نتائج البحث - "Chris Spahr"

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دورية أكاديمية

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes.

المصدر: PLoS ONE, Vol 7, Iss 11, p e49345 (2012)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3507880?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/4b03784bd0594b29a2d0316fd49362ba

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2

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe

المصدر: Journal of medicinal chemistry. 65(6)

مصطلحات موضوعية: Cell Death, Tubulin, Neoplasms, Drug Discovery, Molecular Medicine, Humans, Kinesins, Mitosis, Spindle Apparatus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b073c07dd2504a104516bc02d88ed4
https://pubmed.ncbi.nlm.nih.gov/35286090

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3

Abstract 1834: Identification of an Unexpected 4-Hydroxyproline (4-Hyp) in a CHO-Expressed IL-2 Mutein

المؤلفون: John Hui, Trace Tsuruda, John Robinson, Chris Spahr, Aiko Umeda, Shuai Wu, Iain Campuzano

المصدر: Journal of Biological Chemistry. 299:104072

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c1c2571928fb9dae0f1e4fc1957be0ce
https://doi.org/10.1016/j.jbc.2023.104072

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High Mass Analysis with a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: From Inorganic Salt Clusters to Antibody Conjugates and Beyond

المؤلفون: Jeremy J. Wolff, Joseph A. Loo, Piriya Wongkongkathep, Iain Campuzano, Huilin Li, Michael Nshanian, Chawita Netirojjanakul, Carter Lantz, Chris Spahr

المصدر: J Am Soc Mass Spectrom
Journal of the American Society for Mass Spectrometry, vol 31, iss 5

مصطلحات موضوعية: Immunoconjugates, Dimer, Analytical chemistry, Cesium, membrane proteins, 01 natural sciences, Mass Spectrometry, Fourier transform ion cyclotron resonance, Spectral line, Analytical Chemistry, law.invention, cesium iodide, chemistry.chemical_compound, Structural Biology, law, Monoclonal, nanodiscs, RNA, Small Interfering, Spectroscopy, Fourier Analysis, Antibodies, Monoclonal, monoclonal antibodies, Biotechnology, Physical Chemistry (incl. Structural), Bioengineering, Small Interfering, 010402 general chemistry, Orbitrap, Mass spectrometry, Antibodies, GroEL, Article, Ion, Medicinal and Biomolecular Chemistry, Immunoglobulin kappa-Chains, Maytansine, antibody drug conjugates, 010401 analytical chemistry, native-MS, Chaperonin 60, Cyclotrons, Iodides, 0104 chemical sciences, Molecular Weight, chemistry, siRNA, Immunoglobulin G, RNA, Salts, Conjugate

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e9e889b3f169a9dc6221a849864816
https://doi.org/10.1021/jasms.0c00030

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5

Rapid LC–MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins

المؤلفون: Iain D. G. Campuzano, Pascal F. Egea, James E. Keener, Amit Vaish, Michael T. Marty, Joseph A. Loo, Jennifer L. Lippens, Chris Spahr

المصدر: Analytical Chemistry. 90:13616-13623

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc58a913543e91a79489705f50ff8cfc
https://doi.org/10.1021/acs.analchem.8b03843

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6

High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein

المؤلفون: Stone D.-H. Shi, Kannan Gunasekaran, Chris Spahr, Kenneth W. Walker

المصدر: mAbs. 9:812-819

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14a75f9f95edd772a9fd5c2902d2f56
https://doi.org/10.1080/19420862.2017.1325556

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A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

المؤلفون: Dwight Winters, Todd Hager, Michael Hall, Shanaka Stanislaus, Murielle M. Véniant, Randy Ira Hecht, Chris Spahr, Lei Zhou, Jing Xu, Wei Wang, Yang Li, Junming Yie, Yue-Sheng Li, Liying Deng, Jennifer Weiszmann, Stephen Smith

المصدر: Endocrinology. 158:1314-1327

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, FGF21, Recombinant Fusion Proteins, 030209 endocrinology & metabolism, Plasma protein binding, Biology, Protein Engineering, medicine.disease_cause, Fibroblast growth factor, Diabetes Mellitus, Experimental, Mice, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Drug Stability, In vivo, 3T3-L1 Cells, Internal medicine, medicine, Animals, Humans, Potency, Obesity, Klotho Proteins, Mutation, Immunogenicity, Membrane Proteins, In vitro, Immunoglobulin Fc Fragments, Fibroblast Growth Factors, Mice, Inbred C57BL, Disease Models, Animal, Macaca fascicularis, HEK293 Cells, Treatment Outcome, 030104 developmental biology, Proteolysis, Anti-Obesity Agents, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e301d1ddf343756228eca215f2028d
https://doi.org/10.1210/en.2016-1917

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Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry as a Platform for Characterizing Multimeric Membrane Protein Complexes

المؤلفون: Pascal F. Egea, Iain D. G. Campuzano, Joseph A. Loo, Jennifer L. Lippens, Chris Spahr, Michael Nshanian

المصدر: Journal of the American Society for Mass Spectrometry, vol 29, iss 1

مصطلحات موضوعية: 0301 basic medicine, Protein Denaturation, Detergents, Analytical chemistry, Bioengineering, Mass spectrometry, Aquaporins, Micelle, Article, Dissociation (chemistry), Fourier transform ion cyclotron resonance, Mass Spectrometry, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Medicinal and Biomolecular Chemistry, Tetramer, Structural Biology, Tandem Mass Spectrometry, Native-mass spectrometry, Spectroscopy, Micelles, Chromatography, Liquid, Escherichia coli Proteins, Membrane Proteins, Equipment Design, Cyclotrons, 030104 developmental biology, Monomer, chemistry, Membrane protein, Membrane protein complex, Multiprotein Complexes, Protein Multimerization, Chromatography, Liquid, Physical Chemistry (incl. Structural)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3fc3ef0ede2c63b09e99c1e84bca5c
https://escholarship.org/uc/item/1mf09795

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Protected hinge in the immunoglobulin G2-A2 disulfide isoform

المؤلفون: Yaoqing Diana Liu, Chris Spahr, Leszek Poppe, Gregory C. Flynn, Robert Y.-T. Chou, Stone D.-H. Shi, Thomas M. Dillon

المصدر: Protein Science. 23:1753-1764

مصطلحات موضوعية: chemistry.chemical_classification, Gene isoform, Glycan, biology, Globular protein, Stereochemistry, Mutagenesis, Hinge, Biochemistry, Immunoglobulin G, law.invention, chemistry, law, biology.protein, Recombinant DNA, Antibody, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::73fb1dd8cccef952b8c4f2d0196858c0
https://doi.org/10.1002/pro.2557

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10

Recombinant human lecithin-cholesterol acyltransferase Fc fusion: Analysis of N- and O-linked glycans and identification and elimination of a xylose-based O-linked tetrasaccharide core in the linker region

المؤلفون: Richard Zhang, Zhen Xia, Justin Kim, Hsieng Sen Lu, Jennitte Stevens, Mingyue Zhou, Paul Kodama, Jay Tang, Sophia Siu, Chris Spahr, Sihong Deng, Noi Nuanmanee, Bram Estes

المصدر: Protein Science. 22:1739-1753

مصطلحات موضوعية: chemistry.chemical_classification, Glycan, Glycosylation, Consensus site, biology, Chemistry, Peptide, Biochemistry, Fusion protein, chemistry.chemical_compound, Acyltransferase, biology.protein, Tetrasaccharide, Molecular Biology, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2ee29fd84a9456a29f2701f4d003596f
https://doi.org/10.1002/pro.2373

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