المؤلفون: DeMirci H; Biosciences Division, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States.; PULSE Institute, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States.; Department of Molecular Biology and Genetics, Koc University, 34450 Sariyer/Istanbul, Turkey., Rao Y; Biosciences Division, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States.; Departamento de Físico Química, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción 4030000, Chile., Stoffel GM; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Straße 10, D-35043 Marburg, Germany., Vögeli B; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Straße 10, D-35043 Marburg, Germany., Schell K; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Straße 10, D-35043 Marburg, Germany., Gomez A; Departamento de Físico Química, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción 4030000, Chile., Batyuk A; Linac Coherent Light Source, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States., Gati C; Biosciences Division, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States.; Structural Biology Department, Stanford University Stanford, California 94305, United States., Sierra RG; Linac Coherent Light Source, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States., Hunter MS; Linac Coherent Light Source, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States., Dao EH; Biosciences Division, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States.; PULSE Institute, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States., Ciftci HI; PULSE Institute, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States., Hayes B; Linac Coherent Light Source, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States., Poitevin F; Linac Coherent Light Source, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States., Li PN; Biosciences Division, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States.; Electrical Engineering Department, Stanford University Stanford, California 94305, United States., Kaur M; Structural Biology Department, Stanford University Stanford, California 94305, United States., Tono K; RIKEN SPring-8 Center, Sayo, Hyogo 679-5148, Japan.; Japan Synchrotron Radiation Research Institute, Sayo, Hyogo 679-5198, Japan., Saez DA; Departamento de Físico Química, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción 4030000, Chile.; Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción 00000, Chile., Deutsch S; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Walnut Creek, California 94720, United States., Yoshikuni Y; U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Walnut Creek, California 94720, United States., Grubmüller H; Department of Theoretical and Computational Biophysics, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany., Erb TJ; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Straße 10, D-35043 Marburg, Germany.; LOEWE Center for Synthetic Microbiology (SYNMIKRO), 35032 Marburg, Germany., Vöhringer-Martinez E; Departamento de Físico Química, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción 4030000, Chile., Wakatsuki S; Biosciences Division, SLAC National Accelerator Laboratory Menlo Park, California 94025, United States.; Structural Biology Department, Stanford University Stanford, California 94305, United States.

المصدر: ACS central science [ACS Cent Sci] 2022 Aug 24; Vol. 8 (8), pp. 1091-1101. Date of Electronic Publication: 2022 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE

المؤلفون: Ali TFS; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan., Ciftci HI; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Drug Discovery, Science Farm, Ltd., Kumamoto 862-0976, Japan., Radwan MO; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; National Research Centre, Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, Dokki, Cairo 12622, Egypt., Roshdy E; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.; Department of Chemistry, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526, Japan., Shawky AM; Science and Technology Unit (STU), Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Central Laboratory for Micro-Analysis, Minia University, Minia 61519, Egypt., Abourehab MAS; Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan., Otsuka M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Drug Discovery, Science Farm, Ltd., Kumamoto 862-0976, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.

المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Mar 31; Vol. 15 (4). Date of Electronic Publication: 2022 Mar 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Ciftci HI; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan., Radwan MO; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt., Sever B; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey., Hamdy AK; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Emirdağ S; Chemistry Department, Faculty of Science, Ege University, Izmir 35040, Turkey., Ulusoy NG; Chemistry Department, Faculty of Science, Ege University, Izmir 35040, Turkey., Sozer E; Chemistry Department, Faculty of Science, Ege University, Izmir 35040, Turkey., Can M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Engineering Sciences, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Izmir 35620, Turkey., Yayli N; Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Turkey., Araki N; Department of Tumor Genetics and Biology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan., Otsuka M; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan., Altintop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 11; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Pentacyclic Triterpenes/*chemistry, Apoptosis/drug effects ; Binding Sites ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Glioma/metabolism ; Glioma/pathology ; Half-Life ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Molecular Docking Simulation ; Pentacyclic Triterpenes/metabolism ; Pentacyclic Triterpenes/pharmacology

المؤلفون: Ciftci HI; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Bayrak N; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey., Yıldız M; Chemistry Department, Gebze Technical University, Gebze, Kocaeli, Turkey., Yıldırım H; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey., Sever B; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Otsuka M; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan. Electronic address: mfujita@kumammot-u.ac.jp., Tuyun AF; Department of Chemistry, Faculty of Science, Istanbul University, Fatih, Istanbul, Turkey. Electronic address: aftuyun@istanbul.edu.tr.

المصدر: Bioorganic chemistry [Bioorg Chem] 2021 Sep; Vol. 114, pp. 105160. Date of Electronic Publication: 2021 Jul 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Aminoquinolines/*pharmacology , Antineoplastic Agents/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins c-abl/*antagonists & inhibitors, Aminoquinolines/chemical synthesis ; Aminoquinolines/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; DNA Cleavage ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-abl/metabolism ; Structure-Activity Relationship

المؤلفون: Bayrak N; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey., Ciftci HI; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Yıldız M; Chemistry Department, Gebze Technical University, Gebze, Kocaeli, Turkey., Yıldırım H; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey., Sever B; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Otsuka M; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan. Electronic address: mfujita@kumammot-u.ac.jp., Tuyun AF; Department of Chemistry, Faculty of Science, Istanbul University, Fatih, Istanbul, Turkey. Electronic address: aftuyun@gmail.com.

المصدر: Chemico-biological interactions [Chem Biol Interact] 2021 Aug 25; Vol. 345, pp. 109555. Date of Electronic Publication: 2021 Jun 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Aminoquinolines/*chemistry , Aminoquinolines/*pharmacology , Antineoplastic Agents/*chemistry , Antineoplastic Agents/*pharmacology , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*pathology, Aminoquinolines/chemical synthesis ; Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Line, Tumor ; Chemistry Techniques, Synthetic ; Drug Screening Assays, Antitumor ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy

المؤلفون: Zeytün E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey., Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey., Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey., Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey., Ellakwa DE; Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Ocak Z; Department of Microbiology, Kocaeli State Hospital, Kocaeli 41300, Turkey., Ciftci HI; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan., Otsuka M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan., Radwan MO; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.

المصدر: Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2021; Vol. 21 (9), pp. 1099-1109.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101265649 Publication Model: Print Cited Medium: Internet ISSN: 1875-5992 (Electronic) Linking ISSN: 18715206 NLM ISO Abbreviation: Anticancer Agents Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins c-abl/*antagonists & inhibitors , Thiazoles/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-abl/metabolism ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry

المؤلفون: Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey., Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey., Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey., Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey., Ellakwa DE; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Cairo 11765, Egypt., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan., Radwan MO; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt., Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt., Otsuka M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan., Ciftci HI; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan., Ali TFS; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2020 Nov 07; Vol. 25 (21). Date of Electronic Publication: 2020 Nov 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Cyclooxygenase 2 Inhibitors/*pharmacology , Indoles/*pharmacology , Oxadiazoles/*pharmacology, A549 Cells ; Allosteric Site ; Animals ; Apoptosis ; Benzothiazoles/chemistry ; Catalytic Domain ; Cell Line, Tumor ; Cyclooxygenase 1/chemistry ; Cyclooxygenase 2/chemistry ; Drug Design ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; Erlotinib Hydrochloride/pharmacology ; HCT116 Cells ; Humans ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Molecular Docking Simulation ; Molecular Structure ; Sheep ; Structure-Activity Relationship ; Thiazoles/chemistry

المؤلفون: Ciftci HI; Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan., Can M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan.; Department of Engineering Sciences, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Havaalani Sosesi Caddesi No:25, 35620, Cigli/Izmir, Turkey., Ellakwa DE; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan.; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Greater Cairo, Nasr City, 11651, Egypt., Suner SC; Chemical and Chemical Processing, Vocational School of Lapseki, Canakkale Onsekiz Mart University, 17800, Canakkale, Turkey., Ibrahim MA; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, 12622, Egypt., Oral A; Department of Chemistry, Faculty of Science, Canakkale Onsekiz Mart University, 17020, Canakkale, Turkey., Sekeroglu N; Department of Horticulture, Faculty of Agriculture, Kilis 7 Aralik University, 79000, Kilis, Turkey., Özalp B; Section of Underwater Technology, Vocational School of Ocean Engineering, Canakkale Onsekiz Mart University, 17100, Canakkale, Turkey., Otsuka M; Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan. mfujita@kumamoto-u.ac.jp., Alparslan M; Faculty of Fisheries and Aquaculture, Izmir Katip Celebi University, 35620, Izmir, Turkey. m_alparslan@hotmail.com., Radwan MO; Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan. mohamedradwan@kumamoto-u.ac.jp.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto, 8620973, Japan. mohamedradwan@kumamoto-u.ac.jp.; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, 12622, Egypt. mohamedradwan@kumamoto-u.ac.jp.

المصدر: Investigational new drugs [Invest New Drugs] 2020 Oct; Vol. 38 (5), pp. 1326-1333. Date of Electronic Publication: 2020 Feb 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Porifera*, Antineoplastic Agents/*pharmacology , Biological Products/*pharmacology , Neoplasms/*drug therapy , Protein Kinase Inhibitors/*pharmacology , Receptor, Platelet-Derived Growth Factor beta/*antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors, Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Neoplasms/metabolism ; Turkey

المؤلفون: Radwan MO; Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto 8620976, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 8620973, Japan; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt., Ciftci HI; Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto 8620976, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 8620973, Japan., Ali TFS; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 8620973, Japan; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Koga R; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 8620973, Japan., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 8620973, Japan., Nakata A; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 3510198, Japan., Ito A; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan., Yoshida M; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 1138657, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 8620973, Japan. Electronic address: mfujita@kumamoto-u.ac.jp., Otsuka M; Department of Drug Discovery, Science Farm Ltd., 1-7-30-805 Kuhonji, Chuo-ku, Kumamoto 8620976, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 8620973, Japan. Electronic address: motsuka@gpo.kumamoto-u.ac.jp.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Oct 01; Vol. 30 (19), pp. 127458. Date of Electronic Publication: 2020 Aug 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Aminopyridines/*pharmacology , Cysteamine/*analogs & derivatives , Cysteamine/*pharmacology , Histone Deacetylase Inhibitors/*pharmacology , Sirtuin 2/*antagonists & inhibitors , Trityl Compounds/*pharmacology, Aminopyridines/chemical synthesis ; Aminopyridines/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cysteamine/metabolism ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Sirtuin 2/metabolism ; Structure-Activity Relationship ; Trityl Compounds/chemical synthesis ; Trityl Compounds/metabolism

المؤلفون: Bayrak N; Chemistry Department, Engineering Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey., Yıldırım H; Chemistry Department, Engineering Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey., Yıldız M; Chemistry Department, Gebze Technical University, Kocaeli, Turkey., Radwan MO; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo, Egypt., Otsuka M; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Ciftci HI; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Tuyun AF; Department of Chemistry, Faculty of Science, Istanbul University, Istanbul, Turkey.

المصدر: Chemical biology & drug design [Chem Biol Drug Des] 2020 Mar; Vol. 95 (3), pp. 343-354. Date of Electronic Publication: 2020 Jan 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemical synthesis , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy , Plastoquinone/*chemical synthesis , Protein Kinase Inhibitors/*chemical synthesis , Protein-Tyrosine Kinases/*antagonists & inhibitors, Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; DNA Cleavage/drug effects ; Drug Screening Assays, Antitumor ; Halogenation ; Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/standards ; Plastoquinone/metabolism ; Plastoquinone/pharmacology ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Structure-Activity Relationship