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المؤلفون: Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7c495ed76df00defda047352171a57
https://doi.org/10.1158/1535-7163.c.6531858.v1 -
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المؤلفون: Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb53737462ca7c21b088c7e98afca976
https://doi.org/10.1158/1535-7163.22485255.v1 -
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المؤلفون: Jeremy M. Travins, Carl Crysler, Hufnagel Heather Rae, Karen DiLoreto, Norman Huebert, Michael X. Kolpak, Nalin L. Subasinghe, Jennifer Kirkpatrick, Stephen H. Eisennagel, Bruce E. Tomczuk, Wenxi Pan, Christopher J. Molloy, Ehab Khalil, Nisha S. Ninan, Shelley K. Ballentine, Kristi A. Leonard, Roger F. Bone, Richard Soll, Farah Ali, Michael D. Gaul
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5303-5307
مصطلحات موضوعية: ARDS, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Polyethylene glycol, Pharmacology, Biochemistry, Polyethylene Glycols, Classical complement pathway, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Potency, Protease Inhibitors, Molecular Biology, Complement C1s, Protease, Chemistry, Organic Chemistry, medicine.disease, Amides, Rats, Drug Design, PEGylation, Molecular Medicine, Half-Life
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المؤلفون: Cuifen Hou, Evan Opas, Dana L. Johnson, Monica Singer, Carl Crysler, James C. Lanter, Zhihua Sui, Fu-An Kang, Sandra McKenney, Xuqing Zhang, Nalin L. Subasinghe, Thomas P. Markotan, Christopher J. Molloy
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7496-7501
مصطلحات موضوعية: CCR2, Receptors, CCR2, Transgene, Clinical Biochemistry, hERG, Anti-Inflammatory Agents, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Mice, Transgenic, Inflammation, Pharmacology, Biochemistry, QT interval, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Molecular Biology, biology, Organic Chemistry, Amides, In vitro, Rats, chemistry, Acute Disease, biology.protein, Molecular Medicine, Piperidine, medicine.symptom
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المؤلفون: Christopher J. Molloy, Shelley K. Ballentine, Edward J. Yurkow, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Yanmin Chen, Sanath K. Meegalla, Carl L. Manthey, Mark J. Wall, Bruce E. Tomczuk, Carl R. Illig, Zhao Zhou, Jinsheng Chen, Kenneth J. Wilson, Mark R. Player, Robert R. Donatelli, Margery A. Chaikin
المصدر: Journal of Medicinal Chemistry. 54:7860-7883
مصطلحات موضوعية: Chemistry, medicine.drug_class, Stereochemistry, Arthritis, Carboxamide, Stereoisomerism, Pharmacology, medicine.disease, Anti-inflammatory, Colony stimulating factor 1 receptor, Pharmacokinetics, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Receptor
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المؤلفون: Danielle Lawrence, Yanmin Chen, Mark J. Wall, Carl L. Manthey, Christopher J. Molloy, Edward J. Yurkow, Kenneth J. Wilson, Sanath K. Meegalla, Dana L. Johnson, Carol F. Franks, Bruce E. Tomczuk, Lee Zeng, Shelley K. Ballentine, Baumann Christian Andrew, Zhao Zhou, Judith Baker, Robert R. Donatelli, Lisa Boczon, Carl Crysler, Carl R. Illig, Heidi Ott, Jinsheng Chen, Tuman Robert W, Margery A. Chaikin
المصدر: Molecular Cancer Therapeutics. 8:3151-3161
مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Lung Neoplasms, Myeloid, medicine.medical_treatment, Mice, Nude, Osteoclasts, Bone Neoplasms, Receptor, Macrophage Colony-Stimulating Factor, Cell Growth Processes, Receptor tyrosine kinase, Substrate Specificity, Rats, Sprague-Dawley, Colony stimulating factor 1 receptor, Mice, Piperidines, Osteoclast, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Internal medicine, medicine, Animals, Humans, Protein Kinase Inhibitors, biology, Growth factor, Imidazoles, Mammary Neoplasms, Experimental, Myeloid leukemia, medicine.disease, Immunohistochemistry, Xenograft Model Antitumor Assays, Rats, Leukemia, Myeloid, Acute, Leukemia, Endocrinology, medicine.anatomical_structure, fms-Like Tyrosine Kinase 3, Oncology, Cancer research, biology.protein, Female, FLT3 Inhibitor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1dcd64b489777dd1393ee065709ba7
https://doi.org/10.1158/1535-7163.mct-09-0255 -
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المؤلفون: Yanmin Chen, Christopher J. Molloy, Carl R. Illig, Margery A. Chaikin, Carl L. Manthey, Renee L. DesJarlais, Carl Crysler, Carsten Schubert, Sanath K. Meegalla, Mark R. Player, Jinsheng Chen, Shelley K. Ballentine, Bruce E. Tomczuk, Mark J. Wall, Kenneth J. Wilson
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3632-3637
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Drug Evaluation, Preclinical, Pharmaceutical Science, Receptor, Macrophage Colony-Stimulating Factor, Phenylenediamines, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Potency, Computer Simulation, Drug reaction, Enzyme Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Hydrogen Bonding, Stereoisomerism, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Structure based
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المؤلفون: Renee L. DesJarlais, Carl R. Illig, Shelley K. Ballentine, Margery A. Chaikin, M. Jonathan Rudolph, Carsten Schubert, Kenneth J. Wilson, Bruce E. Tomczuk, Jinsheng Chen, Mark R. Player, Ioanna Petrounia, Mark J. Wall, Christopher J. Molloy, Yanmin Chen, Sanath K. Meegalla, Carl Crysler, Carl L. Manthey
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1642-1648
مصطلحات موضوعية: Models, Molecular, Time Factors, medicine.drug_class, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Arthritis, Receptor, Macrophage Colony-Stimulating Factor, Pharmacology, Biochemistry, Anti-inflammatory, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Structure–activity relationship, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, Organic Chemistry, medicine.disease, In vitro, Enzyme inhibitor, biology.protein, Molecular Medicine, Collagen, Signal transduction
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المؤلفون: Renee L. DesJarlais, Hui Huang, Jennifer Kirkpatrick, Nalin L. Subasinghe, Norman Huebert, Gaul Michael David, Nisha S. Ninan, Joan Gushue, Jeremy M. Travins, Bruce E. Tomczuk, Roger F. Bone, Shelley K. Ballentine, Christopher J. Molloy, Kristi A. Leonard, Ehab Khalil, Hufnagel Heather Rae, Farah Ali, Maxwell D. Cummings, Richard M. Soll, Wenxi Pan, Carl Crysler
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1603-1606
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Disease, Pharmacology, Biochemistry, Structure-Activity Relationship, Classical complement pathway, Heterocyclic Compounds, Drug Discovery, medicine, Animals, Molecular Biology, Binding Sites, Complement C1s, Molecular Structure, biology, Chemistry, Organic Chemistry, medicine.disease, Rats, Complement (complexity), Transplant rejection, Complement system, Hereditary angioedema, Paroxysmal nocturnal hemoglobinuria, biology.protein, Molecular Medicine, Antibody, Half-Life
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المؤلفون: Jinsheng Chen, Carl L. Manthey, Kenneth J. Wilson, Marie Mazzulla, Margery A. Chaikin, Christopher J. Molloy, Bruce E. Tomczuk, Edward J. Yurkow, Shelley K. Ballentine, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Ioanna Petrounia, Robert R. Donatelli, Carl R. Illig, Lisa Boczon, Sanath K. Meegalla, Mark J. Wall, Raymond J. Patch, Mark R. Player
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:2097-2102
مصطلحات موضوعية: Macrophage colony-stimulating factor, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Fluorescence Polarization, Receptor, Macrophage Colony-Stimulating Factor, Quinolones, Biochemistry, Colony stimulating factor 1 receptor, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Structure–activity relationship, RNA, Messenger, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, Molecular Structure, biology, Reverse Transcriptase Polymerase Chain Reaction, Chemistry, Kinase, Macrophage Colony-Stimulating Factor, Macrophages, Cellular Assay, Organic Chemistry, Genes, fos, Rats, Mice, Inbred C57BL, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction, Spleen