نتائج البحث - "Christopher E Mahoney"

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دورية أكاديمية

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77

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2

دورية أكاديمية

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

المؤلفون: Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c50

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3

دورية أكاديمية

Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH

المؤلفون: Eric L. Allen, Danielle B. Ulanet, David Pirman, Christopher E. Mahoney, John Coco, Yaguang Si, Ying Chen, Lingling Huang, Jinmin Ren, Sung Choe, Michelle F. Clasquin, Erin Artin, Zi Peng Fan, Giovanni Cianchetta, Joshua Murtie, Marion Dorsch, Shengfang Jin, Gromoslaw A. Smolen

المصدر: Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)

مصطلحات موضوعية: alpha-ketoglutarate dehydrogenase, oxoglutarate dehydrogenase, OGDH, citric acid cycle, TCA cycle, Krebs cycle, malate-aspartate shuttle, aspartate, cancer metabolism, target validation, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716312918; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/038a8ba083f6473f859242fde11df665

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Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas

المصدر: The American Journal of Human Genetics. 104:651-664

مصطلحات موضوعية: DLST, Adult, Male, 0301 basic medicine, Carcinogenesis, Citric Acid Cycle, Adrenal Gland Neoplasms, Loss of Heterozygosity, Pheochromocytoma, Biology, medicine.disease_cause, Article, Germline, Paraganglioma, Loss of heterozygosity, 03 medical and health sciences, 0302 clinical medicine, Germline mutation, Catalytic Domain, Basic Helix-Loop-Helix Transcription Factors, Genetics, medicine, Humans, Genetic Predisposition to Disease, cancer susceptibility gene, TCA cycle, Gene, Germ-Line Mutation, Genetics (clinical), Gene Expression Profiling, Correction, High-Throughput Nucleotide Sequencing, Methylation, DNA Methylation, Middle Aged, medicine.disease, Phenotype, 030104 developmental biology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Female, Acyltransferases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd586a03004b8250322c4b0219c4845
https://doi.org/10.1016/j.ajhg.2019.02.017

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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Squalene monooxygenase, Science, Cell, Chemical biology, General Physics and Astronomy, Antineoplastic Agents, 02 engineering and technology, Neuroendocrine tumors, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, Drug Delivery Systems, Cell Line, Tumor, medicine, Humans, lcsh:Science, Regulation of gene expression, Multidisciplinary, Cancer, General Chemistry, 021001 nanoscience & nanotechnology, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Cholesterol, Squalene Monooxygenase, Cell culture, Cancer cell, Cancer research, lcsh:Q, Drug Screening Assays, Antitumor, 0210 nano-technology, Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b9963f98863abf7bfee5a9413bdfc9
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77

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6

Preclinical toxicology profile of squalene epoxidase inhibitors

المؤلفون: Andrew J. Olaharski, Rohini Narayanaswamy, Janeta Popovici-Muller, Thomas P. Roddy, Lee Silverman, Raj Nagaraja, Gromoslaw A. Smolen, Stefan Gross, Christopher E. Mahoney, David Pirman

المصدر: Toxicology and applied pharmacology. 401

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43527cd1156cc4bf21aff21aac877d41
https://pubmed.ncbi.nlm.nih.gov/32522582

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Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH

المؤلفون: Erin Artin, Lingling Huang, Joshua Murtie, Danielle Ulanet, Giovanni Cianchetta, Zi Peng Fan, Jinmin Ren, Eric L. Allen, Michelle Clasquin, David Pirman, Ying Chen, Christopher E. Mahoney, Sung Choe, Gromoslaw A. Smolen, Yaguang Si, Marion Dorsch, Shengfang Jin, John Coco

المصدر: Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)

مصطلحات موضوعية: 0301 basic medicine, oxoglutarate dehydrogenase, Cell Respiration, Malate-aspartate shuttle, cancer metabolism, Computational biology, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Metabolomics, OGDH, Cell Line, Tumor, Neoplasms, alpha-ketoglutarate dehydrogenase, medicine, Animals, Humans, Ketoglutarate Dehydrogenase Complex, Enzyme Inhibitors, RNA, Small Interfering, TCA cycle, lcsh:QH301-705.5, chemistry.chemical_classification, Aspartic Acid, aspartate, Cancer, medicine.disease, Citric acid cycle, 030104 developmental biology, Enzyme, chemistry, Biochemistry, malate-aspartate shuttle, target validation, lcsh:Biology (General), Gene Knockdown Techniques, Cancer cell, citric acid cycle, Oxoglutarate dehydrogenase complex, Krebs cycle

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1abfa7781529d89e5650e094709755a
http://www.sciencedirect.com/science/article/pii/S2211124716312918

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Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

المؤلفون: Stephen Y. Chan, Bradley A. Maron, Joseph Loscalzo, Ying-Yi Zhang, Jane A. Leopold, Christopher E Mahoney, Diane E. Handy, Kevin P. White

المصدر: Circulation. 126:963-974

مصطلحات موضوعية: Male, medicine.medical_specialty, Nitric Oxide Synthase Type III, Hypertension, Pulmonary, Pulmonary Artery, Spironolactone, Nitric Oxide, Article, Nitric oxide, Rats, Sprague-Dawley, chemistry.chemical_compound, Mineralocorticoid receptor, Physiology (medical), Internal medicine, medicine, Animals, Humans, Familial Primary Pulmonary Hypertension, Cysteine, Pulmonary Wedge Pressure, Sulfhydryl Compounds, Pulmonary wedge pressure, Aldosterone, Cells, Cultured, Mineralocorticoid Receptor Antagonists, Endothelin-1, business.industry, Endothelial Cells, medicine.disease, Receptor, Endothelin B, Pulmonary hypertension, Endothelin 1, Rats, Disease Models, Animal, Oxidative Stress, Endocrinology, chemistry, Cardiology and Cardiovascular Medicine, Endothelin receptor, business, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9d7dba2e626ff7ea3d72c43a17cd2d
https://doi.org/10.1161/circulationaha.112.094722

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Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo

المؤلفون: Filomena G. Ottaviano, Joseph Loscalzo, Jane A. Leopold, Christopher E Mahoney, Diane E. Handy, Kevin Croce, Richard C Jin, Shiow-Shih Tang, Ying-Yi Zhang, Laura Coleman Anderson

المصدر: Circulation. 123:1963-1973

مصطلحات موضوعية: Blood Platelets, medicine.medical_specialty, Bleeding Time, Genotype, Platelet Aggregation, P-selectin, GPX3, Antioxidants, Article, Mice, chemistry.chemical_compound, Risk Factors, Physiology (medical), Internal medicine, Extracellular, medicine, Animals, Platelet, Platelet activation, Cyclic GMP, Mice, Knockout, chemistry.chemical_classification, Glutathione Peroxidase, Reactive oxygen species, business.industry, Glutathione peroxidase, Infarction, Middle Cerebral Artery, Thrombosis, Glutathione, Adenosine Diphosphate, Disease Models, Animal, P-Selectin, Endocrinology, chemistry, Immunology, Endothelium, Vascular, Reactive Oxygen Species, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf954987a87bf02889fea156b9a5f91
https://doi.org/10.1161/circulationaha.110.000034

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Abstract 3504: A chemical biology screen identifies a unique vulnerability of neuroendocrine cancer cells to SQLE inhibition

المصدر: Cancer Research. 78:3504-3504

مصطلحات موضوعية: Cancer Research, Oncology, Neuroendocrine Cancer, Chemical biology, Vulnerability, Computational biology, Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ef2047d40d97cff8dce69aae5c12daf6
https://doi.org/10.1158/1538-7445.am2018-3504

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