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1دورية أكاديمية
المؤلفون: Julie A Tucker, Neil Bennett, Claire Brassington, Stephen T Durant, Giles Hassall, Geoff Holdgate, Mark McAlister, J Willem M Nissink, Caroline Truman, Martin Watson
المصدر: PLoS ONE, Vol 7, Iss 12, p e50889 (2012)
وصف الملف: electronic resource
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المؤلفون: John Brognard, Owen J. Sansom, Tony Hunter, Crispin J. Miller, Ewelina Testoni, Matthew Collier, Ross Overman, Isabelle Green, Chris Phillips, Hannah K. Pollard, Claire Brassington, Jon A. Read, Lorena A. Puto, Phil Chapman, Susan Mason, Karen Blyth, Yaoyong Li, Eleanor W. Trotter, Hayeon Baik, Natalie L. Stephenson, Anna A. Marusiak
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0722c76c95b7bbc4901db1e2b3ae68
https://doi.org/10.1158/0008-5472.22409912 -
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المؤلفون: Haris Jahic, Kerry E. Murphy-Benenato, P. Ann Boriack-Sjodin, Dan Carcanague, Jenna Harang, Tina Howard, Claire Brassington, Madhusudhan Reddy Gowravaram, Charles J. Eyermann, Lakshmaiah Gingipalli, Herbert Oguto, Sahil Patel, Robert A. Giacobbe, Ludovic Otterbein, Amy Kutschke, James T. Loch, Georgine Ioannidis, Valerie A. Laganas, Michael R. Hale, Adam B. Shapiro, Kevin J. Embrey, Matthew D. Miller
المصدر: Tetrahedron Letters. 56:3108-3112
مصطلحات موضوعية: chemistry.chemical_classification, DNA ligase, biology, Organic Chemistry, biology.organism_classification, Biochemistry, Adenosine, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, medicine, NAD+ kinase, Binding site, LIGA, DNA, Bacteria, medicine.drug
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المؤلفون: Claire Brassington, Giles Hassall, David Whittaker, Richard A. Ward, Alexander L. Breeze, Jonathan Wingfield, Julie A. Tucker, Richard A. Norman, Ryan Greenwood, Martin Vogtherr, Stuart E. Pearson, Kevin Hudson, Jon Winter, Susan E. Critchlow, Gareth M. Davies, Alessandro T. Caputo, Michael Mrosek, Geoffrey A. Holdgate, Louise Goodwin, Jonathan Tart
المصدر: Journal of Medicinal Chemistry. 55:3285-3306
مصطلحات موضوعية: Models, Molecular, Niacinamide, Magnetic Resonance Spectroscopy, Stereochemistry, Lactate dehydrogenase A, Plasma protein binding, Crystallography, X-Ray, Isozyme, Cofactor, Structure-Activity Relationship, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, education, Enzyme Assays, Oxamic Acid, education.field_of_study, L-Lactate Dehydrogenase, Molecular Structure, biology, Chemistry, Nuclear magnetic resonance spectroscopy, Surface Plasmon Resonance, Oxidoreductase inhibitor, Small molecule, Malonates, Rats, Isoenzymes, Biochemistry, Drug Design, biology.protein, Molecular Medicine, Lactate Dehydrogenase 5, Protein Binding
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المؤلفون: Tina Howard, Franco H. Falcone, Paul Gellert, G. Sebastiaan Winkler, Judit E. Debreczeni, Claire Brassington, Ross Overman, Snow Stolnik, Naim Hage, Christopher R. Phillips
المصدر: 'Science Advances ', vol: 1, pages: e1500315-1-e1500315-9 (2015)
Science Advancesمصطلحات موضوعية: Conformational change, Bacterial adhesion, Biology, 03 medical and health sciences, Antigen, Binding site, Research Articles, 030304 developmental biology, X-ray crystallography, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, Helicobacter pylori, 030306 microbiology, SciAdv r-articles, Bacteriology, biology.organism_classification, Molecular biology, LewisB, Protein tertiary structure, digestive system diseases, 3. Good health, Amino acid, Dissociation constant, Biochemistry, chemistry, BabA, Adhesin, Bacterial outer membrane, Research Article
وصف الملف: PDF; application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ed0340c97d9334a87256b7b4054f39
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المؤلفون: Ewelina Testoni, Matthew Collier, Isabelle Green, Christopher R. Phillips, Claire Brassington, Yaoyong Li, Phil Chapman, Ross Overman, Crispin J. Miller, Hannah Pollard, Karen Blyth, Lorena A. Puto, Eleanor W. Trotter, Susan M. Mason, Anna A. Marusiak, Tony Hunter, Owen J. Sansom, John Brognard, Hayeon Baik, Jon Read, Natalie L. Stephenson
المصدر: Cancer research. 76(3)
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Carcinogenesis, MAP Kinase Signaling System, p38 mitogen-activated protein kinases, Mice, Nude, Biology, medicine.disease_cause, Article, MAP2K7, 03 medical and health sciences, Mice, CDKN2B, medicine, Animals, Humans, Mutation, Mice, Inbred BALB C, MAP kinase kinase kinase, Kinase, MAP Kinase Kinase Kinases, Molecular biology, Xenograft Model Antitumor Assays, 030104 developmental biology, Oncology, Colonic Neoplasms, Cancer research, Female, Signal transduction, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b269b8d8e2babc7c88b71cafcfdf84be
https://pubmed.ncbi.nlm.nih.gov/26637668 -
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المؤلفون: Malcolm Anderson, Julie A. Tucker, Ross Overman, Kevin J. Embrey, Kevin Blades, M. Raymond V. Finlay, Alexander L. Breeze, Gary Fairley, Jon Winter, Claire Brassington, S. Joe Patel, Christine M. Chresta, Gail L. Wrigley, Loredana Spadola, Thorsten Nowak, Paul Faulder, Jason Grant Kettle, Paula Perkins, Jonathan Tart
المصدر: Journal of medicinal chemistry. 58(5)
مصطلحات موضوعية: Models, Molecular, GTP', Protein Conformation, Mutant, GTPase, medicine.disease_cause, Crystallography, X-Ray, Proto-Oncogene Proteins p21(ras), Small Molecule Libraries, Drug Discovery, medicine, Humans, HRAS, Binding site, Binding Sites, Molecular Structure, Chemistry, Biochemistry, Covalent bond, Mutation, Biophysics, Molecular Medicine, KRAS, Small molecule binding, SOS1 Protein, Protein Binding
وصف الملف: application/pdf
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المؤلفون: J. Willem M. Nissink, Neil Bennett, Mark S. B. McAlister, Stephen T. Durant, Julie A. Tucker, Martin J Watson, Claire Brassington, Giles Hassall, Caroline Truman, Geoff Holdgate
المصدر: PLoS ONE
PLoS ONE, Vol 7, Iss 12, p e50889 (2012)مصطلحات موضوعية: Protein Structure, Glycoside Hydrolases, Protein Conformation, Biophysics, lcsh:Medicine, DNA repair, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Protein structure, Catalytic Domain, Ribose, Drug Discovery, Molecular Cell Biology, Macromolecular Structure Analysis, Structure–activity relationship, Humans, Biomacromolecule-Ligand Interactions, lcsh:Science, Poly(ADP-ribose) glycohydrolase, Biology, chemistry.chemical_classification, PARG, Multidisciplinary, lcsh:R, Computational Biology, Proteins, Isothermal titration calorimetry, DNA, Small molecule, Enzymes, Nucleic acids, Enzyme, chemistry, Enzyme Structure, lcsh:Q, Research Article, Signal Transduction
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المؤلفون: Janet D. Culshaw, Jason Breed, M. Raymond V. Finlay, Julie A. Tucker, J.J. Stanway, Claire Brassington, Kate Byth, Andy Barker, Malcolm Anderson, Nash Ian Alun, Richard A. Pauptit, Andrew D. Roberts, Andrew Peter Thomas, Hazel M. Weir, Michael A. Walker, David M. Andrews, Nicholas John Newcombe, Eric Fisher, Dave W. Heaton, Helen H.J. McMiken, Clive Green, Sandra E. Oakes
المصدر: Bioorganicmedicinal chemistry letters. 18(20)
مصطلحات موضوعية: Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Cell Cycle Proteins, Crystallography, X-Ray, Biochemistry, Sulfone, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Cyclin-dependent kinase, Drug Discovery, Transferase, Imidazole, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Aniline Compounds, biology, Kinase, Organic Chemistry, Imidazoles, Hydrogen Bonding, Cyclin-Dependent Kinases, Enzyme, chemistry, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, CDK inhibitor