-
1
المؤلفون: Jeffrey A. Engelman, Alice T. Shaw, Jennifer L. Harris, Makoto Nishio, Naoya Fujita, Elizabeth L. Lockerman, Sidra Mahmood, Peter McNamara, Su Hua, Xiuying Sun, Frank Sun, Shailaja Kasibhatla, Jie Li, AnneMarie C. Pferdekamper, Sungjoon Kim, Noriko Yanagitani, Mark M. Awad, Pierre-Yves Michellys, Adam S. Crystal, Justin F. Gainor, Christian C. Lee, Ryohei Katayama, Nanxin Li, Luc Friboulet
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbad5b9475ebf740303ecca033f51a2
https://doi.org/10.1158/2159-8290.22530507.v1 -
2
المؤلفون: Jeffrey A. Engelman, Alice T. Shaw, Jennifer L. Harris, Makoto Nishio, Naoya Fujita, Elizabeth L. Lockerman, Sidra Mahmood, Peter McNamara, Su Hua, Xiuying Sun, Frank Sun, Shailaja Kasibhatla, Jie Li, AnneMarie C. Pferdekamper, Sungjoon Kim, Noriko Yanagitani, Mark M. Awad, Pierre-Yves Michellys, Adam S. Crystal, Justin F. Gainor, Christian C. Lee, Ryohei Katayama, Nanxin Li, Luc Friboulet
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef66a8df7dccfca8800c87972d78cb6
https://doi.org/10.1158/2159-8290.22530510 -
3
المؤلفون: Jeffrey A. Engelman, Alice T. Shaw, Jennifer L. Harris, Makoto Nishio, Naoya Fujita, Elizabeth L. Lockerman, Sidra Mahmood, Peter McNamara, Su Hua, Xiuying Sun, Frank Sun, Shailaja Kasibhatla, Jie Li, AnneMarie C. Pferdekamper, Sungjoon Kim, Noriko Yanagitani, Mark M. Awad, Pierre-Yves Michellys, Adam S. Crystal, Justin F. Gainor, Christian C. Lee, Ryohei Katayama, Nanxin Li, Luc Friboulet
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ea846b0c38725c52287939c9514120
https://doi.org/10.1158/2159-8290.22530513 -
4
المؤلفون: Zhihong Huang, Jennifer Shaffer, Badry Bursulaya, Anna Galkin, Rie Kikkawa, Yelena Sarkisova, Su Hua, John Tellew, Yang Yang, Paul Vincent Rucker, Robert Epple, Jiqing Jiang, Nanxin Li, Chianelli Donatella, Jason Roland, Lintong Li, Sergio Briones, Casey J. N. Mathison, Valentina Molteni, Jacqueline Kinyamu-Akunda, Mu-Yun Gao, John Nelson, Christian C. Lee, Yun Feng Xie, Shailaja Kasibhatla, Chun Li
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Pyrimidine, biology, Kinase, Organic Chemistry, hERG, Cancer, Pharmacology, medicine.disease, Biochemistry, In vitro, chemistry.chemical_compound, Antitarget, chemistry, Tolerability, In vivo, Drug Discovery, biology.protein, medicine
-
5
المؤلفون: Mari Manuia, Wenshuo Lu, Laura J. Kingsley, Zhiwei Ma, Vicki Zhou, Darbi Witmer, Glen Spraggon, Mu-Yun Gao, Pierre-Yves Michellys, Min Lu, Yong Jia, Matthew McNeill, Sarah Greenblatt, Bender Steven Lee, Andreas Kreusch, Gerald Lelais, Xiaohui He, Victor Nikulin, Mei-Ting Vaillancourt, Christian C. Lee, Jacob R. Haling, John Nelson, Ajay A. Vashisht
المصدر: Journal of Medicinal Chemistry. 64:4857-4869
مصطلحات موضوعية: Drug, 0303 health sciences, Protease, Cancer cell proliferation, media_common.quotation_subject, medicine.medical_treatment, 01 natural sciences, 20s proteasome, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Biochemistry, Drug Discovery, medicine, Molecular Medicine, Structure based, Protein folding, Boronic acid, 030304 developmental biology, media_common
-
6
المؤلفون: Badry Bursulaya, Nanxin Li, Yang Yang, Chianelli Donatella, John Nelson, Casey J. N. Mathison, Valentina Molteni, Sergio Briones, Chun Li, Shailaja Kasibhatla, Christian C. Lee, Jason Roland, Zhihong Huang, Jiqing Jiang, Anna Galkin, John Tellew, Robert Epple, Jacqueline Kinyamu-Akunda, Yelena Sarkisova, Mu-Yun Gao, Rie Kikkawa, Lintong Li, Su Hua, Paul Vincent Rucker, Jennifer Shaffer, Yun Feng Xie
المصدر: ACS Medicinal Chemistry Letters. 11:558-565
مصطلحات موضوعية: Pyrimidine, biology, 010405 organic chemistry, Chemistry, Kinase, business.industry, Organic Chemistry, Kinase insert domain receptor, medicine.disease, 01 natural sciences, Biochemistry, Receptor tyrosine kinase, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Text mining, Tolerability, In vivo, Drug Discovery, Cancer research, biology.protein, medicine, Adenocarcinoma, business
-
7
المؤلفون: Ross Strang, Siem Jacob Veenstra, Christian C. Lee, Hans-Günter Zerwes, Joachim Blanz, Gebhard Thoma, Eric Vangrevelinghe, Jörg Berghausen
المصدر: Bioorganic & Medicinal Chemistry Letters. 25(20):4642-4647
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Administration, Oral, Biological Availability, Syk, Pharmaceutical Science, Pharmacology, Fostamatinib, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, Aurora kinase, Drug Discovery, medicine, Animals, Syk Kinase, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, PK/PD models, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Protein-Tyrosine Kinases, Rats, Disease Models, Animal, Thiazoles, Enzyme, chemistry, Rats, Inbred Lew, Micronucleus test, Microsomes, Liver, Molecular Medicine, medicine.drug
-
8
المؤلفون: Ryohei Katayama, Jennifer L. Harris, Sungjoon Kim, Jeffrey A. Engelman, Nanxin Li, Xiuying Sun, Luc Friboulet, Jie Li, Makoto Nishio, Justin F. Gainor, Alice T. Shaw, AnneMarie Culazzo Pferdekamper, Sidra Mahmood, Adam S. Crystal, Pierre-Yves Michellys, Mark M. Awad, Christian C. Lee, Shailaja Kasibhatla, Noriko Yanagitani, Su Hua, Frank Sun, Naoya Fujita, Peter McNamara, Elizabeth L. Lockerman
المصدر: Cancer Discovery. 4:662-673
مصطلحات موضوعية: Alectinib, Lung Neoplasms, Brigatinib, Pyridines, medicine.drug_class, Antineoplastic Agents, Mice, SCID, Biology, Article, Mice, Crizotinib, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, hemic and lymphatic diseases, medicine, Animals, Humans, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Sulfones, Lung cancer, Protein Kinase Inhibitors, Ceritinib, Receptor Protein-Tyrosine Kinases, medicine.disease, Lorlatinib, Tumor Burden, ALK inhibitor, Pyrimidines, Oncology, Drug Resistance, Neoplasm, Mutation, Cancer research, Pyrazoles, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3521888207101a6270a427636b3c56ee
https://doi.org/10.1158/2159-8290.cd-13-0846 -
9
المؤلفون: Tatyana Karabencheva, Christo Z. Christov, Christian C. Lee, Rossen M. Donev, Gary W. Black
المصدر: Mol. BioSyst.. 10:1490-1495
مصطلحات موضوعية: chemistry.chemical_classification, Flexibility (engineering), Protein Conformation, Mutant, Computational Biology, Receptor Protein-Tyrosine Kinases, Molecular Dynamics Simulation, Biology, C700, Crystallography, X-Ray, Protein Structure, Secondary, Protein Structure, Tertiary, Cell biology, Wild type enzyme, Enzyme, chemistry, Biochemistry, Catalytic Domain, hemic and lymphatic diseases, Mutation, Humans, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Molecular Biology, Biotechnology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e46e81c7e6edd00acf1dbb5f2cad6aa
https://doi.org/10.1039/c4mb00141a -
10
المؤلفون: Young Kim, Tove Tuntland, H. Martin Seidel, Thomas H. Marsilje, Nanxin Li, Wei Pei, You-Qun He, Xiaoming Cui, Wendy Richmond, Markus Warmuth, Auzon Steffy, Alex Aycinena, Sungjoon Kim, W. Perry Gordon, Donald S. Karanewsky, AnneMarie Culazzo Pferdekamper, Jin Yunho, Jonathan Chang, Ruo Steensma, Jennifer L. Harris, Bo Liu, Sean B. Joseph, Yelena Sarkisova, Christian C. Lee, Todd Groessl, Bei Chen, Wenshuo Lu, Chopiuk Greg, Tao Jiang, Kevin Johnson, Tetsuo Uno, Pierre-Yves Michellys, Jiqing Jiang, Andrew Phimister, Allen G. Li, Nathanael S. Gray, Badry Bursulaya, Frank Sun, Yongqin Wan, Jie Li
المصدر: Journal of Medicinal Chemistry. 56:5675-5690
مصطلحات موضوعية: Pyrimidine, Brigatinib, Ceritinib, Chemistry, medicine.drug_class, Rational design, Pharmacology, ALK inhibitor, chemistry.chemical_compound, In vivo, hemic and lymphatic diseases, Drug Discovery, medicine, Molecular Medicine, Anaplastic lymphoma kinase, Structure–activity relationship, medicine.drug