.edu.sg., Dong J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Adami E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Viswanathan S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Ng B; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore., Pakkiri LS; Cardiac Department, National University Hospital, Singapore 119074, Singapore., Chothani SP; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Singh BK; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Lim WW; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore., Zhou J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Shekeran SG; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Tan J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore., Lim SY; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore., Goh J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Wang M; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Holgate R; Abzena, Babraham Research Campus, Babraham, Cambridge CB22 3AT, UK., Hearn A; Abzena, Babraham Research Campus, Babraham, Cambridge CB22 3AT, UK., Felkin LE; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Yen PM; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Dear JW; Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK., Drum CL; Cardiovascular Research Institute, National University Health System, Singapore 119228, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Schafer S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore., Cook SA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore. stuart.cook@duke-nus.edu.sg anissa.widjaja@duke-nus.edu.sg.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, UK.

المصدر: Science translational medicine [Sci Transl Med] 2021 Jun 09; Vol. 13 (597).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Chemical and Drug Induced Liver Injury*/drug therapy , Chemical and Drug Induced Liver Injury, Chronic*, Acetaminophen/toxicity ; Animals ; Hepatocytes ; Interleukin-11 ; Interleukin-11 Receptor alpha Subunit ; Liver ; Mice ; Mice, Inbred C57BL

المؤلفون: Dong J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Viswanathan S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Adami E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Singh BK; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Chothani SP; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Ng B; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Lim WW; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Zhou J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Tripathi M; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Ko NSJ; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Shekeran SG; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Tan J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Lim SY; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Wang M; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Lio PM; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Yen PM; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Schafer S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Cook SA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. stuart.cook@duke-nus.edu.sg.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore. stuart.cook@duke-nus.edu.sg.; National Heart and Lung Institute, Imperial College London, London, UK. stuart.cook@duke-nus.edu.sg.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK. stuart.cook@duke-nus.edu.sg., Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. anissa.widjaja@duke-nus.edu.sg.

المصدر: Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 66. Date of Electronic Publication: 2021 Jan 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction*/drug effects, Hepatocytes/*metabolism , Interleukin-11/*metabolism , Lipids/*toxicity , Non-alcoholic Fatty Liver Disease/*metabolism , Non-alcoholic Fatty Liver Disease/*pathology, Adult ; Animals ; Autocrine Communication/drug effects ; Cells, Cultured ; Disease Models, Animal ; Feeding Behavior ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Humans ; Interleukin-11 Receptor alpha Subunit/metabolism ; Interleukin-6/metabolism ; Mice, Knockout ; Models, Biological ; Paracrine Communication/drug effects ; Phenotype ; Mice

المؤلفون: Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School , Singapore., Chothani SP; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School , Singapore., Cook SA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School , Singapore.; National Heart Research Institute Singapore, National Heart Centre Singapore , Singapore.; National Heart and Lung Institute, Imperial College London , London, UK.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus , London, UK.

المصدر: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2020 Oct 02; Vol. 16 (10), pp. 2357-2362. Date of Electronic Publication: 2020 Jun 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-11* , Liver Diseases*/therapy, Animals ; Hepatocytes ; Humans ; Interleukin-6 ; Liver

المؤلفون: Ng B; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Dong J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Viswanathan S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Paleja BS; Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore, Singapore., Adami E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Ko NSJ; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Wang M; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Lim S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Tan J; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Chothani SP; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Albani S; Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore, Singapore., Schafer S; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Cook SA; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart and Lung Institute, Imperial College, London, UK.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK.

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Sep; Vol. 34 (9), pp. 11802-11815. Date of Electronic Publication: 2020 Jul 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: Fibroblasts/*metabolism , Inflammation/*metabolism , Interleukin-11/*metabolism , Interleukin-11 Receptor alpha Subunit/*metabolism , Pulmonary Fibrosis/*metabolism, Animals ; Bleomycin ; Cells, Cultured ; Chronic Disease ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Humans ; Inflammation/genetics ; Interleukin-11/pharmacology ; Interleukin-11 Receptor alpha Subunit/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; NF-kappa B/metabolism ; Phosphorylation ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics

المؤلفون: Ng B; National Heart Centre Singapore, 169609 Singapore, Singapore.; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Dong J; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., D'Agostino G; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Viswanathan S; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Widjaja AA; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Lim WW; National Heart Centre Singapore, 169609 Singapore, Singapore.; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Ko NSJ; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Tan J; National Heart Centre Singapore, 169609 Singapore, Singapore.; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Chothani SP; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Huang B; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Xie C; National Heart Centre Singapore, 169609 Singapore, Singapore., Pua CJ; National Heart Centre Singapore, 169609 Singapore, Singapore., Chacko AM; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Guimarães-Camboa N; Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt 60590, Germany.; German Center for Cardiovascular Research DZHK, Berlin 10785, Germany.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Evans SM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA., Byrne AJ; Fibrosis Research Group, Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK., Maher TM; Fibrosis Research Group, Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.; NIHR Biomedical Research Unit, Royal Brompton Hospital, London SW7 2AZ, UK., Liang J; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Jiang D; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Noble PW; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Schafer S; National Heart Centre Singapore, 169609 Singapore, Singapore.; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore., Cook SA; National Heart Centre Singapore, 169609 Singapore, Singapore. stuart.cook@duke-nus.edu.sg.; Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.; National Heart and Lung Institute, Imperial College, London SW3 6LY, UK.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, UK.

المصدر: Science translational medicine [Sci Transl Med] 2019 Sep 25; Vol. 11 (511).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Idiopathic Pulmonary Fibrosis/*drug therapy , Interleukin-11/*therapeutic use, Animals ; Antibodies, Neutralizing/pharmacology ; Antibodies, Neutralizing/therapeutic use ; Bleomycin ; Fibroblasts/pathology ; Humans ; Idiopathic Pulmonary Fibrosis/pathology ; Interleukin-11 Receptor alpha Subunit/metabolism ; Lung/pathology ; Mice, Knockout ; Severity of Illness Index ; Signal Transduction ; Up-Regulation