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1
المؤلفون: Jo Ann Davis, Christopher F. Bigge, Mehran Jalaie, Seungil Han, Jeffrey F. Ohren, Jing Chen, Noel A. Powell, Fred A. Ciske, Agustin Casimiro-Garcia, Teresa Ellis, Ronald J. Heemstra, Declan Flynn, Nadia Esmaeil
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:767-772
مصطلحات موضوعية: Models, Molecular, Pyridines, Pyridones, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Crystallography, X-Ray, Benzoates, Biochemistry, Partial agonist, Receptor, Angiotensin, Type 1, Inhibitory Concentration 50, Drug Discovery, medicine, Humans, Telmisartan, Receptor, Molecular Biology, ADME, chemistry.chemical_classification, Angiotensin II receptor type 1, Organic Chemistry, Imidazoles, Angiotensin II, PPAR gamma, chemistry, Molecular Medicine, Benzimidazoles, Angiotensin II Type 1 Receptor Blockers, Protein Binding, medicine.drug, Binding domain
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2
المؤلفون: Chad L. Stoner, Teresa Ellis, Robert Ostroski, Ronald J. Heemstra, Jeffrey F. Ohren, Nadia Esmaeil, Christopher F. Bigge, Geyer Andrew George, Jo Ann Davis, Mehran Jalaie, Declan Flynn, Filzen Gary Frederick, Agustin Casimiro-Garcia, Danette Dudley, Jeremy J. Edmunds, Robert P. Schaum, Jing Chen
المصدر: Journal of Medicinal Chemistry. 54:4219-4233
مصطلحات موضوعية: Blood Glucose, Male, Models, Molecular, Transcriptional Activation, medicine.medical_specialty, Pyridines, medicine.medical_treatment, Administration, Oral, Biological Availability, Peroxisome proliferator-activated receptor, Crystallography, X-Ray, Radioligand Assay, Structure-Activity Relationship, Insulin resistance, Rats, Inbred SHR, Internal medicine, Drug Discovery, Renin–angiotensin system, medicine, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Receptor, Antihypertensive Agents, Triglycerides, chemistry.chemical_classification, Insulin, Imidazoles, Stereoisomerism, medicine.disease, Angiotensin II, Rats, Drug Partial Agonism, PPAR gamma, Endocrinology, chemistry, Nuclear receptor, Molecular Medicine, Insulin Resistance, Angiotensin II Type 1 Receptor Blockers
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3
المؤلفون: Christopher F. Bigge, Teresa Padalino, James Pulaski, Kun Song, Wendy Collard, Kimberly A. Stevens, Christopher D. Kane, Lori Royer, Agustin Casimiro-Garcia, Bruce Auerbach, Jo Ann Davis, Patrick I. McConnell, Christine McGregor, Jeffrey F. Ohren
المصدر: Bioorganic & Medicinal Chemistry. 17:7113-7125
مصطلحات موضوعية: chemistry.chemical_classification, Agonist, Triglyceride, Stereochemistry, medicine.drug_class, Insulin, medicine.medical_treatment, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Phenylpropanoic acid, Biochemistry, Chemical synthesis, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, medicine, Molecular Medicine, Molecular Biology
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4
المؤلفون: Robert P. Schaum, Lakshmi Narasimhan, Agustin Casimiro-Garcia, Chad A. Van Huis, Danette Dudley, Kevin J. Filipski, Wayne L. Cody, Christopher F. Bigge, Michael Pamment, Jeremy J. Edmunds, Thomas B. McClanahan, Ronald J. Heemstra, Vaishali Sahasrabudhe, Robert J. Leadley, Igor Mochalkin, J. Thomas Peterson, Jeffrey T. Kohrt
المصدر: Bioorganic & Medicinal Chemistry. 17:2501-2511
مصطلحات موضوعية: Pyrrolidines, medicine.drug_mechanism_of_action, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Administration, Oral, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, In vivo, Oral administration, Drug Discovery, medicine, Humans, Molecular Biology, biology, Organic Chemistry, chemistry, Enzyme inhibitor, Lactam, biology.protein, Molecular Medicine, Half-Life
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5
المؤلفون: Yanhua Zhang, Christopher F. Bigge, Abdul Mutlib, Jeremy J. Edmunds, Hao Chen
المصدر: Chemical Research in Toxicology. 21:1095-1106
مصطلحات موضوعية: Male, Carboxylic acid, Reactive intermediate, Chlorobenzenes, Toxicology, Mass Spectrometry, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Liquid chromatography–mass spectrometry, Amide, Animals, Humans, Derivatization, chemistry.chemical_classification, Chromatography, Molecular Structure, Chemistry, General Medicine, Glutathione, Isocyanate, Rats, Enzyme Activation, Kinetics, Microsomes, Liver, Pyrazoles, Isocyanates, Conjugate
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6
المؤلفون: Christopher F. Bigge, Robert P. Schaum, Kathleen M. Welch, John W. Bryant, Chad A. Van Huis, Tawny K. Dahring, Vaisheli Sahasrabudhe, Ron Heemstra, Liguo Chi, Thomas B. McClanahan, Jeremy J. Edmunds, Jeffrey T. Kohrt, Staci Haarer, Erli Zhang, Robert J. Leadley, Wayne L. Cody, Lakshmi Narasimhan, Kevin J. Filipski, Agustin Casimiro-Garcia, Danette Dudley, Nancy Janiczek, J. Thomas Peterson
المصدر: Chemical Biology & Drug Design. 70:100-112
مصطلحات موضوعية: Male, Pyrrolidines, medicine.drug_mechanism_of_action, Pyridones, Stereochemistry, Antithrombin III, Factor Xa Inhibitor, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Proline, Pharmacology, Blood clotting, Chemistry, Organic Chemistry, Anticoagulants, Rats, Molecular Medicine, Rabbits, Pharmacophore
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7
المؤلفون: Wayne L. Cody, Staci Haarer, Erli Zhang, Chad A. Van Huis, Christopher F. Bigge, Lakshmi Narasimhan, Robert P. Schaum, John W. Bryant, Agustin Casimiro-Garcia, Thomas B. McClanahan, Danette Dudley, Kevin J. Filipski, Robert J. Leadley, Kathleen M. Welch, Jeremy J. Edmunds, Ronald J. Heemstra, Nancy Janiczek, Jeffrey T. Kohrt, J. Thomas Peterson
المصدر: Chemical Biology & Drug Design. 69:444-450
مصطلحات موضوعية: Models, Molecular, Drug, Time Factors, medicine.drug_mechanism_of_action, Chemistry, Pharmaceutical, media_common.quotation_subject, Antithrombin III, Factor Xa Inhibitor, Administration, Oral, Pharmacology, Biochemistry, Pyrrolidine, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Antithrombotic, medicine, Animals, Humans, media_common, Serine protease, biology, Blood clotting, Organic Chemistry, Pyrrolidonecarboxylic Acid, Bioavailability, Models, Chemical, chemistry, Drug Design, biology.protein, Molecular Medicine, Structure based, Crystallization, Protein Binding
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8
المؤلفون: Shrilakshmi Desiraju, Mohamad-Rami Jaber, Jeffrey T. Kohrt, Jeremy J. Edmunds, Christopher F. Bigge, Shaoyi Sun, Chad A. Van Huis, Wayne L. Cody, Agustin Casimiro-Garcia, Danette Dudley, Samarendra N. Maiti, Kevin J. Filipski
المصدر: Tetrahedron Letters. 47:7677-7680
مصطلحات موضوعية: chemistry.chemical_classification, Ligand, Chemistry, Aryl, Aryl halide, Organic Chemistry, Iodide, Halide, chemistry.chemical_element, Biochemistry, Combinatorial chemistry, Copper, Coupling reaction, Catalysis, chemistry.chemical_compound, Drug Discovery
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9
المؤلفون: Jeremy J. Edmunds, Ronald J. Heemstra, Kevin J. Filipski, Agustin Casimiro-Garcia, Danette Dudley, Christopher F. Bigge
المصدر: Expert Opinion on Therapeutic Patents. 16:119-145
مصطلحات موضوعية: Pharmacology, Serine protease, medicine.drug_mechanism_of_action, biology, medicine.drug_class, business.industry, Factor Xa Inhibitor, Anticoagulant, General Medicine, medicine.disease, Venous thrombosis, Thrombin, Drug development, Drug Discovery, Antithrombotic, medicine, biology.protein, business, Discovery and development of direct thrombin inhibitors, medicine.drug
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10
المؤلفون: Dong Liming, Xinjun Hou, Elizabeth A. Lunney, Corinne E. Augelli-Szafran, Deal Judith G, Christopher F. Bigge, Darin Vanderpool, Raymond Andrew Hudack, Nancy Sue Barta, Bradley William Caprathe, Chuangxing Guo, Steve Bender, Richard E. Showalter, Lorraine Kathleen Fay, Arindam Chatterjee
المصدر: Journal of Medicinal Chemistry. 49:1202-1206
مصطلحات موضوعية: Peptidylprolyl isomerase, Aza Compounds, Binding Sites, Neurite, Chemistry, Hydrogen Bonding, Biological activity, Tacrolimus Binding Protein 1A, Isoquinolines, Ligands, Amides, Heterocyclic Compounds, 4 or More Rings, Tacrolimus, Structure-Activity Relationship, Neuroprotective Agents, FKBP, Biochemistry, Cis-trans-Isomerases, Drug Discovery, Molecular Medicine, Structure–activity relationship, Binding site, Cognitive decline