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1دورية أكاديمية
المؤلفون: Hiba Khalidi, Anthonia Onasanwo, Barira Islam, Heeseung Jo, Ciarán Fisher, Rich Aidley, Iain Gardner, Frederic Y. Bois
المصدر: Frontiers in Pharmacology, Vol 13 (2022)
مصطلحات موضوعية: high-throughput, PBPK modelling, simulation, simcyp simulator, automated data collection, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Daniela Rodrigues, Bram Herpers, Sofia Ferreira, Heeseung Jo, Ciarán Fisher, Luke Coyle, Seung-Wook Chung, Jos C. S. Kleinjans, Danyel G. J. Jennen, Theo M. de Kok
المصدر: International Journal of Molecular Sciences, Vol 23, Iss 4, p 2213 (2022)
مصطلحات موضوعية: gefitinib, human intestinal organoids, molecular mechanisms, transcriptomics, toxicity, Biology (General), QH301-705.5, Chemistry, QD1-999
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Daniela Rodrigues, Luke Coyle, Barbara Füzi, Sofia Ferreira, Heeseung Jo, Bram Herpers, Seung-Wook Chung, Ciarán Fisher, Jos C. S. Kleinjans, Danyel Jennen, Theo M. de Kok
المصدر: International Journal of Molecular Sciences, Vol 23, Iss 3, p 1286 (2022)
مصطلحات موضوعية: doxorubicin, toxicity, human organoid models, molecular mechanisms, transcriptomics, Biology (General), QH301-705.5, Chemistry, QD1-999
وصف الملف: electronic resource
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المؤلفون: Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois, Masoud Jamei
المصدر: Drug Metabolism and Disposition. 50:957-967
مصطلحات موضوعية: Pharmacology, Liver, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Humans, Pharmaceutical Science, Drug Interactions, Models, Biological, Clonidine, Permeability
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a755250d51f6b5d0d0d0bd31005c40
https://doi.org/10.1124/dmd.121.000818 -
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المؤلفون: Frédéric Y. Bois, Ciarán Fisher, Ségolène Siméon, Iain Gardner, Katharina Brotzmann, Thomas Braunbeck, Steve Silvester, Richard Maclennan, Paul Walker
المصدر: Reproductive Toxicology. 98:300-303
مصطلحات موضوعية: Valproic Acid, Physiologically based pharmacokinetic modelling, medicine, Developmental toxicity, Zebrafish embryo, Pharmacology, Biology, Toxicology, medicine.drug
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6
المؤلفون: Susanne Hougaard Bennekou, Rabea Graepel, Marcel Leist, Annette Bitsch, Gladys Ouedraogo, Jan G. Hengstler, Sylvia Escher, Hennicke Kamp, Derek Knight, Manuel Pastor, Ulf Norinder, Sharon B. Stuard, Matthias Herzler, Andrew White, Ciarán Fisher, Bob van de Water, Dinant Kroese, Barbara Zdrazil
المصدر: Archives of Toxicology, 93(12), 3643-3667
Archives of Toxicologyمصطلحات موضوعية: 0301 basic medicine, Hazard (logic), Physiologically based pharmacokinetic modelling, Toxicodynamics, Computer science, Health, Toxicology and Mutagenesis, In silico, Computational biology, 010501 environmental sciences, Hazard analysis, Toxicology, Risk Assessment, 01 natural sciences, Hazardous Substances, Workflow, 03 medical and health sciences, Terminology as Topic, ddc:570, Toxicity Tests, Similarity (psychology), Animals, Humans, Computer Simulation, 0105 earth and related environmental sciences, Adverse Outcome Pathways, General Medicine, Models, Theoretical, Toxicokinetics, Chemical hazard, 030104 developmental biology
وصف الملف: application/pdf
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المؤلفون: Alejandro Aguayo-Orozco, Liliana Capinha, Nazanin Golbamaki, Enrico Mombelli, Matthias Wehr, Bart van der Burg, Daria Goldmann, Nanette G Vrijenhoek, Thomas Exner, Richard Maclennan, Katharina Brotzmann, Ulf Norinder, Oliver Hatley, Alice Limonciel, Thomas Braunbeck, Sylvia Escher, Barbara Zdrazil, Frédéric Y. Bois, Paul Jennings, Emilio Benfenati, Domenico Gadaleta, Jose Castel, Ciarán Fisher, Sankalp Jain, Anthony Long, Rabea Graepel, Laia Tolosa, Andrew White, Bob van de Water, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Annette Bitsch, Olivier Taboureau, Iain Gardner
المساهمون: AIMMS, Molecular and Computational Toxicology, Publica
المصدر: Toxicology in Vitro, 79:105269, 1-16. Elsevier Limited
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79مصطلحات موضوعية: Test strategy, Mechanistic hazard assessment, Adverse Outcome Pathways, Computer science, In silico, Gene Expression Profiling, Liver steatosis, Carboxylic Acids, General Medicine, Computational biology, Toxicology, AOP-network, Fatty Liver, Differentially expressed genes, Workflow, Action (philosophy), NAM, Read-across, Adverse Outcome Pathway, Animals, Humans, Computer Simulation, Zebrafish
وصف الملف: application/pdf
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المؤلفون: Jaffar Kisitu, Marcel Leist, Henner Hollert, Ciarán Fisher
مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, Cell Culture Techniques, 030226 pharmacology & pharmacy, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, ddc:570, Toxicokinetics, Animals, Humans, Pharmacokinetics, media_common, Pharmacology, chemistry.chemical_classification, Chromatography, Chemistry, Biomolecule, General Medicine, In vitro, Culture Media, Dissociation constant, Medical Laboratory Technology, 030104 developmental biology, Pharmaceutical Preparations, Cell culture, Lipophilicity, System parameters, ddc:540, Protein Binding
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbeaee9b9a4be5c9f34b364e86d5c12a
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57418 -
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المؤلفون: Anja Wilmes, Tobias Strassfeld, Harry Vrieling, Manoj Kumar, Balázs Mihalik, Costanza Rovida, Giorgia Pallocca, Nanette G Vrijenhoek, Ciarán Fisher, Bart van der Burg, Thomas Braunbeck, Xenia Dolde, Alice Krebs, Zofia Janstova, Béla Z. Schmidt, Wiebke Albrecht, Jan G. Hengstler, Tim Brecklinghaus, David A. Fluri, J. J. W. A. Boei, Thomas Exner, Marcel Leist, Tanja Waldmann, Jaffar Kisitu, Anna-Katharina Holzer, Manuel Pastor, Joh Dokler, Andrea Paola Cediel Ulloa, Paul Jennings, Barbara M.A. van Vugt-Lussenburg, Bas ter Braak, Bob van de Water, Anna Forsby, Maja Brajnik, Wolfgang Moritz, Catherine M. Verfaillie, Johannes P Schimming, Rebecca von Hellfeld, Alice Limonciel, Francois Busquet, Julianna Kobolák, Ugis Sarkans, Regina Stöber, Jessica Lundqvist, Andras Dinnyes
المساهمون: Molecular and Computational Toxicology, AIMMS
المصدر: Archives of Toxicology
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461مصطلحات موضوعية: 0301 basic medicine, Test data generation, Computer science, Health, Toxicology and Mutagenesis, Data validation, HAZARD ASSESSMENT, Toxicology, CELL-CULTURE PRACTICE, Documentation, Policy Making, Cells, Cultured, Zebrafish, media_common, EPITHELIAL-CELLS, General Medicine, data processing, GIVIMP, in vitro toxicology, metadata, nuclear receptor, Test (assessment), Strategy implementation, Europe, Data processing, In Vitro Systems, NEURAL CREST MIGRATION, Life Sciences & Biomedicine, REPRODUCTIVE TOXICITY, Risk Assessment, 03 medical and health sciences, SDG 17 - Partnerships for the Goals, ddc:570, Terminology as Topic, Toxicity Tests, media_common.cataloged_instance, Animals, Humans, European union, Retrospective Studies, In vitro toxicology, Electronic Data Processing, Metadata, Science & Technology, business.industry, 030111 toxicology, Reproducibility of Results, CALUX METHOD, IN-VITRO, Pipeline (software), DRUG DISCOVERY, 030104 developmental biology, Nuclear receptor, DEVELOPMENTAL NEUROTOXICITY DNT, Government Regulation, Software engineering, business, EMBRYONIC STEM-CELLS
وصف الملف: application/pdf; Print-Electronic
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المؤلفون: Carmen Pin, Julio Saez-Rodriguez, Laura I. Furlong, Ciarán Fisher, Loic Laplanche, Panuwat Trairatphisan, Sofia Ferreira, Brian Kevin Park
المصدر: Chemical Research in Toxicology
مصطلحات موضوعية: Pharmacology, 0303 health sciences, Systems toxicology, Computer science, Systems Biology, General Medicine, 010501 environmental sciences, Omics, Toxicology, 01 natural sciences, Data science, Models, Biological, Risk Assessment, 3. Good health, Omics data, 03 medical and health sciences, Drug development, Drug Development, Key (cryptography), Animals, Humans, 030304 developmental biology, 0105 earth and related environmental sciences