المؤلفون: Ying Qin, Dekang Li, Chunting Qi, Huaijiang Xiang, Huyan Meng, Jingli Liu, Shaoqing Zhou, Xinyu Gong, Ying Li, Guifang Xu, Rui Zu, Hang Xie, Yechun Xu, Gang Xu, Zheng Zhang, Shi Chen, Lifeng Pan, Li Tan

المصدر: Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 319-334 (2024)

مصطلحات موضوعية: RIPK1, Necroptosis, Type-II kinase inhibitors, Rational design, Lead optimization, Structure‒activity relationship, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383523004215; https://doaj.org/toc/2211-3835

URL الوصول: https://doaj.org/article/d923a9cf0f7544d983270d45a93222cd

المؤلفون: Dimitry Ofengeim, Yasushi Ito, Ayaz Najafov, Yaoyang Zhang, Bing Shan, Judy Park DeWitt, Juanying Ye, Xumin Zhang, Ansi Chang, Helin Vakifahmetoglu-Norberg, Jiefei Geng, Benedicte Py, Wen Zhou, Palak Amin, Jonilson Berlink Lima, Chunting Qi, Qiang Yu, Bruce Trapp, Junying Yuan

المصدر: Cell Reports, Vol 10, Iss 11, Pp 1836-1849 (2015)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715002090; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/0178a95c3a344ac1b03cbe265055d0cc

المؤلفون: Tao Zhang, Kangyun Dong, Wei Liang, Daichao Xu, Hongguang Xia, Jiefei Geng, Ayaz Najafov, Min Liu, Yanxia Li, Xiaoran Han, Juan Xiao, Zhenzhen Jin, Ting Peng, Yang Gao, Yu Cai, Chunting Qi, Qing Zhang, Anyang Sun, Marta Lipinski, Hong Zhu, Yue Xiong, Pier Paolo Pandolfi, He Li, Qiang Yu, Junying Yuan

المصدر: eLife, Vol 4 (2015)

مصطلحات موضوعية: autophagy, ubiquitination, GPCR, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/06734; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/3e868138a8c44057ad78966bdd7397e1

المؤلفون: Shengyuan Zhang, Liang Li, Gang Xu, Junying Yuan, Yang Liu, Zheng Zhang, Yunyun Wang, Dekang Li, Jizhou Gou, Jing Qu, Ping Zhao, Zhuohao He, Liang Liu, Tongyang Xiao, Guowei Wu, Kangyun Dong, Chunting Qi, Taijie Jin, Ying Li, Yilun Tong, Haoran Peng

المصدر: Cell Research

مصطلحات موضوعية: 2019-20 coronavirus outbreak, Indoles, Coronavirus disease 2019 (COVID-19), viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Down-Regulation, Mice, Transgenic, Biology, Article, Mice, RIPK1, Animals, Humans, Lung, Molecular Biology, Coronavirus RNA-Dependent RNA Polymerase, SARS-CoV-2, Imidazoles, COVID-19, Cell Biology, Viral Load, Virus Internalization, Virology, COVID-19 Drug Treatment, ErbB Receptors, Survival Rate, Mechanisms of disease, Receptor-Interacting Protein Serine-Threonine Kinases, Mutation, Cytokines, Angiotensin-Converting Enzyme 2, Transcriptome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77a63a4d966a9c76bb02a1565e87aaa
https://doi.org/10.1038/s41422-021-00578-7

المؤلفون: Lingli Tan, Hengyue Shan, Chao Han, Zhenfeng Zhang, Jiali Shen, Xiao Zhang, Huaijiang Xiang, Kuankuan Lu, Chunting Qi, Ying Li, Guanglei Zhuang, Gang Chen, Li Tan

المصدر: Journal of medicinal chemistry. 65(20)

مصطلحات موضوعية: Lung Neoplasms, Deubiquitinating Enzymes, Endosomal Sorting Complexes Required for Transport, Carcinoma, Non-Small-Cell Lung, Drug Discovery, Endopeptidases, Proteostasis, Ubiquitination, Molecular Medicine, Humans, Ubiquitin Thiolesterase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb931c9cdff0731a01b07cb954c22ef
https://pubmed.ncbi.nlm.nih.gov/36221183

المؤلفون: Lifeng Lin, Kaixuan Shi, Shaoqing Zhou, Mei-Chun Cai, Caiyan Zhang, Yunheng Sun, Jingyu Zang, Lin Cheng, Kaiyan Ye, Pengfei Ma, Peiye Shen, Meiying Zhang, Yan Cheng, Chunting Qi, Ying Li, Xia Yin, Yiyan Zheng, Li Tan, Guanglei Zhuang, Rongyu Zang

المصدر: Oncogene. 41(12)

مصطلحات موضوعية: Ovarian Neoplasms, Cancer Research, PAX8 Transcription Factor, Cell Cycle, Genetics, SOXF Transcription Factors, Humans, Female, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8885c973a1a34033ee1b5d40b2caaf19
https://pubmed.ncbi.nlm.nih.gov/35124696

المؤلفون: Lei Yan, Jian-He Liu, Qing Zhang, Chunting Qi, Yu Chen, Jingli Liu, Qiang Yu

المصدر: BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
BMC Cancer

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, medicine.medical_treatment, PDGFRβ, Cell, Kidney, Receptor tyrosine kinase, Targeted therapy, 0302 clinical medicine, Surgical oncology, Molecular Targeted Therapy, Phosphorylation, Mice, Inbred BALB C, biology, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Kidney Neoplasms, Activation and function, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Heterografts, Female, Research Article, Stromal cell, Mice, Nude, Stroma cells, Clear cell renal cell carcinomas (ccRCCs), lcsh:RC254-282, 03 medical and health sciences, Cell Line, Tumor, Genetics, medicine, Animals, Humans, Receptor tyrosine kinases (RTKs), Carcinoma, Renal Cell, Gene, Aged, Cell Proliferation, Receptor Protein-Tyrosine Kinases, medicine.disease, Clear cell renal cell carcinoma, 030104 developmental biology, biology.protein, Cancer research, Neoplasm Transplantation, Clear cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe97106db47ae3ce137de5dfef49c34d
https://doi.org/10.1186/s12885-019-6159-2

المؤلفون: Qiang Yu, Junying Yuan, Chunting Qi, Xingyan Li, H. Wang, Dana E. Christofferson, Zhen Liu, Bing Shan, Guowei Wu, Huyan Meng, Taijie Jin, Ying Li

المصدر: Proceedings of the National Academy of Sciences. 115

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Cell Survival, Necroptosis, Amino Acid Motifs, Apoptosis, Proinflammatory cytokine, Mice, Necrosis, 03 medical and health sciences, RIPK1, Protein Domains, Animals, Humans, Phosphorylation, Kinase activity, Death domain, Inflammation, Multidisciplinary, Tumor Necrosis Factor-alpha, Chemistry, Genetic Complementation Test, Exons, Cell biology, Enzyme Activation, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, PNAS Plus, Protein kinase domain, Receptor-Interacting Protein Serine-Threonine Kinases, Mutation, Protein Multimerization, Protein Binding, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd3ecac21663459c4cdda307a6ab5b7
https://doi.org/10.1073/pnas.1722013115

المؤلفون: Ansi Chang, Palak Amin, Yaoyang Zhang, Junying Yuan, Bruce D. Trapp, Yasushi Ito, Qiang Yu, Helin Vakifahmetoglu-Norberg, Judy Park DeWitt, Bénédicte F. Py, Jonilson Berlink Lima, Wen Zhou, Bing Shan, Ayaz Najafov, Xumin Zhang, Jiefei Geng, Chunting Qi, Juanying Ye, Dimitry Ofengeim

المساهمون: Harvard Medical School [Boston] (HMS), Shanghai Institute of Materia Medica - Chinese Academy of Sciences [Shanghai], Fudan University [Shanghai], Karolinska Institutet [Stockholm], Cleveland Clinic, DUTOIT, Soizic

المصدر: Cell Reports, Vol 10, Iss 11, Pp 1836-1849 (2015)
Cell Reports
Cell Reports, 2015, 10 (11), pp.1836-1849. ⟨10.1016/j.celrep.2015.02.051⟩

مصطلحات موضوعية: Programmed cell death, Multiple Sclerosis, [SDV.IMM] Life Sciences [q-bio]/Immunology, Proteome, [SDV]Life Sciences [q-bio], Necroptosis, Apoptosis, Biology, Caspase 8, Article, General Biochemistry, Genetics and Molecular Biology, Proinflammatory cytokine, Mice, Necrosis, 03 medical and health sciences, RIPK1, 0302 clinical medicine, medicine, Animals, Humans, lcsh:QH301-705.5, 030304 developmental biology, Cerebral Cortex, 0303 health sciences, Tumor Necrosis Factor-alpha, Multiple sclerosis, medicine.disease, Oligodendrocyte, 3. Good health, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, Oligodendroglia, medicine.anatomical_structure, lcsh:Biology (General), Spinal Cord, Receptor-Interacting Protein Serine-Threonine Kinases, Immunology, Cancer research, [SDV.IMM]Life Sciences [q-bio]/Immunology, Tumor necrosis factor alpha, Protein Kinases, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d94d68f9409c57d0075a8453e5a5291
https://doi.org/10.1016/j.celrep.2015.02.051

المؤلفون: Qing Zhang, Jingli Liu, Jiawei Liu, Chunting Qi, Shan Kuang, Wuguo Li, Xiaoxiao Sun, Qiang Yu, Zhenhua Sima

المصدر: Cancer Science

مصطلحات موضوعية: STAT3 Transcription Factor, Cancer Research, Apoptosis, IκB kinase, Mitogen-activated protein kinase kinase, Janus kinase 2/signal transducer and activator of transcription 3 pathway, natural compound, Humans, tumor necrosis factor-α/nuclear factor-κB pathway, anticancer drug, Medicine, Chinese Traditional, Phosphorylation, CHUK, Janus kinase 2, MAP kinase kinase kinase, biology, Interleukin-6, Tumor Necrosis Factor-alpha, Chemistry, NF-kappa B, JAK-STAT signaling pathway, Original Articles, General Medicine, Janus Kinase 2, I-kappa B Kinase, Cell biology, Gene Expression Regulation, Neoplastic, HEK293 Cells, 2-Methoxystypandrone, Oncology, Cancer research, biology.protein, Cyclin-dependent kinase 9, Janus kinase, Naphthoquinones, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61cb6b4ffae4da737121094998ba553
https://doi.org/10.1111/cas.12359