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المؤلفون: Marko Breznik, Yunhui Ge, Joseph P. Bluck, Hans Briem, David F. Hahn, Clara D. Christ, Jérémie Mortier, David L. Mobley, Katharina Meier
المصدر: ChemMedChem. 18
مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry
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المؤلفون: Ingo Hartung, Masoud Vedadi, Magda Szewczyk, Volker Badock, Carlo Stresemann, Holger Steuber, Dalia Barsyte-Lovejoy, Shawna Organ, Norbert Schmees, Clara D. Christ, Detlef Stoeckigt, Steven Kennedy, Stefan Gradl, Cheryl H. Arrowsmith, Megha Abbey, Stephan Siegel, Andrea Haegebarth, Manfred Husemann, Fengling Li, Marcus Bauser, Joerg Weiske, Irene Chau, Viacheslav V. Trush, Peter Brown
المصدر: SLAS Discovery. 26:947-960
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Thermal shift assay, High-throughput screening, Antineoplastic Agents, MAP3K2, Biochemistry, Analytical Chemistry, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Humans, Binding site, Protein kinase A, Kinase, Drug discovery, Chemistry, Hydrogen Bonding, Isothermal titration calorimetry, Histone-Lysine N-Methyltransferase, High-Throughput Screening Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Binding, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31088aa45c9fd48a4764afae98765927
https://doi.org/10.1177/24725552211019409 -
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المؤلفون: Andrea Hägebarth, Carl Friedrich Nising, Philip Lienau, Julien Lefranc, Benjamin Bader, Clara D. Christ, Volker K Schulze, Clara Lemos, Simon Holton, Tobias Heinrich, Ulf Bömer, Franz von Nussbaum, Hans Briem, Ekaterina Nevedomskaya, Simon J. Baumgart, Dominik Mumberg, Bernard Haendler, Marcus Bauser, Lara Kuhnke
المصدر: Cellular Oncology. 44:581-594
مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Antineoplastic Agents, AMP-Activated Protein Kinases, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Cell Line, Tumor, Lipid droplet, medicine, Humans, Enzyme Inhibitors, Protein kinase A, Chemistry, Kinase, Prostatic Neoplasms, AMPK, Lipid metabolism, General Medicine, medicine.disease, Androgen receptor, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Chromatin immunoprecipitation, Signal Transduction
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المؤلفون: Katharina Meier, Joseph P. Bluck, Clara D. Christ
المصدر: Free Energy Methods in Drug Discovery: Current State and Future Directions ISBN: 9780841298064
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f3ef9c01b6eb9deef3a0c2d728901906
https://doi.org/10.1021/bk-2021-1397.ch002 -
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المؤلفون: J. Schroeder, Stefan Gradl, Volker Badock, Knut Eis, Benjamin Bader, Hans Briem, Clara D. Christ, Patrick Steigemann, Roman C. Hillig, Duy Nguyen, Jérémie Mortier, Marcus Bauser, Anders Friberg, Dieter Moosmayer, Franziska Siegel
المصدر: ChemMedChem. 15:827-832
مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, Allosteric regulation, Naphthyridinone, Druggability, Computational biology, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Workflow, Covalent bond, Docking (molecular), Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Pharmacophore
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6
المؤلفون: Clara D. Christ, Judith Günther, Katharina Meier, Simon Olsson, Lluís Raich, Frank Noé
المصدر: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciencesمصطلحات موضوعية: 0301 basic medicine, Protein Conformation, alpha-Helical, Transient state, Allosteric regulation, Cell Cycle Proteins, Computational biology, Molecular Dynamics Simulation, Tripartite Motif-Containing Protein 28, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, 03 medical and health sciences, Molecular dynamics, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Histone Acetyltransferases, 030304 developmental biology, Histone binding, 0303 health sciences, Multidisciplinary, Binding Sites, Sequence Homology, Amino Acid, biology, Chemistry, Intracellular Signaling Peptides and Proteins, Rational design, DNA, Markov Chains, 0104 chemical sciences, 3. Good health, Bromodomain, DNA-Binding Proteins, 030104 developmental biology, Histone, Gene Expression Regulation, Acetylation, Physical Sciences, Helix, biology.protein, Thermodynamics, Protein Conformation, beta-Strand, Transcription Factors, General, Co-Repressor Proteins, Sequence Alignment, Protein Binding, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c07c9aa796259799a295f820e61afb
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المؤلفون: Jérémie, Mortier, Anders, Friberg, Volker, Badock, Dieter, Moosmayer, Jens, Schroeder, Patrick, Steigemann, Franziska, Siegel, Stefan, Gradl, Marcus, Bauser, Roman C, Hillig, Hans, Briem, Knut, Eis, Benjamin, Bader, Duy, Nguyen, Clara D, Christ
المصدر: Chemmedchem
مصطلحات موضوعية: free-energy perturbation (FEP), Dose-Response Relationship, Drug, Molecular Structure, Communication, Communications, molecular dynamics, Proto-Oncogene Proteins p21(ras), Structure-Activity Relationship, virtual library design, Allosteric Regulation, medicinal chemistry, Mutation, KRAS, Humans, Enzyme Inhibitors
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المؤلفون: Vincent Wagner, Kai Sommer, Linda Jantz, Matthias Rarey, Hans Briem, Clara D. Christ
المصدر: Chemmedchem
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Macrocyclic Compounds, 010304 chemical physics, Molecular model, Full Paper, Molecular Structure, Drug discovery, Computer science, drug design, molecular modeling, Organic Chemistry, free energy calculations, Full Papers, 01 natural sciences, Biochemistry, Combinatorial chemistry, molecular dynamics, 03 medical and health sciences, 030104 developmental biology, macrocycles, 0103 physical sciences, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics
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9كتاب إلكتروني
المؤلفون: Kira A. Armacost, David C. Thompson, Zoe Cournia, Christophe Chipot, Benoît Roux, Darrin M. York, Woody Sherman, Katharina Meier, Joseph P. Bluck, Clara D. Christ, Nicolas Tielker, Lukas Eberlein, Oliver Beckstein, Stefan Güssregen, Bogdan I. Iorga, Stefan M. Kast, Shuai Liu, Miroslav Suruzhon, Marley L. Samways, Jonathan W. Essex, Ayşegül Özen, Emanuele Perola, Natasja Brooijmans, Joseph Kim, Dilek Coskun, Tai-Sung Lee, Hsu-Chun Tsai, Abir Ganguly, Timothy J. Giese, Jennifer L. Knight, Karl Leswing, Pieter H. Bos, Lingle Wang, Paul Labute, Maximilian Ebert, Lance M. Westerhoff, Zheng Zheng, Eric C. Gladstone
نوع المادة: eBook.
الموضوعات: Thermodynamic potentials, Drugs--Design, Drug development
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المؤلفون: Jérémie Mortier, Marcus Bauser, Stefan Gradl, Volker Badock, Duy Nguyen, Hans Briem, J. Schroeder, Knut Eis, Benjamin Bader, Clara D. Christ, Dieter Moosmayer, Anders Friberg, Roman C. Hillig, Franziska Siegel, Patrick Steigemann
المصدر: ChemMedChem. 15:808-808
مصطلحات موضوعية: Pharmacology, Front cover, Workflow, Covalent bond, Computer science, Organic Chemistry, Drug Discovery, Allosteric regulation, Molecular Medicine, Computational biology, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry