المؤلفون: Frank S. Menniti, Thomas A. Chappie, Christopher J. Schmidt

المصدر: Frontiers in Neuroscience, Vol 14 (2021)

مصطلحات موضوعية: schizophrenia, PDE10A, basal ganglia, dopamine, cyclic nucleotide phosphodiesterase, medium spiny neuron, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2020.600178/full; https://doaj.org/toc/1662-453X

URL الوصول: https://doaj.org/article/3392190e8a0643758a898dc54d6963ec

المؤلفون: John F. Harms, Frank S. Menniti, Christopher J. Schmidt

المصدر: Frontiers in Neuroscience, Vol 13 (2019)

مصطلحات موضوعية: cGMP, PDE9A, phosphodiesterase inhibitor, nitric oxide, nitric oxide synthase, brain, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2019.00837/full; https://doaj.org/toc/1662-453X

URL الوصول: https://doaj.org/article/dd9e962be81043f1945350d390769c0a

المؤلفون: Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, Xuefeng Yan, Maia G. Van Buskirk, Madeline D. Jenkins, Jose A. Montero Santamaria, Kevin P. Maresca, Akihiro Takano, Jeih-San Liow, Thomas A. Chappie, Andrea Varrone, Sangram Nag, Lei Zhang, Zoë A. Hughes, Christopher J. Schmidt, Shawn D. Doran, Andrew Mannes, Paolo Zanotti-Fregonara, Maarten Ooms, Cheryl L. Morse, Sami S. Zoghbi, Christer Halldin, Victor W. Pike, Robert B. Innis

المصدر: Journal of Nuclear Medicine. 63:1919-1924

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::61c7d547cbcb5109418140c2b1e19428
https://doi.org/10.2967/jnumed.122.263838

المؤلفون: Nicholas DeMartinis, Rene N. Lopez, David P. Walling, Adam Ogden, Christopher J. Schmidt, Eve H. Pickering, Lev Gertsik

المصدر: Journal of Clinical Psychopharmacology. 39:318-328

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Phosphodiesterase Inhibitors, medicine.medical_treatment, Phases of clinical research, Placebo, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, Humans, Medicine, Pharmacology (medical), Antipsychotic, Psychiatric Status Rating Scales, Positive and Negative Syndrome Scale, business.industry, Middle Aged, 030227 psychiatry, Clinical trial, Psychiatry and Mental health, Tolerability, Adjunctive treatment, Quinolines, Schizophrenia, Pyrazoles, Drug Therapy, Combination, Female, business, 030217 neurology & neurosurgery, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdce8e5a6aa25fb13e8af6b79286f5a
https://doi.org/10.1097/jcp.0000000000001047

المؤلفون: Jan Mulder, Christopher J. Schmidt, Andrea Varrone, Christer Halldin, Balázs Gulyás, Ignacio Munoz-Sanjuan, Ladislav Mrzljak, Katarina Varnäs, Nicholas Mitsios, Marie Svedberg, Vahri Beaumont, Margaret M. Zaleska

المساهمون: Lee Kong Chian School of Medicine (LKCMedicine)

المصدر: Brain Research. 1711:140-145

مصطلحات موضوعية: 0301 basic medicine, business.industry, General Neuroscience, Putamen, Caudate nucleus, Striatum, Human brain, Nucleus accumbens, Phosphodiesterase 10A, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Basal ganglia, Radioligand, Autoradiography, Medicine, Medicine [Science], Neurology (clinical), PDE10A, business, Molecular Biology, Neuroscience, 030217 neurology & neurosurgery, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3664e55a5616ccc6b765cb33c90b48
https://doi.org/10.1016/j.brainres.2019.01.021

المؤلفون: Stacey Boyer, Christopher J. Schmidt, David P. Walling, Vikas Kumar Dawra, Anindita Banerjee, Nicholas DeMartinis

المصدر: Journal of clinical psychopharmacology. 39(6)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Psychosis, Exacerbation, Phosphodiesterase Inhibitors, Placebo, Severity of Illness Index, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, Internal medicine, medicine, Humans, Pharmacology (medical), Adverse effect, Risperidone, Positive and Negative Syndrome Scale, business.industry, Phosphoric Diester Hydrolases, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Dystonia, Treatment Outcome, Tolerability, Acute Disease, Quinolines, Schizophrenia, Pyrazoles, Female, business, 030217 neurology & neurosurgery, medicine.drug, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672fcd3ee36d6e579136303db2f106ce
https://pubmed.ncbi.nlm.nih.gov/31688451

المؤلفون: Frank S. Menniti, Christopher J. Schmidt, John F. Harms

المصدر: Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 13 (2019)

مصطلحات موضوعية: 0301 basic medicine, brain, Upstream and downstream (transduction), lcsh:RC321-571, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, nitric oxide, Phosphodiesterase inhibitor, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, biology, nitric oxide synthase, Chemistry, PDE9A, General Neuroscience, Phosphodiesterase, Cgmp signaling, Brain disease, Cell biology, cGMP, Nitric oxide synthase, 030104 developmental biology, cognitive disorders, biology.protein, phosphodiesterase inhibitor, Soluble guanylyl cyclase, 030217 neurology & neurosurgery, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac880c66bbd091e43c492af01fec7be2
https://doi.org/10.3389/fnins.2019.00837

المؤلفون: Ashley N. Hanks, Christopher J. Schmidt, Zoë A. Hughes, Joseph R. Hedde

المصدر: Brain, Behavior, and Immunity. 64:285-295

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Lipopolysaccharide, Immunology, Anti-Inflammatory Agents, Pharmacology, Peripheral blood mononuclear cell, 03 medical and health sciences, Behavioral Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, medicine, Translocator protein, Animals, Humans, Potency, Neuroinflammation, Inflammation, Motivation, Microglia, biology, Endocrine and Autonomic Systems, business.industry, Brain, Isoenzymes, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, chemistry, Rats, Inbred Lew, biology.protein, TLR4, Encephalitis, Tumor necrosis factor alpha, Phosphodiesterase 4 Inhibitors, Inflammation Mediators, business, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642d2b0738a62c3eca8e813b4a962252
https://doi.org/10.1016/j.bbi.2017.04.015

المؤلفون: Kimberly F. Fennell, Zhijun Kang, Hirokazu Ueno, William E. Hoffman, Mihály Hajós, Thomas Allen Chappie, Mary Piotrowski, Noha Maklad, Jayvardhan Pandit, John M. Humphrey, Anne W. Schmidt, Edward X. Yang, Patrick Robert Verhoest, Bethany L. Kormos, Jiemin Lu, Eric P. Arnold, Cheng Chang, Christopher J. Schmidt, Robin J. Kleiman, Rebecca E. O’Connor, John F. Harms, Scot Richard Mente, Christopher John Helal, Tracey Boyden, Chewah Lee, Laura McDowell, Michael D. Forman

المصدر: Journal of Medicinal Chemistry. 60:5673-5698

مصطلحات موضوعية: 0301 basic medicine, Drug, Dose calculation, Phosphodiesterase Inhibitors, media_common.quotation_subject, Pharmacology, Crystallography, X-Ray, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, In vivo, Drug Discovery, Animals, Humans, media_common, Chemistry, Brain, Phosphodiesterase, Haplorhini, Penetration (firestop), Cyclic nucleotide phosphodiesterases, Cyclic Nucleotide Phosphodiesterases, Type 2, Rats, Molecular Docking Simulation, 030104 developmental biology, Drug Design, Molecular Medicine, NMDA receptor, Structure based, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146c156bc1785305e9a93e6cd8b6147
https://doi.org/10.1021/acs.jmedchem.7b00397

المؤلفون: Taneli Heikkinen, J. Nikolaj Dybowski, Larry Park, Fernando E. Padovan-Neto, Amyaouch Bradaia, John F. Harms, Vahri Beaumont, Miklós Tóth, Esther Steidl, Sheng Zhong, Margaret M. Zaleska, Kristian Wadel, Ladislav Mrzljak, Kimmo Lehtimäki, Karen M. Ward, Shreaya Chakroborty, Sarah Elschenbroich, Christer Halldin, Andrea Varrone, Christopher J. Schmidt, Afshin Ghavami, WenJin Xu, Ignacio Munoz-Sanjuan, Mei Kwan, Jose Beltran, Bruno Buisson, Christoph Schaab, Jim Rosinski, Daniel J. Lavery, Anthony R. West, Jenny Häggkvist, Melanie Gleyzes, Hai Lin

المصدر: Neuron. 92:1220-1237

مصطلحات موضوعية: 0301 basic medicine, Phosphodiesterase Inhibitors, Striatum, Tritium, Indirect pathway of movement, Basal Ganglia, Mice, 03 medical and health sciences, Cyclic nucleotide, chemistry.chemical_compound, 0302 clinical medicine, Huntington's disease, Subthalamic Nucleus, Basal ganglia, Cyclic AMP, medicine, Animals, Cyclic GMP, Cerebral Cortex, Phosphoric Diester Hydrolases, General Neuroscience, Phosphodiesterase, medicine.disease, Neostriatum, Disease Models, Animal, Subthalamic nucleus, Huntington Disease, 030104 developmental biology, chemistry, Positron-Emission Tomography, Quinolines, Pyrazoles, PDE10A, Psychology, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6283f011b6d3412838635806368ccfc7
https://doi.org/10.1016/j.neuron.2016.10.064