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المؤلفون: DeRatt LG; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Zhang Z; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Pietsch C; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Cisar JS; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Zhang X; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Wang W; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Tanner A; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Matico R; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Shaffer P; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Kazmi F; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Shukla N; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Bush TL; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Patrick A; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Philippar U; Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Attar R; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Edwards JP; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Kuduk SD; Janssen Research and Development, Spring House, Pennsylvania 19477, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11254-11272. Date of Electronic Publication: 2024 Jun 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dihydroorotate Dehydrogenase* , Oxidoreductases Acting on CH-CH Group Donors*/antagonists & inhibitors , Oxidoreductases Acting on CH-CH Group Donors*/metabolism , Leukemia, Myeloid, Acute*/drug therapy , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use , Enzyme Inhibitors*/pharmacokinetics, Humans ; Animals ; Structure-Activity Relationship ; Drug Discovery ; Rats ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacokinetics ; Quinolones/chemistry ; Quinolones/pharmacology ; Quinolones/therapeutic use ; Quinolones/pharmacokinetics ; Quinolones/chemical synthesis ; Cell Line, Tumor ; Molecular Docking Simulation

المؤلفون: DeRatt LG; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Pietsch EC; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Cisar JS; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Jacoby E; Janssen Pharmaceutical Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Kazmi F; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Matico R; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Shaffer P; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Tanner A; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Wang W; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Attar R; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Edwards JP; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States., Kuduk SD; Janssen Pharmaceutical Research and Development, 1400 McKean Rd., Spring House, Pennsylvania 19477, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Feb 07; Vol. 15 (3), pp. 381-387. Date of Electronic Publication: 2024 Feb 07 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Cisar JS; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Pietsch C; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., DeRatt LG; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Kazmi F; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Keohane C; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Legenski K; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Matico R; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Shaffer P; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Simonnet Y; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Tanner A; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Wang CY; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Wang W; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Attar R; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States., Edwards JP; Janssen Research and Development, San Diego, California 92121, United States., Kuduk SD; Janssen Research and Development, 1400 McKean Rd, Spring House, Pennsylvania 19477, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11241-11256. Date of Electronic Publication: 2022 Aug 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dihydroorotate Dehydrogenase*/antagonists & inhibitors , Leukemia, Myeloid, Acute*/drug therapy, Drug Design ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Humans

المؤلفون: Reardon HT; Abide Therapeutics, San Diego, CA, USA., Herbst RA; Abide Therapeutics, San Diego, CA, USA., Henry CL; Abide Therapeutics, San Diego, CA, USA., Herbst DM; Abide Therapeutics, San Diego, CA, USA., Ngo N; Abide Therapeutics, San Diego, CA, USA., Cisar JS; Abide Therapeutics, San Diego, CA, USA.; Janssen Research & Development, Spring House, PA., Weber OD; Abide Therapeutics, San Diego, CA, USA., Niphakis MJ; Abide Therapeutics, San Diego, CA, USA., O'Neill GP; Abide Therapeutics, San Diego, CA, USA.

المصدر: SLAS technology [SLAS Technol] 2019 Oct; Vol. 24 (5), pp. 489-498. Date of Electronic Publication: 2019 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-6311 (Electronic) Linking ISSN: 24726303 NLM ISO Abbreviation: SLAS Technol Subsets: MEDLINE

مواضيع طبية MeSH: Microfluidics/*methods , Proteomics/*methods, Algorithms ; Animals ; Biological Assay ; Mice ; Molecular Weight ; Reproducibility of Results

المؤلفون: Clapper JR; Abide Therapeutics, San Diego, California., Henry CL; Abide Therapeutics, San Diego, California., Niphakis MJ; Abide Therapeutics, San Diego, California., Knize AM; Abide Therapeutics, San Diego, California., Coppola AR; Abide Therapeutics, San Diego, California., Simon GM; Abide Therapeutics, San Diego, California., Ngo N; Abide Therapeutics, San Diego, California., Herbst RA; Abide Therapeutics, San Diego, California., Herbst DM; Abide Therapeutics, San Diego, California., Reed AW; Abide Therapeutics, San Diego, California., Cisar JS; Abide Therapeutics, San Diego, California., Weber OD; Abide Therapeutics, San Diego, California., Viader A; Abide Therapeutics, San Diego, California., Alexander JP; Abide Therapeutics, San Diego, California., Cunningham ML; Abide Therapeutics, San Diego, California., Jones TK; Abide Therapeutics, San Diego, California., Fraser IP; Abide Therapeutics, San Diego, California., Grice CA; Abide Therapeutics, San Diego, California., Ezekowitz RAB; Abide Therapeutics, San Diego, California., O'Neill GP; Abide Therapeutics, San Diego, California., Blankman JL; Abide Therapeutics, San Diego, California jackie@abidetx.com.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2018 Dec; Vol. 367 (3), pp. 494-508. Date of Electronic Publication: 2018 Oct 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids/*metabolism , Enzyme Inhibitors/*pharmacology , Monoacylglycerol Lipases/*antagonists & inhibitors, Analgesics/pharmacology ; Animals ; Antipruritics/pharmacology ; Arachidonic Acids/metabolism ; Brain/drug effects ; Brain/metabolism ; Cell Line, Tumor ; Cyclooxygenase Inhibitors/pharmacology ; Glycerides/metabolism ; Humans ; Hydrolysis/drug effects ; Male ; Mice ; Mice, Inbred ICR ; PC-3 Cells ; Pain/drug therapy ; Pain/metabolism ; Piperidines/pharmacology ; Prostaglandins/pharmacology ; Rats ; Rats, Sprague-Dawley ; Rodentia

المؤلفون: Cisar JS; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Weber OD; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Clapper JR; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Blankman JL; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Henry CL; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Simon GM; Vividion Therapeutics , 3565 General Atomics Court, Suite 100 , San Diego , California 92121 , United States., Alexander JP; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Jones TK; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Ezekowitz RAB; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., O'Neill GP; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Grice CA; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Oct 25; Vol. 61 (20), pp. 9062-9084. Date of Electronic Publication: 2018 Aug 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Monoacylglycerol Lipases/*antagonists & inhibitors , Nervous System Diseases/*drug therapy , Nervous System Diseases/*enzymology , Piperazine/*pharmacology , Piperazines/*pharmacology , Pyrrolidines/*pharmacology, Animals ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Male ; Mice ; Molecular Targeted Therapy ; Pain/drug therapy ; Pain/enzymology ; Piperazine/pharmacokinetics ; Piperazine/therapeutic use ; Piperazines/pharmacokinetics ; Piperazines/therapeutic use ; Pyrrolidines/pharmacokinetics ; Pyrrolidines/therapeutic use ; Rats ; Tissue Distribution

المؤلفون: Lun S; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Guo H, Adamson J, Cisar JS, Davis TD, Chavadi SS, Warren JD, Quadri LE, Tan DS, Bishai WR

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Oct; Vol. 57 (10), pp. 5138-40. Date of Electronic Publication: 2013 Jul 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Lung/*drug effects , Mycobacterium tuberculosis/*drug effects , Oxazoles/*metabolism, Animals ; Female ; Lung/metabolism ; Lung/microbiology ; Mice ; Mice, Inbred BALB C ; Random Allocation

المؤلفون: Li J; Department of Chemistry, Texas A&M University, PO Box 30012, College Station, Texas 77842-3012, USA., Cisar JS, Zhou CY, Vera B, Williams H, Rodríguez AD, Cravatt BF, Romo D

المصدر: Nature chemistry [Nat Chem] 2013 Jun; Vol. 5 (6), pp. 510-7. Date of Electronic Publication: 2013 May 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

مواضيع طبية MeSH: Alkynes/*chemistry , Antineoplastic Agents/*chemistry , Antineoplastic Agents/*pharmacology , Biological Products/*chemistry , Diterpenes/*chemistry , Diterpenes/*pharmacology, Alkenes/chemistry ; Amination ; Aziridines/chemistry ; Catalysis ; Cell Survival/drug effects ; HL-60 Cells ; Humans ; Proteomics ; Rhodium/chemistry ; Structure-Activity Relationship

المؤلفون: Cisar JS; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA., Cravatt BF

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2012 Jun 27; Vol. 134 (25), pp. 10385-8. Date of Electronic Publication: 2012 Jun 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Drug Delivery Systems* , Small Molecule Libraries*/pharmacology, Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Inhibitory Concentration 50 ; Molecular Structure ; Phenotype ; Protein Binding